JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

JmjC domain, hydroxylase, putative

Species:

Leishmania major

UniProt:

E9AD93_LEIMA

TriTrypDb:

LmjF.27.1150 , LMJLV39_270017500 , LMJSD75_270017700

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD93

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0006449	regulation of translational termination	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	2
GO:0018126	protein hydroxylation	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034250	positive regulation of amide metabolic process	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043243	positive regulation of protein-containing complex disassembly	6	2
GO:0043244	regulation of protein-containing complex disassembly	5	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0045727	positive regulation of translation	7	2
GO:0045905	positive regulation of translational termination	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	2
GO:0043565	sequence-specific DNA binding	5	2
GO:0051213	dioxygenase activity	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.457
CLV_C14_Caspase3-7	194	198	PF00656	0.460
CLV_C14_Caspase3-7	447	451	PF00656	0.611
CLV_NRD_NRD_1	211	213	PF00675	0.589
CLV_NRD_NRD_1	416	418	PF00675	0.445
CLV_NRD_NRD_1	47	49	PF00675	0.499
CLV_NRD_NRD_1	88	90	PF00675	0.695
CLV_PCSK_KEX2_1	416	418	PF00082	0.445
CLV_PCSK_KEX2_1	46	48	PF00082	0.488
CLV_PCSK_KEX2_1	484	486	PF00082	0.685
CLV_PCSK_KEX2_1	88	90	PF00082	0.695
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.488
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.685
CLV_PCSK_SKI1_1	295	299	PF00082	0.333
CLV_PCSK_SKI1_1	385	389	PF00082	0.381
CLV_Separin_Metazoa	209	213	PF03568	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SPOP_SBC_1	158	162	PF00917	0.585
DEG_SPOP_SBC_1	68	72	PF00917	0.395
DOC_CDC14_PxL_1	312	320	PF14671	0.473
DOC_CKS1_1	288	293	PF01111	0.513
DOC_PP2B_PxIxI_1	291	297	PF00149	0.477
DOC_PP4_FxxP_1	288	291	PF00568	0.537
DOC_USP7_MATH_1	123	127	PF00917	0.542
DOC_USP7_MATH_1	132	136	PF00917	0.551
DOC_USP7_MATH_1	148	152	PF00917	0.427
DOC_USP7_MATH_1	158	162	PF00917	0.557
DOC_USP7_MATH_1	163	167	PF00917	0.518
DOC_USP7_MATH_1	242	246	PF00917	0.556
DOC_USP7_MATH_1	352	356	PF00917	0.649
DOC_USP7_MATH_1	68	72	PF00917	0.567
DOC_WW_Pin1_4	128	133	PF00397	0.652
DOC_WW_Pin1_4	244	249	PF00397	0.451
DOC_WW_Pin1_4	287	292	PF00397	0.513
DOC_WW_Pin1_4	78	83	PF00397	0.715
LIG_14-3-3_CanoR_1	212	216	PF00244	0.665
LIG_14-3-3_CanoR_1	392	400	PF00244	0.437
LIG_BIR_III_4	33	37	PF00653	0.445
LIG_BRCT_BRCA1_1	257	261	PF00533	0.537
LIG_DCNL_PONY_1	1	4	PF03556	0.479
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.364
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.462
LIG_eIF4E_1	279	285	PF01652	0.537
LIG_EVH1_1	288	292	PF00568	0.522
LIG_FHA_1	325	331	PF00498	0.580
LIG_FHA_1	365	371	PF00498	0.405
LIG_FHA_1	433	439	PF00498	0.495
LIG_FHA_1	70	76	PF00498	0.653
LIG_FHA_1	8	14	PF00498	0.486
LIG_FHA_2	177	183	PF00498	0.466
LIG_FHA_2	288	294	PF00498	0.494
LIG_FHA_2	296	302	PF00498	0.453
LIG_FHA_2	445	451	PF00498	0.547
LIG_FHA_2	81	87	PF00498	0.693
LIG_FHA_2	93	99	PF00498	0.744
LIG_LIR_Apic_2	182	188	PF02991	0.389
LIG_LIR_Apic_2	266	272	PF02991	0.462
LIG_LIR_Gen_1	234	243	PF02991	0.290
LIG_LIR_Gen_1	430	438	PF02991	0.459
LIG_LIR_Gen_1	475	481	PF02991	0.527
LIG_LIR_Gen_1	8	19	PF02991	0.354
LIG_LIR_Nem_3	234	240	PF02991	0.308
LIG_LIR_Nem_3	245	249	PF02991	0.473
LIG_LIR_Nem_3	252	257	PF02991	0.511
LIG_LIR_Nem_3	329	334	PF02991	0.465
LIG_LIR_Nem_3	412	418	PF02991	0.438
LIG_LIR_Nem_3	475	480	PF02991	0.527
LIG_LIR_Nem_3	8	14	PF02991	0.383
LIG_Pex14_1	195	199	PF04695	0.344
LIG_Pex14_1	374	378	PF04695	0.461
LIG_SH2_CRK	185	189	PF00017	0.423
LIG_SH2_CRK	320	324	PF00017	0.512
LIG_SH2_PTP2	239	242	PF00017	0.435
LIG_SH2_STAP1	257	261	PF00017	0.462
LIG_SH2_STAP1	477	481	PF00017	0.528
LIG_SH2_STAT5	139	142	PF00017	0.343
LIG_SH2_STAT5	239	242	PF00017	0.439
LIG_SH2_STAT5	279	282	PF00017	0.501
LIG_SH3_3	18	24	PF00018	0.376
LIG_SH3_3	283	289	PF00018	0.533
LIG_SH3_3	303	309	PF00018	0.482
LIG_SH3_3	310	316	PF00018	0.438
LIG_SH3_3	62	68	PF00018	0.487
LIG_SUMO_SIM_anti_2	401	407	PF11976	0.525
LIG_TRAF2_1	103	106	PF00917	0.575
LIG_TRAF2_1	84	87	PF00917	0.556
LIG_TYR_ITIM	318	323	PF00017	0.334
LIG_WRC_WIRS_1	196	201	PF05994	0.504
MOD_CDK_SPxxK_3	78	85	PF00069	0.698
MOD_CK1_1	162	168	PF00069	0.611
MOD_CK1_1	174	180	PF00069	0.242
MOD_CK1_1	396	402	PF00069	0.541
MOD_CK1_1	430	436	PF00069	0.455
MOD_CK1_1	77	83	PF00069	0.712
MOD_CK2_1	295	301	PF00069	0.328
MOD_CK2_1	80	86	PF00069	0.741
MOD_CK2_1	94	100	PF00069	0.654
MOD_GlcNHglycan	123	126	PF01048	0.549
MOD_GlcNHglycan	161	164	PF01048	0.604
MOD_GlcNHglycan	176	179	PF01048	0.553
MOD_GlcNHglycan	221	225	PF01048	0.539
MOD_GlcNHglycan	33	37	PF01048	0.460
MOD_GlcNHglycan	354	357	PF01048	0.652
MOD_GlcNHglycan	362	365	PF01048	0.532
MOD_GlcNHglycan	411	414	PF01048	0.452
MOD_GSK3_1	117	124	PF00069	0.479
MOD_GSK3_1	128	135	PF00069	0.615
MOD_GSK3_1	148	155	PF00069	0.407
MOD_GSK3_1	158	165	PF00069	0.477
MOD_GSK3_1	253	260	PF00069	0.303
MOD_GSK3_1	360	367	PF00069	0.490
MOD_GSK3_1	74	81	PF00069	0.654
MOD_N-GLC_1	324	329	PF02516	0.406
MOD_N-GLC_1	424	429	PF02516	0.500
MOD_N-GLC_2	262	264	PF02516	0.338
MOD_N-GLC_2	29	31	PF02516	0.486
MOD_N-GLC_2	373	375	PF02516	0.337
MOD_NEK2_1	149	154	PF00069	0.564
MOD_NEK2_1	211	216	PF00069	0.651
MOD_NEK2_1	366	371	PF00069	0.318
MOD_NEK2_1	4	9	PF00069	0.496
MOD_NEK2_2	432	437	PF00069	0.405
MOD_PIKK_1	163	169	PF00454	0.568
MOD_PKA_2	174	180	PF00069	0.531
MOD_PKA_2	211	217	PF00069	0.539
MOD_PKA_2	381	387	PF00069	0.466
MOD_PKA_2	409	415	PF00069	0.493
MOD_Plk_1	427	433	PF00069	0.492
MOD_Plk_1	457	463	PF00069	0.464
MOD_ProDKin_1	128	134	PF00069	0.649
MOD_ProDKin_1	244	250	PF00069	0.303
MOD_ProDKin_1	287	293	PF00069	0.390
MOD_ProDKin_1	78	84	PF00069	0.712
TRG_DiLeu_BaEn_1	401	406	PF01217	0.528
TRG_DiLeu_BaEn_1	476	481	PF01217	0.552
TRG_ENDOCYTIC_2	11	14	PF00928	0.465
TRG_ENDOCYTIC_2	320	323	PF00928	0.388
TRG_ENDOCYTIC_2	477	480	PF00928	0.528
TRG_ER_diArg_1	415	417	PF00400	0.438
TRG_ER_diArg_1	47	49	PF00400	0.479
TRG_NES_CRM1_1	293	303	PF08389	0.424
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I519	Leptomonas seymouri	51%	93%
A0A0S4JI40	Bodo saltans	29%	99%
A0A1X0P4A9	Trypanosomatidae	38%	100%
A0A3R7LP24	Trypanosoma rangeli	39%	100%
A0A3S7X0M0	Leishmania donovani	91%	100%
A4HFP0	Leishmania braziliensis	77%	100%
A4I2R6	Leishmania infantum	91%	100%
D0A5X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q08BY5	Danio rerio	26%	100%
Q67ZB6	Arabidopsis thaliana	25%	100%
V5BD54	Trypanosoma cruzi	41%	100%