Charged multivesicular body protein 2a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania major

UniProt:

E9ADC5_LEIMA

TriTrypDb:

LmjF.27.1440 , LMJLV39_270020800 , LMJSD75_270021000

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	2
GO:0005737	cytoplasm	2	2
GO:0005768	endosome	7	2
GO:0005770	late endosome	8	2
GO:0005771	multivesicular body	9	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0031982	vesicle	4	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0036452	ESCRT complex	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007034	vacuolar transport	4	11
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071985	multivesicular body sorting pathway	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.672
CLV_C14_Caspase3-7	55	59	PF00656	0.326
CLV_NRD_NRD_1	41	43	PF00675	0.349
CLV_NRD_NRD_1	70	72	PF00675	0.326
CLV_NRD_NRD_1	8	10	PF00675	0.563
CLV_PCSK_KEX2_1	20	22	PF00082	0.326
CLV_PCSK_KEX2_1	8	10	PF00082	0.609
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.326
CLV_PCSK_SKI1_1	105	109	PF00082	0.375
CLV_PCSK_SKI1_1	50	54	PF00082	0.325
DOC_MIT_MIM_1	200	211	PF04212	0.549
DOC_USP7_MATH_1	110	114	PF00917	0.359
DOC_USP7_MATH_1	189	193	PF00917	0.782
DOC_USP7_UBL2_3	105	109	PF12436	0.344
DOC_USP7_UBL2_3	211	215	PF12436	0.546
DOC_USP7_UBL2_3	49	53	PF12436	0.326
DOC_USP7_UBL2_3	72	76	PF12436	0.326
DOC_WW_Pin1_4	8	13	PF00397	0.524
LIG_14-3-3_CanoR_1	34	44	PF00244	0.407
LIG_14-3-3_CanoR_1	79	87	PF00244	0.358
LIG_14-3-3_CanoR_1	90	95	PF00244	0.284
LIG_FHA_2	160	166	PF00498	0.326
LIG_FHA_2	193	199	PF00498	0.675
LIG_FHA_2	24	30	PF00498	0.338
LIG_FHA_2	9	15	PF00498	0.512
LIG_PCNA_yPIPBox_3	140	152	PF02747	0.307
LIG_SH2_STAT3	19	22	PF00017	0.456
LIG_TRAF2_1	11	14	PF00917	0.498
LIG_TRAF2_1	162	165	PF00917	0.456
LIG_TRAF2_1	199	202	PF00917	0.770
LIG_TRAF2_1	38	41	PF00917	0.407
LIG_UBA3_1	136	140	PF00899	0.326
LIG_UBA3_1	44	53	PF00899	0.474
MOD_CDK_SPxxK_3	8	15	PF00069	0.630
MOD_CK1_1	192	198	PF00069	0.779
MOD_CK2_1	159	165	PF00069	0.326
MOD_CK2_1	192	198	PF00069	0.680
MOD_CK2_1	35	41	PF00069	0.483
MOD_CK2_1	8	14	PF00069	0.519
MOD_GlcNHglycan	96	99	PF01048	0.487
MOD_GSK3_1	192	199	PF00069	0.733
MOD_GSK3_1	90	97	PF00069	0.330
MOD_NEK2_1	210	215	PF00069	0.588
MOD_NEK2_1	23	28	PF00069	0.341
MOD_NEK2_1	67	72	PF00069	0.353
MOD_NEK2_1	94	99	PF00069	0.330
MOD_PIKK_1	192	198	PF00454	0.663
MOD_PIKK_1	36	42	PF00454	0.388
MOD_PIKK_1	79	85	PF00454	0.353
MOD_Plk_2-3	159	165	PF00069	0.326
MOD_ProDKin_1	8	14	PF00069	0.519
MOD_SUMO_rev_2	38	45	PF00179	0.337
TRG_ER_diArg_1	15	18	PF00400	0.509
TRG_ER_diArg_1	68	71	PF00400	0.326
TRG_ER_diArg_1	7	9	PF00400	0.581
TRG_ER_diArg_1	78	81	PF00400	0.326
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK30	Leptomonas seymouri	89%	100%
A0A0N1IL91	Leptomonas seymouri	32%	99%
A0A0S4JKU7	Bodo saltans	31%	82%
A0A0S4JP11	Bodo saltans	70%	98%
A0A1X0P3A0	Trypanosomatidae	34%	100%
A0A1X0P5A2	Trypanosomatidae	25%	100%
A0A1X0P5N6	Trypanosomatidae	77%	99%
A0A381ML17	Leishmania infantum	100%	100%
A0A3R7RGQ9	Trypanosoma rangeli	32%	99%
A0A3S5H7H9	Leishmania donovani	100%	100%
A0A3S5IQV4	Trypanosoma rangeli	76%	100%
A0A3S7XBB5	Leishmania donovani	31%	99%
A4HFS1	Leishmania braziliensis	92%	100%
A4HPL1	Leishmania braziliensis	33%	99%
A4ID53	Leishmania infantum	31%	99%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A613	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A8K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9ATC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
E9AZ49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O14177	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O14296	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
O43633	Homo sapiens	58%	97%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O96552	Dictyostelium discoideum	28%	100%
P36095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	96%
P36108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	93%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q0WTY4	Arabidopsis thaliana	37%	97%
Q3SX42	Bos taurus	34%	100%
Q4Q174	Leishmania major	31%	100%
Q4R574	Macaca fascicularis	30%	97%
Q54DB1	Dictyostelium discoideum	52%	100%
Q54GK9	Dictyostelium discoideum	34%	100%
Q54P63	Dictyostelium discoideum	28%	100%
Q58CS7	Bos taurus	30%	97%
Q5BKM3	Xenopus tropicalis	27%	98%
Q5E994	Bos taurus	27%	100%
Q5F3A2	Gallus gallus	34%	100%
Q5RAU5	Pongo abelii	31%	97%
Q5RAV2	Pongo abelii	33%	100%
Q5ZHN1	Gallus gallus	55%	98%
Q5ZKX1	Gallus gallus	26%	100%
Q66IV6	Xenopus laevis	34%	100%
Q6DF27	Xenopus tropicalis	27%	100%
Q6DFS6	Xenopus tropicalis	57%	98%
Q6IP52	Xenopus laevis	57%	98%
Q6NRM7	Xenopus laevis	31%	98%
Q6NUD8	Xenopus laevis	23%	100%
Q6NVL7	Xenopus tropicalis	36%	100%
Q6NXD2	Danio rerio	34%	100%
Q6NY88	Danio rerio	28%	97%
Q6PHF0	Danio rerio	24%	100%
Q7LBR1	Homo sapiens	27%	100%
Q7SYR0	Xenopus laevis	33%	100%
Q7SZB5	Xenopus laevis	27%	100%
Q7ZVB1	Danio rerio	27%	100%
Q7ZW25	Danio rerio	50%	98%
Q8BJF9	Mus musculus	34%	100%
Q8CGS4	Rattus norvegicus	30%	96%
Q8LE58	Arabidopsis thaliana	28%	100%
Q921W0	Mus musculus	25%	100%
Q941D5	Arabidopsis thaliana	33%	100%
Q99LU0	Mus musculus	27%	100%
Q9CQ10	Mus musculus	30%	96%
Q9CQD4	Mus musculus	26%	100%
Q9DB34	Mus musculus	58%	97%
Q9SKI2	Arabidopsis thaliana	44%	96%
Q9UQN3	Homo sapiens	33%	100%
Q9Y3E7	Homo sapiens	31%	97%