JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ADB3_LEIMA

TriTrypDb:

LmjF.27.1320 , LMJLV39_270019600 , LMJSD75_270019800

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018195	peptidyl-arginine modification	6	2
GO:0018216	peptidyl-arginine methylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034969	histone arginine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0043985	histone H4-R3 methylation	7	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	2
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	2
GO:0001067	transcription regulatory region nucleic acid binding	4	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0043565	sequence-specific DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:1990837	sequence-specific double-stranded DNA binding	6	2
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.742
CLV_C14_Caspase3-7	244	248	PF00656	0.711
CLV_C14_Caspase3-7	362	366	PF00656	0.407
CLV_NRD_NRD_1	169	171	PF00675	0.635
CLV_NRD_NRD_1	224	226	PF00675	0.710
CLV_NRD_NRD_1	254	256	PF00675	0.662
CLV_NRD_NRD_1	422	424	PF00675	0.299
CLV_NRD_NRD_1	543	545	PF00675	0.401
CLV_NRD_NRD_1	581	583	PF00675	0.515
CLV_PCSK_FUR_1	578	582	PF00082	0.553
CLV_PCSK_KEX2_1	136	138	PF00082	0.637
CLV_PCSK_KEX2_1	143	145	PF00082	0.638
CLV_PCSK_KEX2_1	169	171	PF00082	0.549
CLV_PCSK_KEX2_1	20	22	PF00082	0.598
CLV_PCSK_KEX2_1	254	256	PF00082	0.662
CLV_PCSK_KEX2_1	424	426	PF00082	0.283
CLV_PCSK_KEX2_1	543	545	PF00082	0.428
CLV_PCSK_KEX2_1	580	582	PF00082	0.497
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.644
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.661
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.685
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.283
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.539
CLV_PCSK_SKI1_1	169	173	PF00082	0.473
CLV_PCSK_SKI1_1	425	429	PF00082	0.283
CLV_PCSK_SKI1_1	514	518	PF00082	0.398
CLV_PCSK_SKI1_1	520	524	PF00082	0.455
DEG_APCC_DBOX_1	508	516	PF00400	0.416
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DEG_SPOP_SBC_1	236	240	PF00917	0.652
DOC_CDC14_PxL_1	60	68	PF14671	0.608
DOC_CKS1_1	370	375	PF01111	0.212
DOC_CKS1_1	447	452	PF01111	0.299
DOC_MAPK_gen_1	280	290	PF00069	0.336
DOC_MAPK_gen_1	423	429	PF00069	0.299
DOC_MAPK_gen_1	578	588	PF00069	0.507
DOC_MAPK_MEF2A_6	280	288	PF00069	0.343
DOC_MIT_MIM_1	300	310	PF04212	0.377
DOC_PP1_RVXF_1	423	430	PF00149	0.299
DOC_PP1_RVXF_1	512	519	PF00149	0.397
DOC_PP2B_LxvP_1	428	431	PF13499	0.283
DOC_PP2B_LxvP_1	61	64	PF13499	0.619
DOC_PP4_FxxP_1	281	284	PF00568	0.318
DOC_USP7_MATH_1	201	205	PF00917	0.640
DOC_USP7_MATH_1	235	239	PF00917	0.699
DOC_USP7_MATH_1	399	403	PF00917	0.424
DOC_USP7_MATH_2	265	271	PF00917	0.512
DOC_USP7_UBL2_3	135	139	PF12436	0.732
DOC_WW_Pin1_4	116	121	PF00397	0.711
DOC_WW_Pin1_4	129	134	PF00397	0.650
DOC_WW_Pin1_4	152	157	PF00397	0.665
DOC_WW_Pin1_4	160	165	PF00397	0.582
DOC_WW_Pin1_4	199	204	PF00397	0.649
DOC_WW_Pin1_4	253	258	PF00397	0.599
DOC_WW_Pin1_4	323	328	PF00397	0.387
DOC_WW_Pin1_4	369	374	PF00397	0.212
DOC_WW_Pin1_4	431	436	PF00397	0.324
DOC_WW_Pin1_4	446	451	PF00397	0.217
DOC_WW_Pin1_4	91	96	PF00397	0.531
LIG_14-3-3_CanoR_1	225	233	PF00244	0.574
LIG_14-3-3_CanoR_1	271	275	PF00244	0.513
LIG_14-3-3_CanoR_1	401	407	PF00244	0.320
LIG_14-3-3_CanoR_1	585	589	PF00244	0.603
LIG_14-3-3_CanoR_1	68	78	PF00244	0.460
LIG_Actin_WH2_2	177	194	PF00022	0.401
LIG_AP2alpha_1	277	281	PF02296	0.407
LIG_BRCT_BRCA1_1	21	25	PF00533	0.587
LIG_BRCT_BRCA1_1	592	596	PF00533	0.524
LIG_CtBP_PxDLS_1	450	454	PF00389	0.299
LIG_deltaCOP1_diTrp_1	296	300	PF00928	0.377
LIG_FHA_1	240	246	PF00498	0.623
LIG_FHA_1	28	34	PF00498	0.590
LIG_FHA_1	323	329	PF00498	0.337
LIG_FHA_1	452	458	PF00498	0.302
LIG_FHA_2	331	337	PF00498	0.281
LIG_FHA_2	382	388	PF00498	0.419
LIG_FHA_2	533	539	PF00498	0.636
LIG_FHA_2	585	591	PF00498	0.544
LIG_LIR_Apic_2	279	284	PF02991	0.343
LIG_LIR_Apic_2	3	7	PF02991	0.551
LIG_LIR_Apic_2	367	373	PF02991	0.283
LIG_LIR_Gen_1	22	33	PF02991	0.630
LIG_LIR_Gen_1	379	390	PF02991	0.384
LIG_LIR_Gen_1	47	58	PF02991	0.479
LIG_LIR_Gen_1	74	85	PF02991	0.502
LIG_LIR_Nem_3	22	28	PF02991	0.589
LIG_LIR_Nem_3	261	266	PF02991	0.452
LIG_LIR_Nem_3	295	300	PF02991	0.290
LIG_LIR_Nem_3	338	343	PF02991	0.285
LIG_LIR_Nem_3	357	363	PF02991	0.374
LIG_LIR_Nem_3	379	385	PF02991	0.306
LIG_LIR_Nem_3	47	53	PF02991	0.496
LIG_LIR_Nem_3	74	80	PF02991	0.517
LIG_LIR_Nem_3	94	100	PF02991	0.361
LIG_PDZ_Class_2	595	600	PF00595	0.526
LIG_Pex14_1	456	460	PF04695	0.343
LIG_Pex14_2	100	104	PF04695	0.486
LIG_Pex14_2	277	281	PF04695	0.299
LIG_Pex14_2	356	360	PF04695	0.283
LIG_Pex14_2	548	552	PF04695	0.368
LIG_Pex14_2	596	600	PF04695	0.531
LIG_SH2_CRK	370	374	PF00017	0.374
LIG_SH2_CRK	90	94	PF00017	0.551
LIG_SH2_GRB2like	412	415	PF00017	0.318
LIG_SH2_NCK_1	370	374	PF00017	0.299
LIG_SH2_PTP2	112	115	PF00017	0.553
LIG_SH2_PTP2	77	80	PF00017	0.571
LIG_SH2_STAP1	412	416	PF00017	0.299
LIG_SH2_STAP1	461	465	PF00017	0.283
LIG_SH2_STAT5	112	115	PF00017	0.552
LIG_SH2_STAT5	259	262	PF00017	0.508
LIG_SH2_STAT5	340	343	PF00017	0.289
LIG_SH2_STAT5	370	373	PF00017	0.362
LIG_SH2_STAT5	375	378	PF00017	0.326
LIG_SH2_STAT5	412	415	PF00017	0.299
LIG_SH2_STAT5	50	53	PF00017	0.610
LIG_SH2_STAT5	506	509	PF00017	0.318
LIG_SH2_STAT5	77	80	PF00017	0.446
LIG_SH2_STAT5	90	93	PF00017	0.504
LIG_SH2_STAT5	97	100	PF00017	0.363
LIG_SH3_3	246	252	PF00018	0.736
LIG_SH3_3	281	287	PF00018	0.348
LIG_SH3_3	321	327	PF00018	0.385
LIG_SH3_3	393	399	PF00018	0.407
LIG_SH3_3	444	450	PF00018	0.314
LIG_SUMO_SIM_par_1	286	292	PF11976	0.283
LIG_SUMO_SIM_par_1	29	35	PF11976	0.582
LIG_SUMO_SIM_par_1	449	455	PF11976	0.301
LIG_TRAF2_1	464	467	PF00917	0.396
LIG_TRAF2_1	536	539	PF00917	0.556
LIG_TRFH_1	189	193	PF08558	0.425
LIG_WW_1	186	189	PF00397	0.538
MOD_CDC14_SPxK_1	326	329	PF00782	0.374
MOD_CDK_SPK_2	253	258	PF00069	0.709
MOD_CDK_SPxK_1	129	135	PF00069	0.669
MOD_CDK_SPxK_1	323	329	PF00069	0.424
MOD_CDK_SPxxK_3	129	136	PF00069	0.671
MOD_CK1_1	124	130	PF00069	0.741
MOD_CK1_1	131	137	PF00069	0.705
MOD_CK1_1	204	210	PF00069	0.745
MOD_CK1_1	224	230	PF00069	0.454
MOD_CK1_1	238	244	PF00069	0.663
MOD_CK1_1	270	276	PF00069	0.406
MOD_CK1_1	32	38	PF00069	0.587
MOD_CK1_1	402	408	PF00069	0.438
MOD_CK2_1	100	106	PF00069	0.523
MOD_CK2_1	135	141	PF00069	0.780
MOD_CK2_1	238	244	PF00069	0.748
MOD_CK2_1	270	276	PF00069	0.396
MOD_CK2_1	449	455	PF00069	0.283
MOD_CK2_1	461	467	PF00069	0.283
MOD_CK2_1	532	538	PF00069	0.541
MOD_Cter_Amidation	421	424	PF01082	0.299
MOD_GlcNHglycan	123	126	PF01048	0.746
MOD_GlcNHglycan	207	210	PF01048	0.722
MOD_GlcNHglycan	213	217	PF01048	0.742
MOD_GlcNHglycan	219	222	PF01048	0.771
MOD_GlcNHglycan	319	322	PF01048	0.425
MOD_GlcNHglycan	401	404	PF01048	0.403
MOD_GlcNHglycan	440	443	PF01048	0.416
MOD_GlcNHglycan	526	529	PF01048	0.395
MOD_GlcNHglycan	592	595	PF01048	0.520
MOD_GSK3_1	100	107	PF00069	0.516
MOD_GSK3_1	124	131	PF00069	0.648
MOD_GSK3_1	135	142	PF00069	0.554
MOD_GSK3_1	199	206	PF00069	0.697
MOD_GSK3_1	217	224	PF00069	0.757
MOD_GSK3_1	235	242	PF00069	0.663
MOD_GSK3_1	288	295	PF00069	0.320
MOD_GSK3_1	313	320	PF00069	0.430
MOD_GSK3_1	496	503	PF00069	0.283
MOD_GSK3_1	534	541	PF00069	0.600
MOD_GSK3_1	590	597	PF00069	0.565
MOD_GSK3_1	67	74	PF00069	0.455
MOD_N-GLC_1	129	134	PF02516	0.670
MOD_N-GLC_1	410	415	PF02516	0.283
MOD_N-GLC_1	418	423	PF02516	0.283
MOD_NEK2_1	100	105	PF00069	0.498
MOD_NEK2_1	205	210	PF00069	0.790
MOD_NEK2_1	317	322	PF00069	0.410
MOD_NEK2_1	381	386	PF00069	0.361
MOD_NEK2_1	496	501	PF00069	0.283
MOD_NEK2_1	522	527	PF00069	0.391
MOD_NEK2_1	69	74	PF00069	0.475
MOD_NEK2_2	29	34	PF00069	0.637
MOD_OFUCOSY	67	73	PF10250	0.489
MOD_PIKK_1	224	230	PF00454	0.575
MOD_PIKK_1	500	506	PF00454	0.283
MOD_PKA_1	135	141	PF00069	0.717
MOD_PKA_1	313	319	PF00069	0.374
MOD_PKA_2	100	106	PF00069	0.517
MOD_PKA_2	224	230	PF00069	0.690
MOD_PKA_2	267	273	PF00069	0.405
MOD_PKA_2	584	590	PF00069	0.633
MOD_PKA_2	67	73	PF00069	0.454
MOD_Plk_1	330	336	PF00069	0.242
MOD_Plk_1	461	467	PF00069	0.263
MOD_Plk_1	496	502	PF00069	0.283
MOD_Plk_2-3	331	337	PF00069	0.239
MOD_Plk_2-3	359	365	PF00069	0.416
MOD_Plk_2-3	534	540	PF00069	0.562
MOD_Plk_4	180	186	PF00069	0.409
MOD_Plk_4	29	35	PF00069	0.497
MOD_Plk_4	313	319	PF00069	0.474
MOD_Plk_4	359	365	PF00069	0.312
MOD_Plk_4	584	590	PF00069	0.633
MOD_Plk_4	93	99	PF00069	0.584
MOD_ProDKin_1	116	122	PF00069	0.714
MOD_ProDKin_1	129	135	PF00069	0.651
MOD_ProDKin_1	152	158	PF00069	0.666
MOD_ProDKin_1	160	166	PF00069	0.579
MOD_ProDKin_1	199	205	PF00069	0.652
MOD_ProDKin_1	253	259	PF00069	0.584
MOD_ProDKin_1	323	329	PF00069	0.387
MOD_ProDKin_1	369	375	PF00069	0.212
MOD_ProDKin_1	431	437	PF00069	0.324
MOD_ProDKin_1	446	452	PF00069	0.217
MOD_ProDKin_1	91	97	PF00069	0.534
MOD_SUMO_rev_2	138	145	PF00179	0.762
TRG_AP2beta_CARGO_1	379	389	PF09066	0.318
TRG_ENDOCYTIC_2	112	115	PF00928	0.552
TRG_ENDOCYTIC_2	188	191	PF00928	0.437
TRG_ENDOCYTIC_2	473	476	PF00928	0.283
TRG_ENDOCYTIC_2	50	53	PF00928	0.610
TRG_ENDOCYTIC_2	77	80	PF00928	0.431
TRG_ENDOCYTIC_2	90	93	PF00928	0.489
TRG_ENDOCYTIC_2	97	100	PF00928	0.363
TRG_ER_diArg_1	169	171	PF00400	0.634
TRG_ER_diArg_1	423	426	PF00400	0.299
TRG_ER_diArg_1	543	546	PF00400	0.492
TRG_ER_diArg_1	581	583	PF00400	0.590
TRG_NES_CRM1_1	52	65	PF08389	0.523
TRG_NLS_MonoExtC_3	134	139	PF00514	0.628
TRG_NLS_MonoExtN_4	133	140	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D1	Leptomonas seymouri	73%	100%
A0A0S4JT19	Bodo saltans	45%	100%
A0A1X0P469	Trypanosomatidae	50%	100%
A0A3Q8IE56	Leishmania donovani	94%	100%
A0A422NFR7	Trypanosoma rangeli	51%	100%
A4HFQ9	Leishmania braziliensis	84%	100%
A4I2T5	Leishmania infantum	94%	100%
D0A601	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AZ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BL30	Trypanosoma cruzi	50%	100%