LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
Serine-threonine kinase receptor-associated protein, putative
Species:
Leishmania major
UniProt:
E9ADA3_LEIMA
TriTrypDb:
LmjF.27.1250 , LMJLV39_270018800 , LMJSD75_270019000
Length:
321

Annotations

Annotations by Jardim et al.

Protein kinase, Serine-threonine kinase receptor-associated

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0010494 cytoplasmic stress granule 5 2
GO:0020022 acidocalcisome 5 2
GO:0032797 SMN complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0035770 ribonucleoprotein granule 3 2
GO:0036464 cytoplasmic ribonucleoprotein granule 4 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0099080 supramolecular complex 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0120114 Sm-like protein family complex 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9ADA3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA3

Function

Biological processes
Term Name Level Count
GO:0000387 spliceosomal snRNP assembly 7 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0022618 ribonucleoprotein complex assembly 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0071826 ribonucleoprotein complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 5
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 5
GO:0097159 organic cyclic compound binding 2 5
GO:1901363 heterocyclic compound binding 2 5
GO:0003743 translation initiation factor activity 4 3
GO:0008135 translation factor activity, RNA binding 3 3
GO:0045182 translation regulator activity 1 3
GO:0090079 translation regulator activity, nucleic acid binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 233 237 PF00656 0.433
CLV_C14_Caspase3-7 45 49 PF00656 0.380
CLV_NRD_NRD_1 199 201 PF00675 0.364
CLV_PCSK_KEX2_1 199 201 PF00082 0.478
CLV_PCSK_SKI1_1 122 126 PF00082 0.217
CLV_PCSK_SKI1_1 133 137 PF00082 0.217
CLV_PCSK_SKI1_1 265 269 PF00082 0.320
CLV_PCSK_SKI1_1 61 65 PF00082 0.297
CLV_PCSK_SKI1_1 94 98 PF00082 0.220
DOC_MAPK_DCC_7 199 207 PF00069 0.374
DOC_MAPK_gen_1 199 207 PF00069 0.340
DOC_MAPK_MEF2A_6 199 207 PF00069 0.355
DOC_PP1_RVXF_1 220 227 PF00149 0.327
DOC_PP4_FxxP_1 158 161 PF00568 0.376
DOC_USP7_MATH_1 257 261 PF00917 0.332
DOC_USP7_MATH_1 87 91 PF00917 0.456
DOC_USP7_UBL2_3 261 265 PF12436 0.359
DOC_WW_Pin1_4 157 162 PF00397 0.419
DOC_WW_Pin1_4 247 252 PF00397 0.357
LIG_14-3-3_CanoR_1 288 296 PF00244 0.514
LIG_BIR_II_1 1 5 PF00653 0.545
LIG_BIR_III_2 152 156 PF00653 0.415
LIG_BIR_III_2 59 63 PF00653 0.309
LIG_BRCT_BRCA1_1 167 171 PF00533 0.360
LIG_BRCT_BRCA1_1 222 226 PF00533 0.322
LIG_deltaCOP1_diTrp_1 71 76 PF00928 0.259
LIG_FHA_1 167 173 PF00498 0.321
LIG_FHA_1 33 39 PF00498 0.317
LIG_FHA_1 6 12 PF00498 0.584
LIG_FHA_1 91 97 PF00498 0.406
LIG_FHA_2 147 153 PF00498 0.419
LIG_FHA_2 177 183 PF00498 0.301
LIG_FHA_2 228 234 PF00498 0.341
LIG_FHA_2 237 243 PF00498 0.367
LIG_LIR_Apic_2 157 161 PF02991 0.379
LIG_LIR_Apic_2 2 7 PF02991 0.592
LIG_LIR_Gen_1 223 234 PF02991 0.463
LIG_LIR_Gen_1 99 110 PF02991 0.417
LIG_LIR_Nem_3 223 229 PF02991 0.441
LIG_LIR_Nem_3 48 54 PF02991 0.313
LIG_MLH1_MIPbox_1 167 171 PF16413 0.360
LIG_PDZ_Class_1 316 321 PF00595 0.567
LIG_Pex14_1 72 76 PF04695 0.259
LIG_Pex14_2 285 289 PF04695 0.406
LIG_Pex14_2 84 88 PF04695 0.492
LIG_SH2_PTP2 4 7 PF00017 0.629
LIG_SH2_STAP1 102 106 PF00017 0.406
LIG_SH2_STAP1 317 321 PF00017 0.578
LIG_SH2_STAP1 43 47 PF00017 0.309
LIG_SH2_STAT5 123 126 PF00017 0.406
LIG_SH2_STAT5 170 173 PF00017 0.310
LIG_SH2_STAT5 197 200 PF00017 0.358
LIG_SH2_STAT5 210 213 PF00017 0.360
LIG_SH2_STAT5 4 7 PF00017 0.622
LIG_SH3_1 10 16 PF00018 0.639
LIG_SH3_3 10 16 PF00018 0.622
LIG_TYR_ITIM 41 46 PF00017 0.300
LIG_WRC_WIRS_1 73 78 PF05994 0.406
MOD_CK1_1 157 163 PF00069 0.401
MOD_CK1_1 237 243 PF00069 0.362
MOD_CK1_1 295 301 PF00069 0.417
MOD_CK1_1 32 38 PF00069 0.326
MOD_CK1_1 90 96 PF00069 0.489
MOD_CK2_1 176 182 PF00069 0.293
MOD_CK2_1 227 233 PF00069 0.353
MOD_CK2_1 236 242 PF00069 0.360
MOD_CK2_1 295 301 PF00069 0.406
MOD_Cter_Amidation 111 114 PF01082 0.379
MOD_GlcNHglycan 102 105 PF01048 0.130
MOD_GlcNHglycan 192 196 PF01048 0.437
MOD_GlcNHglycan 297 300 PF01048 0.217
MOD_GlcNHglycan 31 34 PF01048 0.330
MOD_GlcNHglycan 85 88 PF01048 0.240
MOD_GlcNHglycan 89 92 PF01048 0.220
MOD_GlcNHglycan 98 101 PF01048 0.157
MOD_GSK3_1 208 215 PF00069 0.371
MOD_GSK3_1 234 241 PF00069 0.433
MOD_GSK3_1 288 295 PF00069 0.511
MOD_GSK3_1 83 90 PF00069 0.422
MOD_GSK3_1 96 103 PF00069 0.382
MOD_LATS_1 220 226 PF00433 0.314
MOD_LATS_1 286 292 PF00433 0.511
MOD_N-GLC_1 41 46 PF02516 0.296
MOD_NEK2_1 171 176 PF00069 0.400
MOD_NEK2_1 190 195 PF00069 0.191
MOD_NEK2_1 53 58 PF00069 0.277
MOD_PKA_2 190 196 PF00069 0.346
MOD_PKA_2 212 218 PF00069 0.413
MOD_Plk_1 100 106 PF00069 0.438
MOD_Plk_1 146 152 PF00069 0.516
MOD_Plk_1 220 226 PF00069 0.326
MOD_Plk_1 227 233 PF00069 0.345
MOD_Plk_1 265 271 PF00069 0.328
MOD_Plk_2-3 228 234 PF00069 0.338
MOD_Plk_4 166 172 PF00069 0.313
MOD_Plk_4 173 179 PF00069 0.308
MOD_Plk_4 212 218 PF00069 0.363
MOD_Plk_4 47 53 PF00069 0.319
MOD_ProDKin_1 157 163 PF00069 0.419
MOD_ProDKin_1 247 253 PF00069 0.357
MOD_SUMO_rev_2 228 237 PF00179 0.363
MOD_SUMO_rev_2 56 63 PF00179 0.303
TRG_ENDOCYTIC_2 102 105 PF00928 0.460
TRG_ENDOCYTIC_2 43 46 PF00928 0.309
TRG_ER_diArg_1 198 200 PF00400 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4D4 Leptomonas seymouri 95% 100%
A0A0N1I6C2 Leptomonas seymouri 24% 77%
A0A0S4JC99 Bodo saltans 64% 69%
A0A1X0NQ96 Trypanosomatidae 23% 77%
A0A1X0P458 Trypanosomatidae 81% 98%
A0A3Q8IHK6 Leishmania donovani 100% 100%
A0A3R7KDE0 Trypanosoma rangeli 76% 98%
A0A3R7KUH0 Trypanosoma rangeli 26% 76%
A0A3S7WR72 Leishmania donovani 21% 77%
A4H666 Leishmania braziliensis 21% 77%
A4HFQ0 Leishmania braziliensis 98% 100%
A4HUJ0 Leishmania infantum 21% 77%
A4I2S5 Leishmania infantum 100% 100%
A4RDD7 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 23% 94%
A6ZMK5 Saccharomyces cerevisiae (strain YJM789) 24% 93%
A7RM20 Nematostella vectensis 26% 100%
A7TH19 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 24% 93%
A8QBF3 Brugia malayi 21% 98%
A8WVX8 Caenorhabditis briggsae 24% 98%
B0BNA7 Rattus norvegicus 25% 99%
B0XFT7 Culex quinquefasciatus 27% 98%
B3MVL6 Drosophila ananassae 26% 100%
B3N4C7 Drosophila erecta 26% 98%
B4GSH1 Drosophila persimilis 26% 98%
B4I195 Drosophila sechellia 26% 98%
B4JB43 Drosophila grimshawi 26% 98%
B4KGX9 Drosophila mojavensis 26% 100%
B4LUA5 Drosophila virilis 26% 100%
B4N0L0 Drosophila willistoni 26% 100%
B4NW98 Drosophila yakuba 26% 100%
B4Q354 Drosophila simulans 26% 98%
B5FZ19 Taeniopygia guttata 25% 99%
C9ZVL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 77%
D0A5Y4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 98%
D0A8F9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 94%
E3LB80 Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) 26% 96%
E9AN88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 77%
E9AZ28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
F6ZT52 Xenopus tropicalis 21% 68%
O02195 Drosophila melanogaster 26% 98%
P0CS32 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 24% 94%
P0CS33 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 24% 94%
P40217 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 93%
P61964 Homo sapiens 24% 96%
P61965 Mus musculus 24% 96%
P62881 Mus musculus 21% 81%
P62882 Rattus norvegicus 21% 91%
P79083 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 98%
P93340 Nicotiana plumbaginifolia 23% 98%
Q0P593 Bos taurus 23% 77%
Q0V320 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 24% 97%
Q13347 Homo sapiens 25% 99%
Q16K15 Aedes aegypti 27% 98%
Q1HPW4 Bombyx mori 26% 98%
Q29L19 Drosophila pseudoobscura pseudoobscura 26% 98%
Q2GTM8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 25% 94%
Q2KIG2 Bos taurus 24% 96%
Q2TBP4 Bos taurus 25% 79%
Q38884 Arabidopsis thaliana 27% 98%
Q3Y8L7 Chlamydomonas reinhardtii 24% 72%
Q498M4 Rattus norvegicus 24% 96%
Q4P6E2 Ustilago maydis (strain 521 / FGSC 9021) 24% 93%
Q4QHD6 Leishmania major 25% 77%
Q4R8E7 Macaca fascicularis 25% 77%
Q4V7Z1 Xenopus laevis 22% 69%
Q54LT8 Dictyostelium discoideum 38% 100%
Q54MT0 Dictyostelium discoideum 23% 97%
Q5B8Y3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 96%
Q5BK30 Rattus norvegicus 25% 77%
Q5E959 Bos taurus 36% 92%
Q5E966 Bos taurus 25% 99%
Q5EBE8 Xenopus tropicalis 24% 99%
Q5IH81 Oryctolagus cuniculus 25% 96%
Q5M786 Xenopus tropicalis 24% 96%
Q5R7R2 Pongo abelii 25% 99%
Q5XIG8 Rattus norvegicus 36% 92%
Q5ZL33 Gallus gallus 36% 92%
Q66J51 Xenopus laevis 24% 99%
Q6CI08 Yarrowia lipolytica (strain CLIB 122 / E 150) 22% 95%
Q6CKX3 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 22% 93%
Q6FL15 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 23% 93%
Q6P2Y2 Xenopus tropicalis 23% 77%
Q7PP77 Anopheles gambiae 28% 98%
Q7RXH4 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 93%
Q7ZV55 Danio rerio 23% 99%
Q8N136 Homo sapiens 24% 77%
Q965S8 Caenorhabditis elegans 24% 98%
Q9M2Z2 Arabidopsis thaliana 22% 100%
Q9QZD9 Mus musculus 25% 99%
Q9V3J8 Drosophila melanogaster 25% 89%
Q9Y3F4 Homo sapiens 35% 92%
Q9Z1Z2 Mus musculus 36% 92%
V5BP59 Trypanosoma cruzi 24% 77%
V5BQL6 Trypanosoma cruzi 77% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS