Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania major

UniProt:

E9ADA5_LEIMA

TriTrypDb:

LmjF.27.1265 , LMJLV39_270019000 , LMJSD75_270019200

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ADA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0006882	intracellular zinc ion homeostasis	7	7
GO:0009987	cellular process	1	7
GO:0019725	cellular homeostasis	2	7
GO:0030001	metal ion transport	6	2
GO:0030003	intracellular monoatomic cation homeostasis	5	7
GO:0042592	homeostatic process	3	7
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	7
GO:0048878	chemical homeostasis	4	7
GO:0050801	monoatomic ion homeostasis	5	7
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055065	obsolete metal ion homeostasis	7	7
GO:0055069	obsolete zinc ion homeostasis	8	7
GO:0055076	obsolete transition metal ion homeostasis	8	7
GO:0055080	monoatomic cation homeostasis	6	7
GO:0055082	intracellular chemical homeostasis	3	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	7
GO:0072507	obsolete divalent inorganic cation homeostasis	7	7
GO:0098771	inorganic ion homeostasis	6	7

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005385	zinc ion transmembrane transporter activity	7	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7
GO:0046915	transition metal ion transmembrane transporter activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.623
CLV_NRD_NRD_1	314	316	PF00675	0.268
CLV_NRD_NRD_1	583	585	PF00675	0.311
CLV_PCSK_SKI1_1	113	117	PF00082	0.246
CLV_PCSK_SKI1_1	270	274	PF00082	0.439
CLV_PCSK_SKI1_1	290	294	PF00082	0.390
CLV_PCSK_SKI1_1	315	319	PF00082	0.231
CLV_PCSK_SKI1_1	520	524	PF00082	0.237
CLV_PCSK_SKI1_1	538	542	PF00082	0.337
CLV_PCSK_SKI1_1	563	567	PF00082	0.283
CLV_PCSK_SKI1_1	585	589	PF00082	0.336
DEG_SCF_FBW7_2	557	564	PF00400	0.477
DOC_CYCLIN_RxL_1	267	277	PF00134	0.551
DOC_CYCLIN_RxL_1	517	525	PF00134	0.437
DOC_MAPK_gen_1	299	308	PF00069	0.649
DOC_MAPK_gen_1	313	323	PF00069	0.405
DOC_MAPK_MEF2A_6	299	308	PF00069	0.618
DOC_MAPK_MEF2A_6	313	321	PF00069	0.407
DOC_MAPK_NFAT4_5	316	324	PF00069	0.190
DOC_PP1_RVXF_1	268	275	PF00149	0.591
DOC_PP2B_LxvP_1	411	414	PF13499	0.262
DOC_PP2B_LxvP_1	524	527	PF13499	0.511
DOC_PP4_FxxP_1	410	413	PF00568	0.281
DOC_USP7_MATH_1	128	132	PF00917	0.464
DOC_USP7_MATH_1	278	282	PF00917	0.644
DOC_USP7_MATH_1	337	341	PF00917	0.271
DOC_USP7_MATH_1	497	501	PF00917	0.319
DOC_USP7_UBL2_3	290	294	PF12436	0.648
DOC_WW_Pin1_4	274	279	PF00397	0.571
DOC_WW_Pin1_4	549	554	PF00397	0.496
DOC_WW_Pin1_4	557	562	PF00397	0.489
DOC_WW_Pin1_4	57	62	PF00397	0.615
LIG_14-3-3_CanoR_1	45	51	PF00244	0.532
LIG_14-3-3_CanoR_1	66	75	PF00244	0.404
LIG_Actin_WH2_2	278	296	PF00022	0.557
LIG_APCC_ABBA_1	606	611	PF00400	0.542
LIG_BRCT_BRCA1_1	262	266	PF00533	0.190
LIG_BRCT_BRCA1_1	344	348	PF00533	0.228
LIG_EH1_1	203	211	PF00400	0.307
LIG_FHA_1	116	122	PF00498	0.240
LIG_FHA_1	167	173	PF00498	0.434
LIG_FHA_1	26	32	PF00498	0.218
LIG_FHA_1	322	328	PF00498	0.271
LIG_FHA_1	353	359	PF00498	0.230
LIG_FHA_1	516	522	PF00498	0.437
LIG_FHA_1	586	592	PF00498	0.551
LIG_FHA_1	79	85	PF00498	0.333
LIG_FHA_2	271	277	PF00498	0.657
LIG_FHA_2	58	64	PF00498	0.574
LIG_LIR_Gen_1	252	259	PF02991	0.331
LIG_LIR_Gen_1	28	38	PF02991	0.250
LIG_LIR_Gen_1	345	352	PF02991	0.236
LIG_LIR_Gen_1	417	427	PF02991	0.237
LIG_LIR_Gen_1	544	555	PF02991	0.514
LIG_LIR_Nem_3	244	250	PF02991	0.434
LIG_LIR_Nem_3	252	256	PF02991	0.260
LIG_LIR_Nem_3	28	33	PF02991	0.250
LIG_LIR_Nem_3	34	39	PF02991	0.295
LIG_LIR_Nem_3	384	389	PF02991	0.271
LIG_LIR_Nem_3	417	423	PF02991	0.237
LIG_LIR_Nem_3	510	515	PF02991	0.271
LIG_LIR_Nem_3	544	550	PF02991	0.432
LIG_NRBOX	470	476	PF00104	0.271
LIG_Pex14_1	32	36	PF04695	0.271
LIG_PTB_Apo_2	600	607	PF02174	0.520
LIG_SH2_PTP2	401	404	PF00017	0.271
LIG_SH2_SRC	467	470	PF00017	0.271
LIG_SH2_STAP1	362	366	PF00017	0.271
LIG_SH2_STAP1	529	533	PF00017	0.508
LIG_SH2_STAT5	401	404	PF00017	0.271
LIG_SH2_STAT5	420	423	PF00017	0.271
LIG_SH2_STAT5	467	470	PF00017	0.271
LIG_SH2_STAT5	488	491	PF00017	0.224
LIG_SH2_STAT5	580	583	PF00017	0.571
LIG_SH3_3	547	553	PF00018	0.490
LIG_Sin3_3	504	511	PF02671	0.307
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.281
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.333
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.268
LIG_SUMO_SIM_anti_2	477	484	PF11976	0.271
LIG_SUMO_SIM_anti_2	503	510	PF11976	0.271
LIG_SUMO_SIM_par_1	125	132	PF11976	0.273
LIG_SUMO_SIM_par_1	304	310	PF11976	0.533
LIG_SUMO_SIM_par_1	420	425	PF11976	0.271
LIG_SUMO_SIM_par_1	503	510	PF11976	0.271
LIG_SUMO_SIM_par_1	520	525	PF11976	0.481
LIG_UBA3_1	184	191	PF00899	0.521
LIG_Vh1_VBS_1	148	166	PF01044	0.294
LIG_WRC_WIRS_1	33	38	PF05994	0.271
LIG_WRC_WIRS_1	39	44	PF05994	0.271
LIG_WW_3	560	564	PF00397	0.485
MOD_CDK_SPK_2	549	554	PF00069	0.540
MOD_CDK_SPK_2	57	62	PF00069	0.615
MOD_CDK_SPxK_1	557	563	PF00069	0.479
MOD_CDK_SPxxK_3	57	64	PF00069	0.610
MOD_CK1_1	26	32	PF00069	0.281
MOD_CK1_1	283	289	PF00069	0.615
MOD_CK1_1	500	506	PF00069	0.271
MOD_CK1_1	531	537	PF00069	0.487
MOD_CK2_1	447	453	PF00069	0.424
MOD_GlcNHglycan	12	15	PF01048	0.237
MOD_GlcNHglycan	206	209	PF01048	0.280
MOD_GlcNHglycan	215	218	PF01048	0.323
MOD_GlcNHglycan	25	28	PF01048	0.619
MOD_GlcNHglycan	260	263	PF01048	0.333
MOD_GlcNHglycan	282	285	PF01048	0.436
MOD_GlcNHglycan	3	6	PF01048	0.249
MOD_GlcNHglycan	455	458	PF01048	0.270
MOD_GlcNHglycan	499	502	PF01048	0.271
MOD_GlcNHglycan	509	512	PF01048	0.271
MOD_GlcNHglycan	524	527	PF01048	0.355
MOD_GlcNHglycan	581	584	PF01048	0.372
MOD_GlcNHglycan	68	71	PF01048	0.318
MOD_GlcNHglycan	78	81	PF01048	0.247
MOD_GSK3_1	105	112	PF00069	0.665
MOD_GSK3_1	270	277	PF00069	0.617
MOD_GSK3_1	439	446	PF00069	0.436
MOD_GSK3_1	476	483	PF00069	0.296
MOD_GSK3_1	574	581	PF00069	0.578
MOD_GSK3_1	585	592	PF00069	0.486
MOD_GSK3_1	6	13	PF00069	0.373
MOD_N-GLC_1	531	536	PF02516	0.286
MOD_N-GLC_1	575	580	PF02516	0.388
MOD_N-GLC_1	602	607	PF02516	0.302
MOD_NEK2_1	1	6	PF00069	0.444
MOD_NEK2_1	10	15	PF00069	0.259
MOD_NEK2_1	117	122	PF00069	0.273
MOD_NEK2_1	183	188	PF00069	0.349
MOD_NEK2_1	204	209	PF00069	0.354
MOD_NEK2_1	221	226	PF00069	0.726
MOD_NEK2_1	236	241	PF00069	0.163
MOD_NEK2_1	25	30	PF00069	0.370
MOD_NEK2_1	258	263	PF00069	0.333
MOD_NEK2_1	293	298	PF00069	0.589
MOD_NEK2_1	321	326	PF00069	0.271
MOD_NEK2_1	352	357	PF00069	0.240
MOD_NEK2_1	403	408	PF00069	0.471
MOD_NEK2_1	422	427	PF00069	0.160
MOD_NEK2_1	439	444	PF00069	0.437
MOD_NEK2_1	474	479	PF00069	0.271
MOD_NEK2_1	515	520	PF00069	0.437
MOD_NEK2_1	522	527	PF00069	0.510
MOD_NEK2_1	541	546	PF00069	0.538
MOD_NEK2_1	76	81	PF00069	0.274
MOD_OFUCOSY	119	124	PF10250	0.294
MOD_PIKK_1	293	299	PF00454	0.594
MOD_PKA_1	585	591	PF00069	0.528
MOD_PKA_2	108	114	PF00069	0.731
MOD_PKA_2	23	29	PF00069	0.390
MOD_PKA_2	574	580	PF00069	0.533
MOD_PKB_1	107	115	PF00069	0.598
MOD_Plk_1	563	569	PF00069	0.482
MOD_Plk_1	602	608	PF00069	0.498
MOD_Plk_4	117	123	PF00069	0.397
MOD_Plk_4	176	182	PF00069	0.321
MOD_Plk_4	236	242	PF00069	0.480
MOD_Plk_4	26	32	PF00069	0.237
MOD_Plk_4	260	266	PF00069	0.200
MOD_Plk_4	304	310	PF00069	0.531
MOD_Plk_4	353	359	PF00069	0.333
MOD_Plk_4	365	371	PF00069	0.224
MOD_Plk_4	38	44	PF00069	0.271
MOD_Plk_4	422	428	PF00069	0.256
MOD_Plk_4	476	482	PF00069	0.271
MOD_Plk_4	542	548	PF00069	0.537
MOD_Plk_4	602	608	PF00069	0.498
MOD_ProDKin_1	274	280	PF00069	0.573
MOD_ProDKin_1	549	555	PF00069	0.494
MOD_ProDKin_1	557	563	PF00069	0.492
MOD_ProDKin_1	57	63	PF00069	0.611
MOD_SUMO_rev_2	283	292	PF00179	0.556
MOD_SUMO_rev_2	310	318	PF00179	0.490
MOD_SUMO_rev_2	368	375	PF00179	0.437
TRG_DiLeu_BaEn_1	195	200	PF01217	0.381
TRG_DiLeu_BaEn_1	254	259	PF01217	0.293
TRG_DiLeu_BaEn_1	417	422	PF01217	0.237
TRG_DiLeu_BaEn_2	313	319	PF01217	0.437
TRG_DiLeu_BaEn_3	300	306	PF01217	0.590
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.271
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.596
TRG_ENDOCYTIC_2	383	386	PF00928	0.437
TRG_ENDOCYTIC_2	401	404	PF00928	0.271
TRG_ENDOCYTIC_2	420	423	PF00928	0.271
TRG_ENDOCYTIC_2	467	470	PF00928	0.271
TRG_NLS_MonoExtC_3	583	589	PF00514	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB11	Leptomonas seymouri	58%	100%
A0A3Q8IDA3	Leishmania donovani	90%	100%
A4HFQ2	Leishmania braziliensis	79%	92%
A4I2S7	Leishmania infantum	90%	100%
E9AZ30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q28CE7	Xenopus tropicalis	31%	79%