Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADA8_LEIMA

TriTrypDb:

LmjF.27.1280 , LMJLV39_270019200 , LMJSD75_270019400

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0004521	RNA endonuclease activity	5	11
GO:0004525	ribonuclease III activity	6	11
GO:0004540	RNA nuclease activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.467
CLV_NRD_NRD_1	2	4	PF00675	0.626
CLV_PCSK_KEX2_1	120	122	PF00082	0.394
CLV_PCSK_KEX2_1	2	4	PF00082	0.592
CLV_PCSK_SKI1_1	3	7	PF00082	0.579
CLV_Separin_Metazoa	31	35	PF03568	0.612
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DEG_SPOP_SBC_1	23	27	PF00917	0.580
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.489
DOC_PP2B_LxvP_1	46	49	PF13499	0.567
DOC_PP2B_LxvP_1	7	10	PF13499	0.416
DOC_PP4_FxxP_1	45	48	PF00568	0.409
DOC_PP4_FxxP_1	78	81	PF00568	0.346
DOC_USP7_MATH_1	23	27	PF00917	0.689
DOC_USP7_MATH_1	87	91	PF00917	0.458
LIG_14-3-3_CanoR_1	162	172	PF00244	0.520
LIG_14-3-3_CanoR_1	24	30	PF00244	0.657
LIG_14-3-3_CanoR_1	34	42	PF00244	0.658
LIG_FHA_1	166	172	PF00498	0.514
LIG_FHA_1	70	76	PF00498	0.441
LIG_FHA_2	117	123	PF00498	0.426
LIG_FHA_2	60	66	PF00498	0.468
LIG_LIR_Gen_1	122	131	PF02991	0.491
LIG_LIR_Gen_1	26	33	PF02991	0.572
LIG_LIR_Gen_1	72	81	PF02991	0.443
LIG_LIR_Nem_3	122	127	PF02991	0.461
LIG_LIR_Nem_3	26	32	PF02991	0.573
LIG_LIR_Nem_3	62	66	PF02991	0.447
LIG_LIR_Nem_3	72	77	PF02991	0.438
LIG_MYND_1	44	48	PF01753	0.447
LIG_NRBOX	126	132	PF00104	0.471
LIG_PDZ_Class_2	220	225	PF00595	0.482
LIG_Pex14_2	74	78	PF04695	0.390
LIG_SH2_CRK	124	128	PF00017	0.493
LIG_SH2_STAP1	124	128	PF00017	0.491
LIG_SH3_3	36	42	PF00018	0.459
LIG_SUMO_SIM_anti_2	126	135	PF11976	0.405
LIG_SUMO_SIM_par_1	12	19	PF11976	0.529
LIG_SUMO_SIM_par_1	126	135	PF11976	0.414
LIG_SUMO_SIM_par_1	95	102	PF11976	0.479
LIG_TRAF2_1	28	31	PF00917	0.633
LIG_WRC_WIRS_1	113	118	PF05994	0.475
LIG_WW_3	47	51	PF00397	0.434
MOD_CK1_1	15	21	PF00069	0.537
MOD_CK1_1	82	88	PF00069	0.427
MOD_CK2_1	116	122	PF00069	0.427
MOD_CK2_1	183	189	PF00069	0.445
MOD_CK2_1	25	31	PF00069	0.651
MOD_CK2_1	99	105	PF00069	0.457
MOD_GlcNHglycan	154	158	PF01048	0.535
MOD_GlcNHglycan	89	92	PF01048	0.444
MOD_GSK3_1	112	119	PF00069	0.581
MOD_NEK2_1	116	121	PF00069	0.557
MOD_NEK2_1	165	170	PF00069	0.510
MOD_NEK2_1	33	38	PF00069	0.668
MOD_NEK2_1	59	64	PF00069	0.503
MOD_PKA_2	163	169	PF00069	0.531
MOD_PKA_2	23	29	PF00069	0.652
MOD_PKA_2	33	39	PF00069	0.596
MOD_PKB_1	162	170	PF00069	0.591
MOD_Plk_1	53	59	PF00069	0.488
MOD_Plk_4	12	18	PF00069	0.554
MOD_Plk_4	123	129	PF00069	0.398
MOD_Plk_4	99	105	PF00069	0.434
MOD_SUMO_for_1	216	219	PF00179	0.424
TRG_DiLeu_BaEn_1	123	128	PF01217	0.384
TRG_ENDOCYTIC_2	124	127	PF00928	0.500
TRG_ENDOCYTIC_2	29	32	PF00928	0.584
TRG_ER_diArg_1	1	3	PF00400	0.636
TRG_ER_diArg_1	162	165	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWD6	Leptomonas seymouri	73%	100%
A0A0S4JXM7	Bodo saltans	34%	100%
A0A1X0P475	Trypanosomatidae	41%	100%
A0A3S7X0N4	Leishmania donovani	96%	100%
A0A422NFP6	Trypanosoma rangeli	41%	100%
A4HFQ5	Leishmania braziliensis	87%	100%
A4I2T0	Leishmania infantum	96%	100%
D0A5Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZ33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%