WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD92_LEIMA

TriTrypDb:

LmjF.27.1140 , LMJLV39_270017400 , LMJSD75_270017600

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.580
CLV_NRD_NRD_1	106	108	PF00675	0.587
CLV_PCSK_KEX2_1	105	107	PF00082	0.590
DEG_SCF_FBW7_1	275	281	PF00400	0.647
DEG_SCF_FBW7_1	54	61	PF00400	0.565
DEG_SIAH_1	333	341	PF03145	0.553
DEG_SPOP_SBC_1	279	283	PF00917	0.619
DEG_SPOP_SBC_1	502	506	PF00917	0.568
DOC_ANK_TNKS_1	564	571	PF00023	0.668
DOC_CKS1_1	275	280	PF01111	0.660
DOC_CKS1_1	482	487	PF01111	0.655
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.548
DOC_PP1_RVXF_1	2	9	PF00149	0.534
DOC_PP2B_LxvP_1	349	352	PF13499	0.594
DOC_PP2B_LxvP_1	370	373	PF13499	0.536
DOC_PP2B_LxvP_1	571	574	PF13499	0.659
DOC_USP7_MATH_1	264	268	PF00917	0.602
DOC_USP7_MATH_1	279	283	PF00917	0.582
DOC_USP7_MATH_1	317	321	PF00917	0.610
DOC_USP7_MATH_1	334	338	PF00917	0.567
DOC_USP7_MATH_1	378	382	PF00917	0.649
DOC_USP7_MATH_1	423	427	PF00917	0.613
DOC_USP7_MATH_1	433	437	PF00917	0.600
DOC_USP7_MATH_1	441	445	PF00917	0.559
DOC_USP7_MATH_1	450	454	PF00917	0.525
DOC_USP7_MATH_1	476	480	PF00917	0.709
DOC_USP7_MATH_1	483	487	PF00917	0.609
DOC_USP7_MATH_1	503	507	PF00917	0.519
DOC_USP7_MATH_1	510	514	PF00917	0.544
DOC_USP7_MATH_1	548	552	PF00917	0.616
DOC_USP7_MATH_1	564	568	PF00917	0.553
DOC_USP7_MATH_1	58	62	PF00917	0.656
DOC_WW_Pin1_4	212	217	PF00397	0.627
DOC_WW_Pin1_4	227	232	PF00397	0.634
DOC_WW_Pin1_4	274	279	PF00397	0.624
DOC_WW_Pin1_4	336	341	PF00397	0.681
DOC_WW_Pin1_4	374	379	PF00397	0.627
DOC_WW_Pin1_4	389	394	PF00397	0.608
DOC_WW_Pin1_4	398	403	PF00397	0.607
DOC_WW_Pin1_4	410	415	PF00397	0.587
DOC_WW_Pin1_4	481	486	PF00397	0.660
DOC_WW_Pin1_4	54	59	PF00397	0.565
DOC_WW_Pin1_4	578	583	PF00397	0.650
LIG_14-3-3_CanoR_1	106	112	PF00244	0.475
LIG_14-3-3_CanoR_1	156	160	PF00244	0.502
LIG_14-3-3_CanoR_1	295	301	PF00244	0.609
LIG_14-3-3_CanoR_1	44	50	PF00244	0.770
LIG_14-3-3_CanoR_1	90	99	PF00244	0.513
LIG_Actin_WH2_2	70	86	PF00022	0.450
LIG_AP2alpha_2	111	113	PF02296	0.627
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BIR_III_2	457	461	PF00653	0.634
LIG_BRCT_BRCA1_1	436	440	PF00533	0.635
LIG_EVH1_1	274	278	PF00568	0.680
LIG_EVH1_1	571	575	PF00568	0.659
LIG_EVH1_2	573	577	PF00568	0.662
LIG_FHA_1	275	281	PF00498	0.637
LIG_FHA_1	323	329	PF00498	0.607
LIG_FHA_1	342	348	PF00498	0.516
LIG_FHA_1	46	52	PF00498	0.692
LIG_FHA_1	472	478	PF00498	0.699
LIG_IBAR_NPY_1	507	509	PF08397	0.662
LIG_LIR_Apic_2	215	221	PF02991	0.623
LIG_LIR_Apic_2	272	276	PF02991	0.627
LIG_LIR_Apic_2	292	297	PF02991	0.530
LIG_LIR_Apic_2	408	414	PF02991	0.694
LIG_LIR_Apic_2	506	512	PF02991	0.702
LIG_LIR_Gen_1	170	178	PF02991	0.598
LIG_LIR_Nem_3	144	150	PF02991	0.597
LIG_LIR_Nem_3	170	175	PF02991	0.595
LIG_LIR_Nem_3	576	580	PF02991	0.673
LIG_LIR_Nem_3	73	77	PF02991	0.567
LIG_SH2_CRK	294	298	PF00017	0.652
LIG_SH2_CRK	390	394	PF00017	0.688
LIG_SH2_CRK	411	415	PF00017	0.701
LIG_SH2_CRK	509	513	PF00017	0.701
LIG_SH2_GRB2like	99	102	PF00017	0.549
LIG_SH2_NCK_1	218	222	PF00017	0.678
LIG_SH2_NCK_1	390	394	PF00017	0.688
LIG_SH2_SRC	218	221	PF00017	0.634
LIG_SH2_SRC	314	317	PF00017	0.667
LIG_SH2_SRC	509	512	PF00017	0.703
LIG_SH2_STAP1	150	154	PF00017	0.519
LIG_SH2_STAT3	150	153	PF00017	0.519
LIG_SH2_STAT5	223	226	PF00017	0.685
LIG_SH2_STAT5	314	317	PF00017	0.667
LIG_SH3_1	187	193	PF00018	0.628
LIG_SH3_1	273	279	PF00018	0.619
LIG_SH3_3	185	191	PF00018	0.667
LIG_SH3_3	228	234	PF00018	0.773
LIG_SH3_3	256	262	PF00018	0.640
LIG_SH3_3	272	278	PF00018	0.587
LIG_SH3_3	301	307	PF00018	0.653
LIG_SH3_3	313	319	PF00018	0.580
LIG_SH3_3	321	327	PF00018	0.493
LIG_SH3_3	377	383	PF00018	0.616
LIG_SH3_3	399	405	PF00018	0.646
LIG_SH3_3	493	499	PF00018	0.623
LIG_SH3_3	525	531	PF00018	0.679
LIG_SH3_3	569	575	PF00018	0.666
LIG_SH3_3	576	582	PF00018	0.606
LIG_SUMO_SIM_par_1	296	302	PF11976	0.566
LIG_WRC_WIRS_1	553	558	PF05994	0.704
LIG_WRPW_2	577	580	PF00400	0.672
MOD_CDK_SPxxK_3	481	488	PF00069	0.553
MOD_CK1_1	281	287	PF00069	0.721
MOD_CK1_1	299	305	PF00069	0.532
MOD_CK1_1	322	328	PF00069	0.624
MOD_CK1_1	339	345	PF00069	0.532
MOD_CK1_1	428	434	PF00069	0.641
MOD_CK1_1	45	51	PF00069	0.762
MOD_CK1_1	486	492	PF00069	0.643
MOD_CK1_1	513	519	PF00069	0.548
MOD_CK1_1	549	555	PF00069	0.702
MOD_GlcNHglycan	21	24	PF01048	0.662
MOD_GlcNHglycan	25	29	PF01048	0.664
MOD_GlcNHglycan	262	265	PF01048	0.625
MOD_GlcNHglycan	285	288	PF01048	0.697
MOD_GlcNHglycan	31	34	PF01048	0.655
MOD_GlcNHglycan	398	401	PF01048	0.562
MOD_GlcNHglycan	425	428	PF01048	0.716
MOD_GlcNHglycan	430	433	PF01048	0.659
MOD_GlcNHglycan	443	446	PF01048	0.508
MOD_GlcNHglycan	452	455	PF01048	0.614
MOD_GlcNHglycan	478	481	PF01048	0.583
MOD_GlcNHglycan	548	551	PF01048	0.674
MOD_GlcNHglycan	559	562	PF01048	0.608
MOD_GlcNHglycan	566	569	PF01048	0.547
MOD_GlcNHglycan	74	77	PF01048	0.555
MOD_GlcNHglycan	78	81	PF01048	0.485
MOD_GSK3_1	260	267	PF00069	0.696
MOD_GSK3_1	274	281	PF00069	0.569
MOD_GSK3_1	285	292	PF00069	0.568
MOD_GSK3_1	322	329	PF00069	0.596
MOD_GSK3_1	334	341	PF00069	0.595
MOD_GSK3_1	374	381	PF00069	0.637
MOD_GSK3_1	38	45	PF00069	0.677
MOD_GSK3_1	462	469	PF00069	0.632
MOD_GSK3_1	472	479	PF00069	0.657
MOD_GSK3_1	50	57	PF00069	0.574
MOD_GSK3_1	510	517	PF00069	0.630
MOD_GSK3_1	548	555	PF00069	0.686
MOD_GSK3_1	72	79	PF00069	0.583
MOD_GSK3_1	90	97	PF00069	0.401
MOD_N-GLC_1	42	47	PF02516	0.700
MOD_N-GLC_1	423	428	PF02516	0.684
MOD_N-GLC_1	466	471	PF02516	0.593
MOD_N-GLC_1	54	59	PF02516	0.626
MOD_NEK2_1	289	294	PF00069	0.618
MOD_NEK2_1	365	370	PF00069	0.643
MOD_NEK2_1	38	43	PF00069	0.790
MOD_NEK2_1	415	420	PF00069	0.652
MOD_NEK2_1	556	561	PF00069	0.649
MOD_PIKK_1	210	216	PF00454	0.639
MOD_PIKK_1	299	305	PF00454	0.668
MOD_PIKK_1	38	44	PF00454	0.688
MOD_PIKK_1	382	388	PF00454	0.697
MOD_PIKK_1	405	411	PF00454	0.681
MOD_PIKK_1	415	421	PF00454	0.616
MOD_PIKK_1	483	489	PF00454	0.611
MOD_PIKK_1	94	100	PF00454	0.573
MOD_PKA_1	106	112	PF00069	0.589
MOD_PKA_2	106	112	PF00069	0.589
MOD_PKA_2	155	161	PF00069	0.517
MOD_PKA_2	19	25	PF00069	0.621
MOD_PKA_2	564	570	PF00069	0.692
MOD_PKB_1	105	113	PF00069	0.503
MOD_Plk_1	42	48	PF00069	0.656
MOD_Plk_1	466	472	PF00069	0.554
MOD_Plk_4	269	275	PF00069	0.654
MOD_ProDKin_1	212	218	PF00069	0.629
MOD_ProDKin_1	227	233	PF00069	0.635
MOD_ProDKin_1	274	280	PF00069	0.627
MOD_ProDKin_1	336	342	PF00069	0.681
MOD_ProDKin_1	374	380	PF00069	0.627
MOD_ProDKin_1	389	395	PF00069	0.608
MOD_ProDKin_1	398	404	PF00069	0.606
MOD_ProDKin_1	410	416	PF00069	0.589
MOD_ProDKin_1	481	487	PF00069	0.660
MOD_ProDKin_1	54	60	PF00069	0.564
MOD_SUMO_for_1	537	540	PF00179	0.674
MOD_SUMO_rev_2	79	85	PF00179	0.525
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.687
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.637
TRG_ENDOCYTIC_2	149	152	PF00928	0.380
TRG_ENDOCYTIC_2	172	175	PF00928	0.560
TRG_ER_diArg_1	104	107	PF00400	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPV7	Leishmania donovani	88%	100%
A4HFN9	Leishmania braziliensis	61%	100%
A4I2R5	Leishmania infantum	89%	100%
E9AZ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%