Putative translation initiation factor eIF2B subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor eIF2B delta subunit, putative

Species:

Leishmania major

UniProt:

E9AD99_LEIMA

TriTrypDb:

LmjF.27.1210 , LMJLV39_270018100 , LMJSD75_270018300

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.391
CLV_NRD_NRD_1	253	255	PF00675	0.233
CLV_NRD_NRD_1	415	417	PF00675	0.218
CLV_NRD_NRD_1	43	45	PF00675	0.444
CLV_PCSK_FUR_1	235	239	PF00082	0.486
CLV_PCSK_KEX2_1	143	145	PF00082	0.493
CLV_PCSK_KEX2_1	235	237	PF00082	0.389
CLV_PCSK_KEX2_1	253	255	PF00082	0.236
CLV_PCSK_KEX2_1	341	343	PF00082	0.299
CLV_PCSK_KEX2_1	39	41	PF00082	0.420
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.493
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.416
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.303
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.420
CLV_PCSK_SKI1_1	131	135	PF00082	0.556
CLV_PCSK_SKI1_1	245	249	PF00082	0.361
CLV_PCSK_SKI1_1	280	284	PF00082	0.459
CLV_PCSK_SKI1_1	34	38	PF00082	0.427
CLV_PCSK_SKI1_1	40	44	PF00082	0.413
CLV_PCSK_SKI1_1	417	421	PF00082	0.218
CLV_PCSK_SKI1_1	8	12	PF00082	0.587
DEG_APCC_DBOX_1	39	47	PF00400	0.468
DEG_COP1_1	206	215	PF00400	0.496
DEG_COP1_1	423	432	PF00400	0.476
DEG_SPOP_SBC_1	502	506	PF00917	0.504
DOC_CKS1_1	465	470	PF01111	0.563
DOC_CKS1_1	482	487	PF01111	0.402
DOC_MAPK_gen_1	339	346	PF00069	0.511
DOC_MAPK_gen_1	413	422	PF00069	0.418
DOC_MAPK_gen_1	8	18	PF00069	0.584
DOC_MAPK_MEF2A_6	173	181	PF00069	0.456
DOC_MAPK_MEF2A_6	413	422	PF00069	0.418
DOC_MAPK_MEF2A_6	427	434	PF00069	0.418
DOC_MIT_MIM_1	249	259	PF04212	0.438
DOC_PP2B_LxvP_1	210	213	PF13499	0.455
DOC_PP2B_LxvP_1	471	474	PF13499	0.509
DOC_PP4_FxxP_1	415	418	PF00568	0.492
DOC_USP7_MATH_1	123	127	PF00917	0.697
DOC_USP7_MATH_1	211	215	PF00917	0.535
DOC_USP7_MATH_1	308	312	PF00917	0.524
DOC_USP7_MATH_1	502	506	PF00917	0.457
DOC_USP7_MATH_1	92	96	PF00917	0.745
DOC_USP7_UBL2_3	295	299	PF12436	0.458
DOC_USP7_UBL2_3	413	417	PF12436	0.418
DOC_USP7_UBL2_3	45	49	PF12436	0.477
DOC_USP7_UBL2_3	8	12	PF12436	0.557
DOC_WW_Pin1_4	103	108	PF00397	0.728
DOC_WW_Pin1_4	458	463	PF00397	0.436
DOC_WW_Pin1_4	464	469	PF00397	0.431
DOC_WW_Pin1_4	481	486	PF00397	0.519
DOC_WW_Pin1_4	512	517	PF00397	0.413
DOC_WW_Pin1_4	96	101	PF00397	0.665
LIG_14-3-3_CanoR_1	138	145	PF00244	0.634
LIG_14-3-3_CanoR_1	205	210	PF00244	0.482
LIG_14-3-3_CanoR_1	321	325	PF00244	0.435
LIG_14-3-3_CanoR_1	80	86	PF00244	0.690
LIG_Actin_WH2_2	279	297	PF00022	0.389
LIG_Actin_WH2_2	66	82	PF00022	0.334
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	424	428	PF00533	0.420
LIG_EVH1_1	465	469	PF00568	0.369
LIG_FHA_1	204	210	PF00498	0.372
LIG_FHA_1	281	287	PF00498	0.429
LIG_FHA_1	313	319	PF00498	0.441
LIG_FHA_1	367	373	PF00498	0.422
LIG_FHA_1	530	536	PF00498	0.468
LIG_FHA_1	545	551	PF00498	0.425
LIG_FHA_1	86	92	PF00498	0.633
LIG_FHA_2	132	138	PF00498	0.584
LIG_FHA_2	219	225	PF00498	0.434
LIG_LIR_Apic_2	479	485	PF02991	0.512
LIG_LIR_Gen_1	220	231	PF02991	0.316
LIG_LIR_Gen_1	518	527	PF02991	0.498
LIG_LIR_Nem_3	198	203	PF02991	0.362
LIG_LIR_Nem_3	220	226	PF02991	0.327
LIG_LIR_Nem_3	297	301	PF02991	0.435
LIG_LIR_Nem_3	326	330	PF02991	0.512
LIG_LIR_Nem_3	367	373	PF02991	0.416
LIG_LIR_Nem_3	423	429	PF02991	0.432
LIG_MYND_1	469	473	PF01753	0.455
LIG_SH2_CRK	370	374	PF00017	0.418
LIG_SH2_CRK	426	430	PF00017	0.482
LIG_SH2_PTP2	327	330	PF00017	0.512
LIG_SH2_STAT5	309	312	PF00017	0.474
LIG_SH2_STAT5	327	330	PF00017	0.474
LIG_SH2_STAT5	510	513	PF00017	0.418
LIG_SH2_STAT5	519	522	PF00017	0.418
LIG_SH3_3	166	172	PF00018	0.526
LIG_SH3_3	259	265	PF00018	0.488
LIG_SH3_3	463	469	PF00018	0.369
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.347
LIG_SUMO_SIM_par_1	109	115	PF11976	0.555
LIG_SUMO_SIM_par_1	206	214	PF11976	0.481
LIG_SUMO_SIM_par_1	342	348	PF11976	0.418
LIG_TRAF2_1	134	137	PF00917	0.528
LIG_TRAF2_1	4	7	PF00917	0.491
LIG_TRFH_1	512	516	PF08558	0.418
LIG_TYR_ITIM	325	330	PF00017	0.512
LIG_TYR_ITIM	368	373	PF00017	0.418
LIG_UBA3_1	286	295	PF00899	0.381
MOD_CDK_SPxK_1	481	487	PF00069	0.507
MOD_CK1_1	204	210	PF00069	0.438
MOD_CK1_1	297	303	PF00069	0.339
MOD_CK1_1	312	318	PF00069	0.446
MOD_CK1_1	505	511	PF00069	0.480
MOD_CK1_1	52	58	PF00069	0.486
MOD_CK1_1	84	90	PF00069	0.654
MOD_CK1_1	95	101	PF00069	0.540
MOD_CK2_1	1	7	PF00069	0.570
MOD_CK2_1	131	137	PF00069	0.629
MOD_CK2_1	18	24	PF00069	0.407
MOD_CK2_1	211	217	PF00069	0.514
MOD_CK2_1	218	224	PF00069	0.470
MOD_CK2_1	297	303	PF00069	0.309
MOD_CK2_1	320	326	PF00069	0.418
MOD_CK2_1	52	58	PF00069	0.520
MOD_GlcNHglycan	118	121	PF01048	0.574
MOD_GlcNHglycan	125	128	PF01048	0.634
MOD_GlcNHglycan	140	143	PF01048	0.489
MOD_GlcNHglycan	189	192	PF01048	0.388
MOD_GlcNHglycan	197	200	PF01048	0.351
MOD_GlcNHglycan	239	243	PF01048	0.368
MOD_GlcNHglycan	3	6	PF01048	0.550
MOD_GlcNHglycan	347	350	PF01048	0.267
MOD_GlcNHglycan	362	365	PF01048	0.204
MOD_GlcNHglycan	390	393	PF01048	0.312
MOD_GlcNHglycan	478	481	PF01048	0.288
MOD_GlcNHglycan	494	497	PF01048	0.277
MOD_GlcNHglycan	505	508	PF01048	0.219
MOD_GlcNHglycan	51	54	PF01048	0.419
MOD_GlcNHglycan	532	535	PF01048	0.323
MOD_GlcNHglycan	83	86	PF01048	0.656
MOD_GSK3_1	112	119	PF00069	0.635
MOD_GSK3_1	201	208	PF00069	0.385
MOD_GSK3_1	308	315	PF00069	0.440
MOD_GSK3_1	371	378	PF00069	0.454
MOD_GSK3_1	452	459	PF00069	0.551
MOD_GSK3_1	501	508	PF00069	0.460
MOD_GSK3_1	80	87	PF00069	0.604
MOD_GSK3_1	92	99	PF00069	0.512
MOD_N-GLC_1	115	120	PF02516	0.570
MOD_N-GLC_1	218	223	PF02516	0.256
MOD_NEK2_1	203	208	PF00069	0.293
MOD_NEK2_1	294	299	PF00069	0.349
MOD_NEK2_1	319	324	PF00069	0.433
MOD_NEK2_1	388	393	PF00069	0.487
MOD_NEK2_1	422	427	PF00069	0.433
MOD_NEK2_1	476	481	PF00069	0.549
MOD_NEK2_1	492	497	PF00069	0.355
MOD_NEK2_1	503	508	PF00069	0.493
MOD_NEK2_1	530	535	PF00069	0.466
MOD_PIKK_1	545	551	PF00454	0.557
MOD_PKA_2	204	210	PF00069	0.447
MOD_PKA_2	320	326	PF00069	0.423
MOD_PKA_2	476	482	PF00069	0.503
MOD_PKA_2	544	550	PF00069	0.560
MOD_PKB_1	236	244	PF00069	0.325
MOD_Plk_1	218	224	PF00069	0.458
MOD_Plk_1	280	286	PF00069	0.375
MOD_Plk_1	303	309	PF00069	0.430
MOD_Plk_1	366	372	PF00069	0.411
MOD_Plk_1	545	551	PF00069	0.527
MOD_Plk_4	205	211	PF00069	0.419
MOD_Plk_4	297	303	PF00069	0.327
MOD_Plk_4	312	318	PF00069	0.485
MOD_Plk_4	320	326	PF00069	0.440
MOD_Plk_4	375	381	PF00069	0.418
MOD_Plk_4	515	521	PF00069	0.464
MOD_ProDKin_1	103	109	PF00069	0.731
MOD_ProDKin_1	458	464	PF00069	0.436
MOD_ProDKin_1	469	475	PF00069	0.422
MOD_ProDKin_1	481	487	PF00069	0.485
MOD_ProDKin_1	512	518	PF00069	0.413
MOD_ProDKin_1	96	102	PF00069	0.666
MOD_SUMO_rev_2	2	10	PF00179	0.493
MOD_SUMO_rev_2	288	297	PF00179	0.445
TRG_DiLeu_BaEn_1	176	181	PF01217	0.402
TRG_DiLeu_BaEn_1	182	187	PF01217	0.431
TRG_DiLeu_BaEn_2	423	429	PF01217	0.418
TRG_ENDOCYTIC_2	327	330	PF00928	0.512
TRG_ENDOCYTIC_2	370	373	PF00928	0.418
TRG_ENDOCYTIC_2	426	429	PF00928	0.512
TRG_ENDOCYTIC_2	519	522	PF00928	0.458
TRG_ER_diArg_1	234	236	PF00400	0.367
TRG_ER_diArg_1	252	254	PF00400	0.239
TRG_NLS_Bipartite_1	37	52	PF00514	0.457
TRG_NLS_MonoExtN_4	45	52	PF00514	0.465
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D4	Leptomonas seymouri	70%	82%
A0A1X0P4F2	Trypanosomatidae	45%	95%
A0A3Q8IE91	Leishmania donovani	93%	83%
A0A422MX80	Trypanosoma rangeli	53%	91%
A4HFP5	Leishmania braziliensis	89%	100%
A4I2S1	Leishmania infantum	93%	83%
D0A5X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	89%
E9AZ24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P41111	Oryctolagus cuniculus	27%	100%
Q09924	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q3T058	Bos taurus	26%	100%
Q54FM3	Dictyostelium discoideum	25%	90%
Q61749	Mus musculus	25%	100%
Q63186	Rattus norvegicus	25%	100%
Q9UI10	Homo sapiens	25%	100%
V5BHQ4	Trypanosoma cruzi	53%	100%