Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADD1_LEIMA

TriTrypDb:

LmjF.27.1520 , LMJLV39_270021500 , LMJSD75_270021700

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.701
CLV_C14_Caspase3-7	352	356	PF00656	0.712
CLV_C14_Caspase3-7	459	463	PF00656	0.723
CLV_MEL_PAP_1	116	122	PF00089	0.587
CLV_NRD_NRD_1	332	334	PF00675	0.742
CLV_NRD_NRD_1	339	341	PF00675	0.760
CLV_NRD_NRD_1	579	581	PF00675	0.692
CLV_NRD_NRD_1	677	679	PF00675	0.522
CLV_PCSK_FUR_1	329	333	PF00082	0.844
CLV_PCSK_FUR_1	340	344	PF00082	0.571
CLV_PCSK_KEX2_1	331	333	PF00082	0.749
CLV_PCSK_KEX2_1	338	340	PF00082	0.750
CLV_PCSK_KEX2_1	342	344	PF00082	0.728
CLV_PCSK_KEX2_1	581	583	PF00082	0.568
CLV_PCSK_KEX2_1	677	679	PF00082	0.522
CLV_PCSK_KEX2_1	714	716	PF00082	0.580
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.786
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.790
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.527
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.580
CLV_PCSK_SKI1_1	152	156	PF00082	0.492
CLV_PCSK_SKI1_1	33	37	PF00082	0.489
CLV_PCSK_SKI1_1	45	49	PF00082	0.465
CLV_PCSK_SKI1_1	531	535	PF00082	0.462
CLV_PCSK_SKI1_1	54	58	PF00082	0.442
CLV_PCSK_SKI1_1	691	695	PF00082	0.469
CLV_PCSK_SKI1_1	725	729	PF00082	0.625
CLV_PCSK_SKI1_1	74	78	PF00082	0.436
DEG_APCC_DBOX_1	635	643	PF00400	0.605
DEG_APCC_DBOX_1	690	698	PF00400	0.466
DEG_APCC_DBOX_1	724	732	PF00400	0.620
DEG_APCC_DBOX_1	73	81	PF00400	0.459
DEG_ODPH_VHL_1	128	140	PF01847	0.483
DEG_SPOP_SBC_1	196	200	PF00917	0.466
DOC_ANK_TNKS_1	728	735	PF00023	0.444
DOC_CKS1_1	433	438	PF01111	0.512
DOC_CKS1_1	553	558	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.614
DOC_MAPK_gen_1	132	140	PF00069	0.466
DOC_MAPK_gen_1	303	310	PF00069	0.689
DOC_MAPK_gen_1	528	538	PF00069	0.464
DOC_MAPK_MEF2A_6	531	540	PF00069	0.506
DOC_MAPK_MEF2A_6	651	659	PF00069	0.461
DOC_PP1_RVXF_1	31	37	PF00149	0.468
DOC_PP2B_LxvP_1	127	130	PF13499	0.465
DOC_PP4_MxPP_1	193	196	PF00568	0.542
DOC_USP7_MATH_1	189	193	PF00917	0.565
DOC_USP7_MATH_1	203	207	PF00917	0.508
DOC_USP7_MATH_1	311	315	PF00917	0.709
DOC_USP7_MATH_1	369	373	PF00917	0.802
DOC_USP7_MATH_1	391	395	PF00917	0.690
DOC_USP7_MATH_1	455	459	PF00917	0.701
DOC_USP7_MATH_1	549	553	PF00917	0.513
DOC_USP7_MATH_1	685	689	PF00917	0.518
DOC_USP7_MATH_2	519	525	PF00917	0.517
DOC_USP7_UBL2_3	338	342	PF12436	0.762
DOC_WW_Pin1_4	17	22	PF00397	0.485
DOC_WW_Pin1_4	218	223	PF00397	0.595
DOC_WW_Pin1_4	243	248	PF00397	0.624
DOC_WW_Pin1_4	379	384	PF00397	0.763
DOC_WW_Pin1_4	415	420	PF00397	0.557
DOC_WW_Pin1_4	432	437	PF00397	0.508
DOC_WW_Pin1_4	515	520	PF00397	0.544
DOC_WW_Pin1_4	552	557	PF00397	0.605
DOC_WW_Pin1_4	662	667	PF00397	0.577
LIG_14-3-3_CanoR_1	119	128	PF00244	0.472
LIG_14-3-3_CanoR_1	132	141	PF00244	0.487
LIG_14-3-3_CanoR_1	19	29	PF00244	0.547
LIG_14-3-3_CanoR_1	270	278	PF00244	0.513
LIG_14-3-3_CanoR_1	332	341	PF00244	0.712
LIG_14-3-3_CanoR_1	45	51	PF00244	0.471
LIG_14-3-3_CanoR_1	597	602	PF00244	0.566
LIG_14-3-3_CanoR_1	613	622	PF00244	0.352
LIG_14-3-3_CanoR_1	646	655	PF00244	0.587
LIG_Actin_WH2_2	400	418	PF00022	0.569
LIG_eIF4E_1	29	35	PF01652	0.472
LIG_EVH1_2	183	187	PF00568	0.549
LIG_FHA_1	122	128	PF00498	0.467
LIG_FHA_1	196	202	PF00498	0.707
LIG_FHA_1	248	254	PF00498	0.511
LIG_FHA_1	279	285	PF00498	0.605
LIG_FHA_1	305	311	PF00498	0.638
LIG_FHA_1	398	404	PF00498	0.732
LIG_FHA_1	63	69	PF00498	0.490
LIG_FHA_1	650	656	PF00498	0.338
LIG_FHA_1	685	691	PF00498	0.486
LIG_FHA_2	134	140	PF00498	0.488
LIG_FHA_2	295	301	PF00498	0.639
LIG_FHA_2	350	356	PF00498	0.689
LIG_FHA_2	516	522	PF00498	0.532
LIG_FHA_2	555	561	PF00498	0.513
LIG_FHA_2	614	620	PF00498	0.556
LIG_FHA_2	7	13	PF00498	0.494
LIG_LIR_Gen_1	298	309	PF02991	0.650
LIG_LIR_Gen_1	372	381	PF02991	0.579
LIG_LIR_Gen_1	557	567	PF02991	0.574
LIG_LIR_Gen_1	9	17	PF02991	0.476
LIG_LIR_Nem_3	298	304	PF02991	0.641
LIG_LIR_Nem_3	372	377	PF02991	0.579
LIG_LIR_Nem_3	71	76	PF02991	0.463
LIG_LIR_Nem_3	9	13	PF02991	0.482
LIG_NRBOX	252	258	PF00104	0.491
LIG_PTAP_UEV_1	382	387	PF05743	0.582
LIG_SH2_CRK	64	68	PF00017	0.491
LIG_SH2_CRK	699	703	PF00017	0.517
LIG_SH2_CRK	73	77	PF00017	0.454
LIG_SH2_STAP1	675	679	PF00017	0.505
LIG_SH2_STAT3	63	66	PF00017	0.495
LIG_SH2_STAT3	695	698	PF00017	0.469
LIG_SH2_STAT5	252	255	PF00017	0.487
LIG_SH2_STAT5	64	67	PF00017	0.504
LIG_SH2_STAT5	695	698	PF00017	0.469
LIG_SH2_STAT5	8	11	PF00017	0.485
LIG_SH3_3	305	311	PF00018	0.769
LIG_SH3_3	34	40	PF00018	0.499
LIG_SH3_3	348	354	PF00018	0.747
LIG_SH3_3	380	386	PF00018	0.761
LIG_SH3_3	451	457	PF00018	0.623
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.489
LIG_SUMO_SIM_anti_2	652	657	PF11976	0.325
LIG_SUMO_SIM_par_1	306	312	PF11976	0.605
LIG_SUMO_SIM_par_1	348	355	PF11976	0.592
LIG_SUMO_SIM_par_1	46	51	PF11976	0.451
LIG_SUMO_SIM_par_1	640	645	PF11976	0.645
LIG_UBA3_1	425	432	PF00899	0.488
LIG_UBA3_1	727	735	PF00899	0.531
MOD_CK1_1	115	121	PF00069	0.496
MOD_CK1_1	20	26	PF00069	0.530
MOD_CK1_1	251	257	PF00069	0.487
MOD_CK1_1	288	294	PF00069	0.618
MOD_CK1_1	3	9	PF00069	0.558
MOD_CK1_1	349	355	PF00069	0.788
MOD_CK1_1	372	378	PF00069	0.798
MOD_CK1_1	384	390	PF00069	0.674
MOD_CK1_1	418	424	PF00069	0.516
MOD_CK1_1	552	558	PF00069	0.497
MOD_CK1_1	605	611	PF00069	0.535
MOD_CK1_1	649	655	PF00069	0.345
MOD_CK2_1	294	300	PF00069	0.745
MOD_CK2_1	515	521	PF00069	0.546
MOD_CK2_1	554	560	PF00069	0.513
MOD_CK2_1	613	619	PF00069	0.551
MOD_GlcNHglycan	164	167	PF01048	0.495
MOD_GlcNHglycan	205	208	PF01048	0.621
MOD_GlcNHglycan	322	325	PF01048	0.731
MOD_GlcNHglycan	335	338	PF01048	0.705
MOD_GlcNHglycan	383	386	PF01048	0.633
MOD_GlcNHglycan	389	392	PF01048	0.690
MOD_GlcNHglycan	458	461	PF01048	0.794
MOD_GlcNHglycan	5	8	PF01048	0.656
MOD_GlcNHglycan	511	514	PF01048	0.597
MOD_GlcNHglycan	549	552	PF01048	0.488
MOD_GlcNHglycan	604	607	PF01048	0.541
MOD_GSK3_1	111	118	PF00069	0.524
MOD_GSK3_1	195	202	PF00069	0.596
MOD_GSK3_1	226	233	PF00069	0.487
MOD_GSK3_1	243	250	PF00069	0.522
MOD_GSK3_1	345	352	PF00069	0.766
MOD_GSK3_1	369	376	PF00069	0.791
MOD_GSK3_1	377	384	PF00069	0.703
MOD_GSK3_1	387	394	PF00069	0.608
MOD_GSK3_1	397	404	PF00069	0.681
MOD_GSK3_1	582	589	PF00069	0.763
MOD_GSK3_1	627	634	PF00069	0.590
MOD_LATS_1	83	89	PF00433	0.611
MOD_N-GLC_1	377	382	PF02516	0.724
MOD_N-GLC_1	679	684	PF02516	0.610
MOD_N-GLC_2	658	660	PF02516	0.457
MOD_NEK2_1	248	253	PF00069	0.489
MOD_NEK2_1	256	261	PF00069	0.510
MOD_NEK2_1	377	382	PF00069	0.755
MOD_NEK2_1	442	447	PF00069	0.538
MOD_NEK2_1	509	514	PF00069	0.576
MOD_NEK2_1	522	527	PF00069	0.499
MOD_NEK2_1	563	568	PF00069	0.375
MOD_NEK2_2	189	194	PF00069	0.616
MOD_PIKK_1	20	26	PF00454	0.521
MOD_PIKK_1	62	68	PF00454	0.485
MOD_PIKK_1	627	633	PF00454	0.698
MOD_PIKK_1	685	691	PF00454	0.510
MOD_PK_1	586	592	PF00069	0.653
MOD_PK_1	597	603	PF00069	0.559
MOD_PKA_2	118	124	PF00069	0.480
MOD_PKA_2	269	275	PF00069	0.511
MOD_PKA_2	304	310	PF00069	0.573
MOD_PKA_2	596	602	PF00069	0.555
MOD_PKA_2	612	618	PF00069	0.527
MOD_PKB_1	331	339	PF00069	0.829
MOD_PKB_1	343	351	PF00069	0.553
MOD_PKB_1	580	588	PF00069	0.513
MOD_Plk_1	299	305	PF00069	0.742
MOD_Plk_1	345	351	PF00069	0.639
MOD_Plk_1	377	383	PF00069	0.721
MOD_Plk_1	563	569	PF00069	0.373
MOD_Plk_4	226	232	PF00069	0.503
MOD_Plk_4	248	254	PF00069	0.597
MOD_Plk_4	304	310	PF00069	0.692
MOD_Plk_4	346	352	PF00069	0.594
MOD_Plk_4	522	528	PF00069	0.503
MOD_Plk_4	54	60	PF00069	0.476
MOD_Plk_4	549	555	PF00069	0.583
MOD_Plk_4	605	611	PF00069	0.439
MOD_Plk_4	651	657	PF00069	0.462
MOD_ProDKin_1	17	23	PF00069	0.492
MOD_ProDKin_1	218	224	PF00069	0.587
MOD_ProDKin_1	243	249	PF00069	0.615
MOD_ProDKin_1	379	385	PF00069	0.763
MOD_ProDKin_1	415	421	PF00069	0.551
MOD_ProDKin_1	432	438	PF00069	0.511
MOD_ProDKin_1	515	521	PF00069	0.546
MOD_ProDKin_1	552	558	PF00069	0.599
MOD_ProDKin_1	662	668	PF00069	0.572
MOD_SUMO_for_1	341	344	PF00179	0.597
MOD_SUMO_for_1	713	716	PF00179	0.519
MOD_SUMO_rev_2	259	268	PF00179	0.530
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.467
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.615
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.489
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.467
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.479
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.616
TRG_ENDOCYTIC_2	73	76	PF00928	0.457
TRG_ER_diArg_1	329	332	PF00400	0.838
TRG_ER_diArg_1	339	341	PF00400	0.600
TRG_ER_diArg_1	573	576	PF00400	0.483
TRG_ER_diArg_1	677	679	PF00400	0.522
TRG_NLS_MonoExtC_3	337	342	PF00514	0.778
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D1	Leptomonas seymouri	63%	100%
A0A3S7X0R8	Leishmania donovani	94%	100%
A4HFT0	Leishmania braziliensis	79%	100%
A4I368	Leishmania infantum	94%	100%
E9AZ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%