Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADA7_LEIMA

TriTrypDb:

LmjF.27.1275

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.515
CLV_C14_Caspase3-7	243	247	PF00656	0.360
CLV_NRD_NRD_1	222	224	PF00675	0.427
CLV_NRD_NRD_1	264	266	PF00675	0.465
CLV_NRD_NRD_1	323	325	PF00675	0.534
CLV_NRD_NRD_1	381	383	PF00675	0.527
CLV_NRD_NRD_1	392	394	PF00675	0.422
CLV_PCSK_FUR_1	390	394	PF00082	0.401
CLV_PCSK_KEX2_1	222	224	PF00082	0.427
CLV_PCSK_KEX2_1	226	228	PF00082	0.430
CLV_PCSK_KEX2_1	264	266	PF00082	0.465
CLV_PCSK_KEX2_1	323	325	PF00082	0.517
CLV_PCSK_KEX2_1	380	382	PF00082	0.544
CLV_PCSK_KEX2_1	392	394	PF00082	0.417
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.448
CLV_PCSK_PC7_1	222	228	PF00082	0.484
CLV_PCSK_SKI1_1	180	184	PF00082	0.501
CLV_PCSK_SKI1_1	222	226	PF00082	0.496
CLV_PCSK_SKI1_1	233	237	PF00082	0.353
CLV_PCSK_SKI1_1	245	249	PF00082	0.408
CLV_PCSK_SKI1_1	264	268	PF00082	0.489
CLV_Separin_Metazoa	27	31	PF03568	0.591
DEG_APCC_DBOX_1	391	399	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.614
DEG_SCF_FBW7_1	86	91	PF00400	0.589
DOC_ANK_TNKS_1	322	329	PF00023	0.536
DOC_CKS1_1	85	90	PF01111	0.496
DOC_MAPK_FxFP_2	6	9	PF00069	0.608
DOC_MAPK_gen_1	230	238	PF00069	0.460
DOC_MAPK_gen_1	405	414	PF00069	0.593
DOC_PP1_RVXF_1	178	184	PF00149	0.439
DOC_PP2B_LxvP_1	412	415	PF13499	0.590
DOC_PP4_FxxP_1	6	9	PF00568	0.608
DOC_PP4_FxxP_1	85	88	PF00568	0.628
DOC_USP7_MATH_1	137	141	PF00917	0.637
DOC_USP7_MATH_1	190	194	PF00917	0.506
DOC_USP7_MATH_1	271	275	PF00917	0.537
DOC_USP7_MATH_1	351	355	PF00917	0.696
DOC_USP7_MATH_1	36	40	PF00917	0.685
DOC_USP7_MATH_1	371	375	PF00917	0.418
DOC_USP7_MATH_1	416	420	PF00917	0.748
DOC_USP7_MATH_1	88	92	PF00917	0.583
DOC_WW_Pin1_4	133	138	PF00397	0.604
DOC_WW_Pin1_4	267	272	PF00397	0.518
DOC_WW_Pin1_4	275	280	PF00397	0.739
DOC_WW_Pin1_4	30	35	PF00397	0.623
DOC_WW_Pin1_4	330	335	PF00397	0.614
DOC_WW_Pin1_4	342	347	PF00397	0.611
DOC_WW_Pin1_4	65	70	PF00397	0.678
DOC_WW_Pin1_4	84	89	PF00397	0.661
DOC_WW_Pin1_4	92	97	PF00397	0.704
LIG_14-3-3_CanoR_1	117	122	PF00244	0.580
LIG_14-3-3_CanoR_1	125	133	PF00244	0.676
LIG_14-3-3_CanoR_1	257	266	PF00244	0.634
LIG_14-3-3_CanoR_1	273	279	PF00244	0.521
LIG_14-3-3_CanoR_1	30	34	PF00244	0.629
LIG_14-3-3_CanoR_1	37	47	PF00244	0.594
LIG_14-3-3_CanoR_1	390	396	PF00244	0.432
LIG_14-3-3_CanoR_1	417	421	PF00244	0.594
LIG_14-3-3_CanoR_1	79	88	PF00244	0.608
LIG_BRCT_BRCA1_1	2	6	PF00533	0.565
LIG_BRCT_BRCA1_1	262	266	PF00533	0.491
LIG_BRCT_BRCA1_1	315	319	PF00533	0.590
LIG_BRCT_BRCA1_1	422	426	PF00533	0.572
LIG_BRCT_BRCA1_1	81	85	PF00533	0.538
LIG_Clathr_ClatBox_1	169	173	PF01394	0.457
LIG_FHA_1	105	111	PF00498	0.724
LIG_FHA_1	143	149	PF00498	0.600
LIG_LIR_Apic_2	3	9	PF02991	0.606
LIG_LIR_Apic_2	82	88	PF02991	0.618
LIG_LIR_Gen_1	151	161	PF02991	0.543
LIG_LIR_Gen_1	189	198	PF02991	0.392
LIG_LIR_Gen_1	423	434	PF02991	0.577
LIG_LIR_Nem_3	151	156	PF02991	0.568
LIG_LIR_Nem_3	189	194	PF02991	0.387
LIG_LIR_Nem_3	423	429	PF02991	0.574
LIG_MYND_1	434	438	PF01753	0.593
LIG_SH2_CRK	50	54	PF00017	0.565
LIG_SH2_SRC	50	53	PF00017	0.590
LIG_SH2_STAP1	17	21	PF00017	0.524
LIG_SH2_STAT5	101	104	PF00017	0.630
LIG_SH2_STAT5	240	243	PF00017	0.320
LIG_SH2_STAT5	357	360	PF00017	0.641
LIG_SH3_3	350	356	PF00018	0.608
LIG_SH3_3	432	438	PF00018	0.488
LIG_SH3_3	46	52	PF00018	0.591
LIG_SH3_3	90	96	PF00018	0.608
LIG_Sin3_3	168	175	PF02671	0.427
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.403
LIG_SUMO_SIM_par_1	168	174	PF11976	0.453
LIG_TRAF2_1	407	410	PF00917	0.497
MOD_CDC14_SPxK_1	270	273	PF00782	0.495
MOD_CDC14_SPxK_1	68	71	PF00782	0.651
MOD_CDC14_SPxK_1	95	98	PF00782	0.596
MOD_CDK_SPK_2	133	138	PF00069	0.580
MOD_CDK_SPK_2	275	280	PF00069	0.511
MOD_CDK_SPK_2	342	347	PF00069	0.625
MOD_CDK_SPxK_1	267	273	PF00069	0.485
MOD_CDK_SPxK_1	65	71	PF00069	0.655
MOD_CDK_SPxK_1	92	98	PF00069	0.610
MOD_CDK_SPxxK_3	30	37	PF00069	0.626
MOD_CK1_1	140	146	PF00069	0.633
MOD_CK1_1	193	199	PF00069	0.455
MOD_CK1_1	260	266	PF00069	0.585
MOD_CK1_1	274	280	PF00069	0.518
MOD_CK1_1	296	302	PF00069	0.607
MOD_CK1_1	305	311	PF00069	0.592
MOD_CK1_1	332	338	PF00069	0.801
MOD_CK1_1	364	370	PF00069	0.591
MOD_CK1_1	38	44	PF00069	0.691
MOD_CK1_1	419	425	PF00069	0.571
MOD_CK1_1	427	433	PF00069	0.524
MOD_CK1_1	81	87	PF00069	0.755
MOD_DYRK1A_RPxSP_1	347	351	PF00069	0.620
MOD_GlcNHglycan	153	156	PF01048	0.598
MOD_GlcNHglycan	173	176	PF01048	0.347
MOD_GlcNHglycan	21	24	PF01048	0.737
MOD_GlcNHglycan	319	322	PF01048	0.588
MOD_GlcNHglycan	439	442	PF01048	0.593
MOD_GlcNHglycan	81	84	PF01048	0.533
MOD_GSK3_1	133	140	PF00069	0.596
MOD_GSK3_1	267	274	PF00069	0.559
MOD_GSK3_1	301	308	PF00069	0.562
MOD_GSK3_1	313	320	PF00069	0.620
MOD_GSK3_1	347	354	PF00069	0.693
MOD_GSK3_1	35	42	PF00069	0.684
MOD_GSK3_1	358	365	PF00069	0.650
MOD_GSK3_1	416	423	PF00069	0.748
MOD_GSK3_1	63	70	PF00069	0.666
MOD_GSK3_1	75	82	PF00069	0.476
MOD_GSK3_1	84	91	PF00069	0.560
MOD_N-GLC_1	293	298	PF02516	0.606
MOD_N-GLC_1	72	77	PF02516	0.751
MOD_NEK2_1	29	34	PF00069	0.654
MOD_NEK2_1	317	322	PF00069	0.592
MOD_NEK2_1	358	363	PF00069	0.608
MOD_NEK2_2	52	57	PF00069	0.567
MOD_PIKK_1	127	133	PF00454	0.573
MOD_PIKK_1	271	277	PF00454	0.594
MOD_PIKK_1	280	286	PF00454	0.610
MOD_PIKK_1	302	308	PF00454	0.572
MOD_PIKK_1	88	94	PF00454	0.613
MOD_PK_1	117	123	PF00069	0.550
MOD_PKA_2	137	143	PF00069	0.605
MOD_PKA_2	19	25	PF00069	0.628
MOD_PKA_2	218	224	PF00069	0.425
MOD_PKA_2	29	35	PF00069	0.496
MOD_PKA_2	329	335	PF00069	0.588
MOD_PKA_2	36	42	PF00069	0.602
MOD_PKA_2	391	397	PF00069	0.501
MOD_PKA_2	416	422	PF00069	0.572
MOD_PKA_2	78	84	PF00069	0.586
MOD_PKB_1	125	133	PF00069	0.492
MOD_Plk_1	72	78	PF00069	0.647
MOD_Plk_4	190	196	PF00069	0.446
MOD_Plk_4	313	319	PF00069	0.590
MOD_Plk_4	81	87	PF00069	0.548
MOD_ProDKin_1	133	139	PF00069	0.605
MOD_ProDKin_1	267	273	PF00069	0.521
MOD_ProDKin_1	275	281	PF00069	0.741
MOD_ProDKin_1	30	36	PF00069	0.623
MOD_ProDKin_1	330	336	PF00069	0.614
MOD_ProDKin_1	342	348	PF00069	0.608
MOD_ProDKin_1	65	71	PF00069	0.679
MOD_ProDKin_1	84	90	PF00069	0.660
MOD_ProDKin_1	92	98	PF00069	0.706
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.418
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.583
TRG_ENDOCYTIC_2	50	53	PF00928	0.653
TRG_ER_diArg_1	124	127	PF00400	0.561
TRG_ER_diArg_1	264	266	PF00400	0.481
TRG_ER_diArg_1	380	382	PF00400	0.535
TRG_ER_diArg_1	390	393	PF00400	0.425
TRG_ER_diArg_1	98	101	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB3	Leptomonas seymouri	35%	96%
A0A3S7X0N8	Leishmania donovani	87%	100%
A4HFQ4	Leishmania braziliensis	62%	100%
A4I2S9	Leishmania infantum	87%	100%
E9AZ32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%