Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted leucine-rich repeat protein

Species:

Leishmania major

UniProt:

E9ADA9_LEIMA

TriTrypDb:

LmjF.27.1290 , LMJLV39_270019300 , LMJSD75_270019500

Length:

396

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14

Expansion

Sequence features

E9ADA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.324
CLV_NRD_NRD_1	165	167	PF00675	0.678
CLV_NRD_NRD_1	378	380	PF00675	0.517
CLV_PCSK_KEX2_1	378	380	PF00082	0.517
CLV_PCSK_KEX2_1	45	47	PF00082	0.613
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.613
CLV_PCSK_SKI1_1	79	83	PF00082	0.592
CLV_Separin_Metazoa	138	142	PF03568	0.390
DEG_ODPH_VHL_1	185	196	PF01847	0.427
DEG_SPOP_SBC_1	12	16	PF00917	0.554
DEG_SPOP_SBC_1	2	6	PF00917	0.589
DOC_CKS1_1	130	135	PF01111	0.484
DOC_CYCLIN_RxL_1	189	198	PF00134	0.344
DOC_MIT_MIM_1	34	46	PF04212	0.639
DOC_PP1_RVXF_1	226	232	PF00149	0.444
DOC_USP7_MATH_1	12	16	PF00917	0.667
DOC_USP7_MATH_1	120	124	PF00917	0.493
DOC_USP7_MATH_1	326	330	PF00917	0.515
DOC_USP7_MATH_1	81	85	PF00917	0.465
DOC_USP7_MATH_1	90	94	PF00917	0.447
DOC_WW_Pin1_4	129	134	PF00397	0.375
LIG_14-3-3_CanoR_1	147	153	PF00244	0.383
LIG_14-3-3_CanoR_1	192	197	PF00244	0.372
LIG_14-3-3_CanoR_1	296	303	PF00244	0.419
LIG_14-3-3_CanoR_1	362	367	PF00244	0.417
LIG_Actin_WH2_2	245	260	PF00022	0.458
LIG_Actin_WH2_2	347	364	PF00022	0.515
LIG_APCC_ABBA_1	206	211	PF00400	0.278
LIG_FHA_1	116	122	PF00498	0.464
LIG_FHA_1	326	332	PF00498	0.424
LIG_FHA_1	358	364	PF00498	0.488
LIG_FHA_1	385	391	PF00498	0.520
LIG_FHA_1	80	86	PF00498	0.463
LIG_FHA_2	210	216	PF00498	0.449
LIG_FHA_2	3	9	PF00498	0.682
LIG_LIR_Gen_1	190	201	PF02991	0.458
LIG_LIR_Gen_1	223	234	PF02991	0.327
LIG_LIR_Nem_3	190	196	PF02991	0.458
LIG_LIR_Nem_3	223	229	PF02991	0.327
LIG_LIR_Nem_3	253	257	PF02991	0.381
LIG_LIR_Nem_3	97	103	PF02991	0.321
LIG_LRP6_Inhibitor_1	271	277	PF00058	0.373
LIG_LYPXL_SIV_4	64	72	PF13949	0.472
LIG_MAD2	248	256	PF02301	0.489
LIG_PDZ_Class_3	391	396	PF00595	0.538
LIG_SH2_CRK	100	104	PF00017	0.427
LIG_SH2_CRK	226	230	PF00017	0.427
LIG_SH2_CRK	47	51	PF00017	0.591
LIG_SH2_NCK_1	226	230	PF00017	0.397
LIG_SH2_PTP2	130	133	PF00017	0.504
LIG_SH2_STAP1	23	27	PF00017	0.598
LIG_SH2_STAT5	130	133	PF00017	0.504
LIG_SH2_STAT5	65	68	PF00017	0.403
LIG_SH3_1	49	55	PF00018	0.654
LIG_SH3_3	49	55	PF00018	0.562
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.387
LIG_SUMO_SIM_par_1	92	99	PF11976	0.390
LIG_TRAF2_1	218	221	PF00917	0.417
LIG_TRAF2_1	22	25	PF00917	0.563
LIG_TRAF2_1	302	305	PF00917	0.387
LIG_TRAF2_1	32	35	PF00917	0.539
LIG_TYR_ITIM	224	229	PF00017	0.397
LIG_TYR_ITIM	98	103	PF00017	0.372
LIG_WRC_WIRS_1	172	177	PF05994	0.529
MOD_CK1_1	329	335	PF00069	0.409
MOD_CK1_1	357	363	PF00069	0.500
MOD_CK1_1	384	390	PF00069	0.527
MOD_CK1_1	57	63	PF00069	0.587
MOD_CK2_1	2	8	PF00069	0.663
MOD_CK2_1	209	215	PF00069	0.469
MOD_GlcNHglycan	118	121	PF01048	0.478
MOD_GlcNHglycan	133	136	PF01048	0.304
MOD_GlcNHglycan	175	178	PF01048	0.467
MOD_GlcNHglycan	328	331	PF01048	0.421
MOD_GlcNHglycan	345	348	PF01048	0.331
MOD_GlcNHglycan	354	357	PF01048	0.446
MOD_GlcNHglycan	382	386	PF01048	0.542
MOD_GlcNHglycan	58	62	PF01048	0.477
MOD_GSK3_1	116	123	PF00069	0.485
MOD_GSK3_1	148	155	PF00069	0.388
MOD_GSK3_1	321	328	PF00069	0.398
MOD_GSK3_1	352	359	PF00069	0.491
MOD_N-GLC_1	152	157	PF02516	0.512
MOD_N-GLC_1	215	220	PF02516	0.386
MOD_N-GLC_1	272	277	PF02516	0.364
MOD_N-GLC_1	279	284	PF02516	0.371
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	115	120	PF00069	0.283
MOD_NEK2_1	13	18	PF00069	0.574
MOD_NEK2_1	152	157	PF00069	0.409
MOD_NEK2_1	209	214	PF00069	0.423
MOD_NEK2_1	222	227	PF00069	0.239
MOD_NEK2_1	354	359	PF00069	0.526
MOD_NEK2_1	96	101	PF00069	0.311
MOD_NEK2_2	187	192	PF00069	0.444
MOD_OFUCOSY	279	284	PF10250	0.464
MOD_PIKK_1	13	19	PF00454	0.631
MOD_PKA_2	390	396	PF00069	0.440
MOD_Plk_1	215	221	PF00069	0.328
MOD_Plk_1	222	228	PF00069	0.279
MOD_Plk_1	272	278	PF00069	0.366
MOD_Plk_1	96	102	PF00069	0.316
MOD_Plk_2-3	215	221	PF00069	0.371
MOD_Plk_4	120	126	PF00069	0.377
MOD_Plk_4	330	336	PF00069	0.391
MOD_ProDKin_1	129	135	PF00069	0.372
TRG_ENDOCYTIC_2	100	103	PF00928	0.372
TRG_ENDOCYTIC_2	226	229	PF00928	0.385
TRG_ENDOCYTIC_2	65	68	PF00928	0.494
TRG_ER_diArg_1	377	379	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	29%	84%
A0A0N1I317	Leptomonas seymouri	75%	99%
A0A0S4JL85	Bodo saltans	25%	93%
A0A0S4JV86	Bodo saltans	40%	100%
A0A1X0NTY3	Trypanosomatidae	26%	88%
A0A1X0P364	Trypanosomatidae	23%	92%
A0A1X0P4Z4	Trypanosomatidae	49%	100%
A0A3Q8IDE6	Leishmania donovani	95%	100%
A0A3R7L7Y9	Trypanosoma rangeli	26%	89%
A0A3R7NL91	Trypanosoma rangeli	49%	100%
A0A3S5H5G2	Leishmania donovani	27%	90%
A0A3S7WXH1	Leishmania donovani	24%	100%
A0A3S7WZL6	Leishmania donovani	28%	92%
A4H461	Leishmania braziliensis	28%	90%
A4H5X9	Leishmania braziliensis	28%	100%
A4HCM9	Leishmania braziliensis	23%	100%
A4HEQ6	Leishmania braziliensis	24%	95%
A4HFQ6	Leishmania braziliensis	87%	99%
A4HHW0	Leishmania braziliensis	26%	100%
A4HSD0	Leishmania infantum	27%	90%
A4I053	Leishmania infantum	24%	100%
A4I1Y5	Leishmania infantum	28%	92%
A4I2T1	Leishmania infantum	95%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	88%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	95%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	84%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P10775	Sus scrofa	28%	87%
P29315	Rattus norvegicus	24%	87%
Q0VAA2	Homo sapiens	26%	81%
Q14BP6	Mus musculus	27%	100%
Q4Q9E1	Leishmania major	28%	92%
Q4QBG0	Leishmania major	25%	100%
Q4QJI8	Leishmania major	28%	90%
Q6ZQY2	Homo sapiens	28%	100%
Q91VI7	Mus musculus	24%	87%
Q9LE82	Arabidopsis thaliana	26%	74%
Q9M651	Arabidopsis thaliana	27%	73%
V5BPZ7	Trypanosoma cruzi	30%	88%
V5DHF2	Trypanosoma cruzi	49%	100%