Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinoic acid induced 16-like protein, putative

Species:

Leishmania major

UniProt:

E9AD94_LEIMA

TriTrypDb:

LmjF.27.1160 , LMJLV39_270017600 , LMJSD75_270017800

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.557
CLV_C14_Caspase3-7	855	859	PF00656	0.484
CLV_NRD_NRD_1	10	12	PF00675	0.523
CLV_NRD_NRD_1	301	303	PF00675	0.489
CLV_NRD_NRD_1	412	414	PF00675	0.506
CLV_NRD_NRD_1	49	51	PF00675	0.547
CLV_NRD_NRD_1	557	559	PF00675	0.538
CLV_NRD_NRD_1	683	685	PF00675	0.628
CLV_NRD_NRD_1	880	882	PF00675	0.553
CLV_NRD_NRD_1	959	961	PF00675	0.335
CLV_PCSK_KEX2_1	10	12	PF00082	0.523
CLV_PCSK_KEX2_1	412	414	PF00082	0.421
CLV_PCSK_KEX2_1	49	51	PF00082	0.547
CLV_PCSK_KEX2_1	860	862	PF00082	0.455
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.455
CLV_PCSK_SKI1_1	113	117	PF00082	0.554
CLV_PCSK_SKI1_1	194	198	PF00082	0.444
CLV_PCSK_SKI1_1	387	391	PF00082	0.487
CLV_PCSK_SKI1_1	417	421	PF00082	0.365
CLV_PCSK_SKI1_1	550	554	PF00082	0.373
CLV_PCSK_SKI1_1	669	673	PF00082	0.563
CLV_PCSK_SKI1_1	872	876	PF00082	0.475
DEG_APCC_DBOX_1	386	394	PF00400	0.519
DEG_APCC_DBOX_1	416	424	PF00400	0.403
DEG_APCC_DBOX_1	452	460	PF00400	0.368
DEG_SCF_FBW7_1	938	944	PF00400	0.637
DEG_SCF_TRCP1_1	695	701	PF00400	0.558
DEG_SPOP_SBC_1	318	322	PF00917	0.706
DEG_SPOP_SBC_1	900	904	PF00917	0.746
DOC_CDC14_PxL_1	368	376	PF14671	0.372
DOC_CDC14_PxL_1	616	624	PF14671	0.419
DOC_CKS1_1	938	943	PF01111	0.638
DOC_CYCLIN_RxL_1	191	200	PF00134	0.475
DOC_CYCLIN_RxL_1	384	394	PF00134	0.456
DOC_CYCLIN_RxL_1	545	556	PF00134	0.382
DOC_CYCLIN_yClb5_NLxxxL_5	387	393	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.274
DOC_MAPK_gen_1	748	758	PF00069	0.632
DOC_MAPK_JIP1_4	289	295	PF00069	0.439
DOC_MAPK_MEF2A_6	289	297	PF00069	0.429
DOC_MAPK_MEF2A_6	872	879	PF00069	0.461
DOC_MAPK_NFAT4_5	872	880	PF00069	0.356
DOC_MAPK_RevD_3	848	861	PF00069	0.452
DOC_PP1_RVXF_1	543	549	PF00149	0.529
DOC_PP2B_LxvP_1	187	190	PF13499	0.486
DOC_PP2B_LxvP_1	293	296	PF13499	0.489
DOC_PP2B_LxvP_1	389	392	PF13499	0.310
DOC_PP2B_LxvP_1	995	998	PF13499	0.436
DOC_PP4_MxPP_1	771	774	PF00568	0.557
DOC_USP7_MATH_1	144	148	PF00917	0.745
DOC_USP7_MATH_1	169	173	PF00917	0.757
DOC_USP7_MATH_1	23	27	PF00917	0.607
DOC_USP7_MATH_1	325	329	PF00917	0.647
DOC_USP7_MATH_1	39	43	PF00917	0.719
DOC_USP7_MATH_1	422	426	PF00917	0.401
DOC_USP7_MATH_1	427	431	PF00917	0.539
DOC_USP7_MATH_1	601	605	PF00917	0.690
DOC_USP7_MATH_1	609	613	PF00917	0.537
DOC_USP7_MATH_1	774	778	PF00917	0.603
DOC_USP7_MATH_1	898	902	PF00917	0.685
DOC_USP7_MATH_1	941	945	PF00917	0.745
DOC_WW_Pin1_4	139	144	PF00397	0.699
DOC_WW_Pin1_4	165	170	PF00397	0.654
DOC_WW_Pin1_4	514	519	PF00397	0.509
DOC_WW_Pin1_4	54	59	PF00397	0.584
DOC_WW_Pin1_4	707	712	PF00397	0.613
DOC_WW_Pin1_4	810	815	PF00397	0.495
DOC_WW_Pin1_4	826	831	PF00397	0.384
DOC_WW_Pin1_4	884	889	PF00397	0.581
DOC_WW_Pin1_4	934	939	PF00397	0.645
LIG_14-3-3_CanoR_1	417	426	PF00244	0.409
LIG_14-3-3_CanoR_1	453	457	PF00244	0.382
LIG_14-3-3_CanoR_1	480	486	PF00244	0.352
LIG_14-3-3_CanoR_1	645	653	PF00244	0.493
LIG_14-3-3_CanoR_1	684	691	PF00244	0.574
LIG_14-3-3_CanoR_1	766	774	PF00244	0.632
LIG_14-3-3_CanoR_1	851	857	PF00244	0.406
LIG_14-3-3_CanoR_1	88	92	PF00244	0.495
LIG_Actin_WH2_2	656	671	PF00022	0.557
LIG_AP2alpha_2	431	433	PF02296	0.502
LIG_APCC_ABBA_1	875	880	PF00400	0.357
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	126	130	PF00533	0.590
LIG_BRCT_BRCA1_1	911	915	PF00533	0.481
LIG_Clathr_ClatBox_1	390	394	PF01394	0.342
LIG_Clathr_ClatBox_1	749	753	PF01394	0.512
LIG_deltaCOP1_diTrp_1	67	76	PF00928	0.396
LIG_EH1_1	830	838	PF00400	0.496
LIG_eIF4E_1	831	837	PF01652	0.497
LIG_FHA_1	14	20	PF00498	0.521
LIG_FHA_1	327	333	PF00498	0.588
LIG_FHA_1	353	359	PF00498	0.455
LIG_FHA_1	452	458	PF00498	0.431
LIG_FHA_1	46	52	PF00498	0.573
LIG_FHA_1	468	474	PF00498	0.431
LIG_FHA_1	493	499	PF00498	0.528
LIG_FHA_1	585	591	PF00498	0.639
LIG_FHA_1	613	619	PF00498	0.481
LIG_FHA_1	650	656	PF00498	0.399
LIG_FHA_1	814	820	PF00498	0.510
LIG_FHA_1	884	890	PF00498	0.669
LIG_FHA_2	361	367	PF00498	0.445
LIG_FHA_2	656	662	PF00498	0.479
LIG_FHA_2	82	88	PF00498	0.514
LIG_FHA_2	853	859	PF00498	0.408
LIG_GBD_Chelix_1	529	537	PF00786	0.417
LIG_LIR_Apic_2	615	620	PF02991	0.526
LIG_LIR_Gen_1	355	365	PF02991	0.343
LIG_LIR_Gen_1	67	76	PF02991	0.397
LIG_LIR_LC3C_4	839	842	PF02991	0.531
LIG_LIR_Nem_3	355	360	PF02991	0.348
LIG_LIR_Nem_3	611	617	PF02991	0.399
LIG_LIR_Nem_3	67	72	PF02991	0.373
LIG_LIR_Nem_3	74	79	PF02991	0.388
LIG_NRBOX	105	111	PF00104	0.422
LIG_NRBOX	259	265	PF00104	0.419
LIG_NRBOX	720	726	PF00104	0.485
LIG_NRBOX	745	751	PF00104	0.504
LIG_NRBOX	852	858	PF00104	0.533
LIG_Pex14_2	130	134	PF04695	0.681
LIG_PTB_Apo_2	564	571	PF02174	0.453
LIG_Rb_pABgroove_1	911	919	PF01858	0.530
LIG_SH2_CRK	193	197	PF00017	0.469
LIG_SH2_CRK	917	921	PF00017	0.521
LIG_SH2_CRK	967	971	PF00017	0.572
LIG_SH2_CRK	985	989	PF00017	0.385
LIG_SH2_PTP2	617	620	PF00017	0.422
LIG_SH2_SRC	974	977	PF00017	0.440
LIG_SH2_SRC	978	981	PF00017	0.413
LIG_SH2_STAP1	571	575	PF00017	0.656
LIG_SH2_STAP1	917	921	PF00017	0.430
LIG_SH2_STAP1	967	971	PF00017	0.520
LIG_SH2_STAT3	243	246	PF00017	0.500
LIG_SH2_STAT5	399	402	PF00017	0.402
LIG_SH2_STAT5	474	477	PF00017	0.406
LIG_SH2_STAT5	617	620	PF00017	0.422
LIG_SH2_STAT5	75	78	PF00017	0.382
LIG_SH2_STAT5	831	834	PF00017	0.503
LIG_SH2_STAT5	854	857	PF00017	0.410
LIG_SH2_STAT5	974	977	PF00017	0.534
LIG_SH2_STAT5	978	981	PF00017	0.545
LIG_SH2_STAT5	985	988	PF00017	0.582
LIG_SH2_STAT5	994	997	PF00017	0.391
LIG_SH3_3	137	143	PF00018	0.710
LIG_SH3_3	200	206	PF00018	0.600
LIG_SH3_3	572	578	PF00018	0.656
LIG_SH3_3	603	609	PF00018	0.648
LIG_SH3_3	908	914	PF00018	0.505
LIG_SH3_3	935	941	PF00018	0.633
LIG_Sin3_3	838	845	PF02671	0.439
LIG_SUMO_SIM_anti_2	291	296	PF11976	0.334
LIG_SUMO_SIM_anti_2	652	658	PF11976	0.533
LIG_SUMO_SIM_anti_2	843	849	PF11976	0.505
LIG_SUMO_SIM_par_1	328	335	PF11976	0.419
LIG_SUMO_SIM_par_1	652	658	PF11976	0.504
LIG_SUMO_SIM_par_1	907	912	PF11976	0.605
LIG_TRAF2_1	405	408	PF00917	0.496
LIG_TRAF2_1	439	442	PF00917	0.383
LIG_TYR_ITIM	852	857	PF00017	0.524
LIG_TYR_ITIM	965	970	PF00017	0.581
LIG_TYR_ITIM	983	988	PF00017	0.430
LIG_UBA3_1	237	245	PF00899	0.363
LIG_UBA3_1	297	303	PF00899	0.418
LIG_UBA3_1	456	461	PF00899	0.405
LIG_UBA3_1	498	504	PF00899	0.524
LIG_UBA3_1	767	772	PF00899	0.707
LIG_UBA3_1	91	100	PF00899	0.580
LIG_UBA3_1	992	996	PF00899	0.565
LIG_WRC_WIRS_1	610	615	PF05994	0.412
LIG_WW_1	190	193	PF00397	0.390
MOD_CDC14_SPxK_1	887	890	PF00782	0.613
MOD_CDK_SPxK_1	884	890	PF00069	0.588
MOD_CDK_SPxxK_3	884	891	PF00069	0.594
MOD_CK1_1	133	139	PF00069	0.630
MOD_CK1_1	172	178	PF00069	0.617
MOD_CK1_1	326	332	PF00069	0.539
MOD_CK1_1	517	523	PF00069	0.398
MOD_CK1_1	57	63	PF00069	0.505
MOD_CK1_1	612	618	PF00069	0.457
MOD_CK1_1	701	707	PF00069	0.721
MOD_CK1_1	723	729	PF00069	0.664
MOD_CK1_1	777	783	PF00069	0.621
MOD_CK1_1	813	819	PF00069	0.638
MOD_CK1_1	829	835	PF00069	0.447
MOD_CK1_1	901	907	PF00069	0.659
MOD_CK1_1	937	943	PF00069	0.620
MOD_CK1_1	945	951	PF00069	0.454
MOD_CK2_1	139	145	PF00069	0.628
MOD_CK2_1	360	366	PF00069	0.391
MOD_CK2_1	402	408	PF00069	0.481
MOD_CK2_1	601	607	PF00069	0.568
MOD_CK2_1	655	661	PF00069	0.539
MOD_CK2_1	81	87	PF00069	0.508
MOD_CK2_1	943	949	PF00069	0.564
MOD_GlcNHglycan	137	140	PF01048	0.750
MOD_GlcNHglycan	145	149	PF01048	0.799
MOD_GlcNHglycan	169	172	PF01048	0.670
MOD_GlcNHglycan	272	276	PF01048	0.532
MOD_GlcNHglycan	323	326	PF01048	0.742
MOD_GlcNHglycan	34	37	PF01048	0.706
MOD_GlcNHglycan	420	423	PF01048	0.525
MOD_GlcNHglycan	523	526	PF01048	0.406
MOD_GlcNHglycan	539	542	PF01048	0.465
MOD_GlcNHglycan	560	563	PF01048	0.583
MOD_GlcNHglycan	582	585	PF01048	0.670
MOD_GlcNHglycan	646	649	PF01048	0.554
MOD_GlcNHglycan	695	698	PF01048	0.686
MOD_GlcNHglycan	700	703	PF01048	0.672
MOD_GlcNHglycan	706	709	PF01048	0.602
MOD_GlcNHglycan	725	728	PF01048	0.495
MOD_GlcNHglycan	768	771	PF01048	0.654
MOD_GlcNHglycan	945	948	PF01048	0.673
MOD_GlcNHglycan	949	953	PF01048	0.594
MOD_GSK3_1	13	20	PF00069	0.701
MOD_GSK3_1	135	142	PF00069	0.704
MOD_GSK3_1	160	167	PF00069	0.789
MOD_GSK3_1	169	176	PF00069	0.699
MOD_GSK3_1	219	226	PF00069	0.508
MOD_GSK3_1	23	30	PF00069	0.704
MOD_GSK3_1	316	323	PF00069	0.612
MOD_GSK3_1	326	333	PF00069	0.581
MOD_GSK3_1	398	405	PF00069	0.496
MOD_GSK3_1	418	425	PF00069	0.401
MOD_GSK3_1	451	458	PF00069	0.429
MOD_GSK3_1	484	491	PF00069	0.428
MOD_GSK3_1	517	524	PF00069	0.454
MOD_GSK3_1	580	587	PF00069	0.663
MOD_GSK3_1	608	615	PF00069	0.543
MOD_GSK3_1	640	647	PF00069	0.619
MOD_GSK3_1	719	726	PF00069	0.643
MOD_GSK3_1	776	783	PF00069	0.659
MOD_GSK3_1	809	816	PF00069	0.580
MOD_GSK3_1	825	832	PF00069	0.337
MOD_GSK3_1	852	859	PF00069	0.477
MOD_GSK3_1	937	944	PF00069	0.658
MOD_N-GLC_1	941	946	PF02516	0.605
MOD_NEK2_1	130	135	PF00069	0.700
MOD_NEK2_1	173	178	PF00069	0.624
MOD_NEK2_1	197	202	PF00069	0.554
MOD_NEK2_1	27	32	PF00069	0.685
MOD_NEK2_1	360	365	PF00069	0.386
MOD_NEK2_1	418	423	PF00069	0.442
MOD_NEK2_1	481	486	PF00069	0.446
MOD_NEK2_1	537	542	PF00069	0.421
MOD_NEK2_1	552	557	PF00069	0.419
MOD_NEK2_1	590	595	PF00069	0.585
MOD_NEK2_1	639	644	PF00069	0.604
MOD_NEK2_1	655	660	PF00069	0.315
MOD_NEK2_1	674	679	PF00069	0.399
MOD_NEK2_1	720	725	PF00069	0.600
MOD_NEK2_1	840	845	PF00069	0.405
MOD_NEK2_1	856	861	PF00069	0.430
MOD_NEK2_1	899	904	PF00069	0.554
MOD_NEK2_1	909	914	PF00069	0.512
MOD_NEK2_2	609	614	PF00069	0.472
MOD_PIKK_1	352	358	PF00454	0.463
MOD_PIKK_1	381	387	PF00454	0.558
MOD_PIKK_1	403	409	PF00454	0.575
MOD_PIKK_1	467	473	PF00454	0.463
MOD_PIKK_1	986	992	PF00454	0.520
MOD_PK_1	100	106	PF00069	0.369
MOD_PKA_1	302	308	PF00069	0.503
MOD_PKA_1	412	418	PF00069	0.436
MOD_PKA_1	558	564	PF00069	0.543
MOD_PKA_1	684	690	PF00069	0.541
MOD_PKA_1	890	896	PF00069	0.508
MOD_PKA_2	288	294	PF00069	0.444
MOD_PKA_2	412	418	PF00069	0.436
MOD_PKA_2	452	458	PF00069	0.370
MOD_PKA_2	644	650	PF00069	0.506
MOD_PKA_2	704	710	PF00069	0.613
MOD_PKA_2	87	93	PF00069	0.583
MOD_PKB_1	764	772	PF00069	0.570
MOD_Plk_1	271	277	PF00069	0.631
MOD_Plk_1	633	639	PF00069	0.669
MOD_Plk_1	674	680	PF00069	0.584
MOD_Plk_1	86	92	PF00069	0.557
MOD_Plk_2-3	675	681	PF00069	0.610
MOD_Plk_2-3	94	100	PF00069	0.520
MOD_Plk_4	100	106	PF00069	0.414
MOD_Plk_4	281	287	PF00069	0.418
MOD_Plk_4	288	294	PF00069	0.322
MOD_Plk_4	344	350	PF00069	0.547
MOD_Plk_4	452	458	PF00069	0.429
MOD_Plk_4	481	487	PF00069	0.368
MOD_Plk_4	507	513	PF00069	0.361
MOD_Plk_4	57	63	PF00069	0.478
MOD_Plk_4	609	615	PF00069	0.438
MOD_Plk_4	634	640	PF00069	0.663
MOD_Plk_4	649	655	PF00069	0.374
MOD_Plk_4	720	726	PF00069	0.494
MOD_Plk_4	832	838	PF00069	0.412
MOD_Plk_4	852	858	PF00069	0.415
MOD_Plk_4	87	93	PF00069	0.617
MOD_ProDKin_1	139	145	PF00069	0.702
MOD_ProDKin_1	165	171	PF00069	0.652
MOD_ProDKin_1	514	520	PF00069	0.513
MOD_ProDKin_1	54	60	PF00069	0.568
MOD_ProDKin_1	707	713	PF00069	0.586
MOD_ProDKin_1	810	816	PF00069	0.489
MOD_ProDKin_1	826	832	PF00069	0.391
MOD_ProDKin_1	884	890	PF00069	0.588
MOD_ProDKin_1	934	940	PF00069	0.648
MOD_SUMO_for_1	439	442	PF00179	0.383
MOD_SUMO_rev_2	629	635	PF00179	0.580
TRG_DiLeu_BaEn_1	386	391	PF01217	0.415
TRG_DiLeu_BaEn_1	634	639	PF01217	0.638
TRG_DiLeu_BaEn_1	87	92	PF01217	0.498
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.368
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.384
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.527
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.347
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.499
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.501
TRG_ENDOCYTIC_2	193	196	PF00928	0.377
TRG_ENDOCYTIC_2	571	574	PF00928	0.656
TRG_ENDOCYTIC_2	616	619	PF00928	0.398
TRG_ENDOCYTIC_2	854	857	PF00928	0.410
TRG_ENDOCYTIC_2	917	920	PF00928	0.408
TRG_ENDOCYTIC_2	967	970	PF00928	0.573
TRG_ENDOCYTIC_2	985	988	PF00928	0.386
TRG_ENDOCYTIC_2	994	997	PF00928	0.573
TRG_ER_diArg_1	49	51	PF00400	0.547
TRG_ER_diArg_1	761	764	PF00400	0.511
TRG_NES_CRM1_1	287	299	PF08389	0.435
TRG_NES_CRM1_1	94	107	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	748	753	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X3	Leptomonas seymouri	51%	91%
A0A0S4JF10	Bodo saltans	24%	100%
A0A1X0P440	Trypanosomatidae	32%	97%
A0A3S5H7H7	Leishmania donovani	92%	100%
A0A3S5IQJ7	Trypanosoma rangeli	29%	100%
A4HFP1	Leishmania braziliensis	76%	100%
A4I2R7	Leishmania infantum	92%	100%
E9AZ19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5BHP8	Trypanosoma cruzi	30%	100%