Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

protein phosphatase 2C, putative

Species:

Leishmania major

UniProt:

E9AD96_LEIMA

TriTrypDb:

LmjF.27.1180 , LMJLV39_270017800 , LMJSD75_270018000

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD96

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004722	protein serine/threonine phosphatase activity	4	8
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0017018	myosin phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.707
CLV_NRD_NRD_1	3	5	PF00675	0.569
CLV_PCSK_KEX2_1	11	13	PF00082	0.385
CLV_PCSK_KEX2_1	3	5	PF00082	0.569
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.438
CLV_PCSK_SKI1_1	335	339	PF00082	0.439
DEG_APCC_DBOX_1	334	342	PF00400	0.534
DEG_APCC_KENBOX_2	53	57	PF00400	0.534
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	329	338	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.483
DOC_MAPK_gen_1	192	199	PF00069	0.445
DOC_MAPK_MEF2A_6	261	270	PF00069	0.517
DOC_MAPK_MEF2A_6	384	392	PF00069	0.441
DOC_PP2B_LxvP_1	266	269	PF13499	0.496
DOC_PP2B_LxvP_1	38	41	PF13499	0.288
DOC_PP4_FxxP_1	414	417	PF00568	0.696
DOC_USP7_MATH_1	151	155	PF00917	0.663
DOC_USP7_MATH_1	179	183	PF00917	0.760
DOC_USP7_MATH_1	368	372	PF00917	0.440
DOC_USP7_MATH_1	85	89	PF00917	0.435
DOC_USP7_MATH_2	403	409	PF00917	0.662
DOC_WW_Pin1_4	256	261	PF00397	0.437
DOC_WW_Pin1_4	364	369	PF00397	0.404
LIG_14-3-3_CanoR_1	12	16	PF00244	0.441
LIG_14-3-3_CanoR_1	192	199	PF00244	0.619
LIG_14-3-3_CanoR_1	205	215	PF00244	0.463
LIG_14-3-3_CanoR_1	302	310	PF00244	0.377
LIG_14-3-3_CanoR_1	332	338	PF00244	0.473
LIG_APCC_ABBA_1	296	301	PF00400	0.538
LIG_BRCT_BRCA1_1	403	407	PF00533	0.626
LIG_Clathr_ClatBox_1	130	134	PF01394	0.367
LIG_Clathr_ClatBox_1	267	271	PF01394	0.438
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.431
LIG_EH1_1	289	297	PF00400	0.389
LIG_eIF4E_1	75	81	PF01652	0.468
LIG_FHA_1	107	113	PF00498	0.420
LIG_FHA_1	144	150	PF00498	0.529
LIG_FHA_1	161	167	PF00498	0.654
LIG_FHA_1	194	200	PF00498	0.526
LIG_FHA_1	224	230	PF00498	0.335
LIG_FHA_1	278	284	PF00498	0.466
LIG_FHA_1	387	393	PF00498	0.436
LIG_FHA_2	112	118	PF00498	0.446
LIG_FHA_2	193	199	PF00498	0.502
LIG_FHA_2	257	263	PF00498	0.469
LIG_FHA_2	334	340	PF00498	0.552
LIG_Integrin_isoDGR_2	232	234	PF01839	0.480
LIG_LIR_Apic_2	411	417	PF02991	0.644
LIG_LIR_Gen_1	126	136	PF02991	0.468
LIG_LIR_Gen_1	281	292	PF02991	0.358
LIG_LIR_Gen_1	34	45	PF02991	0.439
LIG_LIR_Nem_3	126	131	PF02991	0.472
LIG_LIR_Nem_3	281	287	PF02991	0.345
LIG_LIR_Nem_3	294	300	PF02991	0.369
LIG_LIR_Nem_3	34	40	PF02991	0.507
LIG_LIR_Nem_3	87	92	PF02991	0.423
LIG_LYPXL_L_2	287	296	PF13949	0.323
LIG_NRBOX	333	339	PF00104	0.495
LIG_PCNA_yPIPBox_3	330	338	PF02747	0.507
LIG_REV1ctd_RIR_1	13	22	PF16727	0.409
LIG_SH2_SRC	73	76	PF00017	0.419
LIG_SH2_STAP1	128	132	PF00017	0.435
LIG_SH2_STAP1	64	68	PF00017	0.379
LIG_SH2_STAT3	248	251	PF00017	0.476
LIG_SH2_STAT5	215	218	PF00017	0.445
LIG_SH2_STAT5	221	224	PF00017	0.366
LIG_SH2_STAT5	237	240	PF00017	0.571
LIG_SH2_STAT5	309	312	PF00017	0.550
LIG_SH2_STAT5	328	331	PF00017	0.578
LIG_SH2_STAT5	75	78	PF00017	0.454
LIG_SH3_3	133	139	PF00018	0.586
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.448
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.347
LIG_SUMO_SIM_par_1	129	134	PF11976	0.585
LIG_SUMO_SIM_par_1	386	393	PF11976	0.495
LIG_TRAF2_1	114	117	PF00917	0.448
MOD_CDK_SPK_2	256	261	PF00069	0.458
MOD_CK1_1	154	160	PF00069	0.591
MOD_CK1_1	256	262	PF00069	0.462
MOD_CK2_1	111	117	PF00069	0.365
MOD_CK2_1	171	177	PF00069	0.742
MOD_CK2_1	21	27	PF00069	0.430
MOD_CK2_1	405	411	PF00069	0.668
MOD_Cter_Amidation	9	12	PF01082	0.500
MOD_GlcNHglycan	153	156	PF01048	0.698
MOD_GlcNHglycan	181	184	PF01048	0.689
MOD_GlcNHglycan	210	213	PF01048	0.339
MOD_GlcNHglycan	407	410	PF01048	0.651
MOD_GlcNHglycan	64	67	PF01048	0.361
MOD_GSK3_1	150	157	PF00069	0.651
MOD_GSK3_1	169	176	PF00069	0.655
MOD_GSK3_1	179	186	PF00069	0.751
MOD_GSK3_1	188	195	PF00069	0.504
MOD_GSK3_1	364	371	PF00069	0.404
MOD_GSK3_1	386	393	PF00069	0.438
MOD_GSK3_1	401	408	PF00069	0.612
MOD_GSK3_1	95	102	PF00069	0.562
MOD_N-GLC_1	256	261	PF02516	0.475
MOD_NEK2_1	111	116	PF00069	0.357
MOD_NEK2_1	150	155	PF00069	0.708
MOD_NEK2_1	390	395	PF00069	0.446
MOD_NEK2_2	85	90	PF00069	0.440
MOD_NEK2_2	95	100	PF00069	0.446
MOD_PIKK_1	21	27	PF00454	0.366
MOD_PIKK_1	302	308	PF00454	0.369
MOD_PKA_1	11	17	PF00069	0.388
MOD_PKA_2	11	17	PF00069	0.427
MOD_Plk_1	169	175	PF00069	0.731
MOD_Plk_1	223	229	PF00069	0.334
MOD_Plk_1	386	392	PF00069	0.376
MOD_Plk_2-3	181	187	PF00069	0.680
MOD_Plk_4	223	229	PF00069	0.394
MOD_Plk_4	324	330	PF00069	0.636
MOD_Plk_4	386	392	PF00069	0.376
MOD_Plk_4	48	54	PF00069	0.436
MOD_ProDKin_1	256	262	PF00069	0.441
MOD_ProDKin_1	364	370	PF00069	0.398
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.468
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.427
TRG_ENDOCYTIC_2	128	131	PF00928	0.453
TRG_ENDOCYTIC_2	73	76	PF00928	0.382
TRG_ER_diArg_1	2	4	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC93	Leptomonas seymouri	61%	100%
A0A0S4JF75	Bodo saltans	29%	80%
A0A3S7X0P0	Leishmania donovani	93%	100%
A4HFP3	Leishmania braziliensis	76%	100%
A4I2R9	Leishmania infantum	93%	100%
E9AZ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%