Arginine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginyl-tRNA synthetase, putative

Species:

Leishmania major

UniProt:

E9ADB2_LEIMA

TriTrypDb:

LmjF.27.1310 , LMJLV39_270019500 , LMJSD75_270019700

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	yes	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ADB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006420	arginyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043038	amino acid activation	4	12
GO:0043039	tRNA aminoacylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004814	arginine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.614
CLV_C14_Caspase3-7	485	489	PF00656	0.511
CLV_MEL_PAP_1	407	413	PF00089	0.346
CLV_NRD_NRD_1	301	303	PF00675	0.615
CLV_NRD_NRD_1	588	590	PF00675	0.311
CLV_NRD_NRD_1	99	101	PF00675	0.549
CLV_PCSK_KEX2_1	185	187	PF00082	0.315
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.326
CLV_PCSK_SKI1_1	106	110	PF00082	0.554
CLV_PCSK_SKI1_1	206	210	PF00082	0.325
CLV_PCSK_SKI1_1	310	314	PF00082	0.544
CLV_PCSK_SKI1_1	358	362	PF00082	0.567
CLV_PCSK_SKI1_1	490	494	PF00082	0.311
DEG_APCC_DBOX_1	368	376	PF00400	0.554
DEG_APCC_DBOX_1	665	673	PF00400	0.522
DEG_Nend_UBRbox_4	1	3	PF02207	0.631
DEG_ODPH_VHL_1	379	392	PF01847	0.491
DOC_CKS1_1	606	611	PF01111	0.522
DOC_CYCLIN_RxL_1	152	163	PF00134	0.617
DOC_CYCLIN_RxL_1	273	283	PF00134	0.536
DOC_CYCLIN_RxL_1	674	687	PF00134	0.563
DOC_MAPK_DCC_7	384	392	PF00069	0.614
DOC_MAPK_FxFP_2	411	414	PF00069	0.511
DOC_MAPK_gen_1	122	130	PF00069	0.513
DOC_MAPK_gen_1	219	226	PF00069	0.606
DOC_MAPK_gen_1	361	370	PF00069	0.517
DOC_MAPK_gen_1	384	392	PF00069	0.529
DOC_MAPK_gen_1	493	502	PF00069	0.602
DOC_MAPK_gen_1	678	686	PF00069	0.536
DOC_MAPK_HePTP_8	382	394	PF00069	0.602
DOC_MAPK_MEF2A_6	122	130	PF00069	0.565
DOC_MAPK_MEF2A_6	364	372	PF00069	0.638
DOC_MAPK_MEF2A_6	385	394	PF00069	0.546
DOC_MAPK_MEF2A_6	92	99	PF00069	0.614
DOC_PP1_RVXF_1	153	160	PF00149	0.614
DOC_PP2B_PxIxI_1	33	39	PF00149	0.553
DOC_PP4_FxxP_1	130	133	PF00568	0.511
DOC_PP4_FxxP_1	269	272	PF00568	0.549
DOC_PP4_FxxP_1	411	414	PF00568	0.511
DOC_SPAK_OSR1_1	437	441	PF12202	0.563
DOC_USP7_MATH_1	321	325	PF00917	0.702
DOC_USP7_UBL2_3	109	113	PF12436	0.647
DOC_USP7_UBL2_3	15	19	PF12436	0.602
DOC_USP7_UBL2_3	299	303	PF12436	0.495
DOC_USP7_UBL2_3	357	361	PF12436	0.511
DOC_WW_Pin1_4	605	610	PF00397	0.522
DOC_WW_Pin1_4	63	68	PF00397	0.542
LIG_14-3-3_CanoR_1	302	308	PF00244	0.406
LIG_14-3-3_CanoR_1	410	414	PF00244	0.522
LIG_14-3-3_CanoR_1	620	625	PF00244	0.609
LIG_14-3-3_CanoR_1	674	678	PF00244	0.522
LIG_Actin_WH2_2	132	147	PF00022	0.522
LIG_Actin_WH2_2	536	554	PF00022	0.524
LIG_Actin_WH2_2	612	629	PF00022	0.554
LIG_Actin_WH2_2	663	680	PF00022	0.522
LIG_BRCT_BRCA1_1	648	652	PF00533	0.522
LIG_BRCT_BRCA1_1	90	94	PF00533	0.567
LIG_Clathr_ClatBox_1	683	687	PF01394	0.563
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.511
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.512
LIG_FAT_LD_1	372	380	PF03623	0.545
LIG_FHA_1	23	29	PF00498	0.496
LIG_FHA_1	426	432	PF00498	0.558
LIG_FHA_1	497	503	PF00498	0.522
LIG_FHA_1	5	11	PF00498	0.504
LIG_FHA_1	621	627	PF00498	0.546
LIG_FHA_1	678	684	PF00498	0.614
LIG_FHA_2	259	265	PF00498	0.556
LIG_FHA_2	343	349	PF00498	0.553
LIG_FHA_2	462	468	PF00498	0.631
LIG_FHA_2	483	489	PF00498	0.522
LIG_FHA_2	606	612	PF00498	0.519
LIG_FHA_2	626	632	PF00498	0.421
LIG_LIR_Apic_2	129	133	PF02991	0.511
LIG_LIR_Apic_2	267	272	PF02991	0.551
LIG_LIR_Gen_1	249	258	PF02991	0.502
LIG_LIR_Gen_1	388	398	PF02991	0.609
LIG_LIR_Gen_1	432	443	PF02991	0.555
LIG_LIR_Gen_1	562	569	PF02991	0.572
LIG_LIR_Gen_1	639	648	PF02991	0.522
LIG_LIR_Gen_1	91	99	PF02991	0.593
LIG_LIR_Nem_3	175	180	PF02991	0.579
LIG_LIR_Nem_3	249	254	PF02991	0.521
LIG_LIR_Nem_3	25	29	PF02991	0.500
LIG_LIR_Nem_3	267	273	PF02991	0.603
LIG_LIR_Nem_3	388	394	PF02991	0.545
LIG_LIR_Nem_3	432	438	PF02991	0.601
LIG_LIR_Nem_3	573	579	PF02991	0.364
LIG_LIR_Nem_3	646	651	PF02991	0.542
LIG_LIR_Nem_3	91	97	PF02991	0.593
LIG_MAD2	125	133	PF02301	0.536
LIG_MAD2	54	62	PF02301	0.529
LIG_MLH1_MIPbox_1	648	652	PF16413	0.522
LIG_PDZ_Class_3	687	692	PF00595	0.522
LIG_Pex14_1	173	177	PF04695	0.511
LIG_Pex14_2	391	395	PF04695	0.536
LIG_Pex14_2	648	652	PF04695	0.522
LIG_SH2_CRK	255	259	PF00017	0.540
LIG_SH2_CRK	270	274	PF00017	0.467
LIG_SH2_CRK	581	585	PF00017	0.522
LIG_SH2_SRC	579	582	PF00017	0.511
LIG_SH2_STAP1	559	563	PF00017	0.511
LIG_SH2_STAT3	383	386	PF00017	0.553
LIG_SH2_STAT5	183	186	PF00017	0.536
LIG_SH2_STAT5	191	194	PF00017	0.536
LIG_SH2_STAT5	242	245	PF00017	0.563
LIG_SH2_STAT5	255	258	PF00017	0.471
LIG_SH2_STAT5	424	427	PF00017	0.614
LIG_SH2_STAT5	448	451	PF00017	0.536
LIG_SH2_STAT5	548	551	PF00017	0.511
LIG_SH3_1	24	30	PF00018	0.614
LIG_SH3_3	24	30	PF00018	0.580
LIG_SH3_3	269	275	PF00018	0.515
LIG_SH3_4	361	368	PF00018	0.442
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.536
LIG_SUMO_SIM_anti_2	680	685	PF11976	0.614
LIG_SUMO_SIM_par_1	622	628	PF11976	0.513
LIG_SUMO_SIM_par_1	668	673	PF11976	0.522
LIG_TRAF2_1	231	234	PF00917	0.536
LIG_TRAF2_1	247	250	PF00917	0.536
LIG_TRAF2_1	261	264	PF00917	0.505
LIG_TRAF2_1	298	301	PF00917	0.563
LIG_TRAF2_1	30	33	PF00917	0.563
LIG_TRAF2_1	594	597	PF00917	0.532
LIG_TRAF2_1	608	611	PF00917	0.483
LIG_TRFH_1	26	30	PF08558	0.563
LIG_TYR_ITIM	546	551	PF00017	0.514
LIG_UBA3_1	179	185	PF00899	0.519
LIG_UBA3_1	334	340	PF00899	0.528
LIG_UBA3_1	375	384	PF00899	0.477
LIG_UBA3_1	540	547	PF00899	0.554
MOD_CDK_SPxxK_3	605	612	PF00069	0.522
MOD_CK1_1	199	205	PF00069	0.578
MOD_CK1_1	496	502	PF00069	0.511
MOD_CK1_1	570	576	PF00069	0.406
MOD_CK1_1	605	611	PF00069	0.614
MOD_CK2_1	244	250	PF00069	0.520
MOD_CK2_1	258	264	PF00069	0.511
MOD_CK2_1	295	301	PF00069	0.564
MOD_CK2_1	342	348	PF00069	0.528
MOD_CK2_1	353	359	PF00069	0.469
MOD_CK2_1	605	611	PF00069	0.550
MOD_Cter_Amidation	488	491	PF01082	0.332
MOD_GlcNHglycan	129	133	PF01048	0.329
MOD_GlcNHglycan	495	498	PF01048	0.317
MOD_GlcNHglycan	568	572	PF01048	0.428
MOD_GSK3_1	18	25	PF00069	0.535
MOD_GSK3_1	249	256	PF00069	0.656
MOD_GSK3_1	310	317	PF00069	0.555
MOD_GSK3_1	349	356	PF00069	0.466
MOD_GSK3_1	422	429	PF00069	0.511
MOD_GSK3_1	523	530	PF00069	0.554
MOD_GSK3_1	673	680	PF00069	0.614
MOD_N-GLC_1	646	651	PF02516	0.363
MOD_N-GLC_1	95	100	PF02516	0.336
MOD_NEK2_1	144	149	PF00069	0.542
MOD_NEK2_1	551	556	PF00069	0.520
MOD_NEK2_1	567	572	PF00069	0.369
MOD_NEK2_1	662	667	PF00069	0.536
MOD_PIKK_1	28	34	PF00454	0.483
MOD_PIKK_1	314	320	PF00454	0.599
MOD_PIKK_1	523	529	PF00454	0.554
MOD_PIKK_1	54	60	PF00454	0.614
MOD_PK_1	402	408	PF00069	0.602
MOD_PK_1	583	589	PF00069	0.511
MOD_PKA_2	144	150	PF00069	0.522
MOD_PKA_2	409	415	PF00069	0.522
MOD_PKA_2	673	679	PF00069	0.522
MOD_Plk_1	199	205	PF00069	0.571
MOD_Plk_1	233	239	PF00069	0.512
MOD_Plk_1	349	355	PF00069	0.502
MOD_Plk_1	510	516	PF00069	0.522
MOD_Plk_1	602	608	PF00069	0.614
MOD_Plk_1	610	616	PF00069	0.614
MOD_Plk_1	670	676	PF00069	0.522
MOD_Plk_1	95	101	PF00069	0.536
MOD_Plk_2-3	472	478	PF00069	0.578
MOD_Plk_4	144	150	PF00069	0.521
MOD_Plk_4	265	271	PF00069	0.532
MOD_Plk_4	402	408	PF00069	0.627
MOD_Plk_4	620	626	PF00069	0.515
MOD_ProDKin_1	605	611	PF00069	0.522
MOD_ProDKin_1	63	69	PF00069	0.542
MOD_SUMO_rev_2	298	304	PF00179	0.425
MOD_SUMO_rev_2	356	362	PF00179	0.465
TRG_DiLeu_BaEn_4	350	356	PF01217	0.582
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.614
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.554
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.614
TRG_ENDOCYTIC_2	255	258	PF00928	0.511
TRG_ENDOCYTIC_2	270	273	PF00928	0.511
TRG_ENDOCYTIC_2	435	438	PF00928	0.511
TRG_ENDOCYTIC_2	455	458	PF00928	0.421
TRG_ENDOCYTIC_2	548	551	PF00928	0.514
TRG_ENDOCYTIC_2	563	566	PF00928	0.439
TRG_ENDOCYTIC_2	581	584	PF00928	0.467
TRG_ENDOCYTIC_2	642	645	PF00928	0.522
TRG_NES_CRM1_1	504	519	PF08389	0.536
TRG_NLS_MonoExtN_4	119	126	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S4	Leptomonas seymouri	85%	100%
A0A0S4JSY3	Bodo saltans	59%	100%
A0A1X0P461	Trypanosomatidae	69%	100%
A0A3Q8IED7	Leishmania donovani	97%	100%
A0A3R7MEE6	Trypanosoma rangeli	70%	100%
A4HFQ8	Leishmania braziliensis	91%	100%
A4I2T4	Leishmania infantum	97%	100%
D0A5Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AZ37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q7URC7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	31%	100%
Q971X1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	100%
V5BQK5	Trypanosoma cruzi	68%	100%