Polyprenol reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADD0_LEIMA

TriTrypDb:

LmjF.27.1510 , LMJLV39_270021400 , LMJSD75_270021600

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0031090	organelle membrane	3	7

Expansion

Sequence features

E9ADD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADD0

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	9
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	9
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	9
GO:0006629	lipid metabolic process	3	9
GO:0006720	isoprenoid metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0008299	isoprenoid biosynthetic process	4	2
GO:0008300	isoprenoid catabolic process	5	9
GO:0008610	lipid biosynthetic process	4	2
GO:0009056	catabolic process	2	9
GO:0009058	biosynthetic process	2	9
GO:0009987	cellular process	1	9
GO:0016042	lipid catabolic process	4	9
GO:0016093	polyprenol metabolic process	4	9
GO:0016094	polyprenol biosynthetic process	5	2
GO:0016095	polyprenol catabolic process	5	9
GO:0019348	dolichol metabolic process	5	9
GO:0019408	dolichol biosynthetic process	6	2
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044242	cellular lipid catabolic process	4	9
GO:0044248	cellular catabolic process	3	9
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	9
GO:0044281	small molecule metabolic process	2	9
GO:0044282	small molecule catabolic process	3	9
GO:0044283	small molecule biosynthetic process	3	2
GO:0046164	alcohol catabolic process	4	9
GO:0046165	alcohol biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901137	carbohydrate derivative biosynthetic process	4	9
GO:1901575	organic substance catabolic process	3	9
GO:1901576	organic substance biosynthetic process	3	9
GO:1901615	organic hydroxy compound metabolic process	3	9
GO:1901616	organic hydroxy compound catabolic process	4	9
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	5	9
GO:0016229	steroid dehydrogenase activity	3	9
GO:0016491	oxidoreductase activity	2	9
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	9
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	4	9
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	7
GO:0102389	polyprenol reductase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.561
CLV_NRD_NRD_1	144	146	PF00675	0.331
CLV_NRD_NRD_1	318	320	PF00675	0.476
CLV_NRD_NRD_1	349	351	PF00675	0.445
CLV_NRD_NRD_1	452	454	PF00675	0.347
CLV_NRD_NRD_1	462	464	PF00675	0.354
CLV_PCSK_KEX2_1	318	320	PF00082	0.466
CLV_PCSK_KEX2_1	349	351	PF00082	0.465
CLV_PCSK_KEX2_1	452	454	PF00082	0.347
CLV_PCSK_KEX2_1	462	464	PF00082	0.354
CLV_PCSK_SKI1_1	10	14	PF00082	0.365
CLV_PCSK_SKI1_1	16	20	PF00082	0.350
CLV_PCSK_SKI1_1	2	6	PF00082	0.395
CLV_PCSK_SKI1_1	266	270	PF00082	0.468
CLV_PCSK_SKI1_1	470	474	PF00082	0.457
CLV_PCSK_SKI1_1	61	65	PF00082	0.399
DEG_APCC_DBOX_1	1	9	PF00400	0.599
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_SPOP_SBC_1	30	34	PF00917	0.570
DOC_CKS1_1	338	343	PF01111	0.668
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.451
DOC_MAPK_gen_1	218	227	PF00069	0.598
DOC_MAPK_MEF2A_6	37	46	PF00069	0.555
DOC_PP2B_LxvP_1	195	198	PF13499	0.369
DOC_USP7_MATH_1	170	174	PF00917	0.465
DOC_USP7_MATH_1	175	179	PF00917	0.488
DOC_USP7_MATH_1	241	245	PF00917	0.380
DOC_USP7_MATH_1	253	257	PF00917	0.415
DOC_USP7_MATH_1	325	329	PF00917	0.675
DOC_USP7_MATH_1	354	358	PF00917	0.563
DOC_USP7_MATH_1	421	425	PF00917	0.487
DOC_USP7_MATH_1	430	434	PF00917	0.474
DOC_WW_Pin1_4	125	130	PF00397	0.455
DOC_WW_Pin1_4	184	189	PF00397	0.553
DOC_WW_Pin1_4	293	298	PF00397	0.646
DOC_WW_Pin1_4	331	336	PF00397	0.775
DOC_WW_Pin1_4	337	342	PF00397	0.730
LIG_14-3-3_CanoR_1	10	19	PF00244	0.595
LIG_14-3-3_CanoR_1	140	149	PF00244	0.566
LIG_14-3-3_CanoR_1	209	216	PF00244	0.634
LIG_14-3-3_CanoR_1	254	262	PF00244	0.510
LIG_14-3-3_CanoR_1	352	361	PF00244	0.641
LIG_14-3-3_CanoR_1	37	43	PF00244	0.559
LIG_14-3-3_CanoR_1	409	417	PF00244	0.430
LIG_Actin_WH2_2	21	39	PF00022	0.577
LIG_Actin_WH2_2	279	296	PF00022	0.343
LIG_Actin_WH2_2	485	503	PF00022	0.610
LIG_BRCT_BRCA1_1	67	71	PF00533	0.427
LIG_EH1_1	151	159	PF00400	0.391
LIG_EH1_1	375	383	PF00400	0.485
LIG_FHA_1	13	19	PF00498	0.598
LIG_FHA_1	153	159	PF00498	0.382
LIG_FHA_1	211	217	PF00498	0.553
LIG_FHA_1	222	228	PF00498	0.474
LIG_FHA_1	233	239	PF00498	0.401
LIG_FHA_1	272	278	PF00498	0.320
LIG_FHA_1	31	37	PF00498	0.506
LIG_FHA_1	324	330	PF00498	0.537
LIG_FHA_1	368	374	PF00498	0.535
LIG_FHA_1	378	384	PF00498	0.369
LIG_FHA_1	459	465	PF00498	0.622
LIG_FHA_2	338	344	PF00498	0.659
LIG_FHA_2	409	415	PF00498	0.459
LIG_FHA_2	445	451	PF00498	0.552
LIG_FHA_2	469	475	PF00498	0.572
LIG_LIR_Gen_1	148	157	PF02991	0.401
LIG_LIR_Gen_1	226	236	PF02991	0.344
LIG_LIR_Gen_1	414	425	PF02991	0.483
LIG_LIR_Gen_1	68	79	PF02991	0.436
LIG_LIR_Nem_3	148	152	PF02991	0.401
LIG_LIR_Nem_3	226	231	PF02991	0.344
LIG_LIR_Nem_3	314	320	PF02991	0.628
LIG_LIR_Nem_3	414	420	PF02991	0.486
LIG_LIR_Nem_3	68	74	PF02991	0.403
LIG_LIR_Nem_3	82	86	PF02991	0.395
LIG_PALB2_WD40_1	423	431	PF16756	0.224
LIG_Pex14_1	67	71	PF04695	0.433
LIG_Pex14_2	137	141	PF04695	0.602
LIG_Pex14_2	164	168	PF04695	0.446
LIG_Pex14_2	515	519	PF04695	0.638
LIG_Pex14_2	79	83	PF04695	0.416
LIG_SH2_CRK	351	355	PF00017	0.544
LIG_SH2_STAP1	113	117	PF00017	0.489
LIG_SH2_STAP1	355	359	PF00017	0.591
LIG_SH2_STAP1	369	373	PF00017	0.498
LIG_SH2_STAT5	153	156	PF00017	0.344
LIG_SH2_STAT5	237	240	PF00017	0.344
LIG_SH2_STAT5	369	372	PF00017	0.516
LIG_SH3_3	187	193	PF00018	0.465
LIG_SH3_3	24	30	PF00018	0.586
LIG_SH3_3	361	367	PF00018	0.535
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.420
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.378
LIG_SUMO_SIM_par_1	181	187	PF11976	0.431
MOD_CK1_1	178	184	PF00069	0.570
MOD_CK1_1	248	254	PF00069	0.429
MOD_CK1_1	31	37	PF00069	0.569
MOD_CK1_1	408	414	PF00069	0.546
MOD_CK2_1	300	306	PF00069	0.662
MOD_CK2_1	337	343	PF00069	0.674
MOD_CK2_1	408	414	PF00069	0.438
MOD_CK2_1	444	450	PF00069	0.424
MOD_GlcNHglycan	113	116	PF01048	0.701
MOD_GlcNHglycan	159	162	PF01048	0.396
MOD_GlcNHglycan	243	246	PF01048	0.458
MOD_GlcNHglycan	411	414	PF01048	0.751
MOD_GlcNHglycan	428	431	PF01048	0.482
MOD_GlcNHglycan	447	450	PF01048	0.392
MOD_GlcNHglycan	466	469	PF01048	0.405
MOD_GlcNHglycan	92	95	PF01048	0.683
MOD_GSK3_1	141	148	PF00069	0.544
MOD_GSK3_1	152	159	PF00069	0.327
MOD_GSK3_1	170	177	PF00069	0.343
MOD_GSK3_1	241	248	PF00069	0.492
MOD_GSK3_1	271	278	PF00069	0.372
MOD_GSK3_1	293	300	PF00069	0.696
MOD_GSK3_1	389	396	PF00069	0.506
MOD_GSK3_1	405	412	PF00069	0.521
MOD_GSK3_1	426	433	PF00069	0.444
MOD_GSK3_1	464	471	PF00069	0.602
MOD_N-GLC_1	458	463	PF02516	0.388
MOD_N-GLC_2	358	360	PF02516	0.398
MOD_NEK2_1	133	138	PF00069	0.413
MOD_NEK2_1	152	157	PF00069	0.323
MOD_NEK2_1	210	215	PF00069	0.597
MOD_NEK2_1	324	329	PF00069	0.687
MOD_NEK2_1	444	449	PF00069	0.434
MOD_NEK2_1	464	469	PF00069	0.399
MOD_NEK2_2	232	237	PF00069	0.344
MOD_PIKK_1	10	16	PF00454	0.596
MOD_PIKK_1	253	259	PF00454	0.501
MOD_PIKK_1	304	310	PF00454	0.637
MOD_PKA_1	145	151	PF00069	0.494
MOD_PKA_2	141	147	PF00069	0.565
MOD_PKA_2	208	214	PF00069	0.623
MOD_PKA_2	253	259	PF00069	0.511
MOD_PKA_2	408	414	PF00069	0.435
MOD_Plk_4	133	139	PF00069	0.467
MOD_Plk_4	178	184	PF00069	0.466
MOD_Plk_4	223	229	PF00069	0.498
MOD_Plk_4	232	238	PF00069	0.328
MOD_Plk_4	285	291	PF00069	0.592
MOD_Plk_4	377	383	PF00069	0.405
MOD_Plk_4	434	440	PF00069	0.452
MOD_Plk_4	67	73	PF00069	0.418
MOD_ProDKin_1	125	131	PF00069	0.455
MOD_ProDKin_1	184	190	PF00069	0.550
MOD_ProDKin_1	293	299	PF00069	0.652
MOD_ProDKin_1	331	337	PF00069	0.775
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.365
TRG_ENDOCYTIC_2	66	69	PF00928	0.379
TRG_ER_diArg_1	317	319	PF00400	0.666
TRG_ER_diArg_1	348	350	PF00400	0.656
TRG_ER_diArg_1	452	454	PF00400	0.547
TRG_ER_diArg_1	462	464	PF00400	0.554
TRG_NES_CRM1_1	199	212	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXY2	Leptomonas seymouri	42%	100%
A0A1X0P483	Trypanosomatidae	31%	100%
A0A3Q8ICQ8	Leishmania donovani	92%	100%
A0A3R7NH72	Trypanosoma rangeli	34%	100%
A4HFS9	Leishmania braziliensis	73%	100%
A4I367	Leishmania infantum	92%	100%
D0A619	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%