Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADA0_LEIMA

TriTrypDb:

LmjF.27.1220 , LMJLV39_270018200 , LMJSD75_270018400

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.502
CLV_C14_Caspase3-7	309	313	PF00656	0.590
CLV_NRD_NRD_1	212	214	PF00675	0.539
CLV_NRD_NRD_1	23	25	PF00675	0.481
CLV_NRD_NRD_1	233	235	PF00675	0.538
CLV_NRD_NRD_1	258	260	PF00675	0.471
CLV_NRD_NRD_1	369	371	PF00675	0.480
CLV_NRD_NRD_1	373	375	PF00675	0.488
CLV_NRD_NRD_1	409	411	PF00675	0.649
CLV_NRD_NRD_1	70	72	PF00675	0.762
CLV_PCSK_FUR_1	367	371	PF00082	0.476
CLV_PCSK_KEX2_1	233	235	PF00082	0.671
CLV_PCSK_KEX2_1	258	260	PF00082	0.483
CLV_PCSK_KEX2_1	34	36	PF00082	0.574
CLV_PCSK_KEX2_1	369	371	PF00082	0.531
CLV_PCSK_KEX2_1	373	375	PF00082	0.531
CLV_PCSK_KEX2_1	70	72	PF00082	0.758
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.639
CLV_PCSK_PC7_1	229	235	PF00082	0.619
CLV_PCSK_PC7_1	254	260	PF00082	0.388
CLV_PCSK_PC7_1	369	375	PF00082	0.612
CLV_PCSK_PC7_1	66	72	PF00082	0.656
CLV_PCSK_SKI1_1	105	109	PF00082	0.565
CLV_PCSK_SKI1_1	111	115	PF00082	0.584
CLV_PCSK_SKI1_1	184	188	PF00082	0.498
CLV_PCSK_SKI1_1	213	217	PF00082	0.554
CLV_PCSK_SKI1_1	259	263	PF00082	0.561
CLV_Separin_Metazoa	106	110	PF03568	0.625
CLV_Separin_Metazoa	185	189	PF03568	0.570
DEG_APCC_DBOX_1	258	266	PF00400	0.529
DEG_APCC_DBOX_1	372	380	PF00400	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SPOP_SBC_1	75	79	PF00917	0.527
DOC_CYCLIN_RxL_1	102	112	PF00134	0.500
DOC_MAPK_gen_1	31	39	PF00069	0.550
DOC_MAPK_MEF2A_6	172	179	PF00069	0.538
DOC_PP2B_LxvP_1	80	83	PF13499	0.533
DOC_USP7_MATH_1	357	361	PF00917	0.557
DOC_USP7_MATH_1	405	409	PF00917	0.569
DOC_USP7_MATH_1	69	73	PF00917	0.762
DOC_USP7_UBL2_3	21	25	PF12436	0.466
LIG_Clathr_ClatBox_1	13	17	PF01394	0.598
LIG_FHA_2	101	107	PF00498	0.594
LIG_FHA_2	195	201	PF00498	0.664
LIG_FHA_2	244	250	PF00498	0.632
LIG_FHA_2	299	305	PF00498	0.661
LIG_FHA_2	359	365	PF00498	0.580
LIG_LIR_Nem_3	129	135	PF02991	0.568
LIG_Rb_pABgroove_1	321	329	PF01858	0.583
LIG_SH2_STAP1	158	162	PF00017	0.509
LIG_SH2_STAP1	327	331	PF00017	0.579
LIG_SH2_STAT5	132	135	PF00017	0.625
LIG_SH2_STAT5	29	32	PF00017	0.552
LIG_SH2_STAT5	375	378	PF00017	0.468
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.495
LIG_SUMO_SIM_par_1	5	10	PF11976	0.637
LIG_TRAF2_1	128	131	PF00917	0.532
LIG_UBA3_1	86	93	PF00899	0.451
MOD_CK1_1	100	106	PF00069	0.674
MOD_CK1_1	40	46	PF00069	0.617
MOD_CK1_1	53	59	PF00069	0.670
MOD_CK1_1	62	68	PF00069	0.650
MOD_CK1_1	76	82	PF00069	0.571
MOD_CK2_1	100	106	PF00069	0.635
MOD_CK2_1	194	200	PF00069	0.614
MOD_CK2_1	2	8	PF00069	0.678
MOD_CK2_1	358	364	PF00069	0.538
MOD_CK2_1	92	98	PF00069	0.715
MOD_GlcNHglycan	148	151	PF01048	0.730
MOD_GlcNHglycan	351	354	PF01048	0.648
MOD_GlcNHglycan	407	410	PF01048	0.697
MOD_GlcNHglycan	67	70	PF01048	0.721
MOD_GlcNHglycan	71	74	PF01048	0.701
MOD_GSK3_1	140	147	PF00069	0.614
MOD_GSK3_1	194	201	PF00069	0.541
MOD_GSK3_1	33	40	PF00069	0.535
MOD_GSK3_1	386	393	PF00069	0.514
MOD_GSK3_1	400	407	PF00069	0.574
MOD_GSK3_1	50	57	PF00069	0.558
MOD_GSK3_1	65	72	PF00069	0.614
MOD_GSK3_1	74	81	PF00069	0.600
MOD_LATS_1	356	362	PF00433	0.558
MOD_N-GLC_1	145	150	PF02516	0.507
MOD_N-GLC_1	40	45	PF02516	0.564
MOD_NEK2_1	30	35	PF00069	0.511
MOD_NEK2_1	326	331	PF00069	0.495
MOD_NEK2_1	37	42	PF00069	0.538
MOD_NEK2_1	50	55	PF00069	0.458
MOD_NEK2_1	7	12	PF00069	0.504
MOD_PIKK_1	15	21	PF00454	0.462
MOD_PIKK_1	198	204	PF00454	0.574
MOD_PIKK_1	59	65	PF00454	0.677
MOD_PKA_1	233	239	PF00069	0.446
MOD_PKA_2	233	239	PF00069	0.711
MOD_PKA_2	30	36	PF00069	0.625
MOD_PKA_2	349	355	PF00069	0.473
MOD_PKA_2	386	392	PF00069	0.461
MOD_PKA_2	405	411	PF00069	0.709
MOD_PKA_2	50	56	PF00069	0.460
MOD_PKA_2	65	71	PF00069	0.752
MOD_Plk_1	358	364	PF00069	0.549
MOD_Plk_1	97	103	PF00069	0.572
MOD_Plk_4	2	8	PF00069	0.557
MOD_Plk_4	358	364	PF00069	0.507
MOD_Plk_4	390	396	PF00069	0.491
MOD_SUMO_for_1	119	122	PF00179	0.677
MOD_SUMO_for_1	215	218	PF00179	0.404
MOD_SUMO_rev_2	208	215	PF00179	0.507
MOD_SUMO_rev_2	38	48	PF00179	0.574
TRG_ENDOCYTIC_2	132	135	PF00928	0.534
TRG_ENDOCYTIC_2	281	284	PF00928	0.598
TRG_ER_diArg_1	251	254	PF00400	0.537
TRG_ER_diArg_1	258	260	PF00400	0.485
TRG_ER_diArg_1	367	370	PF00400	0.591
TRG_ER_diArg_1	373	375	PF00400	0.563
TRG_NES_CRM1_1	131	144	PF08389	0.566
TRG_NES_CRM1_1	285	298	PF08389	0.490
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ5	Leptomonas seymouri	62%	96%
A0A1X0P450	Trypanosomatidae	30%	100%
A0A3R7M124	Trypanosoma rangeli	27%	100%
A0A3S7X0N0	Leishmania donovani	88%	100%
A4HFP7	Leishmania braziliensis	70%	96%
A4I2S2	Leishmania infantum	88%	100%
D0A5Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
V5AT73	Trypanosoma cruzi	27%	100%