RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania major

UniProt:

E9AD98_LEIMA

TriTrypDb:

LmjF.27.1200 , LMJLV39_270018000 , LMJSD75_270018200

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.761
CLV_NRD_NRD_1	162	164	PF00675	0.748
CLV_NRD_NRD_1	24	26	PF00675	0.754
CLV_NRD_NRD_1	402	404	PF00675	0.850
CLV_NRD_NRD_1	71	73	PF00675	0.672
CLV_NRD_NRD_1	97	99	PF00675	0.792
CLV_PCSK_FUR_1	95	99	PF00082	0.799
CLV_PCSK_KEX2_1	162	164	PF00082	0.725
CLV_PCSK_KEX2_1	24	26	PF00082	0.783
CLV_PCSK_KEX2_1	288	290	PF00082	0.593
CLV_PCSK_KEX2_1	402	404	PF00082	0.850
CLV_PCSK_KEX2_1	71	73	PF00082	0.672
CLV_PCSK_KEX2_1	97	99	PF00082	0.792
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.589
CLV_PCSK_PC7_1	284	290	PF00082	0.598
CLV_PCSK_SKI1_1	125	129	PF00082	0.761
CLV_PCSK_SKI1_1	75	79	PF00082	0.751
DEG_APCC_DBOX_1	247	255	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.834
DEG_SPOP_SBC_1	139	143	PF00917	0.633
DEG_SPOP_SBC_1	181	185	PF00917	0.763
DEG_SPOP_SBC_1	330	334	PF00917	0.726
DOC_MAPK_gen_1	125	134	PF00069	0.608
DOC_MAPK_gen_1	24	32	PF00069	0.686
DOC_MAPK_gen_1	97	106	PF00069	0.722
DOC_MAPK_MEF2A_6	25	34	PF00069	0.683
DOC_PP2B_LxvP_1	389	392	PF13499	0.758
DOC_PP4_FxxP_1	237	240	PF00568	0.530
DOC_USP7_MATH_1	139	143	PF00917	0.750
DOC_USP7_MATH_1	14	18	PF00917	0.604
DOC_USP7_MATH_1	161	165	PF00917	0.719
DOC_USP7_MATH_1	181	185	PF00917	0.588
DOC_USP7_MATH_1	190	194	PF00917	0.673
DOC_USP7_MATH_1	196	200	PF00917	0.599
DOC_USP7_MATH_1	318	322	PF00917	0.551
DOC_USP7_MATH_1	324	328	PF00917	0.551
DOC_USP7_MATH_1	330	334	PF00917	0.588
DOC_USP7_MATH_1	63	67	PF00917	0.642
DOC_WW_Pin1_4	147	152	PF00397	0.793
DOC_WW_Pin1_4	182	187	PF00397	0.829
DOC_WW_Pin1_4	192	197	PF00397	0.663
DOC_WW_Pin1_4	25	30	PF00397	0.502
DOC_WW_Pin1_4	326	331	PF00397	0.663
DOC_WW_Pin1_4	334	339	PF00397	0.633
DOC_WW_Pin1_4	367	372	PF00397	0.740
DOC_WW_Pin1_4	66	71	PF00397	0.759
DOC_WW_Pin1_4	7	12	PF00397	0.813
DOC_WW_Pin1_4	82	87	PF00397	0.605
DOC_WW_Pin1_4	88	93	PF00397	0.818
LIG_14-3-3_CanoR_1	162	168	PF00244	0.776
LIG_14-3-3_CanoR_1	248	252	PF00244	0.530
LIG_14-3-3_CanoR_1	64	70	PF00244	0.805
LIG_14-3-3_CanoR_1	72	78	PF00244	0.737
LIG_14-3-3_CanoR_1	97	106	PF00244	0.838
LIG_Actin_WH2_2	27	42	PF00022	0.604
LIG_DLG_GKlike_1	163	171	PF00625	0.697
LIG_FHA_1	147	153	PF00498	0.762
LIG_FHA_1	166	172	PF00498	0.542
LIG_FHA_1	21	27	PF00498	0.733
LIG_FHA_1	314	320	PF00498	0.582
LIG_FHA_1	349	355	PF00498	0.659
LIG_FHA_1	380	386	PF00498	0.619
LIG_FHA_1	63	69	PF00498	0.723
LIG_FHA_2	141	147	PF00498	0.643
LIG_FHA_2	340	346	PF00498	0.598
LIG_LIR_Gen_1	321	330	PF02991	0.535
LIG_LIR_Nem_3	321	325	PF02991	0.616
LIG_PTB_Apo_2	223	230	PF02174	0.530
LIG_SH2_GRB2like	222	225	PF00017	0.452
LIG_SH2_SRC	312	315	PF00017	0.550
LIG_SH2_STAP1	314	318	PF00017	0.577
LIG_SH2_STAT3	301	304	PF00017	0.567
LIG_SH2_STAT3	314	317	PF00017	0.416
LIG_SH2_STAT5	21	24	PF00017	0.658
LIG_SH2_STAT5	222	225	PF00017	0.452
LIG_SH2_STAT5	301	304	PF00017	0.644
LIG_SH2_STAT5	90	93	PF00017	0.613
LIG_SH3_1	8	14	PF00018	0.597
LIG_SH3_3	129	135	PF00018	0.673
LIG_SH3_3	183	189	PF00018	0.807
LIG_SH3_3	23	29	PF00018	0.637
LIG_SH3_3	373	379	PF00018	0.837
LIG_SH3_3	390	396	PF00018	0.591
LIG_SH3_3	8	14	PF00018	0.733
LIG_SUMO_SIM_par_1	28	33	PF11976	0.610
LIG_TRAF2_1	176	179	PF00917	0.807
LIG_TRAF2_1	397	400	PF00917	0.765
LIG_WRC_WIRS_1	319	324	PF05994	0.605
MOD_CAAXbox	412	415	PF01239	0.818
MOD_CDC14_SPxK_1	69	72	PF00782	0.748
MOD_CDK_SPK_2	66	71	PF00069	0.603
MOD_CDK_SPxK_1	66	72	PF00069	0.758
MOD_CDK_SPxxK_3	12	19	PF00069	0.716
MOD_CDK_SPxxK_3	147	154	PF00069	0.827
MOD_CDK_SPxxK_3	88	95	PF00069	0.848
MOD_CK1_1	108	114	PF00069	0.805
MOD_CK1_1	144	150	PF00069	0.696
MOD_CK1_1	15	21	PF00069	0.698
MOD_CK1_1	155	161	PF00069	0.709
MOD_CK1_1	166	172	PF00069	0.661
MOD_CK1_1	174	180	PF00069	0.527
MOD_CK1_1	184	190	PF00069	0.548
MOD_CK1_1	269	275	PF00069	0.546
MOD_CK1_1	329	335	PF00069	0.651
MOD_CK1_1	387	393	PF00069	0.758
MOD_CK1_1	401	407	PF00069	0.534
MOD_CK1_1	44	50	PF00069	0.675
MOD_CK1_1	51	57	PF00069	0.758
MOD_CK1_1	66	72	PF00069	0.635
MOD_CK1_1	7	13	PF00069	0.801
MOD_CK1_1	85	91	PF00069	0.529
MOD_CK2_1	197	203	PF00069	0.786
MOD_CK2_1	204	210	PF00069	0.681
MOD_CK2_1	30	36	PF00069	0.564
MOD_CK2_1	339	345	PF00069	0.601
MOD_CK2_1	394	400	PF00069	0.696
MOD_DYRK1A_RPxSP_1	25	29	PF00069	0.685
MOD_GlcNHglycan	108	111	PF01048	0.700
MOD_GlcNHglycan	192	195	PF01048	0.665
MOD_GlcNHglycan	271	274	PF01048	0.775
MOD_GlcNHglycan	326	329	PF01048	0.723
MOD_GlcNHglycan	43	46	PF01048	0.755
MOD_GlcNHglycan	58	61	PF01048	0.662
MOD_GlcNHglycan	65	68	PF01048	0.733
MOD_GSK3_1	102	109	PF00069	0.727
MOD_GSK3_1	140	147	PF00069	0.701
MOD_GSK3_1	15	22	PF00069	0.666
MOD_GSK3_1	161	168	PF00069	0.808
MOD_GSK3_1	170	177	PF00069	0.663
MOD_GSK3_1	180	187	PF00069	0.529
MOD_GSK3_1	192	199	PF00069	0.635
MOD_GSK3_1	202	209	PF00069	0.649
MOD_GSK3_1	324	331	PF00069	0.596
MOD_GSK3_1	394	401	PF00069	0.764
MOD_GSK3_1	44	51	PF00069	0.728
MOD_GSK3_1	52	59	PF00069	0.756
MOD_GSK3_1	62	69	PF00069	0.590
MOD_GSK3_1	82	89	PF00069	0.565
MOD_N-GLC_2	356	358	PF02516	0.726
MOD_NEK2_1	106	111	PF00069	0.807
MOD_NEK2_1	167	172	PF00069	0.751
MOD_NEK2_1	180	185	PF00069	0.624
MOD_NEK2_1	266	271	PF00069	0.705
MOD_NEK2_1	297	302	PF00069	0.418
MOD_NEK2_1	39	44	PF00069	0.757
MOD_NEK2_1	48	53	PF00069	0.692
MOD_NEK2_1	56	61	PF00069	0.630
MOD_NEK2_2	256	261	PF00069	0.677
MOD_PIKK_1	112	118	PF00454	0.756
MOD_PIKK_1	155	161	PF00454	0.582
MOD_PIKK_1	313	319	PF00454	0.578
MOD_PIKK_1	384	390	PF00454	0.767
MOD_PIKK_1	48	54	PF00454	0.832
MOD_PK_1	202	208	PF00069	0.680
MOD_PKA_1	97	103	PF00069	0.795
MOD_PKA_2	161	167	PF00069	0.815
MOD_PKA_2	174	180	PF00069	0.595
MOD_PKA_2	247	253	PF00069	0.530
MOD_PKA_2	379	385	PF00069	0.765
MOD_PKA_2	39	45	PF00069	0.583
MOD_PKA_2	401	407	PF00069	0.840
MOD_PKA_2	63	69	PF00069	0.762
MOD_PKA_2	70	76	PF00069	0.707
MOD_PKA_2	97	103	PF00069	0.805
MOD_PKB_1	95	103	PF00069	0.833
MOD_Plk_1	202	208	PF00069	0.602
MOD_Plk_4	167	173	PF00069	0.732
MOD_Plk_4	297	303	PF00069	0.416
MOD_Plk_4	30	36	PF00069	0.564
MOD_Plk_4	73	79	PF00069	0.768
MOD_ProDKin_1	147	153	PF00069	0.793
MOD_ProDKin_1	182	188	PF00069	0.829
MOD_ProDKin_1	192	198	PF00069	0.660
MOD_ProDKin_1	25	31	PF00069	0.501
MOD_ProDKin_1	326	332	PF00069	0.664
MOD_ProDKin_1	334	340	PF00069	0.634
MOD_ProDKin_1	367	373	PF00069	0.742
MOD_ProDKin_1	66	72	PF00069	0.758
MOD_ProDKin_1	7	13	PF00069	0.813
MOD_ProDKin_1	82	88	PF00069	0.608
TRG_ER_diArg_1	24	26	PF00400	0.754
TRG_ER_diArg_1	307	310	PF00400	0.575
TRG_ER_diArg_1	402	405	PF00400	0.847
TRG_ER_diArg_1	70	72	PF00400	0.659
TRG_ER_diArg_1	95	98	PF00400	0.793
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0M5	Leishmania donovani	86%	100%
A4HFP6	Leishmania braziliensis	49%	99%
E9AHF8	Leishmania infantum	86%	100%
E9AZ23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%