Acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acyltransferase

Gene product:

diacylglycerol acyltransferase, putative

Species:

Leishmania major

UniProt:

E9ADD8_LEIMA

TriTrypDb:

LmjF.27.1560 , LMJLV39_270021900 , LMJSD75_270022100

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	4
GO:0016020	membrane	2	5
GO:0031090	organelle membrane	3	4
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ADD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADD8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006638	neutral lipid metabolic process	4	2
GO:0006639	acylglycerol metabolic process	5	2
GO:0006641	triglyceride metabolic process	6	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019432	triglyceride biosynthetic process	6	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046460	neutral lipid biosynthetic process	4	2
GO:0046463	acylglycerol biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004144	diacylglycerol O-acyltransferase activity	7	2
GO:0008374	O-acyltransferase activity	5	6
GO:0016411	acylglycerol O-acyltransferase activity	6	2
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.382
CLV_NRD_NRD_1	276	278	PF00675	0.337
CLV_NRD_NRD_1	293	295	PF00675	0.182
CLV_NRD_NRD_1	312	314	PF00675	0.293
CLV_PCSK_KEX2_1	150	152	PF00082	0.382
CLV_PCSK_KEX2_1	276	278	PF00082	0.346
CLV_PCSK_KEX2_1	292	294	PF00082	0.225
CLV_PCSK_KEX2_1	314	316	PF00082	0.479
CLV_PCSK_KEX2_1	327	329	PF00082	0.367
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.479
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.367
CLV_PCSK_SKI1_1	182	186	PF00082	0.382
CLV_PCSK_SKI1_1	287	291	PF00082	0.303
CLV_Separin_Metazoa	172	176	PF03568	0.582
DEG_APCC_DBOX_1	199	207	PF00400	0.582
DEG_APCC_DBOX_1	224	232	PF00400	0.537
DEG_APCC_DBOX_1	249	257	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DOC_CKS1_1	249	254	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.537
DOC_MAPK_DCC_7	200	209	PF00069	0.480
DOC_MAPK_FxFP_2	233	236	PF00069	0.503
DOC_MAPK_gen_1	222	230	PF00069	0.525
DOC_MAPK_HePTP_8	197	209	PF00069	0.582
DOC_MAPK_MEF2A_6	200	209	PF00069	0.480
DOC_MAPK_MEF2A_6	222	230	PF00069	0.582
DOC_MAPK_MEF2A_6	242	249	PF00069	0.355
DOC_MAPK_MEF2A_6	250	257	PF00069	0.471
DOC_MAPK_NFAT4_5	242	250	PF00069	0.537
DOC_PP1_RVXF_1	227	234	PF00149	0.503
DOC_PP1_RVXF_1	45	52	PF00149	0.582
DOC_PP2B_LxvP_1	131	134	PF13499	0.446
DOC_PP2B_LxvP_1	245	248	PF13499	0.503
DOC_PP2B_LxvP_1	261	264	PF13499	0.503
DOC_PP4_FxxP_1	233	236	PF00568	0.503
DOC_PP4_FxxP_1	243	246	PF00568	0.503
DOC_PP4_FxxP_1	249	252	PF00568	0.503
DOC_USP7_MATH_1	176	180	PF00917	0.446
DOC_USP7_MATH_1	196	200	PF00917	0.491
DOC_USP7_MATH_1	321	325	PF00917	0.660
DOC_WW_Pin1_4	248	253	PF00397	0.503
LIG_14-3-3_CanoR_1	120	130	PF00244	0.519
LIG_14-3-3_CanoR_1	150	154	PF00244	0.582
LIG_14-3-3_CanoR_1	159	164	PF00244	0.582
LIG_14-3-3_CanoR_1	175	185	PF00244	0.427
LIG_14-3-3_CanoR_1	225	229	PF00244	0.582
LIG_14-3-3_CanoR_1	250	256	PF00244	0.503
LIG_14-3-3_CanoR_1	276	283	PF00244	0.537
LIG_14-3-3_CanoR_1	50	58	PF00244	0.582
LIG_Actin_WH2_2	126	144	PF00022	0.485
LIG_Actin_WH2_2	99	115	PF00022	0.582
LIG_APCC_ABBAyCdc20_2	56	62	PF00400	0.582
LIG_BRCT_BRCA1_1	47	51	PF00533	0.516
LIG_Clathr_ClatBox_1	304	308	PF01394	0.516
LIG_eIF4E_1	299	305	PF01652	0.559
LIG_FHA_1	188	194	PF00498	0.522
LIG_FHA_1	252	258	PF00498	0.503
LIG_LIR_Gen_1	100	111	PF02991	0.582
LIG_LIR_Gen_1	190	198	PF02991	0.582
LIG_LIR_Gen_1	280	291	PF02991	0.503
LIG_LIR_Gen_1	48	59	PF02991	0.582
LIG_LIR_LC3C_4	254	257	PF02991	0.537
LIG_LIR_Nem_3	100	106	PF02991	0.582
LIG_LIR_Nem_3	190	195	PF02991	0.582
LIG_LIR_Nem_3	280	286	PF02991	0.503
LIG_LIR_Nem_3	48	54	PF02991	0.555
LIG_LYPXL_yS_3	299	302	PF13949	0.556
LIG_NRBOX	25	31	PF00104	0.282
LIG_RPA_C_Fungi	154	166	PF08784	0.282
LIG_SH2_GRB2like	66	69	PF00017	0.381
LIG_SH2_STAT5	121	124	PF00017	0.473
LIG_SH2_STAT5	282	285	PF00017	0.362
LIG_SH2_STAT5	32	35	PF00017	0.549
LIG_SH2_STAT5	58	61	PF00017	0.366
LIG_SH2_STAT5	66	69	PF00017	0.278
LIG_SH2_STAT5	87	90	PF00017	0.381
LIG_SH3_3	199	205	PF00018	0.322
LIG_SH3_3	2	8	PF00018	0.598
LIG_SH3_3	233	239	PF00018	0.362
LIG_SH3_3	253	259	PF00018	0.155
LIG_SH3_3	70	76	PF00018	0.381
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.322
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.362
LIG_SUMO_SIM_anti_2	303	311	PF11976	0.533
LIG_SUMO_SIM_par_1	162	167	PF11976	0.473
LIG_SUMO_SIM_par_1	179	187	PF11976	0.203
LIG_SUMO_SIM_par_1	259	265	PF11976	0.391
LIG_SUMO_SIM_par_1	303	311	PF11976	0.533
LIG_TYR_ITIM	30	35	PF00017	0.473
LIG_WRC_WIRS_1	88	93	PF05994	0.473
MOD_CK1_1	149	155	PF00069	0.473
MOD_CK1_1	45	51	PF00069	0.381
MOD_GlcNHglycan	36	39	PF01048	0.463
MOD_GSK3_1	121	128	PF00069	0.473
MOD_GSK3_1	149	156	PF00069	0.385
MOD_GSK3_1	45	52	PF00069	0.381
MOD_NEK2_1	102	107	PF00069	0.389
MOD_NEK2_1	146	151	PF00069	0.470
MOD_NEK2_1	164	169	PF00069	0.184
MOD_NEK2_2	282	287	PF00069	0.409
MOD_NEK2_2	87	92	PF00069	0.473
MOD_PIKK_1	184	190	PF00454	0.368
MOD_PIKK_1	42	48	PF00454	0.473
MOD_PIKK_1	82	88	PF00454	0.473
MOD_PK_1	159	165	PF00069	0.473
MOD_PKA_1	276	282	PF00069	0.409
MOD_PKA_2	149	155	PF00069	0.473
MOD_PKA_2	224	230	PF00069	0.473
MOD_PKA_2	276	282	PF00069	0.409
MOD_PKA_2	49	55	PF00069	0.473
MOD_Plk_1	153	159	PF00069	0.381
MOD_Plk_1	82	88	PF00069	0.473
MOD_Plk_4	125	131	PF00069	0.473
MOD_Plk_4	159	165	PF00069	0.322
MOD_Plk_4	251	257	PF00069	0.362
MOD_ProDKin_1	248	254	PF00069	0.362
TRG_DiLeu_BaEn_1	181	186	PF01217	0.409
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.473
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.473
TRG_ENDOCYTIC_2	299	302	PF00928	0.436
TRG_ENDOCYTIC_2	32	35	PF00928	0.457
TRG_ENDOCYTIC_2	66	69	PF00928	0.322
TRG_ER_diArg_1	275	277	PF00400	0.409
TRG_ER_diArg_1	291	294	PF00400	0.206
TRG_NLS_MonoCore_2	312	317	PF00514	0.607
TRG_NLS_MonoExtN_4	313	318	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IHU0	Bodo saltans	31%	79%
A0A0S4J1B8	Bodo saltans	26%	97%
A0A0S4JRA5	Bodo saltans	40%	100%
A0A0S4JT55	Bodo saltans	25%	71%
A0A3R7NQK7	Trypanosoma rangeli	28%	66%
A0A3S7X0T2	Leishmania donovani	96%	100%
A1A442	Ricinus communis	28%	97%
A2ADU8	Mus musculus	29%	98%
A2ADU9	Mus musculus	25%	100%
A4I2V0	Leishmania infantum	96%	100%
A6QP72	Bos taurus	28%	98%
C9ZK51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	67%
E8NHG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
K7K424	Glycine max	30%	100%
O74850	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	96%
Q08650	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	79%
Q28C88	Xenopus tropicalis	27%	99%
Q2KHS5	Xenopus laevis	26%	99%
Q3KPP4	Xenopus laevis	26%	99%
Q3SYC2	Homo sapiens	27%	99%
Q4V9F0	Danio rerio	30%	91%
Q54GC1	Dictyostelium discoideum	28%	100%
Q58HT5	Homo sapiens	25%	100%
Q5FVP8	Rattus norvegicus	26%	85%
Q5M7F4	Xenopus laevis	25%	99%
Q5M8H5	Xenopus tropicalis	26%	99%
Q6E1M8	Mus musculus	27%	99%
Q6E213	Homo sapiens	26%	99%
Q6P342	Xenopus tropicalis	27%	91%
Q6PAZ3	Xenopus laevis	27%	91%
Q6ZPD8	Homo sapiens	28%	98%
Q70VZ7	Bos taurus	27%	99%
Q70VZ8	Bos taurus	26%	91%
Q75BY0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	72%
Q80W94	Mus musculus	28%	99%
Q86VF5	Homo sapiens	28%	97%
Q91ZV4	Mus musculus	27%	99%
Q96PD6	Homo sapiens	25%	99%
Q96PD7	Homo sapiens	26%	85%
Q96UY1	Umbelopsis ramanniana	34%	95%
Q96UY2	Umbelopsis ramanniana	29%	93%
Q9ASU1	Arabidopsis thaliana	29%	100%
Q9DCV3	Mus musculus	26%	85%