t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADB6_LEIMA

TriTrypDb:

LmjF.27.1350 , LMJLV39_270019900 , LMJSD75_270020100

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.573
CLV_C14_Caspase3-7	156	160	PF00656	0.574
CLV_NRD_NRD_1	14	16	PF00675	0.655
CLV_NRD_NRD_1	166	168	PF00675	0.640
CLV_NRD_NRD_1	187	189	PF00675	0.642
CLV_NRD_NRD_1	281	283	PF00675	0.728
CLV_PCSK_KEX2_1	14	16	PF00082	0.656
CLV_PCSK_KEX2_1	175	177	PF00082	0.639
CLV_PCSK_KEX2_1	187	189	PF00082	0.632
CLV_PCSK_KEX2_1	281	283	PF00082	0.694
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.659
CLV_PCSK_SKI1_1	176	180	PF00082	0.655
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_CKS1_1	233	238	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	161	164	PF00134	0.630
DOC_PP2B_LxvP_1	161	164	PF13499	0.630
DOC_PP4_FxxP_1	295	298	PF00568	0.666
DOC_USP7_MATH_1	100	104	PF00917	0.567
DOC_USP7_MATH_1	205	209	PF00917	0.714
DOC_USP7_MATH_1	67	71	PF00917	0.590
DOC_USP7_MATH_1	83	87	PF00917	0.593
DOC_WW_Pin1_4	169	174	PF00397	0.570
DOC_WW_Pin1_4	212	217	PF00397	0.647
DOC_WW_Pin1_4	224	229	PF00397	0.709
DOC_WW_Pin1_4	232	237	PF00397	0.621
DOC_WW_Pin1_4	253	258	PF00397	0.701
DOC_WW_Pin1_4	266	271	PF00397	0.603
DOC_WW_Pin1_4	81	86	PF00397	0.635
LIG_14-3-3_CanoR_1	152	158	PF00244	0.549
LIG_14-3-3_CanoR_1	167	172	PF00244	0.666
LIG_14-3-3_CanoR_1	218	228	PF00244	0.784
LIG_14-3-3_CanoR_1	263	273	PF00244	0.675
LIG_Actin_WH2_2	57	74	PF00022	0.631
LIG_BRCT_BRCA1_1	97	101	PF00533	0.558
LIG_FHA_1	124	130	PF00498	0.611
LIG_FHA_1	219	225	PF00498	0.628
LIG_FHA_1	233	239	PF00498	0.570
LIG_FHA_1	32	38	PF00498	0.592
LIG_FHA_2	63	69	PF00498	0.555
LIG_FHA_2	89	95	PF00498	0.686
LIG_IBAR_NPY_1	181	183	PF08397	0.689
LIG_LIR_Apic_2	230	236	PF02991	0.693
LIG_LIR_Gen_1	117	128	PF02991	0.431
LIG_LIR_Gen_1	98	109	PF02991	0.740
LIG_LIR_Nem_3	117	123	PF02991	0.425
LIG_LIR_Nem_3	309	314	PF02991	0.577
LIG_LIR_Nem_3	98	104	PF02991	0.740
LIG_LYPXL_SIV_4	182	190	PF13949	0.630
LIG_PTB_Apo_2	237	244	PF02174	0.574
LIG_PTB_Phospho_1	237	243	PF10480	0.572
LIG_SH2_CRK	120	124	PF00017	0.544
LIG_SH2_CRK	233	237	PF00017	0.693
LIG_SH2_NCK_1	233	237	PF00017	0.693
LIG_SH2_STAT3	145	148	PF00017	0.615
LIG_SH2_STAT5	243	246	PF00017	0.641
LIG_SH3_2	9	14	PF14604	0.630
LIG_SH3_3	225	231	PF00018	0.725
LIG_SH3_3	3	9	PF00018	0.680
LIG_SH3_3	77	83	PF00018	0.691
LIG_SH3_CIN85_PxpxPR_1	9	14	PF14604	0.605
LIG_SUMO_SIM_par_1	36	41	PF11976	0.469
LIG_TRAF2_1	110	113	PF00917	0.529
LIG_WW_3	11	15	PF00397	0.633
MOD_CDC14_SPxK_1	172	175	PF00782	0.565
MOD_CDC14_SPxK_1	215	218	PF00782	0.682
MOD_CDC14_SPxK_1	256	259	PF00782	0.665
MOD_CDK_SPxK_1	169	175	PF00069	0.569
MOD_CDK_SPxK_1	212	218	PF00069	0.681
MOD_CDK_SPxK_1	253	259	PF00069	0.666
MOD_CDK_SPxxK_3	169	176	PF00069	0.569
MOD_CK1_1	204	210	PF00069	0.689
MOD_CK1_1	220	226	PF00069	0.749
MOD_CK1_1	227	233	PF00069	0.701
MOD_CK1_1	245	251	PF00069	0.654
MOD_CK1_1	258	264	PF00069	0.627
MOD_Cter_Amidation	173	176	PF01082	0.568
MOD_DYRK1A_RPxSP_1	81	85	PF00069	0.577
MOD_GlcNHglycan	203	206	PF01048	0.641
MOD_GlcNHglycan	250	253	PF01048	0.651
MOD_GlcNHglycan	40	43	PF01048	0.654
MOD_GSK3_1	100	107	PF00069	0.492
MOD_GSK3_1	197	204	PF00069	0.683
MOD_GSK3_1	205	212	PF00069	0.641
MOD_GSK3_1	216	223	PF00069	0.727
MOD_GSK3_1	227	234	PF00069	0.707
MOD_GSK3_1	241	248	PF00069	0.743
MOD_GSK3_1	63	70	PF00069	0.555
MOD_GSK3_1	83	90	PF00069	0.613
MOD_N-GLC_1	198	203	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.736
MOD_NEK2_1	123	128	PF00069	0.576
MOD_NEK2_1	153	158	PF00069	0.580
MOD_NEK2_1	38	43	PF00069	0.567
MOD_NEK2_1	62	67	PF00069	0.699
MOD_NEK2_2	67	72	PF00069	0.561
MOD_PIKK_1	112	118	PF00454	0.572
MOD_PIKK_1	134	140	PF00454	0.580
MOD_PIKK_1	44	50	PF00454	0.608
MOD_PK_1	167	173	PF00069	0.669
MOD_PKA_1	167	173	PF00069	0.669
MOD_PKA_2	217	223	PF00069	0.803
MOD_PKA_2	258	264	PF00069	0.713
MOD_Plk_1	198	204	PF00069	0.591
MOD_Plk_1	205	211	PF00069	0.666
MOD_Plk_1	67	73	PF00069	0.527
MOD_ProDKin_1	169	175	PF00069	0.569
MOD_ProDKin_1	212	218	PF00069	0.649
MOD_ProDKin_1	224	230	PF00069	0.708
MOD_ProDKin_1	232	238	PF00069	0.621
MOD_ProDKin_1	253	259	PF00069	0.703
MOD_ProDKin_1	266	272	PF00069	0.603
MOD_ProDKin_1	81	87	PF00069	0.639
MOD_SUMO_rev_2	55	63	PF00179	0.550
TRG_ENDOCYTIC_2	120	123	PF00928	0.539
TRG_ENDOCYTIC_2	314	317	PF00928	0.627
TRG_ER_diArg_1	13	15	PF00400	0.654
TRG_ER_diArg_1	281	283	PF00400	0.805
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX8	Leptomonas seymouri	32%	87%
A0A3Q8IEA3	Leishmania donovani	87%	100%
A4HFR2	Leishmania braziliensis	54%	100%
A4I2T8	Leishmania infantum	87%	100%
E9AZ41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%