Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADC4_LEIMA

TriTrypDb:

LmjF.27.1430 , LMJLV39_270020700 , LMJSD75_270020900

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	669	675	PF00089	0.440
CLV_NRD_NRD_1	306	308	PF00675	0.577
CLV_NRD_NRD_1	386	388	PF00675	0.746
CLV_NRD_NRD_1	575	577	PF00675	0.495
CLV_NRD_NRD_1	656	658	PF00675	0.455
CLV_NRD_NRD_1	898	900	PF00675	0.529
CLV_PCSK_KEX2_1	261	263	PF00082	0.652
CLV_PCSK_KEX2_1	306	308	PF00082	0.577
CLV_PCSK_KEX2_1	388	390	PF00082	0.788
CLV_PCSK_KEX2_1	575	577	PF00082	0.566
CLV_PCSK_KEX2_1	656	658	PF00082	0.455
CLV_PCSK_KEX2_1	822	824	PF00082	0.568
CLV_PCSK_KEX2_1	898	900	PF00082	0.529
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.634
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.667
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.568
CLV_PCSK_PC7_1	384	390	PF00082	0.691
CLV_PCSK_PC7_1	571	577	PF00082	0.474
CLV_PCSK_SKI1_1	131	135	PF00082	0.518
CLV_PCSK_SKI1_1	232	236	PF00082	0.532
CLV_PCSK_SKI1_1	269	273	PF00082	0.597
CLV_PCSK_SKI1_1	306	310	PF00082	0.641
CLV_PCSK_SKI1_1	415	419	PF00082	0.616
CLV_PCSK_SKI1_1	503	507	PF00082	0.640
CLV_PCSK_SKI1_1	65	69	PF00082	0.437
CLV_PCSK_SKI1_1	77	81	PF00082	0.428
CLV_PCSK_SKI1_1	806	810	PF00082	0.569
CLV_PCSK_SKI1_1	899	903	PF00082	0.538
DEG_APCC_DBOX_1	162	170	PF00400	0.582
DEG_Nend_UBRbox_2	1	3	PF02207	0.572
DEG_SPOP_SBC_1	512	516	PF00917	0.666
DOC_CKS1_1	469	474	PF01111	0.597
DOC_CYCLIN_RxL_1	266	274	PF00134	0.570
DOC_CYCLIN_RxL_1	303	312	PF00134	0.649
DOC_MAPK_gen_1	45	54	PF00069	0.549
DOC_MAPK_gen_1	675	684	PF00069	0.578
DOC_MAPK_MEF2A_6	110	119	PF00069	0.527
DOC_MAPK_MEF2A_6	45	54	PF00069	0.549
DOC_MAPK_MEF2A_6	746	754	PF00069	0.466
DOC_MAPK_MEF2A_6	81	88	PF00069	0.431
DOC_PP1_RVXF_1	114	120	PF00149	0.321
DOC_PP1_RVXF_1	788	795	PF00149	0.544
DOC_PP2B_LxvP_1	288	291	PF13499	0.676
DOC_PP4_FxxP_1	272	275	PF00568	0.588
DOC_USP7_MATH_1	104	108	PF00917	0.675
DOC_USP7_MATH_1	211	215	PF00917	0.632
DOC_USP7_MATH_1	249	253	PF00917	0.611
DOC_USP7_MATH_1	29	33	PF00917	0.471
DOC_USP7_MATH_1	299	303	PF00917	0.570
DOC_USP7_MATH_1	390	394	PF00917	0.734
DOC_USP7_MATH_1	413	417	PF00917	0.576
DOC_USP7_MATH_1	43	47	PF00917	0.487
DOC_USP7_MATH_1	513	517	PF00917	0.627
DOC_USP7_MATH_1	543	547	PF00917	0.684
DOC_USP7_MATH_1	601	605	PF00917	0.630
DOC_USP7_MATH_1	646	650	PF00917	0.587
DOC_USP7_MATH_1	842	846	PF00917	0.642
DOC_USP7_MATH_1	850	854	PF00917	0.597
DOC_WW_Pin1_4	247	252	PF00397	0.630
DOC_WW_Pin1_4	271	276	PF00397	0.774
DOC_WW_Pin1_4	3	8	PF00397	0.547
DOC_WW_Pin1_4	347	352	PF00397	0.556
DOC_WW_Pin1_4	382	387	PF00397	0.619
DOC_WW_Pin1_4	468	473	PF00397	0.730
DOC_WW_Pin1_4	483	488	PF00397	0.568
DOC_WW_Pin1_4	55	60	PF00397	0.512
DOC_WW_Pin1_4	597	602	PF00397	0.633
DOC_WW_Pin1_4	641	646	PF00397	0.604
DOC_WW_Pin1_4	832	837	PF00397	0.617
DOC_WW_Pin1_4	93	98	PF00397	0.457
LIG_14-3-3_CanoR_1	116	120	PF00244	0.467
LIG_14-3-3_CanoR_1	232	239	PF00244	0.531
LIG_14-3-3_CanoR_1	307	316	PF00244	0.473
LIG_14-3-3_CanoR_1	389	398	PF00244	0.733
LIG_14-3-3_CanoR_1	45	51	PF00244	0.582
LIG_14-3-3_CanoR_1	463	469	PF00244	0.706
LIG_14-3-3_CanoR_1	503	513	PF00244	0.768
LIG_14-3-3_CanoR_1	55	59	PF00244	0.439
LIG_14-3-3_CanoR_1	558	564	PF00244	0.760
LIG_14-3-3_CanoR_1	576	584	PF00244	0.420
LIG_14-3-3_CanoR_1	734	740	PF00244	0.511
LIG_14-3-3_CanoR_1	771	780	PF00244	0.651
LIG_14-3-3_CanoR_1	793	801	PF00244	0.682
LIG_14-3-3_CanoR_1	883	892	PF00244	0.569
LIG_Actin_WH2_2	662	679	PF00022	0.528
LIG_APCC_ABBA_1	5	10	PF00400	0.355
LIG_APCC_ABBAyCdc20_2	306	312	PF00400	0.549
LIG_BRCT_BRCA1_1	26	30	PF00533	0.463
LIG_BRCT_BRCA1_1	473	477	PF00533	0.699
LIG_BRCT_BRCA1_1	5	9	PF00533	0.449
LIG_BRCT_BRCA1_1	669	673	PF00533	0.588
LIG_BRCT_BRCA1_1	95	99	PF00533	0.399
LIG_BRCT_BRCA1_2	669	675	PF00533	0.598
LIG_FHA_1	154	160	PF00498	0.475
LIG_FHA_1	201	207	PF00498	0.598
LIG_FHA_1	266	272	PF00498	0.673
LIG_FHA_1	523	529	PF00498	0.690
LIG_FHA_1	55	61	PF00498	0.424
LIG_FHA_1	638	644	PF00498	0.624
LIG_FHA_1	784	790	PF00498	0.641
LIG_FHA_1	891	897	PF00498	0.552
LIG_FHA_2	163	169	PF00498	0.593
LIG_FHA_2	202	208	PF00498	0.569
LIG_FHA_2	369	375	PF00498	0.629
LIG_FHA_2	430	436	PF00498	0.640
LIG_FHA_2	560	566	PF00498	0.580
LIG_FHA_2	604	610	PF00498	0.537
LIG_FHA_2	687	693	PF00498	0.557
LIG_GBD_Chelix_1	896	904	PF00786	0.538
LIG_LIR_Gen_1	241	251	PF02991	0.640
LIG_LIR_Gen_1	279	288	PF02991	0.650
LIG_LIR_Gen_1	326	337	PF02991	0.488
LIG_LIR_Gen_1	352	363	PF02991	0.478
LIG_LIR_Gen_1	582	592	PF02991	0.440
LIG_LIR_Nem_3	241	247	PF02991	0.631
LIG_LIR_Nem_3	279	283	PF02991	0.647
LIG_LIR_Nem_3	326	332	PF02991	0.529
LIG_LIR_Nem_3	352	358	PF02991	0.474
LIG_LIR_Nem_3	562	566	PF02991	0.574
LIG_LIR_Nem_3	582	587	PF02991	0.390
LIG_LIR_Nem_3	659	665	PF02991	0.520
LIG_LIR_Nem_3	670	676	PF02991	0.523
LIG_LIR_Nem_3	80	86	PF02991	0.597
LIG_MLH1_MIPbox_1	5	9	PF16413	0.419
LIG_PDZ_Class_3	900	905	PF00595	0.538
LIG_Pex14_2	272	276	PF04695	0.513
LIG_SH2_CRK	329	333	PF00017	0.460
LIG_SH2_CRK	662	666	PF00017	0.521
LIG_SH2_PTP2	331	334	PF00017	0.456
LIG_SH2_SRC	329	332	PF00017	0.462
LIG_SH2_STAP1	182	186	PF00017	0.542
LIG_SH2_STAP1	329	333	PF00017	0.473
LIG_SH2_STAP1	488	492	PF00017	0.643
LIG_SH2_STAP1	498	502	PF00017	0.541
LIG_SH2_STAP1	588	592	PF00017	0.610
LIG_SH2_STAT3	498	501	PF00017	0.603
LIG_SH2_STAT3	531	534	PF00017	0.665
LIG_SH2_STAT5	331	334	PF00017	0.478
LIG_SH2_STAT5	336	339	PF00017	0.544
LIG_SH2_STAT5	455	458	PF00017	0.679
LIG_SH2_STAT5	91	94	PF00017	0.453
LIG_SH3_1	466	472	PF00018	0.688
LIG_SH3_3	207	213	PF00018	0.594
LIG_SH3_3	245	251	PF00018	0.629
LIG_SH3_3	272	278	PF00018	0.570
LIG_SH3_3	466	472	PF00018	0.688
LIG_SH3_3	833	839	PF00018	0.589
LIG_Sin3_3	629	636	PF02671	0.616
LIG_SUMO_SIM_anti_2	565	573	PF11976	0.591
LIG_SUMO_SIM_par_1	856	863	PF11976	0.460
LIG_SxIP_EBH_1	248	262	PF03271	0.551
LIG_TRAF2_1	402	405	PF00917	0.679
LIG_WRC_WIRS_1	354	359	PF05994	0.567
MOD_CDC14_SPxK_1	274	277	PF00782	0.626
MOD_CDC14_SPxK_1	385	388	PF00782	0.578
MOD_CDK_SPK_2	382	387	PF00069	0.579
MOD_CDK_SPxK_1	271	277	PF00069	0.627
MOD_CDK_SPxK_1	382	388	PF00069	0.581
MOD_CDK_SPxxK_3	382	389	PF00069	0.621
MOD_CK1_1	201	207	PF00069	0.664
MOD_CK1_1	250	256	PF00069	0.630
MOD_CK1_1	349	355	PF00069	0.532
MOD_CK1_1	356	362	PF00069	0.539
MOD_CK1_1	368	374	PF00069	0.508
MOD_CK1_1	400	406	PF00069	0.681
MOD_CK1_1	46	52	PF00069	0.526
MOD_CK1_1	516	522	PF00069	0.563
MOD_CK1_1	526	532	PF00069	0.609
MOD_CK1_1	618	624	PF00069	0.649
MOD_CK2_1	196	202	PF00069	0.590
MOD_CK2_1	400	406	PF00069	0.655
MOD_CK2_1	429	435	PF00069	0.643
MOD_CK2_1	603	609	PF00069	0.533
MOD_GlcNHglycan	106	109	PF01048	0.637
MOD_GlcNHglycan	123	126	PF01048	0.361
MOD_GlcNHglycan	194	197	PF01048	0.707
MOD_GlcNHglycan	198	201	PF01048	0.649
MOD_GlcNHglycan	257	260	PF01048	0.646
MOD_GlcNHglycan	288	291	PF01048	0.726
MOD_GlcNHglycan	299	302	PF01048	0.600
MOD_GlcNHglycan	31	34	PF01048	0.555
MOD_GlcNHglycan	392	395	PF01048	0.710
MOD_GlcNHglycan	515	518	PF01048	0.590
MOD_GlcNHglycan	528	531	PF01048	0.765
MOD_GlcNHglycan	545	548	PF01048	0.649
MOD_GlcNHglycan	603	606	PF01048	0.603
MOD_GlcNHglycan	618	621	PF01048	0.617
MOD_GlcNHglycan	715	718	PF01048	0.615
MOD_GlcNHglycan	775	778	PF01048	0.550
MOD_GlcNHglycan	795	798	PF01048	0.594
MOD_GlcNHglycan	811	815	PF01048	0.541
MOD_GlcNHglycan	817	820	PF01048	0.711
MOD_GlcNHglycan	844	847	PF01048	0.652
MOD_GlcNHglycan	852	855	PF01048	0.729
MOD_GSK3_1	192	199	PF00069	0.677
MOD_GSK3_1	201	208	PF00069	0.565
MOD_GSK3_1	286	293	PF00069	0.649
MOD_GSK3_1	295	302	PF00069	0.585
MOD_GSK3_1	343	350	PF00069	0.549
MOD_GSK3_1	464	471	PF00069	0.640
MOD_GSK3_1	512	519	PF00069	0.632
MOD_GSK3_1	522	529	PF00069	0.565
MOD_GSK3_1	548	555	PF00069	0.655
MOD_GSK3_1	597	604	PF00069	0.658
MOD_GSK3_1	611	618	PF00069	0.514
MOD_GSK3_1	637	644	PF00069	0.615
MOD_GSK3_1	663	670	PF00069	0.518
MOD_GSK3_1	709	716	PF00069	0.588
MOD_GSK3_1	886	893	PF00069	0.677
MOD_N-GLC_1	221	226	PF02516	0.462
MOD_N-GLC_1	552	557	PF02516	0.678
MOD_N-GLC_1	597	602	PF02516	0.500
MOD_N-GLC_1	712	717	PF02516	0.650
MOD_N-GLC_2	35	37	PF02516	0.500
MOD_NEK2_1	115	120	PF00069	0.477
MOD_NEK2_1	16	21	PF00069	0.614
MOD_NEK2_1	162	167	PF00069	0.593
MOD_NEK2_1	24	29	PF00069	0.478
MOD_NEK2_1	367	372	PF00069	0.632
MOD_NEK2_1	445	450	PF00069	0.587
MOD_NEK2_1	54	59	PF00069	0.428
MOD_NEK2_1	665	670	PF00069	0.593
MOD_NEK2_1	735	740	PF00069	0.452
MOD_NEK2_1	773	778	PF00069	0.590
MOD_NEK2_1	795	800	PF00069	0.617
MOD_NEK2_1	809	814	PF00069	0.527
MOD_NEK2_1	871	876	PF00069	0.581
MOD_PIKK_1	221	227	PF00454	0.495
MOD_PIKK_1	637	643	PF00454	0.581
MOD_PIKK_1	646	652	PF00454	0.505
MOD_PKA_2	115	121	PF00069	0.327
MOD_PKA_2	162	168	PF00069	0.588
MOD_PKA_2	276	282	PF00069	0.660
MOD_PKA_2	390	396	PF00069	0.735
MOD_PKA_2	46	52	PF00069	0.556
MOD_PKA_2	54	60	PF00069	0.453
MOD_PKA_2	570	576	PF00069	0.552
MOD_PKA_2	709	715	PF00069	0.636
MOD_PKA_2	735	741	PF00069	0.454
MOD_PKA_2	773	779	PF00069	0.554
MOD_PKB_1	387	395	PF00069	0.625
MOD_Plk_1	182	188	PF00069	0.544
MOD_Plk_1	201	207	PF00069	0.583
MOD_Plk_1	221	227	PF00069	0.461
MOD_Plk_1	552	558	PF00069	0.681
MOD_Plk_2-3	164	170	PF00069	0.522
MOD_Plk_2-3	202	208	PF00069	0.524
MOD_Plk_4	46	52	PF00069	0.550
MOD_Plk_4	488	494	PF00069	0.562
MOD_Plk_4	523	529	PF00069	0.599
MOD_Plk_4	565	571	PF00069	0.611
MOD_Plk_4	886	892	PF00069	0.572
MOD_ProDKin_1	247	253	PF00069	0.632
MOD_ProDKin_1	271	277	PF00069	0.775
MOD_ProDKin_1	3	9	PF00069	0.546
MOD_ProDKin_1	347	353	PF00069	0.551
MOD_ProDKin_1	382	388	PF00069	0.621
MOD_ProDKin_1	468	474	PF00069	0.731
MOD_ProDKin_1	483	489	PF00069	0.560
MOD_ProDKin_1	55	61	PF00069	0.519
MOD_ProDKin_1	597	603	PF00069	0.635
MOD_ProDKin_1	641	647	PF00069	0.599
MOD_ProDKin_1	832	838	PF00069	0.617
MOD_ProDKin_1	93	99	PF00069	0.451
MOD_SUMO_rev_2	697	706	PF00179	0.544
TRG_DiLeu_BaEn_1	317	322	PF01217	0.508
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.659
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.522
TRG_ENDOCYTIC_2	329	332	PF00928	0.462
TRG_ENDOCYTIC_2	662	665	PF00928	0.516
TRG_ER_diArg_1	305	307	PF00400	0.669
TRG_ER_diArg_1	386	389	PF00400	0.745
TRG_ER_diArg_1	575	577	PF00400	0.496
TRG_ER_diArg_1	655	657	PF00400	0.458
TRG_ER_diArg_1	898	900	PF00400	0.541
TRG_NES_CRM1_1	229	241	PF08389	0.544
TRG_NLS_MonoCore_2	387	392	PF00514	0.760
TRG_NLS_MonoExtC_3	386	391	PF00514	0.778
TRG_NLS_MonoExtN_4	384	391	PF00514	0.847
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA8	Leptomonas seymouri	48%	97%
A0A381ML15	Leishmania infantum	89%	99%
A0A3S7X0S0	Leishmania donovani	89%	99%
A4HFR9	Leishmania braziliensis	71%	99%
E9AZ48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%