Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADD6_LEIMA

TriTrypDb:

LmjF.27.1570 , LMJLV39_270022000 , LMJSD75_270022200

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.386
CLV_C14_Caspase3-7	265	269	PF00656	0.514
CLV_NRD_NRD_1	107	109	PF00675	0.468
CLV_NRD_NRD_1	11	13	PF00675	0.449
CLV_NRD_NRD_1	202	204	PF00675	0.455
CLV_NRD_NRD_1	3	5	PF00675	0.550
CLV_NRD_NRD_1	355	357	PF00675	0.418
CLV_NRD_NRD_1	433	435	PF00675	0.554
CLV_PCSK_FUR_1	105	109	PF00082	0.415
CLV_PCSK_KEX2_1	107	109	PF00082	0.468
CLV_PCSK_KEX2_1	11	13	PF00082	0.449
CLV_PCSK_KEX2_1	202	204	PF00082	0.455
CLV_PCSK_KEX2_1	3	5	PF00082	0.550
CLV_PCSK_KEX2_1	354	356	PF00082	0.385
CLV_PCSK_KEX2_1	433	435	PF00082	0.554
CLV_PCSK_SKI1_1	108	112	PF00082	0.572
CLV_PCSK_SKI1_1	121	125	PF00082	0.371
CLV_PCSK_SKI1_1	133	137	PF00082	0.345
CLV_PCSK_SKI1_1	139	143	PF00082	0.281
CLV_PCSK_SKI1_1	202	206	PF00082	0.332
DEG_APCC_DBOX_1	95	103	PF00400	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.671
DOC_CDC14_PxL_1	267	275	PF14671	0.514
DOC_CYCLIN_RxL_1	197	211	PF00134	0.452
DOC_MAPK_gen_1	202	209	PF00069	0.438
DOC_MAPK_gen_1	3	9	PF00069	0.603
DOC_MAPK_MEF2A_6	202	209	PF00069	0.345
DOC_MAPK_NFAT4_5	202	210	PF00069	0.349
DOC_PP1_RVXF_1	119	125	PF00149	0.507
DOC_PP4_FxxP_1	274	277	PF00568	0.656
DOC_USP7_MATH_1	336	340	PF00917	0.448
DOC_WW_Pin1_4	17	22	PF00397	0.508
DOC_WW_Pin1_4	332	337	PF00397	0.470
DOC_WW_Pin1_4	424	429	PF00397	0.509
LIG_14-3-3_CanoR_1	152	157	PF00244	0.397
LIG_14-3-3_CanoR_1	355	361	PF00244	0.425
LIG_14-3-3_CanoR_1	77	85	PF00244	0.468
LIG_Actin_WH2_2	380	398	PF00022	0.375
LIG_AP2alpha_1	149	153	PF02296	0.332
LIG_APCC_ABBA_1	63	68	PF00400	0.397
LIG_BIR_III_2	268	272	PF00653	0.547
LIG_BIR_III_2	291	295	PF00653	0.643
LIG_BIR_III_2	319	323	PF00653	0.423
LIG_BRCT_BRCA1_1	136	140	PF00533	0.504
LIG_CaM_IQ_9	150	165	PF13499	0.498
LIG_CSL_BTD_1	18	21	PF09270	0.511
LIG_CtBP_PxDLS_1	423	427	PF00389	0.543
LIG_FHA_1	130	136	PF00498	0.433
LIG_FHA_1	258	264	PF00498	0.539
LIG_FHA_1	29	35	PF00498	0.515
LIG_FHA_2	129	135	PF00498	0.419
LIG_FHA_2	232	238	PF00498	0.519
LIG_FHA_2	33	39	PF00498	0.548
LIG_FHA_2	371	377	PF00498	0.417
LIG_FHA_2	398	404	PF00498	0.399
LIG_FHA_2	427	433	PF00498	0.532
LIG_GBD_Chelix_1	262	270	PF00786	0.554
LIG_HCF-1_HBM_1	175	178	PF13415	0.426
LIG_LIR_Gen_1	151	161	PF02991	0.358
LIG_LIR_Gen_1	367	377	PF02991	0.395
LIG_LIR_Nem_3	151	156	PF02991	0.347
LIG_LIR_Nem_3	175	181	PF02991	0.440
LIG_LIR_Nem_3	198	204	PF02991	0.330
LIG_LIR_Nem_3	367	372	PF02991	0.506
LIG_LIR_Nem_3	389	395	PF02991	0.422
LIG_MYND_1	271	275	PF01753	0.625
LIG_Pex14_2	149	153	PF04695	0.332
LIG_REV1ctd_RIR_1	154	164	PF16727	0.413
LIG_REV1ctd_RIR_1	390	400	PF16727	0.372
LIG_SH2_NCK_1	87	91	PF00017	0.422
LIG_SH2_STAP1	55	59	PF00017	0.420
LIG_SH2_STAT5	178	181	PF00017	0.370
LIG_SH2_STAT5	327	330	PF00017	0.385
LIG_SH3_2	428	433	PF14604	0.497
LIG_SH3_3	269	275	PF00018	0.614
LIG_SH3_3	425	431	PF00018	0.502
LIG_SH3_3	43	49	PF00018	0.428
LIG_TRAF2_1	35	38	PF00917	0.434
LIG_TYR_ITIM	85	90	PF00017	0.396
LIG_WRC_WIRS_1	153	158	PF05994	0.400
MOD_CK1_1	414	420	PF00069	0.624
MOD_CK1_1	80	86	PF00069	0.470
MOD_CK2_1	111	117	PF00069	0.612
MOD_CK2_1	128	134	PF00069	0.361
MOD_CK2_1	177	183	PF00069	0.339
MOD_CK2_1	231	237	PF00069	0.496
MOD_CK2_1	32	38	PF00069	0.442
MOD_CK2_1	370	376	PF00069	0.443
MOD_CK2_1	397	403	PF00069	0.396
MOD_CK2_1	426	432	PF00069	0.615
MOD_CK2_1	85	91	PF00069	0.396
MOD_GlcNHglycan	113	116	PF01048	0.538
MOD_GlcNHglycan	136	139	PF01048	0.420
MOD_GlcNHglycan	25	28	PF01048	0.565
MOD_GlcNHglycan	257	260	PF01048	0.580
MOD_GlcNHglycan	414	417	PF01048	0.541
MOD_GlcNHglycan	81	85	PF01048	0.431
MOD_GSK3_1	17	24	PF00069	0.497
MOD_GSK3_1	28	35	PF00069	0.478
MOD_GSK3_1	332	339	PF00069	0.412
MOD_GSK3_1	69	76	PF00069	0.493
MOD_N-GLC_1	21	26	PF02516	0.618
MOD_NEK2_1	111	116	PF00069	0.625
MOD_NEK2_1	69	74	PF00069	0.506
MOD_PKA_2	231	237	PF00069	0.545
MOD_PKA_2	409	415	PF00069	0.463
MOD_PKB_1	354	362	PF00069	0.428
MOD_PKB_1	75	83	PF00069	0.535
MOD_Plk_1	340	346	PF00069	0.432
MOD_Plk_1	80	86	PF00069	0.464
MOD_Plk_2-3	208	214	PF00069	0.378
MOD_Plk_4	152	158	PF00069	0.403
MOD_ProDKin_1	17	23	PF00069	0.510
MOD_ProDKin_1	332	338	PF00069	0.466
MOD_ProDKin_1	424	430	PF00069	0.505
MOD_SUMO_rev_2	129	138	PF00179	0.515
TRG_AP2beta_CARGO_1	151	160	PF09066	0.413
TRG_DiLeu_BaEn_1	403	408	PF01217	0.434
TRG_ENDOCYTIC_2	178	181	PF00928	0.442
TRG_ENDOCYTIC_2	201	204	PF00928	0.347
TRG_ENDOCYTIC_2	369	372	PF00928	0.390
TRG_ENDOCYTIC_2	44	47	PF00928	0.418
TRG_ENDOCYTIC_2	87	90	PF00928	0.401
TRG_ER_diArg_1	146	149	PF00400	0.435
TRG_ER_diArg_1	2	4	PF00400	0.574
TRG_ER_diArg_1	201	203	PF00400	0.434
TRG_ER_diArg_1	219	222	PF00400	0.319
TRG_ER_diArg_1	354	356	PF00400	0.385
TRG_ER_diArg_1	433	435	PF00400	0.556
TRG_ER_diArg_1	75	78	PF00400	0.518
TRG_NES_CRM1_1	386	399	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	203	208	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE13	Leptomonas seymouri	63%	90%
A0A1X0P4A4	Trypanosomatidae	48%	92%
A0A381ML35	Leishmania infantum	97%	100%
A0A3Q8IGD4	Leishmania donovani	97%	100%
A0A3Q8IQ02	Leishmania donovani	97%	100%
A0A3R7LRX2	Trypanosoma rangeli	53%	97%
A4HFT4	Leishmania braziliensis	84%	98%
D0A626	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9AZ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%