S1-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD95_LEIMA

TriTrypDb:

LmjF.27.1170 , LMJLV39_270017700 , LMJSD75_270017900

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.710
CLV_C14_Caspase3-7	70	74	PF00656	0.706
CLV_NRD_NRD_1	105	107	PF00675	0.596
CLV_NRD_NRD_1	5	7	PF00675	0.640
CLV_PCSK_SKI1_1	11	15	PF00082	0.597
CLV_PCSK_SKI1_1	151	155	PF00082	0.689
CLV_PCSK_SKI1_1	163	167	PF00082	0.645
CLV_PCSK_SKI1_1	220	224	PF00082	0.700
CLV_PCSK_SKI1_1	45	49	PF00082	0.602
DEG_APCC_DBOX_1	162	170	PF00400	0.773
DEG_SPOP_SBC_1	176	180	PF00917	0.659
DEG_SPOP_SBC_1	56	60	PF00917	0.602
DOC_MAPK_gen_1	106	116	PF00069	0.566
DOC_MAPK_MEF2A_6	107	116	PF00069	0.575
DOC_MAPK_MEF2A_6	27	36	PF00069	0.701
DOC_PP1_RVXF_1	108	114	PF00149	0.581
DOC_USP7_MATH_1	56	60	PF00917	0.682
DOC_USP7_MATH_1	66	70	PF00917	0.635
DOC_USP7_MATH_1	78	82	PF00917	0.733
DOC_USP7_MATH_1	83	87	PF00917	0.708
DOC_USP7_UBL2_3	7	11	PF12436	0.637
DOC_WW_Pin1_4	129	134	PF00397	0.593
DOC_WW_Pin1_4	35	40	PF00397	0.594
DOC_WW_Pin1_4	85	90	PF00397	0.656
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_4	19	23	PF00653	0.641
LIG_Clathr_ClatBox_1	95	99	PF01394	0.644
LIG_FHA_1	177	183	PF00498	0.617
LIG_LIR_Apic_2	21	26	PF02991	0.600
LIG_PDZ_Class_3	240	245	PF00595	0.689
LIG_SH2_SRC	17	20	PF00017	0.693
LIG_SH2_STAP1	172	176	PF00017	0.688
LIG_SH2_STAT5	17	20	PF00017	0.689
LIG_SH3_3	99	105	PF00018	0.613
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.592
LIG_SUMO_SIM_par_1	118	124	PF11976	0.592
LIG_SUMO_SIM_par_1	94	99	PF11976	0.639
LIG_WRC_WIRS_1	136	141	PF05994	0.644
MOD_CK1_1	181	187	PF00069	0.692
MOD_CK1_1	204	210	PF00069	0.722
MOD_CK1_1	58	64	PF00069	0.722
MOD_CK1_1	69	75	PF00069	0.723
MOD_CK1_1	88	94	PF00069	0.765
MOD_CK2_1	204	210	PF00069	0.713
MOD_CK2_1	56	62	PF00069	0.703
MOD_Cter_Amidation	4	7	PF01082	0.645
MOD_GlcNHglycan	1	4	PF01048	0.642
MOD_GlcNHglycan	189	192	PF01048	0.684
MOD_GlcNHglycan	19	23	PF01048	0.572
MOD_GlcNHglycan	53	56	PF01048	0.685
MOD_GlcNHglycan	85	88	PF01048	0.754
MOD_GlcNHglycan	90	93	PF01048	0.521
MOD_GSK3_1	125	132	PF00069	0.711
MOD_GSK3_1	172	179	PF00069	0.624
MOD_GSK3_1	192	199	PF00069	0.459
MOD_GSK3_1	51	58	PF00069	0.634
MOD_N-GLC_1	196	201	PF02516	0.778
MOD_NEK2_1	18	23	PF00069	0.633
MOD_NEK2_2	125	130	PF00069	0.631
MOD_PIKK_1	11	17	PF00454	0.745
MOD_PKA_2	192	198	PF00069	0.752
MOD_PKB_1	149	157	PF00069	0.614
MOD_Plk_4	135	141	PF00069	0.568
MOD_Plk_4	178	184	PF00069	0.649
MOD_ProDKin_1	129	135	PF00069	0.594
MOD_ProDKin_1	35	41	PF00069	0.588
MOD_ProDKin_1	85	91	PF00069	0.656
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I4	Leptomonas seymouri	61%	97%
A0A1X0P448	Trypanosomatidae	37%	83%
A0A3Q8IEC6	Leishmania donovani	90%	100%
A0A3R7MDN0	Trypanosoma rangeli	44%	100%
A4HFP2	Leishmania braziliensis	82%	100%
A4I2R8	Leishmania infantum	90%	100%
D0A5X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B8N2	Trypanosoma cruzi	46%	100%