Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADB7_LEIMA

TriTrypDb:

LmjF.27.1360 , LMJLV39_270020000 , LMJSD75_270020200

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.550
CLV_NRD_NRD_1	142	144	PF00675	0.536
CLV_NRD_NRD_1	187	189	PF00675	0.554
CLV_NRD_NRD_1	300	302	PF00675	0.575
CLV_NRD_NRD_1	317	319	PF00675	0.457
CLV_NRD_NRD_1	349	351	PF00675	0.598
CLV_NRD_NRD_1	357	359	PF00675	0.498
CLV_NRD_NRD_1	364	366	PF00675	0.465
CLV_NRD_NRD_1	394	396	PF00675	0.517
CLV_NRD_NRD_1	410	412	PF00675	0.516
CLV_NRD_NRD_1	418	420	PF00675	0.498
CLV_NRD_NRD_1	512	514	PF00675	0.689
CLV_NRD_NRD_1	77	79	PF00675	0.718
CLV_PCSK_FUR_1	75	79	PF00082	0.716
CLV_PCSK_KEX2_1	120	122	PF00082	0.550
CLV_PCSK_KEX2_1	142	144	PF00082	0.536
CLV_PCSK_KEX2_1	246	248	PF00082	0.647
CLV_PCSK_KEX2_1	300	302	PF00082	0.575
CLV_PCSK_KEX2_1	315	317	PF00082	0.472
CLV_PCSK_KEX2_1	349	351	PF00082	0.683
CLV_PCSK_KEX2_1	357	359	PF00082	0.661
CLV_PCSK_KEX2_1	364	366	PF00082	0.418
CLV_PCSK_KEX2_1	394	396	PF00082	0.530
CLV_PCSK_KEX2_1	409	411	PF00082	0.576
CLV_PCSK_KEX2_1	418	420	PF00082	0.493
CLV_PCSK_KEX2_1	511	513	PF00082	0.612
CLV_PCSK_KEX2_1	525	527	PF00082	0.606
CLV_PCSK_KEX2_1	77	79	PF00082	0.718
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.540
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.647
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.579
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.584
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.612
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.648
CLV_PCSK_SKI1_1	197	201	PF00082	0.534
CLV_PCSK_SKI1_1	235	239	PF00082	0.575
CLV_PCSK_SKI1_1	288	292	PF00082	0.723
CLV_PCSK_SKI1_1	394	398	PF00082	0.518
CLV_PCSK_SKI1_1	536	540	PF00082	0.663
CLV_Separin_Metazoa	443	447	PF03568	0.592
DEG_APCC_DBOX_1	157	165	PF00400	0.658
DEG_APCC_DBOX_1	394	402	PF00400	0.570
DEG_Kelch_actinfilin_1	97	101	PF01344	0.638
DEG_SIAH_1	610	618	PF03145	0.684
DEG_SPOP_SBC_1	548	552	PF00917	0.696
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.628
DOC_MAPK_gen_1	315	324	PF00069	0.569
DOC_MAPK_gen_1	534	543	PF00069	0.574
DOC_MAPK_MEF2A_6	130	137	PF00069	0.554
DOC_MAPK_MEF2A_6	29	37	PF00069	0.596
DOC_MAPK_NFAT4_5	130	138	PF00069	0.450
DOC_PP1_RVXF_1	195	202	PF00149	0.529
DOC_PP2B_LxvP_1	103	106	PF13499	0.622
DOC_PP2B_LxvP_1	564	567	PF13499	0.755
DOC_PP2B_LxvP_1	95	98	PF13499	0.620
DOC_PP4_FxxP_1	2	5	PF00568	0.652
DOC_PP4_FxxP_1	634	637	PF00568	0.693
DOC_PP4_MxPP_1	621	624	PF00568	0.741
DOC_SPAK_OSR1_1	121	125	PF12202	0.558
DOC_USP7_MATH_1	175	179	PF00917	0.574
DOC_USP7_MATH_1	276	280	PF00917	0.667
DOC_USP7_MATH_1	42	46	PF00917	0.667
DOC_USP7_MATH_1	528	532	PF00917	0.724
DOC_USP7_MATH_1	544	548	PF00917	0.700
DOC_USP7_MATH_1	575	579	PF00917	0.723
DOC_USP7_MATH_1	582	586	PF00917	0.601
DOC_USP7_MATH_1	59	63	PF00917	0.682
DOC_USP7_MATH_1	595	599	PF00917	0.657
DOC_USP7_UBL2_3	339	343	PF12436	0.645
DOC_WW_Pin1_4	292	297	PF00397	0.729
DOC_WW_Pin1_4	673	678	PF00397	0.676
DOC_WW_Pin1_4	76	81	PF00397	0.715
LIG_14-3-3_CanoR_1	143	147	PF00244	0.552
LIG_14-3-3_CanoR_1	174	180	PF00244	0.570
LIG_14-3-3_CanoR_1	536	542	PF00244	0.730
LIG_BIR_III_4	250	254	PF00653	0.524
LIG_CaM_IQ_9	134	150	PF13499	0.547
LIG_CtBP_PxDLS_1	170	174	PF00389	0.451
LIG_deltaCOP1_diTrp_1	147	157	PF00928	0.561
LIG_FHA_1	10	16	PF00498	0.585
LIG_FHA_1	289	295	PF00498	0.695
LIG_FHA_1	538	544	PF00498	0.827
LIG_LIR_Gen_1	129	140	PF02991	0.485
LIG_LIR_Gen_1	193	202	PF02991	0.530
LIG_LIR_Nem_3	129	135	PF02991	0.486
LIG_LIR_Nem_3	193	198	PF02991	0.618
LIG_LIR_Nem_3	30	34	PF02991	0.556
LIG_LIR_Nem_3	585	591	PF02991	0.790
LIG_LIR_Nem_3	628	632	PF02991	0.682
LIG_LYPXL_yS_3	658	661	PF13949	0.732
LIG_SH2_CRK	366	370	PF00017	0.486
LIG_SH2_CRK	588	592	PF00017	0.618
LIG_SH2_PTP2	132	135	PF00017	0.551
LIG_SH2_SRC	274	277	PF00017	0.769
LIG_SH2_SRC	579	582	PF00017	0.747
LIG_SH2_SRC	588	591	PF00017	0.648
LIG_SH2_STAP1	128	132	PF00017	0.622
LIG_SH2_STAP1	195	199	PF00017	0.536
LIG_SH2_STAP1	366	370	PF00017	0.623
LIG_SH2_STAT5	118	121	PF00017	0.562
LIG_SH2_STAT5	132	135	PF00017	0.438
LIG_SH2_STAT5	502	505	PF00017	0.614
LIG_SH3_1	646	652	PF00018	0.671
LIG_SH3_3	260	266	PF00018	0.585
LIG_SH3_3	554	560	PF00018	0.626
LIG_SH3_3	566	572	PF00018	0.703
LIG_SH3_3	578	584	PF00018	0.568
LIG_SH3_3	589	595	PF00018	0.675
LIG_SH3_3	621	627	PF00018	0.728
LIG_SH3_3	635	641	PF00018	0.542
LIG_SH3_3	646	652	PF00018	0.574
LIG_SH3_3	656	662	PF00018	0.593
LIG_SH3_3	674	680	PF00018	0.468
LIG_SH3_3	98	104	PF00018	0.586
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.527
LIG_SUMO_SIM_par_1	97	102	PF11976	0.638
LIG_TRAF2_1	290	293	PF00917	0.806
LIG_TRAF2_1	388	391	PF00917	0.639
LIG_TRAF2_1	402	405	PF00917	0.501
LIG_TRAF2_1	421	424	PF00917	0.398
LIG_TRAF2_1	478	481	PF00917	0.651
LIG_TRAF2_1	68	71	PF00917	0.698
MOD_CDC14_SPxK_1	83	86	PF00782	0.670
MOD_CDK_SPxK_1	80	86	PF00069	0.687
MOD_CK1_1	279	285	PF00069	0.747
MOD_CK1_1	45	51	PF00069	0.690
MOD_CK1_1	547	553	PF00069	0.792
MOD_CK1_1	676	682	PF00069	0.677
MOD_CK2_1	292	298	PF00069	0.647
MOD_CK2_1	419	425	PF00069	0.565
MOD_CK2_1	622	628	PF00069	0.684
MOD_CK2_1	65	71	PF00069	0.702
MOD_Cter_Amidation	244	247	PF01082	0.566
MOD_Cter_Amidation	75	78	PF01082	0.718
MOD_GlcNHglycan	44	47	PF01048	0.690
MOD_GlcNHglycan	551	554	PF01048	0.661
MOD_GlcNHglycan	597	600	PF01048	0.717
MOD_GSK3_1	175	182	PF00069	0.599
MOD_GSK3_1	284	291	PF00069	0.717
MOD_GSK3_1	41	48	PF00069	0.681
MOD_GSK3_1	544	551	PF00069	0.760
MOD_GSK3_1	611	618	PF00069	0.739
MOD_GSK3_1	669	676	PF00069	0.726
MOD_GSK3_1	76	83	PF00069	0.800
MOD_N-GLC_1	52	57	PF02516	0.779
MOD_N-GLC_2	252	254	PF02516	0.535
MOD_PIKK_1	279	285	PF00454	0.750
MOD_PIKK_1	528	534	PF00454	0.674
MOD_PKA_1	142	148	PF00069	0.553
MOD_PKA_1	246	252	PF00069	0.604
MOD_PKA_1	419	425	PF00069	0.586
MOD_PKA_2	142	148	PF00069	0.558
MOD_PKA_2	246	252	PF00069	0.604
MOD_Plk_1	128	134	PF00069	0.524
MOD_Plk_1	202	208	PF00069	0.494
MOD_Plk_1	372	378	PF00069	0.556
MOD_Plk_4	10	16	PF00069	0.583
MOD_Plk_4	175	181	PF00069	0.575
MOD_Plk_4	611	617	PF00069	0.655
MOD_ProDKin_1	292	298	PF00069	0.720
MOD_ProDKin_1	673	679	PF00069	0.676
MOD_ProDKin_1	76	82	PF00069	0.714
MOD_SUMO_for_1	370	373	PF00179	0.561
MOD_SUMO_rev_2	159	164	PF00179	0.609
MOD_SUMO_rev_2	518	527	PF00179	0.607
MOD_SUMO_rev_2	83	93	PF00179	0.590
TRG_DiLeu_BaEn_1	320	325	PF01217	0.568
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.527
TRG_DiLeu_LyEn_5	30	35	PF01217	0.517
TRG_DiLeu_LyEn_5	320	325	PF01217	0.645
TRG_ENDOCYTIC_2	132	135	PF00928	0.492
TRG_ENDOCYTIC_2	195	198	PF00928	0.489
TRG_ENDOCYTIC_2	366	369	PF00928	0.487
TRG_ENDOCYTIC_2	588	591	PF00928	0.759
TRG_ENDOCYTIC_2	658	661	PF00928	0.672
TRG_ER_diArg_1	119	121	PF00400	0.546
TRG_ER_diArg_1	299	301	PF00400	0.546
TRG_ER_diArg_1	316	318	PF00400	0.561
TRG_ER_diArg_1	325	328	PF00400	0.523
TRG_ER_diArg_1	349	352	PF00400	0.683
TRG_ER_diArg_1	364	366	PF00400	0.400
TRG_ER_diArg_1	408	411	PF00400	0.612
TRG_ER_diArg_1	445	448	PF00400	0.537
TRG_ER_diArg_1	512	515	PF00400	0.623
TRG_ER_diArg_1	74	77	PF00400	0.709
TRG_NLS_Bipartite_1	496	515	PF00514	0.700
TRG_NLS_MonoCore_2	140	145	PF00514	0.544
TRG_NLS_MonoExtC_3	141	147	PF00514	0.546
TRG_NLS_MonoExtC_3	510	515	PF00514	0.688
TRG_NLS_MonoExtN_4	141	146	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL8	Leptomonas seymouri	53%	99%
A0A3Q8ICQ0	Leishmania donovani	93%	100%
A0A422NFT2	Trypanosoma rangeli	31%	100%
A4HFR3	Leishmania braziliensis	73%	100%
A4I2T9	Leishmania infantum	93%	100%
E9AZ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%