Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADB4_LEIMA

TriTrypDb:

LmjF.27.1330 , LMJLV39_270019700 , LMJSD75_270019900

Length:

433

Annotations

LeishMANIAdb annotations

A conserved protein only found in kinetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4

Expansion

Sequence features

E9ADB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	172	178	PF00089	0.471
CLV_NRD_NRD_1	275	277	PF00675	0.510
CLV_NRD_NRD_1	284	286	PF00675	0.540
CLV_NRD_NRD_1	289	291	PF00675	0.566
CLV_NRD_NRD_1	308	310	PF00675	0.522
CLV_NRD_NRD_1	404	406	PF00675	0.549
CLV_NRD_NRD_1	428	430	PF00675	0.729
CLV_PCSK_FUR_1	282	286	PF00082	0.529
CLV_PCSK_KEX2_1	15	17	PF00082	0.494
CLV_PCSK_KEX2_1	282	284	PF00082	0.554
CLV_PCSK_KEX2_1	289	291	PF00082	0.567
CLV_PCSK_KEX2_1	308	310	PF00082	0.525
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.494
CLV_PCSK_PC7_1	279	285	PF00082	0.545
CLV_PCSK_SKI1_1	129	133	PF00082	0.452
CLV_PCSK_SKI1_1	232	236	PF00082	0.364
CLV_Separin_Metazoa	68	72	PF03568	0.340
DEG_APCC_DBOX_1	128	136	PF00400	0.253
DOC_CKS1_1	166	171	PF01111	0.294
DOC_CYCLIN_RxL_1	12	22	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.372
DOC_MAPK_gen_1	15	23	PF00069	0.330
DOC_MAPK_gen_1	308	315	PF00069	0.403
DOC_MAPK_gen_1	405	411	PF00069	0.367
DOC_MAPK_MEF2A_6	15	23	PF00069	0.308
DOC_MAPK_MEF2A_6	71	78	PF00069	0.288
DOC_SPAK_OSR1_1	175	179	PF12202	0.269
DOC_USP7_MATH_1	331	335	PF00917	0.576
DOC_WW_Pin1_4	165	170	PF00397	0.319
DOC_WW_Pin1_4	232	237	PF00397	0.576
DOC_WW_Pin1_4	46	51	PF00397	0.315
LIG_14-3-3_CanoR_1	133	138	PF00244	0.335
LIG_14-3-3_CanoR_1	175	179	PF00244	0.291
LIG_14-3-3_CanoR_1	202	211	PF00244	0.335
LIG_14-3-3_CanoR_1	243	253	PF00244	0.442
LIG_14-3-3_CanoR_1	82	87	PF00244	0.318
LIG_14-3-3_CterR_2	429	433	PF00244	0.534
LIG_APCC_ABBA_1	23	28	PF00400	0.275
LIG_BRCT_BRCA1_1	135	139	PF00533	0.302
LIG_BRCT_BRCA1_1	172	176	PF00533	0.262
LIG_BRCT_BRCA1_1	333	337	PF00533	0.678
LIG_BRCT_BRCA1_2	333	339	PF00533	0.675
LIG_deltaCOP1_diTrp_1	343	350	PF00928	0.560
LIG_FHA_1	195	201	PF00498	0.288
LIG_FHA_1	305	311	PF00498	0.292
LIG_FHA_2	165	171	PF00498	0.350
LIG_FHA_2	388	394	PF00498	0.316
LIG_FHA_2	411	417	PF00498	0.408
LIG_FHA_2	421	427	PF00498	0.438
LIG_FHA_2	83	89	PF00498	0.331
LIG_IBAR_NPY_1	297	299	PF08397	0.386
LIG_LIR_Apic_2	343	349	PF02991	0.559
LIG_LIR_Gen_1	193	204	PF02991	0.344
LIG_LIR_Gen_1	210	219	PF02991	0.187
LIG_LIR_Gen_1	247	257	PF02991	0.300
LIG_LIR_Gen_1	28	39	PF02991	0.268
LIG_LIR_Gen_1	393	402	PF02991	0.310
LIG_LIR_Gen_1	5	12	PF02991	0.318
LIG_LIR_Nem_3	193	199	PF02991	0.342
LIG_LIR_Nem_3	210	215	PF02991	0.249
LIG_LIR_Nem_3	247	253	PF02991	0.288
LIG_LIR_Nem_3	28	34	PF02991	0.273
LIG_LIR_Nem_3	319	323	PF02991	0.331
LIG_LIR_Nem_3	334	340	PF02991	0.673
LIG_LIR_Nem_3	389	395	PF02991	0.285
LIG_LIR_Nem_3	5	11	PF02991	0.321
LIG_LIR_Nem_3	81	86	PF02991	0.312
LIG_MYND_1	352	356	PF01753	0.573
LIG_Pex14_1	346	350	PF04695	0.562
LIG_PTB_Apo_2	293	300	PF02174	0.369
LIG_PTB_Phospho_1	293	299	PF10480	0.329
LIG_SH2_CRK	250	254	PF00017	0.281
LIG_SH2_CRK	62	66	PF00017	0.273
LIG_SH2_GRB2like	294	297	PF00017	0.451
LIG_SH2_NCK_1	31	35	PF00017	0.259
LIG_SH2_NCK_1	62	66	PF00017	0.273
LIG_SH2_PTP2	395	398	PF00017	0.384
LIG_SH2_STAP1	196	200	PF00017	0.300
LIG_SH2_STAP1	26	30	PF00017	0.263
LIG_SH2_STAP1	392	396	PF00017	0.275
LIG_SH2_STAP1	8	12	PF00017	0.261
LIG_SH2_STAT3	105	108	PF00017	0.373
LIG_SH2_STAT3	125	128	PF00017	0.168
LIG_SH2_STAT3	311	314	PF00017	0.319
LIG_SH2_STAT5	125	128	PF00017	0.255
LIG_SH2_STAT5	137	140	PF00017	0.266
LIG_SH2_STAT5	196	199	PF00017	0.289
LIG_SH2_STAT5	214	217	PF00017	0.266
LIG_SH2_STAT5	250	253	PF00017	0.296
LIG_SH2_STAT5	257	260	PF00017	0.315
LIG_SH2_STAT5	299	302	PF00017	0.344
LIG_SH2_STAT5	318	321	PF00017	0.314
LIG_SH2_STAT5	395	398	PF00017	0.280
LIG_SH3_3	163	169	PF00018	0.323
LIG_SH3_3	332	338	PF00018	0.536
LIG_SH3_3	346	352	PF00018	0.561
LIG_SH3_3	369	375	PF00018	0.266
LIG_TRAF2_1	85	88	PF00917	0.277
LIG_TRFH_1	37	41	PF08558	0.308
LIG_TYR_ITIM	194	199	PF00017	0.435
LIG_UBA3_1	329	336	PF00899	0.441
MOD_CDK_SPK_2	232	237	PF00069	0.454
MOD_CK1_1	316	322	PF00069	0.369
MOD_CK1_1	49	55	PF00069	0.450
MOD_CK2_1	189	195	PF00069	0.400
MOD_CK2_1	410	416	PF00069	0.585
MOD_CK2_1	82	88	PF00069	0.361
MOD_GlcNHglycan	246	249	PF01048	0.302
MOD_GlcNHglycan	315	318	PF01048	0.381
MOD_GlcNHglycan	430	433	PF01048	0.604
MOD_GSK3_1	170	177	PF00069	0.310
MOD_GSK3_1	194	201	PF00069	0.369
MOD_GSK3_1	420	427	PF00069	0.576
MOD_GSK3_1	78	85	PF00069	0.364
MOD_N-GLC_1	110	115	PF02516	0.405
MOD_NEK2_1	112	117	PF00069	0.363
MOD_NEK2_1	119	124	PF00069	0.360
MOD_NEK2_1	19	24	PF00069	0.452
MOD_NEK2_1	313	318	PF00069	0.275
MOD_NEK2_1	325	330	PF00069	0.249
MOD_NEK2_1	78	83	PF00069	0.345
MOD_NEK2_1	95	100	PF00069	0.382
MOD_NEK2_2	174	179	PF00069	0.309
MOD_NEK2_2	331	336	PF00069	0.606
MOD_NEK2_2	387	392	PF00069	0.364
MOD_NMyristoyl	1	7	PF02799	0.475
MOD_PIKK_1	119	125	PF00454	0.501
MOD_PIKK_1	202	208	PF00454	0.457
MOD_PKA_2	174	180	PF00069	0.346
MOD_PKA_2	275	281	PF00069	0.383
MOD_Plk_1	87	93	PF00069	0.454
MOD_Plk_2-3	189	195	PF00069	0.369
MOD_Plk_2-3	412	418	PF00069	0.566
MOD_Plk_2-3	88	94	PF00069	0.342
MOD_Plk_4	121	127	PF00069	0.379
MOD_Plk_4	133	139	PF00069	0.286
MOD_Plk_4	325	331	PF00069	0.278
MOD_Plk_4	387	393	PF00069	0.352
MOD_ProDKin_1	165	171	PF00069	0.387
MOD_ProDKin_1	232	238	PF00069	0.465
MOD_ProDKin_1	46	52	PF00069	0.377
TRG_DiLeu_BaEn_1	195	200	PF01217	0.444
TRG_DiLeu_BaEn_4	87	93	PF01217	0.309
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.354
TRG_ENDOCYTIC_2	116	119	PF00928	0.371
TRG_ENDOCYTIC_2	196	199	PF00928	0.428
TRG_ENDOCYTIC_2	214	217	PF00928	0.172
TRG_ENDOCYTIC_2	221	224	PF00928	0.351
TRG_ENDOCYTIC_2	250	253	PF00928	0.266
TRG_ENDOCYTIC_2	31	34	PF00928	0.295
TRG_ENDOCYTIC_2	395	398	PF00928	0.357
TRG_ENDOCYTIC_2	62	65	PF00928	0.312
TRG_ENDOCYTIC_2	8	11	PF00928	0.359
TRG_ENDOCYTIC_2	83	86	PF00928	0.411
TRG_ER_diArg_1	240	243	PF00400	0.498
TRG_ER_diArg_1	281	284	PF00400	0.428
TRG_ER_diArg_1	308	310	PF00400	0.395
TRG_ER_diArg_1	398	401	PF00400	0.410
TRG_NES_CRM1_1	156	170	PF08389	0.362
TRG_NES_CRM1_1	301	314	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH9	Leptomonas seymouri	87%	100%
A0A0S4JSX9	Bodo saltans	65%	100%
A0A1X0P4G9	Trypanosomatidae	74%	100%
A0A3R7KAE6	Trypanosoma rangeli	73%	100%
A0A3S7X0P9	Leishmania donovani	98%	100%
A4HFR0	Leishmania braziliensis	92%	100%
A4I2T6	Leishmania infantum	98%	100%
D0A602	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AZ39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DHE8	Trypanosoma cruzi	72%	83%