CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania major

UniProt:

E9ADC6_LEIMA

TriTrypDb:

LmjF.27.1450 , LMJLV39_270020900 , LMJSD75_270021100

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ADC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.329
CLV_C14_Caspase3-7	47	51	PF00656	0.328
CLV_C14_Caspase3-7	641	645	PF00656	0.581
CLV_C14_Caspase3-7	722	726	PF00656	0.723
CLV_MEL_PAP_1	834	840	PF00089	0.725
CLV_NRD_NRD_1	148	150	PF00675	0.378
CLV_NRD_NRD_1	184	186	PF00675	0.350
CLV_NRD_NRD_1	277	279	PF00675	0.406
CLV_NRD_NRD_1	314	316	PF00675	0.377
CLV_NRD_NRD_1	791	793	PF00675	0.591
CLV_PCSK_KEX2_1	132	134	PF00082	0.417
CLV_PCSK_KEX2_1	163	165	PF00082	0.355
CLV_PCSK_KEX2_1	184	186	PF00082	0.370
CLV_PCSK_KEX2_1	314	316	PF00082	0.377
CLV_PCSK_KEX2_1	678	680	PF00082	0.745
CLV_PCSK_KEX2_1	791	793	PF00082	0.543
CLV_PCSK_KEX2_1	849	851	PF00082	0.694
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.406
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.355
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.747
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.550
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.666
CLV_PCSK_PC7_1	180	186	PF00082	0.403
CLV_PCSK_SKI1_1	129	133	PF00082	0.350
CLV_PCSK_SKI1_1	249	253	PF00082	0.396
CLV_PCSK_SKI1_1	279	283	PF00082	0.379
CLV_PCSK_SKI1_1	314	318	PF00082	0.382
CLV_PCSK_SKI1_1	346	350	PF00082	0.337
CLV_PCSK_SKI1_1	421	425	PF00082	0.363
CLV_PCSK_SKI1_1	448	452	PF00082	0.391
CLV_PCSK_SKI1_1	77	81	PF00082	0.521
DEG_MDM2_SWIB_1	366	374	PF02201	0.306
DEG_ODPH_VHL_1	324	337	PF01847	0.410
DOC_CYCLIN_RxL_1	290	298	PF00134	0.495
DOC_CYCLIN_yClb5_NLxxxL_5	638	647	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	125	128	PF00134	0.430
DOC_MAPK_gen_1	11	18	PF00069	0.523
DOC_MAPK_gen_1	184	191	PF00069	0.286
DOC_MAPK_gen_1	369	379	PF00069	0.322
DOC_MAPK_MEF2A_6	11	20	PF00069	0.525
DOC_MAPK_MEF2A_6	519	526	PF00069	0.394
DOC_MAPK_NFAT4_5	519	527	PF00069	0.493
DOC_PP1_RVXF_1	247	253	PF00149	0.348
DOC_PP1_RVXF_1	419	426	PF00149	0.306
DOC_PP1_RVXF_1	792	799	PF00149	0.617
DOC_PP2B_LxvP_1	125	128	PF13499	0.430
DOC_PP4_FxxP_1	14	17	PF00568	0.529
DOC_USP7_MATH_1	217	221	PF00917	0.476
DOC_USP7_MATH_1	404	408	PF00917	0.422
DOC_USP7_MATH_1	470	474	PF00917	0.424
DOC_USP7_MATH_1	562	566	PF00917	0.636
DOC_USP7_MATH_1	584	588	PF00917	0.467
DOC_USP7_MATH_1	664	668	PF00917	0.663
DOC_USP7_MATH_1	721	725	PF00917	0.778
DOC_USP7_MATH_1	804	808	PF00917	0.728
DOC_USP7_UBL2_3	275	279	PF12436	0.430
DOC_USP7_UBL2_3	786	790	PF12436	0.582
DOC_WW_Pin1_4	378	383	PF00397	0.306
DOC_WW_Pin1_4	538	543	PF00397	0.547
DOC_WW_Pin1_4	824	829	PF00397	0.727
LIG_14-3-3_CanoR_1	133	142	PF00244	0.409
LIG_14-3-3_CanoR_1	149	154	PF00244	0.388
LIG_14-3-3_CanoR_1	21	26	PF00244	0.444
LIG_14-3-3_CanoR_1	346	351	PF00244	0.306
LIG_14-3-3_CanoR_1	369	375	PF00244	0.391
LIG_14-3-3_CanoR_1	511	515	PF00244	0.341
LIG_14-3-3_CanoR_1	62	69	PF00244	0.501
LIG_14-3-3_CanoR_1	624	628	PF00244	0.536
LIG_14-3-3_CanoR_1	71	78	PF00244	0.401
LIG_Actin_WH2_2	298	316	PF00022	0.398
LIG_APCC_ABBA_1	523	528	PF00400	0.388
LIG_APCC_ABBA_1	546	551	PF00400	0.456
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BIR_III_4	758	762	PF00653	0.710
LIG_BRCT_BRCA1_1	135	139	PF00533	0.439
LIG_BRCT_BRCA1_1	240	244	PF00533	0.483
LIG_BRCT_BRCA1_1	64	68	PF00533	0.585
LIG_BRCT_BRCA1_1	809	813	PF00533	0.662
LIG_FHA_1	142	148	PF00498	0.442
LIG_FHA_1	149	155	PF00498	0.346
LIG_FHA_1	20	26	PF00498	0.561
LIG_FHA_1	28	34	PF00498	0.568
LIG_FHA_1	296	302	PF00498	0.449
LIG_FHA_1	304	310	PF00498	0.321
LIG_FHA_1	347	353	PF00498	0.311
LIG_FHA_1	566	572	PF00498	0.715
LIG_FHA_1	699	705	PF00498	0.709
LIG_FHA_1	78	84	PF00498	0.452
LIG_FHA_2	185	191	PF00498	0.486
LIG_FHA_2	243	249	PF00498	0.442
LIG_FHA_2	624	630	PF00498	0.548
LIG_FHA_2	639	645	PF00498	0.568
LIG_FHA_2	651	657	PF00498	0.700
LIG_FHA_2	71	77	PF00498	0.419
LIG_FXI_DFP_1	716	720	PF00024	0.754
LIG_Integrin_RGD_1	844	846	PF01839	0.529
LIG_LIR_Gen_1	136	147	PF02991	0.417
LIG_LIR_Gen_1	165	172	PF02991	0.369
LIG_LIR_Gen_1	186	196	PF02991	0.269
LIG_LIR_Gen_1	241	252	PF02991	0.452
LIG_LIR_Gen_1	287	296	PF02991	0.361
LIG_LIR_Gen_1	392	402	PF02991	0.340
LIG_LIR_Gen_1	95	104	PF02991	0.396
LIG_LIR_Nem_3	136	142	PF02991	0.346
LIG_LIR_Nem_3	152	158	PF02991	0.398
LIG_LIR_Nem_3	165	169	PF02991	0.273
LIG_LIR_Nem_3	186	191	PF02991	0.267
LIG_LIR_Nem_3	241	247	PF02991	0.447
LIG_LIR_Nem_3	287	291	PF02991	0.344
LIG_LIR_Nem_3	373	378	PF02991	0.367
LIG_LIR_Nem_3	392	398	PF02991	0.156
LIG_LIR_Nem_3	776	780	PF02991	0.594
LIG_LIR_Nem_3	87	93	PF02991	0.377
LIG_LIR_Nem_3	95	100	PF02991	0.364
LIG_MLH1_MIPbox_1	135	139	PF16413	0.439
LIG_MYND_1	123	127	PF01753	0.405
LIG_NRBOX	228	234	PF00104	0.386
LIG_NRBOX	351	357	PF00104	0.426
LIG_NRBOX	373	379	PF00104	0.322
LIG_NRBOX	519	525	PF00104	0.493
LIG_OCRL_FandH_1	394	406	PF00620	0.322
LIG_Pex14_2	366	370	PF04695	0.306
LIG_Pex14_2	545	549	PF04695	0.464
LIG_Pex14_2	97	101	PF04695	0.372
LIG_PTB_Apo_2	365	372	PF02174	0.322
LIG_PTB_Phospho_1	365	371	PF10480	0.322
LIG_SH2_CRK	371	375	PF00017	0.309
LIG_SH2_NCK_1	42	46	PF00017	0.314
LIG_SH2_SRC	42	45	PF00017	0.510
LIG_SH2_SRC	93	96	PF00017	0.493
LIG_SH2_STAP1	111	115	PF00017	0.382
LIG_SH2_STAP1	166	170	PF00017	0.352
LIG_SH2_STAP1	263	267	PF00017	0.363
LIG_SH2_STAP1	64	68	PF00017	0.603
LIG_SH2_STAP1	738	742	PF00017	0.725
LIG_SH2_STAT3	609	612	PF00017	0.396
LIG_SH2_STAT3	64	67	PF00017	0.469
LIG_SH2_STAT5	138	141	PF00017	0.514
LIG_SH2_STAT5	157	160	PF00017	0.332
LIG_SH2_STAT5	161	164	PF00017	0.354
LIG_SH2_STAT5	288	291	PF00017	0.372
LIG_SH2_STAT5	590	593	PF00017	0.455
LIG_SH2_STAT5	93	96	PF00017	0.458
LIG_SH3_1	124	130	PF00018	0.387
LIG_SH3_2	127	132	PF14604	0.392
LIG_SH3_3	124	130	PF00018	0.396
LIG_SH3_3	13	19	PF00018	0.520
LIG_SH3_3	455	461	PF00018	0.405
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.290
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.322
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.492
LIG_SUMO_SIM_par_1	376	381	PF11976	0.322
LIG_SUMO_SIM_par_1	433	439	PF11976	0.306
LIG_TRAF2_1	274	277	PF00917	0.511
LIG_TRAF2_1	326	329	PF00917	0.448
LIG_TYR_ITIM	153	158	PF00017	0.334
LIG_UBA3_1	243	249	PF00899	0.357
LIG_UBA3_1	250	254	PF00899	0.393
LIG_UBA3_1	352	360	PF00899	0.306
LIG_UBA3_1	377	383	PF00899	0.319
LIG_WRC_WIRS_1	28	33	PF05994	0.484
LIG_WW_3	126	130	PF00397	0.477
MOD_CDK_SPK_2	378	383	PF00069	0.306
MOD_CDK_SPxxK_3	824	831	PF00069	0.732
MOD_CK1_1	2	8	PF00069	0.526
MOD_CK1_1	234	240	PF00069	0.522
MOD_CK1_1	303	309	PF00069	0.425
MOD_CK1_1	473	479	PF00069	0.407
MOD_CK1_1	510	516	PF00069	0.358
MOD_CK1_1	565	571	PF00069	0.662
MOD_CK1_1	582	588	PF00069	0.574
MOD_CK1_1	667	673	PF00069	0.745
MOD_CK1_1	70	76	PF00069	0.461
MOD_CK1_1	807	813	PF00069	0.580
MOD_CK2_1	195	201	PF00069	0.370
MOD_CK2_1	242	248	PF00069	0.442
MOD_CK2_1	271	277	PF00069	0.460
MOD_CK2_1	627	633	PF00069	0.565
MOD_GlcNHglycan	203	206	PF01048	0.454
MOD_GlcNHglycan	387	390	PF01048	0.368
MOD_GlcNHglycan	477	480	PF01048	0.424
MOD_GlcNHglycan	594	597	PF01048	0.485
MOD_GlcNHglycan	629	633	PF01048	0.533
MOD_GlcNHglycan	650	653	PF01048	0.559
MOD_GlcNHglycan	661	664	PF01048	0.601
MOD_GlcNHglycan	686	692	PF01048	0.794
MOD_GlcNHglycan	766	769	PF01048	0.733
MOD_GlcNHglycan	802	805	PF01048	0.584
MOD_GlcNHglycan	806	809	PF01048	0.606
MOD_GlcNHglycan	810	813	PF01048	0.613
MOD_GSK3_1	231	238	PF00069	0.419
MOD_GSK3_1	27	34	PF00069	0.569
MOD_GSK3_1	300	307	PF00069	0.406
MOD_GSK3_1	385	392	PF00069	0.329
MOD_GSK3_1	471	478	PF00069	0.435
MOD_GSK3_1	562	569	PF00069	0.651
MOD_GSK3_1	579	586	PF00069	0.607
MOD_GSK3_1	618	625	PF00069	0.492
MOD_GSK3_1	63	70	PF00069	0.496
MOD_GSK3_1	760	767	PF00069	0.691
MOD_GSK3_1	800	807	PF00069	0.573
MOD_GSK3_1	820	827	PF00069	0.771
MOD_N-GLC_1	471	476	PF02516	0.398
MOD_N-GLC_1	565	570	PF02516	0.547
MOD_N-GLC_1	592	597	PF02516	0.472
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	100	105	PF00069	0.360
MOD_NEK2_1	162	167	PF00069	0.348
MOD_NEK2_1	172	177	PF00069	0.337
MOD_NEK2_1	195	200	PF00069	0.371
MOD_NEK2_1	233	238	PF00069	0.410
MOD_NEK2_1	295	300	PF00069	0.429
MOD_NEK2_1	337	342	PF00069	0.386
MOD_NEK2_1	574	579	PF00069	0.585
MOD_NEK2_1	638	643	PF00069	0.618
MOD_NEK2_1	760	765	PF00069	0.754
MOD_NEK2_2	257	262	PF00069	0.371
MOD_NEK2_2	370	375	PF00069	0.391
MOD_PIKK_1	133	139	PF00454	0.414
MOD_PIKK_1	438	444	PF00454	0.453
MOD_PIKK_1	618	624	PF00454	0.519
MOD_PIKK_1	63	69	PF00454	0.524
MOD_PKA_1	149	155	PF00069	0.441
MOD_PKA_1	184	190	PF00069	0.492
MOD_PKA_2	148	154	PF00069	0.413
MOD_PKA_2	184	190	PF00069	0.480
MOD_PKA_2	510	516	PF00069	0.356
MOD_PKA_2	623	629	PF00069	0.523
MOD_PKA_2	638	644	PF00069	0.599
MOD_PKA_2	70	76	PF00069	0.426
MOD_PKA_2	836	842	PF00069	0.749
MOD_PKB_1	60	68	PF00069	0.534
MOD_PKB_1	835	843	PF00069	0.645
MOD_Plk_1	301	307	PF00069	0.396
MOD_Plk_2-3	44	50	PF00069	0.471
MOD_Plk_2-3	709	715	PF00069	0.664
MOD_Plk_4	149	155	PF00069	0.389
MOD_Plk_4	172	178	PF00069	0.457
MOD_Plk_4	184	190	PF00069	0.492
MOD_Plk_4	2	8	PF00069	0.513
MOD_Plk_4	238	244	PF00069	0.478
MOD_Plk_4	284	290	PF00069	0.353
MOD_Plk_4	348	354	PF00069	0.325
MOD_Plk_4	362	368	PF00069	0.453
MOD_Plk_4	44	50	PF00069	0.557
MOD_Plk_4	513	519	PF00069	0.350
MOD_ProDKin_1	378	384	PF00069	0.306
MOD_ProDKin_1	538	544	PF00069	0.545
MOD_ProDKin_1	824	830	PF00069	0.725
MOD_SUMO_rev_2	274	281	PF00179	0.413
MOD_SUMO_rev_2	47	56	PF00179	0.549
MOD_SUMO_rev_2	481	490	PF00179	0.417
MOD_SUMO_rev_2	558	565	PF00179	0.720
TRG_DiLeu_BaEn_1	776	781	PF01217	0.580
TRG_DiLeu_BaEn_2	247	253	PF01217	0.387
TRG_DiLeu_BaEn_3	43	49	PF01217	0.316
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.306
TRG_ENDOCYTIC_2	155	158	PF00928	0.335
TRG_ENDOCYTIC_2	166	169	PF00928	0.357
TRG_ENDOCYTIC_2	226	229	PF00928	0.361
TRG_ENDOCYTIC_2	288	291	PF00928	0.348
TRG_ENDOCYTIC_2	319	322	PF00928	0.485
TRG_ENDOCYTIC_2	371	374	PF00928	0.309
TRG_ENDOCYTIC_2	375	378	PF00928	0.302
TRG_ER_diArg_1	313	315	PF00400	0.378
TRG_ER_diArg_1	60	63	PF00400	0.586
TRG_ER_diArg_1	613	616	PF00400	0.427
TRG_ER_diArg_1	831	834	PF00400	0.658
TRG_ER_diArg_1	835	838	PF00400	0.644
TRG_ER_diArg_1	850	853	PF00400	0.455
TRG_NES_CRM1_1	538	551	PF08389	0.525
TRG_NES_CRM1_1	89	102	PF08389	0.365
TRG_NLS_MonoCore_2	789	794	PF00514	0.600
TRG_NLS_MonoExtC_3	789	794	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ4	Leptomonas seymouri	80%	100%
A0A0S4JS41	Bodo saltans	52%	100%
A0A1X0P4I0	Trypanosomatidae	62%	100%
A0A3R7MHJ2	Trypanosoma rangeli	60%	100%
A0A3S7X0Q5	Leishmania donovani	95%	100%
A4HFS2	Leishmania braziliensis	85%	100%
A4I371	Leishmania infantum	95%	100%
D0A614	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZ50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G0SEQ5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	27%	82%
O36021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	99%
Q12176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
V5DHD7	Trypanosoma cruzi	59%	100%