Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

E9ADA6_LEIMA

TriTrypDb:

LmjF.27.1270 , LMJLV39_270019100 , LMJSD75_270019300

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.708
CLV_C14_Caspase3-7	333	337	PF00656	0.346
CLV_C14_Caspase3-7	445	449	PF00656	0.284
CLV_C14_Caspase3-7	561	565	PF00656	0.340
CLV_NRD_NRD_1	116	118	PF00675	0.528
CLV_NRD_NRD_1	122	124	PF00675	0.558
CLV_NRD_NRD_1	246	248	PF00675	0.358
CLV_NRD_NRD_1	377	379	PF00675	0.348
CLV_NRD_NRD_1	464	466	PF00675	0.348
CLV_PCSK_KEX2_1	116	118	PF00082	0.535
CLV_PCSK_KEX2_1	121	123	PF00082	0.552
CLV_PCSK_KEX2_1	245	247	PF00082	0.402
CLV_PCSK_KEX2_1	377	379	PF00082	0.370
CLV_PCSK_KEX2_1	482	484	PF00082	0.273
CLV_PCSK_KEX2_1	51	53	PF00082	0.479
CLV_PCSK_KEX2_1	85	87	PF00082	0.446
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.273
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.479
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.446
CLV_PCSK_PC7_1	117	123	PF00082	0.635
CLV_PCSK_SKI1_1	180	184	PF00082	0.736
CLV_PCSK_SKI1_1	319	323	PF00082	0.434
CLV_PCSK_SKI1_1	342	346	PF00082	0.314
CLV_PCSK_SKI1_1	466	470	PF00082	0.275
CLV_PCSK_SKI1_1	63	67	PF00082	0.521
CLV_PCSK_SKI1_1	85	89	PF00082	0.493
DEG_APCC_DBOX_1	341	349	PF00400	0.294
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DOC_ANK_TNKS_1	132	139	PF00023	0.489
DOC_CYCLIN_RxL_1	461	472	PF00134	0.277
DOC_CYCLIN_RxL_1	60	71	PF00134	0.494
DOC_CYCLIN_yClb5_NLxxxL_5	562	571	PF00134	0.348
DOC_MAPK_gen_1	245	252	PF00069	0.278
DOC_MAPK_gen_1	518	526	PF00069	0.401
DOC_MAPK_gen_1	97	105	PF00069	0.610
DOC_MAPK_MEF2A_6	413	421	PF00069	0.308
DOC_PIKK_1	160	167	PF02985	0.518
DOC_PP1_RVXF_1	357	363	PF00149	0.401
DOC_PP1_RVXF_1	464	471	PF00149	0.330
DOC_PP1_RVXF_1	61	68	PF00149	0.467
DOC_USP7_MATH_1	223	227	PF00917	0.682
DOC_USP7_MATH_1	317	321	PF00917	0.399
DOC_USP7_UBL2_3	3	7	PF12436	0.525
DOC_USP7_UBL2_3	97	101	PF12436	0.547
DOC_WW_Pin1_4	180	185	PF00397	0.605
DOC_WW_Pin1_4	192	197	PF00397	0.509
DOC_WW_Pin1_4	204	209	PF00397	0.717
DOC_WW_Pin1_4	265	270	PF00397	0.273
DOC_WW_Pin1_4	313	318	PF00397	0.309
LIG_14-3-3_CanoR_1	172	177	PF00244	0.587
LIG_14-3-3_CanoR_1	228	237	PF00244	0.733
LIG_14-3-3_CanoR_1	292	298	PF00244	0.286
LIG_APCC_ABBAyCdc20_2	63	69	PF00400	0.479
LIG_BIR_III_4	541	545	PF00653	0.401
LIG_BRCT_BRCA1_1	237	241	PF00533	0.570
LIG_BRCT_BRCA1_1	295	299	PF00533	0.360
LIG_BRCT_BRCA1_1	411	415	PF00533	0.275
LIG_BRCT_BRCA1_1	497	501	PF00533	0.404
LIG_BRCT_BRCA1_2	498	504	PF00533	0.385
LIG_Clathr_ClatBox_1	65	69	PF01394	0.486
LIG_deltaCOP1_diTrp_1	546	552	PF00928	0.320
LIG_eIF4E_1	60	66	PF01652	0.465
LIG_EVH1_2	474	478	PF00568	0.401
LIG_FAT_LD_1	164	172	PF03623	0.621
LIG_FHA_1	177	183	PF00498	0.691
LIG_FHA_1	229	235	PF00498	0.705
LIG_FHA_1	289	295	PF00498	0.340
LIG_FHA_1	503	509	PF00498	0.447
LIG_FHA_1	82	88	PF00498	0.549
LIG_FHA_2	107	113	PF00498	0.376
LIG_FHA_2	369	375	PF00498	0.327
LIG_FHA_2	556	562	PF00498	0.401
LIG_FHA_2	76	82	PF00498	0.602
LIG_Integrin_RGD_1	133	135	PF01839	0.496
LIG_LIR_Apic_2	450	456	PF02991	0.267
LIG_LIR_Gen_1	195	206	PF02991	0.613
LIG_LIR_Gen_1	238	249	PF02991	0.365
LIG_LIR_Gen_1	296	304	PF02991	0.305
LIG_LIR_Gen_1	339	348	PF02991	0.304
LIG_LIR_Gen_1	393	402	PF02991	0.348
LIG_LIR_Gen_1	519	527	PF02991	0.313
LIG_LIR_Gen_1	546	557	PF02991	0.353
LIG_LIR_Gen_1	9	18	PF02991	0.487
LIG_LIR_Nem_3	195	201	PF02991	0.619
LIG_LIR_Nem_3	238	244	PF02991	0.432
LIG_LIR_Nem_3	276	282	PF02991	0.349
LIG_LIR_Nem_3	296	300	PF02991	0.283
LIG_LIR_Nem_3	324	329	PF02991	0.280
LIG_LIR_Nem_3	339	343	PF02991	0.216
LIG_LIR_Nem_3	361	365	PF02991	0.357
LIG_LIR_Nem_3	393	397	PF02991	0.348
LIG_LIR_Nem_3	435	441	PF02991	0.401
LIG_LIR_Nem_3	519	524	PF02991	0.289
LIG_LIR_Nem_3	546	552	PF02991	0.274
LIG_LIR_Nem_3	9	13	PF02991	0.442
LIG_LYPXL_SIV_4	57	65	PF13949	0.466
LIG_MLH1_MIPbox_1	498	502	PF16413	0.298
LIG_PCNA_yPIPBox_3	161	172	PF02747	0.523
LIG_Pex14_1	380	384	PF04695	0.401
LIG_PTB_Apo_2	251	258	PF02174	0.260
LIG_PTB_Apo_2	53	60	PF02174	0.489
LIG_PTB_Phospho_1	251	257	PF10480	0.275
LIG_PTB_Phospho_1	53	59	PF10480	0.490
LIG_REV1ctd_RIR_1	499	508	PF16727	0.401
LIG_REV1ctd_RIR_1	65	73	PF16727	0.524
LIG_SH2_CRK	173	177	PF00017	0.614
LIG_SH2_CRK	198	202	PF00017	0.639
LIG_SH2_CRK	453	457	PF00017	0.260
LIG_SH2_CRK	471	475	PF00017	0.275
LIG_SH2_CRK	521	525	PF00017	0.275
LIG_SH2_GRB2like	257	260	PF00017	0.275
LIG_SH2_GRB2like	54	57	PF00017	0.491
LIG_SH2_GRB2like	60	63	PF00017	0.466
LIG_SH2_NCK_1	173	177	PF00017	0.561
LIG_SH2_NCK_1	198	202	PF00017	0.639
LIG_SH2_NCK_1	471	475	PF00017	0.353
LIG_SH2_NCK_1	54	58	PF00017	0.436
LIG_SH2_SRC	54	57	PF00017	0.491
LIG_SH2_STAP1	10	14	PF00017	0.477
LIG_SH2_STAP1	230	234	PF00017	0.666
LIG_SH2_STAP1	24	28	PF00017	0.528
LIG_SH2_STAP1	538	542	PF00017	0.353
LIG_SH2_STAP1	54	58	PF00017	0.391
LIG_SH2_STAT3	379	382	PF00017	0.304
LIG_SH2_STAT5	198	201	PF00017	0.540
LIG_SH2_STAT5	230	233	PF00017	0.584
LIG_SH2_STAT5	273	276	PF00017	0.401
LIG_SH2_STAT5	279	282	PF00017	0.275
LIG_SH2_STAT5	394	397	PF00017	0.348
LIG_SH2_STAT5	441	444	PF00017	0.275
LIG_SH2_STAT5	538	541	PF00017	0.267
LIG_SH2_STAT5	569	572	PF00017	0.286
LIG_SH2_STAT5	60	63	PF00017	0.359
LIG_SH3_3	188	194	PF00018	0.707
LIG_SH3_3	198	204	PF00018	0.703
LIG_SH3_3	207	213	PF00018	0.718
LIG_SH3_3	25	31	PF00018	0.582
LIG_SH3_3	400	406	PF00018	0.447
LIG_SUMO_SIM_par_1	503	510	PF11976	0.243
LIG_TRAF2_1	396	399	PF00917	0.283
LIG_TYR_ITIM	171	176	PF00017	0.602
LIG_TYR_ITSM	517	524	PF00017	0.294
LIG_UBA3_1	477	482	PF00899	0.284
LIG_WRC_WIRS_1	294	299	PF05994	0.294
MOD_CAAXbox	572	575	PF01239	0.427
MOD_CDC14_SPxK_1	316	319	PF00782	0.353
MOD_CDK_SPxK_1	313	319	PF00069	0.353
MOD_CK1_1	159	165	PF00069	0.660
MOD_CK1_1	226	232	PF00069	0.672
MOD_CK1_1	368	374	PF00069	0.441
MOD_CK1_1	430	436	PF00069	0.390
MOD_CK1_1	514	520	PF00069	0.361
MOD_CK2_1	106	112	PF00069	0.530
MOD_CK2_1	160	166	PF00069	0.569
MOD_CK2_1	199	205	PF00069	0.746
MOD_CK2_1	368	374	PF00069	0.308
MOD_CK2_1	6	12	PF00069	0.496
MOD_GlcNHglycan	223	226	PF01048	0.694
MOD_GlcNHglycan	313	316	PF01048	0.468
MOD_GlcNHglycan	319	322	PF01048	0.341
MOD_GlcNHglycan	399	403	PF01048	0.351
MOD_GlcNHglycan	471	474	PF01048	0.385
MOD_GlcNHglycan	513	516	PF01048	0.371
MOD_GSK3_1	155	162	PF00069	0.652
MOD_GSK3_1	172	179	PF00069	0.560
MOD_GSK3_1	192	199	PF00069	0.606
MOD_GSK3_1	309	316	PF00069	0.382
MOD_GSK3_1	411	418	PF00069	0.298
MOD_GSK3_1	491	498	PF00069	0.464
MOD_GSK3_1	507	514	PF00069	0.169
MOD_N-GLC_1	160	165	PF02516	0.569
MOD_N-GLC_1	180	185	PF02516	0.426
MOD_N-GLC_1	265	270	PF02516	0.368
MOD_N-GLC_1	304	309	PF02516	0.303
MOD_N-GLC_1	330	335	PF02516	0.401
MOD_N-GLC_1	354	359	PF02516	0.346
MOD_N-GLC_1	386	391	PF02516	0.260
MOD_N-GLC_1	415	420	PF02516	0.348
MOD_N-GLC_1	448	453	PF02516	0.273
MOD_N-GLC_1	496	501	PF02516	0.413
MOD_N-GLC_2	254	256	PF02516	0.260
MOD_N-GLC_2	62	64	PF02516	0.461
MOD_NEK2_1	13	18	PF00069	0.484
MOD_NEK2_1	148	153	PF00069	0.670
MOD_NEK2_1	197	202	PF00069	0.538
MOD_NEK2_1	252	257	PF00069	0.310
MOD_NEK2_1	275	280	PF00069	0.342
MOD_NEK2_1	283	288	PF00069	0.282
MOD_NEK2_1	293	298	PF00069	0.212
MOD_NEK2_1	311	316	PF00069	0.395
MOD_NEK2_1	329	334	PF00069	0.344
MOD_NEK2_1	415	420	PF00069	0.383
MOD_NEK2_1	447	452	PF00069	0.348
MOD_NEK2_1	469	474	PF00069	0.292
MOD_NEK2_1	477	482	PF00069	0.306
MOD_NEK2_1	516	521	PF00069	0.308
MOD_NEK2_2	240	245	PF00069	0.515
MOD_PIKK_1	330	336	PF00454	0.320
MOD_PIKK_1	75	81	PF00454	0.529
MOD_PK_1	172	178	PF00069	0.594
MOD_PK_1	386	392	PF00069	0.320
MOD_PKB_1	170	178	PF00069	0.585
MOD_Plk_1	159	165	PF00069	0.542
MOD_Plk_1	386	392	PF00069	0.265
MOD_Plk_1	398	404	PF00069	0.294
MOD_Plk_1	415	421	PF00069	0.225
MOD_Plk_1	447	453	PF00069	0.395
MOD_Plk_1	496	502	PF00069	0.413
MOD_Plk_2-3	106	112	PF00069	0.607
MOD_Plk_2-3	160	166	PF00069	0.622
MOD_Plk_4	106	112	PF00069	0.375
MOD_Plk_4	257	263	PF00069	0.367
MOD_Plk_4	275	281	PF00069	0.378
MOD_Plk_4	386	392	PF00069	0.270
MOD_Plk_4	448	454	PF00069	0.327
MOD_Plk_4	496	502	PF00069	0.417
MOD_Plk_4	507	513	PF00069	0.236
MOD_ProDKin_1	180	186	PF00069	0.608
MOD_ProDKin_1	192	198	PF00069	0.514
MOD_ProDKin_1	204	210	PF00069	0.715
MOD_ProDKin_1	265	271	PF00069	0.273
MOD_ProDKin_1	313	319	PF00069	0.309
MOD_SUMO_for_1	45	48	PF00179	0.507
MOD_SUMO_rev_2	102	110	PF00179	0.493
MOD_SUMO_rev_2	303	312	PF00179	0.298
MOD_SUMO_rev_2	90	98	PF00179	0.565
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.401
TRG_ENDOCYTIC_2	10	13	PF00928	0.424
TRG_ENDOCYTIC_2	107	110	PF00928	0.533
TRG_ENDOCYTIC_2	173	176	PF00928	0.615
TRG_ENDOCYTIC_2	198	201	PF00928	0.640
TRG_ENDOCYTIC_2	326	329	PF00928	0.320
TRG_ENDOCYTIC_2	394	397	PF00928	0.348
TRG_ENDOCYTIC_2	487	490	PF00928	0.334
TRG_ENDOCYTIC_2	521	524	PF00928	0.275
TRG_ENDOCYTIC_2	58	61	PF00928	0.473
TRG_ER_diArg_1	121	123	PF00400	0.577
TRG_ER_diArg_1	170	173	PF00400	0.717
TRG_ER_diArg_1	244	247	PF00400	0.456
TRG_ER_diArg_1	377	379	PF00400	0.348
TRG_NLS_Bipartite_1	465	486	PF00514	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S4	Leptomonas seymouri	65%	97%
A0A0S4IVV7	Bodo saltans	28%	98%
A0A1X0NIL8	Trypanosomatidae	25%	75%
A0A1X0P5M1	Trypanosomatidae	42%	100%
A0A3Q8IGB5	Leishmania donovani	96%	100%
A0A422NFS3	Trypanosoma rangeli	42%	100%
A4HFQ3	Leishmania braziliensis	83%	100%
A4I2S8	Leishmania infantum	96%	100%
A4IBF1	Leishmania infantum	25%	100%
B2GUX4	Rattus norvegicus	28%	100%
D0A5Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AZ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9Q9U0	Mus musculus	27%	100%
P36026	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	80%
Q2KJ72	Bos taurus	28%	100%
Q2NL57	Xenopus laevis	23%	73%
Q7ZXR7	Xenopus laevis	22%	71%
Q91W36	Mus musculus	27%	100%
Q9H0E7	Homo sapiens	25%	81%
Q9HFS7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	72%
Q9Y6I4	Homo sapiens	27%	100%
V5BQL0	Trypanosoma cruzi	43%	100%