Choline kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Choline kinase

Gene product:

choline kinase

Species:

Leishmania major

UniProt:

E9ADC3_LEIMA

TriTrypDb:

LmjF.27.1420 , LMJLV39_270020600 , LMJSD75_270020800

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006646	phosphatidylethanolamine biosynthetic process	6	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006656	phosphatidylcholine biosynthetic process	5	2
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046337	phosphatidylethanolamine metabolic process	6	2
GO:0046470	phosphatidylcholine metabolic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004103	choline kinase activity	5	5
GO:0004305	ethanolamine kinase activity	5	2
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.479
CLV_NRD_NRD_1	482	484	PF00675	0.252
CLV_NRD_NRD_1	535	537	PF00675	0.326
CLV_PCSK_KEX2_1	130	132	PF00082	0.538
CLV_PCSK_KEX2_1	261	263	PF00082	0.415
CLV_PCSK_KEX2_1	495	497	PF00082	0.252
CLV_PCSK_KEX2_1	535	537	PF00082	0.360
CLV_PCSK_KEX2_1	59	61	PF00082	0.675
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.538
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.415
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.252
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.627
CLV_PCSK_SKI1_1	130	134	PF00082	0.654
CLV_PCSK_SKI1_1	356	360	PF00082	0.313
CLV_PCSK_SKI1_1	496	500	PF00082	0.252
CLV_PCSK_SKI1_1	51	55	PF00082	0.575
CLV_PCSK_SKI1_1	539	543	PF00082	0.348
CLV_PCSK_SKI1_1	570	574	PF00082	0.366
CLV_PCSK_SKI1_1	590	594	PF00082	0.228
CLV_PCSK_SKI1_1	77	81	PF00082	0.591
CLV_PCSK_SKI1_1	86	90	PF00082	0.539
DEG_SPOP_SBC_1	552	556	PF00917	0.460
DOC_AGCK_PIF_2	319	324	PF00069	0.479
DOC_CDC14_PxL_1	507	515	PF14671	0.440
DOC_CKS1_1	109	114	PF01111	0.656
DOC_CKS1_1	200	205	PF01111	0.521
DOC_CYCLIN_RxL_1	587	599	PF00134	0.321
DOC_MAPK_gen_1	481	491	PF00069	0.458
DOC_MAPK_MEF2A_6	16	25	PF00069	0.364
DOC_PP1_RVXF_1	485	492	PF00149	0.452
DOC_PP1_RVXF_1	568	575	PF00149	0.364
DOC_PP2B_LxvP_1	220	223	PF13499	0.615
DOC_PP2B_LxvP_1	308	311	PF13499	0.452
DOC_PP4_FxxP_1	123	126	PF00568	0.612
DOC_PP4_FxxP_1	200	203	PF00568	0.502
DOC_USP7_MATH_1	280	284	PF00917	0.418
DOC_USP7_MATH_1	525	529	PF00917	0.375
DOC_USP7_MATH_1	547	551	PF00917	0.488
DOC_USP7_MATH_1	552	556	PF00917	0.526
DOC_USP7_MATH_1	636	640	PF00917	0.428
DOC_USP7_UBL2_3	373	377	PF12436	0.468
DOC_USP7_UBL2_3	55	59	PF12436	0.420
DOC_WW_Pin1_4	108	113	PF00397	0.618
DOC_WW_Pin1_4	195	200	PF00397	0.576
DOC_WW_Pin1_4	239	244	PF00397	0.606
DOC_WW_Pin1_4	247	252	PF00397	0.573
DOC_WW_Pin1_4	548	553	PF00397	0.489
DOC_WW_Pin1_4	66	71	PF00397	0.632
DOC_WW_Pin1_4	77	82	PF00397	0.536
LIG_14-3-3_CanoR_1	131	139	PF00244	0.542
LIG_14-3-3_CanoR_1	211	217	PF00244	0.552
LIG_14-3-3_CanoR_1	230	237	PF00244	0.565
LIG_14-3-3_CanoR_1	238	243	PF00244	0.531
LIG_14-3-3_CanoR_1	443	453	PF00244	0.479
LIG_APCC_ABBA_1	272	277	PF00400	0.363
LIG_BIR_III_2	140	144	PF00653	0.537
LIG_BRCT_BRCA1_1	300	304	PF00533	0.452
LIG_FHA_1	111	117	PF00498	0.694
LIG_FHA_1	200	206	PF00498	0.681
LIG_FHA_1	248	254	PF00498	0.711
LIG_FHA_1	266	272	PF00498	0.331
LIG_FHA_1	291	297	PF00498	0.474
LIG_FHA_1	413	419	PF00498	0.449
LIG_FHA_2	163	169	PF00498	0.601
LIG_FHA_2	394	400	PF00498	0.457
LIG_LIR_Apic_2	122	126	PF02991	0.613
LIG_LIR_Apic_2	198	203	PF02991	0.494
LIG_LIR_Apic_2	326	332	PF02991	0.468
LIG_LIR_Gen_1	149	158	PF02991	0.534
LIG_LIR_Gen_1	302	313	PF02991	0.452
LIG_LIR_Gen_1	330	341	PF02991	0.451
LIG_LIR_Gen_1	415	422	PF02991	0.452
LIG_LIR_Gen_1	436	445	PF02991	0.411
LIG_LIR_Gen_1	604	613	PF02991	0.491
LIG_LIR_Nem_3	149	154	PF02991	0.537
LIG_LIR_Nem_3	270	275	PF02991	0.362
LIG_LIR_Nem_3	302	308	PF02991	0.500
LIG_LIR_Nem_3	317	322	PF02991	0.494
LIG_LIR_Nem_3	326	331	PF02991	0.383
LIG_LIR_Nem_3	374	379	PF02991	0.452
LIG_LIR_Nem_3	415	420	PF02991	0.452
LIG_LIR_Nem_3	497	501	PF02991	0.445
LIG_LIR_Nem_3	509	513	PF02991	0.469
LIG_LIR_Nem_3	514	520	PF02991	0.490
LIG_LIR_Nem_3	604	609	PF02991	0.384
LIG_LIR_Nem_3	617	623	PF02991	0.306
LIG_LIR_Nem_3	626	631	PF02991	0.322
LIG_LYPXL_yS_3	510	513	PF13949	0.440
LIG_NRBOX	49	55	PF00104	0.415
LIG_NRBOX	590	596	PF00104	0.315
LIG_PCNA_yPIPBox_3	16	24	PF02747	0.335
LIG_PDZ_Class_3	637	642	PF00595	0.464
LIG_Pex14_2	4	8	PF04695	0.401
LIG_PTAP_UEV_1	253	258	PF05743	0.455
LIG_PTB_Apo_2	266	273	PF02174	0.394
LIG_SH2_CRK	305	309	PF00017	0.452
LIG_SH2_CRK	329	333	PF00017	0.581
LIG_SH2_NCK_1	329	333	PF00017	0.446
LIG_SH2_NCK_1	501	505	PF00017	0.452
LIG_SH2_SRC	313	316	PF00017	0.440
LIG_SH2_SRC	324	327	PF00017	0.440
LIG_SH2_SRC	409	412	PF00017	0.468
LIG_SH2_STAP1	517	521	PF00017	0.452
LIG_SH2_STAT5	313	316	PF00017	0.452
LIG_SH2_STAT5	324	327	PF00017	0.452
LIG_SH2_STAT5	329	332	PF00017	0.415
LIG_SH2_STAT5	409	412	PF00017	0.452
LIG_SH2_STAT5	462	465	PF00017	0.457
LIG_SH2_STAT5	493	496	PF00017	0.452
LIG_SH2_STAT5	520	523	PF00017	0.342
LIG_SH2_STAT5	631	634	PF00017	0.343
LIG_SH3_3	111	117	PF00018	0.611
LIG_SH3_3	175	181	PF00018	0.579
LIG_SH3_3	248	254	PF00018	0.635
LIG_SUMO_SIM_par_1	382	387	PF11976	0.411
LIG_SUMO_SIM_par_1	593	599	PF11976	0.300
LIG_TRAF2_1	212	215	PF00917	0.593
LIG_TYR_ITIM	303	308	PF00017	0.452
LIG_TYR_ITIM	320	325	PF00017	0.452
LIG_UBA3_1	410	416	PF00899	0.452
LIG_UBA3_1	452	460	PF00899	0.440
LIG_WRC_WIRS_1	163	168	PF05994	0.602
LIG_WRC_WIRS_1	527	532	PF05994	0.267
MOD_CDK_SPxK_1	77	83	PF00069	0.551
MOD_CDK_SPxxK_3	77	84	PF00069	0.553
MOD_CK1_1	119	125	PF00069	0.612
MOD_CK1_1	173	179	PF00069	0.607
MOD_CK1_1	209	215	PF00069	0.560
MOD_CK1_1	298	304	PF00069	0.462
MOD_CK1_1	389	395	PF00069	0.479
MOD_CK1_1	444	450	PF00069	0.479
MOD_CK1_1	550	556	PF00069	0.545
MOD_CK1_1	599	605	PF00069	0.289
MOD_CK1_1	66	72	PF00069	0.649
MOD_CK1_1	75	81	PF00069	0.557
MOD_CK2_1	162	168	PF00069	0.601
MOD_CK2_1	209	215	PF00069	0.538
MOD_CK2_1	398	404	PF00069	0.411
MOD_CK2_1	451	457	PF00069	0.441
MOD_CK2_1	572	578	PF00069	0.507
MOD_CMANNOS	603	606	PF00535	0.296
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.586
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.543
MOD_GlcNHglycan	156	159	PF01048	0.701
MOD_GlcNHglycan	254	257	PF01048	0.505
MOD_GlcNHglycan	263	266	PF01048	0.422
MOD_GlcNHglycan	277	283	PF01048	0.400
MOD_GlcNHglycan	446	449	PF01048	0.279
MOD_GlcNHglycan	473	476	PF01048	0.252
MOD_GlcNHglycan	613	616	PF01048	0.428
MOD_GlcNHglycan	91	94	PF01048	0.726
MOD_GSK3_1	115	122	PF00069	0.629
MOD_GSK3_1	142	149	PF00069	0.585
MOD_GSK3_1	154	161	PF00069	0.668
MOD_GSK3_1	162	169	PF00069	0.519
MOD_GSK3_1	195	202	PF00069	0.587
MOD_GSK3_1	205	212	PF00069	0.545
MOD_GSK3_1	222	229	PF00069	0.689
MOD_GSK3_1	23	30	PF00069	0.333
MOD_GSK3_1	261	268	PF00069	0.438
MOD_GSK3_1	386	393	PF00069	0.458
MOD_GSK3_1	516	523	PF00069	0.452
MOD_GSK3_1	547	554	PF00069	0.497
MOD_GSK3_1	62	69	PF00069	0.668
MOD_N-GLC_1	548	553	PF02516	0.501
MOD_N-GLC_2	170	172	PF02516	0.536
MOD_NEK2_1	166	171	PF00069	0.633
MOD_NEK2_1	206	211	PF00069	0.662
MOD_NEK2_1	304	309	PF00069	0.452
MOD_NEK2_1	367	372	PF00069	0.459
MOD_NEK2_1	4	9	PF00069	0.326
MOD_NEK2_1	410	415	PF00069	0.452
MOD_NEK2_1	441	446	PF00069	0.455
MOD_NEK2_1	491	496	PF00069	0.514
MOD_NEK2_1	601	606	PF00069	0.315
MOD_NEK2_2	63	68	PF00069	0.683
MOD_OFUCOSY	67	73	PF10250	0.578
MOD_PIKK_1	116	122	PF00454	0.632
MOD_PIKK_1	142	148	PF00454	0.569
MOD_PIKK_1	367	373	PF00454	0.452
MOD_PIKK_1	420	426	PF00454	0.457
MOD_PIKK_1	72	78	PF00454	0.638
MOD_PKA_1	130	136	PF00069	0.542
MOD_PKA_1	261	267	PF00069	0.441
MOD_PKA_2	130	136	PF00069	0.542
MOD_PKA_2	210	216	PF00069	0.540
MOD_PKA_2	229	235	PF00069	0.563
MOD_PKA_2	237	243	PF00069	0.532
MOD_PKA_2	261	267	PF00069	0.441
MOD_PKA_2	298	304	PF00069	0.452
MOD_PKA_2	352	358	PF00069	0.452
MOD_PKA_2	367	373	PF00069	0.452
MOD_PKA_2	404	410	PF00069	0.467
MOD_PKA_2	434	440	PF00069	0.479
MOD_Plk_1	398	404	PF00069	0.457
MOD_Plk_4	146	152	PF00069	0.583
MOD_Plk_4	27	33	PF00069	0.317
MOD_Plk_4	280	286	PF00069	0.347
MOD_Plk_4	304	310	PF00069	0.494
MOD_Plk_4	4	10	PF00069	0.323
MOD_Plk_4	434	440	PF00069	0.563
MOD_Plk_4	451	457	PF00069	0.396
MOD_Plk_4	516	522	PF00069	0.452
MOD_Plk_4	526	532	PF00069	0.325
MOD_ProDKin_1	108	114	PF00069	0.617
MOD_ProDKin_1	195	201	PF00069	0.573
MOD_ProDKin_1	239	245	PF00069	0.606
MOD_ProDKin_1	247	253	PF00069	0.564
MOD_ProDKin_1	548	554	PF00069	0.490
MOD_ProDKin_1	66	72	PF00069	0.634
MOD_ProDKin_1	77	83	PF00069	0.536
TRG_DiLeu_BaEn_1	406	411	PF01217	0.452
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.390
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.452
TRG_ENDOCYTIC_2	305	308	PF00928	0.500
TRG_ENDOCYTIC_2	322	325	PF00928	0.489
TRG_ENDOCYTIC_2	328	331	PF00928	0.452
TRG_ENDOCYTIC_2	333	336	PF00928	0.439
TRG_ENDOCYTIC_2	375	378	PF00928	0.457
TRG_ENDOCYTIC_2	510	513	PF00928	0.452
TRG_ENDOCYTIC_2	631	634	PF00928	0.370
TRG_ER_diArg_1	534	536	PF00400	0.359
TRG_NLS_MonoExtN_4	81	87	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C8	Leptomonas seymouri	58%	100%
A0A3Q8IPY5	Leishmania donovani	92%	100%
A4HFS0	Leishmania braziliensis	73%	100%
A4I2U4	Leishmania infantum	92%	100%
E9AZ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%