Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADC2_LEIMA

TriTrypDb:

LmjF.27.1410 , LMJLV39_270020500 , LMJSD75_270020700

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.501
CLV_NRD_NRD_1	69	71	PF00675	0.566
CLV_PCSK_KEX2_1	69	71	PF00082	0.566
CLV_PCSK_SKI1_1	204	208	PF00082	0.442
CLV_PCSK_SKI1_1	223	227	PF00082	0.271
CLV_PCSK_SKI1_1	349	353	PF00082	0.461
CLV_PCSK_SKI1_1	63	67	PF00082	0.533
DEG_APCC_DBOX_1	348	356	PF00400	0.377
DEG_Nend_UBRbox_2	1	3	PF02207	0.520
DEG_SPOP_SBC_1	134	138	PF00917	0.666
DOC_ANK_TNKS_1	302	309	PF00023	0.442
DOC_CKS1_1	224	229	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.478
DOC_MAPK_gen_1	50	58	PF00069	0.531
DOC_MAPK_MEF2A_6	342	350	PF00069	0.397
DOC_MAPK_MEF2A_6	50	58	PF00069	0.570
DOC_PP2B_LxvP_1	299	302	PF13499	0.502
DOC_PP4_FxxP_1	31	34	PF00568	0.564
DOC_USP7_MATH_1	127	131	PF00917	0.752
DOC_USP7_MATH_1	135	139	PF00917	0.618
DOC_USP7_MATH_1	285	289	PF00917	0.526
DOC_USP7_MATH_2	317	323	PF00917	0.545
DOC_USP7_UBL2_3	12	16	PF12436	0.389
DOC_USP7_UBL2_3	6	10	PF12436	0.434
DOC_WW_Pin1_4	223	228	PF00397	0.550
DOC_WW_Pin1_4	236	241	PF00397	0.331
DOC_WW_Pin1_4	30	35	PF00397	0.503
LIG_14-3-3_CanoR_1	109	113	PF00244	0.426
LIG_14-3-3_CanoR_1	141	147	PF00244	0.578
LIG_14-3-3_CanoR_1	162	171	PF00244	0.533
LIG_14-3-3_CanoR_1	204	213	PF00244	0.469
LIG_14-3-3_CanoR_1	342	346	PF00244	0.479
LIG_Actin_WH2_2	156	174	PF00022	0.460
LIG_APCC_ABBA_1	274	279	PF00400	0.581
LIG_BRCT_BRCA1_1	23	27	PF00533	0.624
LIG_FHA_1	159	165	PF00498	0.353
LIG_FHA_1	191	197	PF00498	0.449
LIG_FHA_1	236	242	PF00498	0.434
LIG_FHA_1	269	275	PF00498	0.451
LIG_FHA_1	287	293	PF00498	0.486
LIG_FHA_1	53	59	PF00498	0.638
LIG_FHA_1	60	66	PF00498	0.517
LIG_FHA_2	153	159	PF00498	0.549
LIG_FHA_2	88	94	PF00498	0.377
LIG_LIR_Apic_2	29	34	PF02991	0.561
LIG_LIR_Gen_1	111	120	PF02991	0.607
LIG_LIR_Gen_1	183	192	PF02991	0.427
LIG_LIR_Gen_1	310	317	PF02991	0.604
LIG_LIR_Gen_1	43	51	PF02991	0.446
LIG_LIR_Nem_3	111	116	PF02991	0.553
LIG_LIR_Nem_3	183	188	PF02991	0.404
LIG_LIR_Nem_3	310	316	PF02991	0.545
LIG_LIR_Nem_3	43	47	PF02991	0.410
LIG_NRP_CendR_1	374	375	PF00754	0.713
LIG_Pex14_2	181	185	PF04695	0.461
LIG_Pex14_2	188	192	PF04695	0.503
LIG_Pex14_2	27	31	PF04695	0.553
LIG_SH2_CRK	144	148	PF00017	0.480
LIG_SH2_CRK	313	317	PF00017	0.613
LIG_SH2_NCK_1	358	362	PF00017	0.523
LIG_SH2_SRC	358	361	PF00017	0.526
LIG_SH2_STAT3	365	368	PF00017	0.589
LIG_SH2_STAT5	13	16	PF00017	0.446
LIG_SH2_STAT5	144	147	PF00017	0.557
LIG_SH2_STAT5	266	269	PF00017	0.363
LIG_SH2_STAT5	365	368	PF00017	0.634
LIG_SH3_3	221	227	PF00018	0.490
LIG_SUMO_SIM_par_1	114	119	PF11976	0.550
LIG_SUMO_SIM_par_1	54	60	PF11976	0.567
LIG_SUMO_SIM_par_1	89	96	PF11976	0.511
LIG_TYR_ITIM	257	262	PF00017	0.430
LIG_WRC_WIRS_1	143	148	PF05994	0.561
LIG_WRC_WIRS_1	178	183	PF05994	0.477
MOD_CDK_SPxK_1	223	229	PF00069	0.498
MOD_CK1_1	122	128	PF00069	0.727
MOD_CK1_1	137	143	PF00069	0.584
MOD_CK1_1	180	186	PF00069	0.495
MOD_CK1_1	190	196	PF00069	0.371
MOD_CK1_1	21	27	PF00069	0.577
MOD_CK1_1	215	221	PF00069	0.557
MOD_CK1_1	59	65	PF00069	0.540
MOD_CK2_1	152	158	PF00069	0.505
MOD_CK2_1	163	169	PF00069	0.441
MOD_CK2_1	312	318	PF00069	0.616
MOD_CK2_1	319	325	PF00069	0.490
MOD_CK2_1	341	347	PF00069	0.404
MOD_CK2_1	87	93	PF00069	0.434
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.495
MOD_GlcNHglycan	121	124	PF01048	0.636
MOD_GlcNHglycan	165	168	PF01048	0.503
MOD_GlcNHglycan	173	176	PF01048	0.475
MOD_GlcNHglycan	23	26	PF01048	0.633
MOD_GlcNHglycan	362	365	PF01048	0.497
MOD_GlcNHglycan	79	82	PF01048	0.579
MOD_GSK3_1	114	121	PF00069	0.628
MOD_GSK3_1	129	136	PF00069	0.706
MOD_GSK3_1	158	165	PF00069	0.361
MOD_GSK3_1	17	24	PF00069	0.614
MOD_GSK3_1	177	184	PF00069	0.337
MOD_GSK3_1	52	59	PF00069	0.600
MOD_N-GLC_1	370	375	PF02516	0.693
MOD_NEK2_1	116	121	PF00069	0.683
MOD_NEK2_1	171	176	PF00069	0.456
MOD_NEK2_1	181	186	PF00069	0.343
MOD_NEK2_1	195	200	PF00069	0.306
MOD_NEK2_1	312	317	PF00069	0.610
MOD_NEK2_1	42	47	PF00069	0.394
MOD_NEK2_2	152	157	PF00069	0.460
MOD_OFUCOSY	212	219	PF10250	0.428
MOD_PIKK_1	283	289	PF00454	0.548
MOD_PKA_2	108	114	PF00069	0.446
MOD_PKA_2	171	177	PF00069	0.525
MOD_PKA_2	341	347	PF00069	0.477
MOD_PKA_2	49	55	PF00069	0.620
MOD_Plk_1	158	164	PF00069	0.354
MOD_Plk_1	17	23	PF00069	0.612
MOD_Plk_1	42	48	PF00069	0.431
MOD_Plk_2-3	319	325	PF00069	0.529
MOD_Plk_4	108	114	PF00069	0.476
MOD_Plk_4	142	148	PF00069	0.577
MOD_Plk_4	177	183	PF00069	0.395
MOD_Plk_4	319	325	PF00069	0.529
MOD_Plk_4	87	93	PF00069	0.433
MOD_ProDKin_1	223	229	PF00069	0.556
MOD_ProDKin_1	236	242	PF00069	0.344
MOD_ProDKin_1	30	36	PF00069	0.498
MOD_SUMO_rev_2	80	88	PF00179	0.573
TRG_DiLeu_BaEn_1	319	324	PF01217	0.568
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.496
TRG_ENDOCYTIC_2	144	147	PF00928	0.475
TRG_ENDOCYTIC_2	259	262	PF00928	0.403
TRG_ENDOCYTIC_2	313	316	PF00928	0.605
TRG_ENDOCYTIC_2	358	361	PF00928	0.487
TRG_ER_diArg_1	302	305	PF00400	0.462
TRG_ER_diArg_1	68	70	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R9	Leptomonas seymouri	59%	96%
A0A0S4JR94	Bodo saltans	28%	100%
A0A3Q8IDF7	Leishmania donovani	95%	100%
A0A422NFS8	Trypanosoma rangeli	36%	100%
A4HFR8	Leishmania braziliensis	79%	99%
A4I2U3	Leishmania infantum	95%	100%
D0A609	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AZ46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B0Z1	Trypanosoma cruzi	36%	100%