Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADC8_LEIMA

TriTrypDb:

LmjF.27.1490 , LMJLV39_270021200 , LMJSD75_270021400

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.734
CLV_NRD_NRD_1	293	295	PF00675	0.664
CLV_NRD_NRD_1	348	350	PF00675	0.784
CLV_NRD_NRD_1	355	357	PF00675	0.696
CLV_NRD_NRD_1	361	363	PF00675	0.672
CLV_NRD_NRD_1	455	457	PF00675	0.541
CLV_NRD_NRD_1	535	537	PF00675	0.559
CLV_PCSK_KEX2_1	208	210	PF00082	0.734
CLV_PCSK_KEX2_1	348	350	PF00082	0.784
CLV_PCSK_KEX2_1	355	357	PF00082	0.696
CLV_PCSK_KEX2_1	360	362	PF00082	0.678
CLV_PCSK_KEX2_1	445	447	PF00082	0.540
CLV_PCSK_KEX2_1	455	457	PF00082	0.477
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.536
CLV_PCSK_PC7_1	356	362	PF00082	0.768
CLV_PCSK_SKI1_1	283	287	PF00082	0.638
CLV_PCSK_SKI1_1	296	300	PF00082	0.725
CLV_PCSK_SKI1_1	445	449	PF00082	0.525
CLV_PCSK_SKI1_1	512	516	PF00082	0.652
CLV_PCSK_SKI1_1	537	541	PF00082	0.555
CLV_PCSK_SKI1_1	91	95	PF00082	0.430
CLV_Separin_Metazoa	613	617	PF03568	0.549
DEG_APCC_DBOX_1	437	445	PF00400	0.567
DEG_SPOP_SBC_1	265	269	PF00917	0.707
DOC_CKS1_1	643	648	PF01111	0.777
DOC_CYCLIN_RxL_1	443	453	PF00134	0.578
DOC_MAPK_gen_1	228	237	PF00069	0.800
DOC_MAPK_gen_1	294	301	PF00069	0.718
DOC_MAPK_gen_1	34	42	PF00069	0.510
DOC_MAPK_gen_1	466	474	PF00069	0.598
DOC_MAPK_MEF2A_6	231	239	PF00069	0.799
DOC_MAPK_MEF2A_6	468	476	PF00069	0.614
DOC_PP2B_LxvP_1	192	195	PF13499	0.721
DOC_PP2B_LxvP_1	299	302	PF13499	0.805
DOC_PP2B_LxvP_1	480	483	PF13499	0.663
DOC_PP2B_LxvP_1	572	575	PF13499	0.474
DOC_SPAK_OSR1_1	121	125	PF12202	0.403
DOC_USP7_MATH_1	16	20	PF00917	0.522
DOC_USP7_MATH_1	243	247	PF00917	0.709
DOC_USP7_MATH_1	265	269	PF00917	0.733
DOC_USP7_MATH_1	302	306	PF00917	0.782
DOC_USP7_MATH_1	583	587	PF00917	0.718
DOC_USP7_MATH_1	604	608	PF00917	0.736
DOC_USP7_MATH_1	615	619	PF00917	0.769
DOC_USP7_MATH_1	635	639	PF00917	0.709
DOC_USP7_MATH_1	650	654	PF00917	0.511
DOC_USP7_MATH_1	658	662	PF00917	0.625
DOC_USP7_MATH_2	409	415	PF00917	0.472
DOC_USP7_UBL2_3	537	541	PF12436	0.579
DOC_WW_Pin1_4	183	188	PF00397	0.787
DOC_WW_Pin1_4	201	206	PF00397	0.739
DOC_WW_Pin1_4	217	222	PF00397	0.737
DOC_WW_Pin1_4	258	263	PF00397	0.797
DOC_WW_Pin1_4	289	294	PF00397	0.681
DOC_WW_Pin1_4	405	410	PF00397	0.577
DOC_WW_Pin1_4	485	490	PF00397	0.704
DOC_WW_Pin1_4	52	57	PF00397	0.495
DOC_WW_Pin1_4	593	598	PF00397	0.750
DOC_WW_Pin1_4	631	636	PF00397	0.762
DOC_WW_Pin1_4	642	647	PF00397	0.665
DOC_WW_Pin1_4	676	681	PF00397	0.692
DOC_WW_Pin1_4	83	88	PF00397	0.581
LIG_14-3-3_CanoR_1	123	129	PF00244	0.498
LIG_14-3-3_CanoR_1	266	274	PF00244	0.660
LIG_14-3-3_CanoR_1	294	299	PF00244	0.558
LIG_14-3-3_CanoR_1	355	364	PF00244	0.717
LIG_14-3-3_CanoR_1	370	379	PF00244	0.546
LIG_14-3-3_CanoR_1	419	427	PF00244	0.563
LIG_14-3-3_CanoR_1	508	516	PF00244	0.672
LIG_14-3-3_CanoR_1	649	657	PF00244	0.690
LIG_14-3-3_CanoR_1	684	692	PF00244	0.703
LIG_Actin_WH2_2	271	288	PF00022	0.616
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_CSL_BTD_1	399	402	PF09270	0.700
LIG_CtBP_PxDLS_1	409	413	PF00389	0.483
LIG_FHA_1	187	193	PF00498	0.692
LIG_FHA_1	211	217	PF00498	0.733
LIG_FHA_1	469	475	PF00498	0.611
LIG_FHA_1	49	55	PF00498	0.442
LIG_FHA_2	159	165	PF00498	0.675
LIG_FHA_2	5	11	PF00498	0.450
LIG_FHA_2	622	628	PF00498	0.579
LIG_HCF-1_HBM_1	116	119	PF13415	0.580
LIG_LIR_Apic_2	104	110	PF02991	0.520
LIG_LIR_Gen_1	116	125	PF02991	0.457
LIG_LIR_Gen_1	418	428	PF02991	0.637
LIG_LIR_Gen_1	672	680	PF02991	0.769
LIG_LIR_Nem_3	116	122	PF02991	0.473
LIG_LIR_Nem_3	418	423	PF02991	0.636
LIG_SH2_CRK	152	156	PF00017	0.613
LIG_SH2_CRK	184	188	PF00017	0.685
LIG_SH2_CRK	643	647	PF00017	0.781
LIG_SH2_GRB2like	134	137	PF00017	0.449
LIG_SH2_NCK_1	184	188	PF00017	0.556
LIG_SH2_SRC	526	529	PF00017	0.638
LIG_SH2_STAT5	119	122	PF00017	0.466
LIG_SH2_STAT5	184	187	PF00017	0.599
LIG_SH2_STAT5	526	529	PF00017	0.614
LIG_SH2_STAT5	673	676	PF00017	0.773
LIG_SH2_STAT5	72	75	PF00017	0.465
LIG_SH3_3	188	194	PF00018	0.720
LIG_SH3_3	396	402	PF00018	0.749
LIG_SH3_3	403	409	PF00018	0.733
LIG_SH3_3	471	477	PF00018	0.672
LIG_SH3_3	481	487	PF00018	0.613
LIG_SH3_3	492	498	PF00018	0.669
LIG_SH3_3	513	519	PF00018	0.572
LIG_SH3_3	53	59	PF00018	0.478
LIG_SUMO_SIM_par_1	137	142	PF11976	0.509
LIG_SUMO_SIM_par_1	408	414	PF11976	0.476
LIG_SUMO_SIM_par_1	50	55	PF11976	0.474
LIG_SUMO_SIM_par_1	559	564	PF11976	0.542
LIG_SUMO_SIM_par_1	690	695	PF11976	0.640
LIG_SUMO_SIM_par_1	77	83	PF11976	0.439
LIG_TRAF2_1	7	10	PF00917	0.591
LIG_UBA3_1	274	283	PF00899	0.568
LIG_UBA3_1	284	289	PF00899	0.569
LIG_UBA3_1	546	552	PF00899	0.646
LIG_WRC_WIRS_1	125	130	PF05994	0.512
MOD_CDC14_SPxK_1	292	295	PF00782	0.697
MOD_CDK_SPK_2	289	294	PF00069	0.696
MOD_CDK_SPxK_1	289	295	PF00069	0.693
MOD_CDK_SPxxK_3	201	208	PF00069	0.740
MOD_CDK_SPxxK_3	289	296	PF00069	0.697
MOD_CDK_SPxxK_3	642	649	PF00069	0.782
MOD_CK1_1	159	165	PF00069	0.637
MOD_CK1_1	177	183	PF00069	0.691
MOD_CK1_1	186	192	PF00069	0.700
MOD_CK1_1	220	226	PF00069	0.753
MOD_CK1_1	269	275	PF00069	0.628
MOD_CK1_1	27	33	PF00069	0.431
MOD_CK1_1	309	315	PF00069	0.715
MOD_CK1_1	371	377	PF00069	0.710
MOD_CK1_1	633	639	PF00069	0.721
MOD_CK1_1	83	89	PF00069	0.514
MOD_CK2_1	309	315	PF00069	0.780
MOD_CK2_1	362	368	PF00069	0.732
MOD_CK2_1	4	10	PF00069	0.452
MOD_CK2_1	405	411	PF00069	0.707
MOD_CK2_1	418	424	PF00069	0.406
MOD_CMANNOS	66	69	PF00535	0.481
MOD_GlcNHglycan	157	161	PF01048	0.613
MOD_GlcNHglycan	170	173	PF01048	0.792
MOD_GlcNHglycan	176	179	PF01048	0.649
MOD_GlcNHglycan	196	199	PF01048	0.711
MOD_GlcNHglycan	229	234	PF01048	0.738
MOD_GlcNHglycan	243	246	PF01048	0.630
MOD_GlcNHglycan	308	311	PF01048	0.804
MOD_GlcNHglycan	329	333	PF01048	0.724
MOD_GlcNHglycan	338	341	PF01048	0.639
MOD_GlcNHglycan	364	367	PF01048	0.728
MOD_GlcNHglycan	368	373	PF01048	0.731
MOD_GlcNHglycan	375	378	PF01048	0.767
MOD_GlcNHglycan	420	423	PF01048	0.497
MOD_GlcNHglycan	575	578	PF01048	0.648
MOD_GlcNHglycan	608	611	PF01048	0.736
MOD_GlcNHglycan	617	620	PF01048	0.616
MOD_GlcNHglycan	652	655	PF01048	0.794
MOD_GlcNHglycan	82	85	PF01048	0.442
MOD_GSK3_1	182	189	PF00069	0.668
MOD_GSK3_1	217	224	PF00069	0.695
MOD_GSK3_1	265	272	PF00069	0.637
MOD_GSK3_1	302	309	PF00069	0.748
MOD_GSK3_1	368	375	PF00069	0.578
MOD_GSK3_1	48	55	PF00069	0.440
MOD_GSK3_1	602	609	PF00069	0.728
MOD_GSK3_1	626	633	PF00069	0.711
MOD_GSK3_1	645	652	PF00069	0.754
MOD_GSK3_1	659	666	PF00069	0.695
MOD_LATS_1	353	359	PF00433	0.783
MOD_N-GLC_1	341	346	PF02516	0.751
MOD_N-GLC_1	362	367	PF02516	0.776
MOD_N-GLC_1	372	377	PF02516	0.672
MOD_N-GLC_1	4	9	PF02516	0.344
MOD_NEK2_1	379	384	PF00069	0.743
MOD_NEK2_1	430	435	PF00069	0.662
MOD_PIKK_1	101	107	PF00454	0.451
MOD_PIKK_1	269	275	PF00454	0.621
MOD_PIKK_1	595	601	PF00454	0.764
MOD_PK_1	559	565	PF00069	0.544
MOD_PKA_1	294	300	PF00069	0.560
MOD_PKA_1	355	361	PF00069	0.748
MOD_PKA_2	265	271	PF00069	0.649
MOD_PKA_2	354	360	PF00069	0.768
MOD_PKA_2	418	424	PF00069	0.576
MOD_PKA_2	507	513	PF00069	0.678
MOD_PKA_2	615	621	PF00069	0.675
MOD_PKA_2	683	689	PF00069	0.718
MOD_PKB_1	121	129	PF00069	0.495
MOD_PKB_1	360	368	PF00069	0.748
MOD_Plk_1	4	10	PF00069	0.492
MOD_Plk_1	410	416	PF00069	0.618
MOD_Plk_1	439	445	PF00069	0.531
MOD_Plk_1	542	548	PF00069	0.419
MOD_Plk_2-3	311	317	PF00069	0.740
MOD_Plk_4	130	136	PF00069	0.434
MOD_Plk_4	187	193	PF00069	0.748
MOD_Plk_4	211	217	PF00069	0.688
MOD_Plk_4	294	300	PF00069	0.746
MOD_Plk_4	439	445	PF00069	0.568
MOD_Plk_4	526	532	PF00069	0.562
MOD_Plk_4	542	548	PF00069	0.581
MOD_Plk_4	669	675	PF00069	0.767
MOD_ProDKin_1	183	189	PF00069	0.790
MOD_ProDKin_1	201	207	PF00069	0.739
MOD_ProDKin_1	217	223	PF00069	0.739
MOD_ProDKin_1	258	264	PF00069	0.797
MOD_ProDKin_1	289	295	PF00069	0.681
MOD_ProDKin_1	405	411	PF00069	0.575
MOD_ProDKin_1	485	491	PF00069	0.707
MOD_ProDKin_1	52	58	PF00069	0.489
MOD_ProDKin_1	593	599	PF00069	0.752
MOD_ProDKin_1	631	637	PF00069	0.761
MOD_ProDKin_1	642	648	PF00069	0.663
MOD_ProDKin_1	676	682	PF00069	0.693
MOD_ProDKin_1	83	89	PF00069	0.586
MOD_SUMO_rev_2	277	285	PF00179	0.600
MOD_SUMO_rev_2	488	498	PF00179	0.743
MOD_SUMO_rev_2	528	535	PF00179	0.641
TRG_ENDOCYTIC_2	119	122	PF00928	0.463
TRG_ENDOCYTIC_2	152	155	PF00928	0.615
TRG_ENDOCYTIC_2	673	676	PF00928	0.773
TRG_ER_diArg_1	207	209	PF00400	0.737
TRG_ER_diArg_1	360	362	PF00400	0.812
TRG_NES_CRM1_1	439	451	PF08389	0.531
TRG_NES_CRM1_1	553	566	PF08389	0.546
TRG_NLS_MonoExtN_4	293	298	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C9	Leptomonas seymouri	45%	100%
A0A0S4JNV6	Bodo saltans	31%	100%
A0A3Q8IEB2	Leishmania donovani	92%	100%
A4HFS5	Leishmania braziliensis	66%	100%
A4I365	Leishmania infantum	91%	100%
E9AZ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%