RGS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADB5_LEIMA

TriTrypDb:

LmjF.27.1340 , LMJLV39_270019800 , LMJSD75_270020000

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	251	253	PF00675	0.600
CLV_NRD_NRD_1	260	262	PF00675	0.632
CLV_NRD_NRD_1	314	316	PF00675	0.742
CLV_NRD_NRD_1	342	344	PF00675	0.549
CLV_PCSK_KEX2_1	250	252	PF00082	0.565
CLV_PCSK_KEX2_1	259	261	PF00082	0.594
CLV_PCSK_KEX2_1	314	316	PF00082	0.859
CLV_PCSK_PC7_1	247	253	PF00082	0.482
CLV_PCSK_SKI1_1	325	329	PF00082	0.715
CLV_PCSK_SKI1_1	52	56	PF00082	0.722
DEG_APCC_DBOX_1	155	163	PF00400	0.548
DEG_APCC_KENBOX_2	201	205	PF00400	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.678
DEG_SCF_FBW7_1	78	85	PF00400	0.808
DEG_SCF_FBW7_1	86	92	PF00400	0.675
DOC_ANK_TNKS_1	78	85	PF00023	0.575
DOC_CKS1_1	269	274	PF01111	0.709
DOC_CKS1_1	39	44	PF01111	0.710
DOC_CKS1_1	86	91	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.727
DOC_MAPK_gen_1	143	150	PF00069	0.590
DOC_MAPK_gen_1	156	164	PF00069	0.485
DOC_MAPK_gen_1	339	348	PF00069	0.673
DOC_MAPK_HePTP_8	45	57	PF00069	0.586
DOC_MAPK_MEF2A_6	158	166	PF00069	0.656
DOC_MAPK_MEF2A_6	48	57	PF00069	0.698
DOC_PP1_RVXF_1	179	186	PF00149	0.624
DOC_PP1_RVXF_1	341	348	PF00149	0.612
DOC_PP4_MxPP_1	80	83	PF00568	0.730
DOC_SPAK_OSR1_1	172	176	PF12202	0.554
DOC_USP7_MATH_1	90	94	PF00917	0.704
DOC_USP7_UBL2_3	48	52	PF12436	0.781
DOC_WW_Pin1_4	268	273	PF00397	0.710
DOC_WW_Pin1_4	297	302	PF00397	0.752
DOC_WW_Pin1_4	38	43	PF00397	0.765
DOC_WW_Pin1_4	78	83	PF00397	0.812
DOC_WW_Pin1_4	85	90	PF00397	0.689
LIG_14-3-3_CanoR_1	207	215	PF00244	0.545
LIG_14-3-3_CanoR_1	264	268	PF00244	0.586
LIG_APCC_ABBA_1	229	234	PF00400	0.529
LIG_APCC_ABBAyCdc20_2	228	234	PF00400	0.529
LIG_FHA_1	103	109	PF00498	0.441
LIG_FHA_1	209	215	PF00498	0.564
LIG_FHA_1	330	336	PF00498	0.716
LIG_FHA_1	39	45	PF00498	0.786
LIG_FHA_1	86	92	PF00498	0.730
LIG_FHA_2	163	169	PF00498	0.555
LIG_FHA_2	331	337	PF00498	0.660
LIG_LIR_Gen_1	178	187	PF02991	0.554
LIG_LIR_Gen_1	212	223	PF02991	0.625
LIG_LIR_Nem_3	178	182	PF02991	0.569
LIG_LIR_Nem_3	212	218	PF02991	0.610
LIG_NRBOX	158	164	PF00104	0.556
LIG_Pex14_2	120	124	PF04695	0.578
LIG_SH2_STAP1	179	183	PF00017	0.507
LIG_SH2_STAP1	215	219	PF00017	0.565
LIG_SH2_STAT5	68	71	PF00017	0.710
LIG_SH3_3	18	24	PF00018	0.615
LIG_SH3_3	271	277	PF00018	0.673
LIG_SH3_3	80	86	PF00018	0.725
LIG_SH3_4	48	55	PF00018	0.742
LIG_SUMO_SIM_par_1	162	168	PF11976	0.659
LIG_TRAF2_1	267	270	PF00917	0.677
LIG_UBA3_1	219	228	PF00899	0.412
MOD_CDK_SPK_2	82	87	PF00069	0.725
MOD_CDK_SPxxK_3	297	304	PF00069	0.601
MOD_CK1_1	116	122	PF00069	0.448
MOD_CK1_1	129	135	PF00069	0.635
MOD_CK1_1	316	322	PF00069	0.853
MOD_CK1_1	329	335	PF00069	0.535
MOD_CK1_1	60	66	PF00069	0.706
MOD_CK1_1	74	80	PF00069	0.609
MOD_CK1_1	85	91	PF00069	0.644
MOD_CK2_1	162	168	PF00069	0.535
MOD_CK2_1	315	321	PF00069	0.797
MOD_CK2_1	328	334	PF00069	0.647
MOD_CK2_1	347	353	PF00069	0.750
MOD_GlcNHglycan	115	118	PF01048	0.602
MOD_GlcNHglycan	127	131	PF01048	0.447
MOD_GlcNHglycan	265	268	PF01048	0.696
MOD_GlcNHglycan	315	318	PF01048	0.803
MOD_GlcNHglycan	61	65	PF01048	0.677
MOD_GSK3_1	309	316	PF00069	0.778
MOD_GSK3_1	326	333	PF00069	0.523
MOD_GSK3_1	60	67	PF00069	0.649
MOD_GSK3_1	74	81	PF00069	0.620
MOD_GSK3_1	85	92	PF00069	0.721
MOD_N-GLC_1	287	292	PF02516	0.786
MOD_NEK2_1	113	118	PF00069	0.690
MOD_NEK2_1	162	167	PF00069	0.521
MOD_NEK2_1	238	243	PF00069	0.672
MOD_NEK2_1	59	64	PF00069	0.660
MOD_PIKK_1	238	244	PF00454	0.560
MOD_PIKK_1	5	11	PF00454	0.642
MOD_PKA_2	263	269	PF00069	0.655
MOD_PKA_2	313	319	PF00069	0.619
MOD_PKA_2	321	327	PF00069	0.615
MOD_PKB_1	306	314	PF00069	0.655
MOD_Plk_1	64	70	PF00069	0.746
MOD_Plk_4	108	114	PF00069	0.611
MOD_Plk_4	116	122	PF00069	0.510
MOD_Plk_4	64	70	PF00069	0.711
MOD_ProDKin_1	268	274	PF00069	0.706
MOD_ProDKin_1	297	303	PF00069	0.754
MOD_ProDKin_1	38	44	PF00069	0.763
MOD_ProDKin_1	78	84	PF00069	0.810
MOD_ProDKin_1	85	91	PF00069	0.691
TRG_DiLeu_BaEn_2	177	183	PF01217	0.527
TRG_DiLeu_BaEn_2	233	239	PF01217	0.536
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.576
TRG_ENDOCYTIC_2	179	182	PF00928	0.554
TRG_ENDOCYTIC_2	215	218	PF00928	0.538
TRG_ER_diArg_1	156	159	PF00400	0.621
TRG_ER_diArg_1	250	252	PF00400	0.572
TRG_ER_diArg_1	259	261	PF00400	0.542
TRG_ER_diArg_1	304	307	PF00400	0.612
TRG_ER_diArg_1	338	341	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE2	Leptomonas seymouri	42%	74%
A0A3S7X0P6	Leishmania donovani	86%	100%
A4HFR1	Leishmania braziliensis	57%	91%
A4I2T7	Leishmania infantum	86%	100%
E9AZ40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%