C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ADB1_LEIMA

TriTrypDb:

LmjF.27.1300 , LMJLV39_270019400 , LMJSD75_270019600

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADB1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003724	RNA helicase activity	3	2
GO:0003824	catalytic activity	1	2
GO:0004386	helicase activity	2	2
GO:0005488	binding	1	12
GO:0008186	ATP-dependent activity, acting on RNA	2	2
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	8
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.716
CLV_NRD_NRD_1	34	36	PF00675	0.500
CLV_NRD_NRD_1	416	418	PF00675	0.413
CLV_NRD_NRD_1	68	70	PF00675	0.778
CLV_PCSK_KEX2_1	156	158	PF00082	0.674
CLV_PCSK_KEX2_1	254	256	PF00082	0.554
CLV_PCSK_KEX2_1	351	353	PF00082	0.417
CLV_PCSK_KEX2_1	527	529	PF00082	0.759
CLV_PCSK_KEX2_1	68	70	PF00082	0.716
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.554
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.417
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.759
CLV_PCSK_SKI1_1	133	137	PF00082	0.362
CLV_PCSK_SKI1_1	194	198	PF00082	0.275
CLV_PCSK_SKI1_1	244	248	PF00082	0.303
CLV_PCSK_SKI1_1	52	56	PF00082	0.582
DEG_COP1_1	38	49	PF00400	0.434
DOC_CKS1_1	135	140	PF01111	0.552
DOC_CKS1_1	500	505	PF01111	0.600
DOC_CYCLIN_RxL_1	191	199	PF00134	0.552
DOC_MAPK_DCC_7	417	426	PF00069	0.377
DOC_MAPK_gen_1	242	249	PF00069	0.562
DOC_MAPK_MEF2A_6	181	188	PF00069	0.448
DOC_MAPK_MEF2A_6	417	426	PF00069	0.377
DOC_PP1_RVXF_1	470	477	PF00149	0.515
DOC_PP4_FxxP_1	308	311	PF00568	0.542
DOC_PP4_FxxP_1	430	433	PF00568	0.415
DOC_USP7_MATH_1	163	167	PF00917	0.696
DOC_USP7_MATH_1	169	173	PF00917	0.672
DOC_USP7_MATH_1	22	26	PF00917	0.532
DOC_USP7_MATH_1	58	62	PF00917	0.701
DOC_USP7_UBL2_3	142	146	PF12436	0.584
DOC_USP7_UBL2_3	414	418	PF12436	0.413
DOC_WD40_RPTOR_TOS_1	182	187	PF00400	0.473
DOC_WW_Pin1_4	134	139	PF00397	0.535
DOC_WW_Pin1_4	499	504	PF00397	0.601
LIG_14-3-3_CanoR_1	292	299	PF00244	0.526
LIG_14-3-3_CanoR_1	30	35	PF00244	0.508
LIG_14-3-3_CanoR_1	300	309	PF00244	0.470
LIG_14-3-3_CanoR_1	486	494	PF00244	0.556
LIG_Actin_WH2_2	325	342	PF00022	0.425
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BIR_III_2	505	509	PF00653	0.463
LIG_BRCT_BRCA1_1	304	308	PF00533	0.565
LIG_EVH1_2	176	180	PF00568	0.696
LIG_FAT_LD_1	7	15	PF03623	0.466
LIG_FHA_1	188	194	PF00498	0.478
LIG_FHA_1	225	231	PF00498	0.536
LIG_FHA_1	289	295	PF00498	0.619
LIG_FHA_1	485	491	PF00498	0.491
LIG_FHA_2	211	217	PF00498	0.536
LIG_FHA_2	406	412	PF00498	0.397
LIG_FHA_2	486	492	PF00498	0.495
LIG_FHA_2	500	506	PF00498	0.404
LIG_Integrin_RGD_1	102	104	PF01839	0.804
LIG_LIR_Apic_2	305	311	PF02991	0.535
LIG_LIR_Gen_1	216	225	PF02991	0.504
LIG_LIR_Gen_1	304	314	PF02991	0.524
LIG_LIR_Gen_1	410	420	PF02991	0.404
LIG_LIR_Gen_1	455	462	PF02991	0.437
LIG_LIR_Nem_3	216	221	PF02991	0.496
LIG_LIR_Nem_3	304	309	PF02991	0.460
LIG_LIR_Nem_3	410	415	PF02991	0.399
LIG_LIR_Nem_3	436	441	PF02991	0.397
LIG_LIR_Nem_3	455	459	PF02991	0.413
LIG_LIR_Nem_3	464	470	PF02991	0.367
LIG_NRP_CendR_1	527	529	PF00754	0.759
LIG_PCNA_yPIPBox_3	4	13	PF02747	0.528
LIG_PTB_Apo_2	406	413	PF02174	0.397
LIG_PTB_Phospho_1	406	412	PF10480	0.399
LIG_SH2_CRK	376	380	PF00017	0.548
LIG_SH2_CRK	412	416	PF00017	0.371
LIG_SH2_GRB2like	423	426	PF00017	0.346
LIG_SH2_PTP2	423	426	PF00017	0.362
LIG_SH2_SRC	462	465	PF00017	0.538
LIG_SH2_STAP1	412	416	PF00017	0.384
LIG_SH2_STAP1	462	466	PF00017	0.536
LIG_SH2_STAP1	494	498	PF00017	0.481
LIG_SH2_STAT3	439	442	PF00017	0.394
LIG_SH2_STAT5	195	198	PF00017	0.529
LIG_SH2_STAT5	320	323	PF00017	0.482
LIG_SH2_STAT5	423	426	PF00017	0.346
LIG_SH2_STAT5	439	442	PF00017	0.445
LIG_SH3_3	132	138	PF00018	0.517
LIG_SH3_3	183	189	PF00018	0.435
LIG_SH3_3	43	49	PF00018	0.566
LIG_SH3_3	497	503	PF00018	0.543
LIG_SH3_3	74	80	PF00018	0.738
LIG_SUMO_SIM_par_1	245	250	PF11976	0.552
LIG_SxIP_EBH_1	414	427	PF03271	0.425
LIG_TYR_ITAM	409	426	PF00017	0.399
LIG_TYR_ITIM	421	426	PF00017	0.363
LIG_UBA3_1	246	254	PF00899	0.660
LIG_UBA3_1	385	393	PF00899	0.551
LIG_UBA3_1	466	472	PF00899	0.553
LIG_WRC_WIRS_1	303	308	PF05994	0.477
LIG_WW_3	78	82	PF00397	0.654
MOD_CK1_1	493	499	PF00069	0.551
MOD_CK2_1	147	153	PF00069	0.517
MOD_CK2_1	210	216	PF00069	0.502
MOD_CK2_1	457	463	PF00069	0.440
MOD_CK2_1	485	491	PF00069	0.492
MOD_Cter_Amidation	525	528	PF01082	0.740
MOD_GlcNHglycan	165	168	PF01048	0.765
MOD_GlcNHglycan	249	252	PF01048	0.504
MOD_GlcNHglycan	81	84	PF01048	0.766
MOD_GSK3_1	288	295	PF00069	0.624
MOD_GSK3_1	330	337	PF00069	0.473
MOD_GSK3_1	448	455	PF00069	0.397
MOD_GSK3_1	490	497	PF00069	0.487
MOD_N-GLC_1	207	212	PF02516	0.284
MOD_N-GLC_1	428	433	PF02516	0.375
MOD_NEK2_1	16	21	PF00069	0.524
MOD_NEK2_1	196	201	PF00069	0.540
MOD_NEK2_1	247	252	PF00069	0.628
MOD_NEK2_1	294	299	PF00069	0.525
MOD_NEK2_1	319	324	PF00069	0.542
MOD_NEK2_1	457	462	PF00069	0.479
MOD_NEK2_1	485	490	PF00069	0.447
MOD_PIKK_1	196	202	PF00454	0.532
MOD_PIKK_1	334	340	PF00454	0.496
MOD_PIKK_1	357	363	PF00454	0.518
MOD_PIKK_1	40	46	PF00454	0.421
MOD_PIKK_1	440	446	PF00454	0.478
MOD_PKA_1	35	41	PF00069	0.523
MOD_PKA_2	147	153	PF00069	0.484
MOD_PKA_2	416	422	PF00069	0.408
MOD_PKA_2	485	491	PF00069	0.554
MOD_Plk_1	224	230	PF00069	0.529
MOD_Plk_1	428	434	PF00069	0.399
MOD_Plk_1	490	496	PF00069	0.513
MOD_Plk_4	294	300	PF00069	0.510
MOD_Plk_4	416	422	PF00069	0.399
MOD_Plk_4	452	458	PF00069	0.418
MOD_ProDKin_1	134	140	PF00069	0.535
MOD_ProDKin_1	499	505	PF00069	0.604
MOD_SUMO_for_1	253	256	PF00179	0.523
MOD_SUMO_rev_2	514	521	PF00179	0.583
TRG_DiLeu_BaEn_4	436	442	PF01217	0.396
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.388
TRG_ENDOCYTIC_2	376	379	PF00928	0.551
TRG_ENDOCYTIC_2	412	415	PF00928	0.389
TRG_ENDOCYTIC_2	423	426	PF00928	0.346
TRG_ENDOCYTIC_2	438	441	PF00928	0.414
TRG_ER_diArg_1	156	158	PF00400	0.692
TRG_ER_diArg_1	401	404	PF00400	0.553
TRG_NES_CRM1_1	18	29	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C0	Leptomonas seymouri	79%	99%
A0A0S4JP69	Bodo saltans	46%	100%
A0A1X0P4C7	Trypanosomatidae	48%	100%
A0A3S5H7H8	Leishmania donovani	99%	100%
A0A422NFN8	Trypanosoma rangeli	49%	100%
A4HFQ7	Leishmania braziliensis	88%	100%
A4I2T3	Leishmania infantum	99%	100%
D0A5Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AZ36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BGH6	Trypanosoma cruzi	49%	100%