Putative intraflagellar transport protein IFT88

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 88, putative

Species:

Leishmania major

UniProt:

E9AD91_LEIMA

TriTrypDb:

LmjF.27.1130 , LMJLV39_270017300 , LMJSD75_270017500

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	12
GO:0030990	intraciliary transport particle	2	2
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097546	ciliary base	2	2
GO:0097730	non-motile cilium	5	2
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AD91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD91

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0007163	establishment or maintenance of cell polarity	2	2
GO:0008361	regulation of cell size	5	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030010	establishment of cell polarity	3	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0032535	regulation of cellular component size	4	2
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	2
GO:0044782	cilium organization	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0060271	cilium assembly	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090066	regulation of anatomical structure size	3	2
GO:0099111	microtubule-based transport	4	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1905515	non-motile cilium assembly	7	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0019894	kinesin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	780	784	PF00656	0.708
CLV_NRD_NRD_1	249	251	PF00675	0.426
CLV_NRD_NRD_1	343	345	PF00675	0.565
CLV_NRD_NRD_1	356	358	PF00675	0.410
CLV_NRD_NRD_1	360	362	PF00675	0.369
CLV_NRD_NRD_1	657	659	PF00675	0.283
CLV_NRD_NRD_1	673	675	PF00675	0.290
CLV_NRD_NRD_1	745	747	PF00675	0.742
CLV_NRD_NRD_1	760	762	PF00675	0.524
CLV_PCSK_KEX2_1	121	123	PF00082	0.580
CLV_PCSK_KEX2_1	174	176	PF00082	0.526
CLV_PCSK_KEX2_1	318	320	PF00082	0.358
CLV_PCSK_KEX2_1	343	345	PF00082	0.592
CLV_PCSK_KEX2_1	360	362	PF00082	0.350
CLV_PCSK_KEX2_1	422	424	PF00082	0.508
CLV_PCSK_KEX2_1	535	537	PF00082	0.334
CLV_PCSK_KEX2_1	656	658	PF00082	0.281
CLV_PCSK_KEX2_1	665	667	PF00082	0.287
CLV_PCSK_KEX2_1	673	675	PF00082	0.287
CLV_PCSK_KEX2_1	744	746	PF00082	0.752
CLV_PCSK_KEX2_1	760	762	PF00082	0.507
CLV_PCSK_KEX2_1	792	794	PF00082	0.755
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.597
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.538
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.358
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.616
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.508
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.350
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.276
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.755
CLV_PCSK_SKI1_1	250	254	PF00082	0.316
CLV_PCSK_SKI1_1	319	323	PF00082	0.442
CLV_PCSK_SKI1_1	345	349	PF00082	0.509
CLV_PCSK_SKI1_1	363	367	PF00082	0.353
CLV_PCSK_SKI1_1	444	448	PF00082	0.347
CLV_PCSK_SKI1_1	532	536	PF00082	0.287
CLV_PCSK_SKI1_1	78	82	PF00082	0.587
CLV_PCSK_SKI1_1	795	799	PF00082	0.738
DEG_Kelch_Keap1_1	458	463	PF01344	0.360
DEG_Nend_UBRbox_3	1	3	PF02207	0.729
DEG_SPOP_SBC_1	21	25	PF00917	0.681
DOC_CDC14_PxL_1	113	121	PF14671	0.591
DOC_CKS1_1	12	17	PF01111	0.673
DOC_CYCLIN_RxL_1	519	529	PF00134	0.287
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.453
DOC_MAPK_gen_1	343	349	PF00069	0.607
DOC_PP1_RVXF_1	216	223	PF00149	0.413
DOC_PP1_RVXF_1	627	634	PF00149	0.360
DOC_PP1_RVXF_1	82	89	PF00149	0.605
DOC_PP2B_LxvP_1	374	377	PF13499	0.320
DOC_PP4_FxxP_1	12	15	PF00568	0.663
DOC_PP4_FxxP_1	29	32	PF00568	0.738
DOC_USP7_MATH_1	284	288	PF00917	0.302
DOC_USP7_MATH_1	588	592	PF00917	0.468
DOC_USP7_MATH_1	79	83	PF00917	0.585
DOC_USP7_MATH_1	797	801	PF00917	0.668
DOC_USP7_UBL2_3	136	140	PF12436	0.415
DOC_USP7_UBL2_3	162	166	PF12436	0.379
DOC_USP7_UBL2_3	247	251	PF12436	0.434
DOC_USP7_UBL2_3	432	436	PF12436	0.402
DOC_USP7_UBL2_3	491	495	PF12436	0.407
DOC_USP7_UBL2_3	703	707	PF12436	0.432
DOC_USP7_UBL2_3	792	796	PF12436	0.778
DOC_WW_Pin1_4	11	16	PF00397	0.631
DOC_WW_Pin1_4	253	258	PF00397	0.321
LIG_14-3-3_CanoR_1	636	642	PF00244	0.382
LIG_14-3-3_CanoR_1	744	753	PF00244	0.729
LIG_14-3-3_CanoR_1	78	86	PF00244	0.606
LIG_APCC_ABBA_1	524	529	PF00400	0.287
LIG_APCC_ABBA_1	774	779	PF00400	0.447
LIG_APCC_ABBAyCdc20_2	523	529	PF00400	0.302
LIG_EH_1	26	30	PF12763	0.732
LIG_eIF4E_1	465	471	PF01652	0.437
LIG_eIF4E_1	475	481	PF01652	0.341
LIG_FHA_1	12	18	PF00498	0.704
LIG_FHA_1	187	193	PF00498	0.346
LIG_FHA_1	205	211	PF00498	0.360
LIG_FHA_1	299	305	PF00498	0.394
LIG_FHA_1	401	407	PF00498	0.526
LIG_FHA_1	703	709	PF00498	0.477
LIG_FHA_2	288	294	PF00498	0.372
LIG_GBD_Chelix_1	180	188	PF00786	0.431
LIG_Integrin_RGD_1	658	660	PF01839	0.344
LIG_LIR_Apic_2	26	32	PF02991	0.762
LIG_LIR_Apic_2	57	62	PF02991	0.613
LIG_LIR_Gen_1	212	220	PF02991	0.374
LIG_LIR_Gen_1	287	292	PF02991	0.277
LIG_LIR_Gen_1	301	310	PF02991	0.287
LIG_LIR_Gen_1	320	329	PF02991	0.409
LIG_LIR_Gen_1	463	472	PF02991	0.370
LIG_LIR_Gen_1	564	574	PF02991	0.372
LIG_LIR_Gen_1	6	17	PF02991	0.555
LIG_LIR_Gen_1	644	652	PF02991	0.287
LIG_LIR_Nem_3	212	216	PF02991	0.349
LIG_LIR_Nem_3	287	291	PF02991	0.277
LIG_LIR_Nem_3	301	305	PF02991	0.287
LIG_LIR_Nem_3	320	324	PF02991	0.415
LIG_LIR_Nem_3	463	468	PF02991	0.517
LIG_LIR_Nem_3	564	569	PF02991	0.359
LIG_LIR_Nem_3	6	12	PF02991	0.551
LIG_LIR_Nem_3	602	607	PF02991	0.360
LIG_PALB2_WD40_1	561	569	PF16756	0.343
LIG_PCNA_yPIPBox_3	605	617	PF02747	0.340
LIG_Pex14_1	383	387	PF04695	0.330
LIG_Pex14_1	616	620	PF04695	0.313
LIG_PTB_Apo_2	216	223	PF02174	0.398
LIG_PTB_Apo_2	621	628	PF02174	0.349
LIG_PTB_Phospho_1	621	627	PF10480	0.345
LIG_REV1ctd_RIR_1	631	640	PF16727	0.356
LIG_SH2_CRK	213	217	PF00017	0.353
LIG_SH2_CRK	249	253	PF00017	0.434
LIG_SH2_CRK	387	391	PF00017	0.329
LIG_SH2_GRB2like	200	203	PF00017	0.375
LIG_SH2_GRB2like	459	462	PF00017	0.470
LIG_SH2_SRC	200	203	PF00017	0.375
LIG_SH2_SRC	387	390	PF00017	0.453
LIG_SH2_SRC	424	427	PF00017	0.493
LIG_SH2_SRC	459	462	PF00017	0.470
LIG_SH2_SRC	527	530	PF00017	0.287
LIG_SH2_SRC	548	551	PF00017	0.322
LIG_SH2_SRC	600	603	PF00017	0.329
LIG_SH2_STAP1	190	194	PF00017	0.343
LIG_SH2_STAP1	206	210	PF00017	0.353
LIG_SH2_STAP1	288	292	PF00017	0.287
LIG_SH2_STAP1	387	391	PF00017	0.329
LIG_SH2_STAP1	527	531	PF00017	0.287
LIG_SH2_STAP1	627	631	PF00017	0.333
LIG_SH2_STAT3	236	239	PF00017	0.321
LIG_SH2_STAT3	684	687	PF00017	0.459
LIG_SH2_STAT5	206	209	PF00017	0.416
LIG_SH2_STAT5	236	239	PF00017	0.358
LIG_SH2_STAT5	242	245	PF00017	0.156
LIG_SH2_STAT5	364	367	PF00017	0.419
LIG_SH2_STAT5	389	392	PF00017	0.334
LIG_SH2_STAT5	418	421	PF00017	0.397
LIG_SH2_STAT5	451	454	PF00017	0.329
LIG_SH2_STAT5	600	603	PF00017	0.324
LIG_SH2_STAT5	620	623	PF00017	0.328
LIG_SH2_STAT5	661	664	PF00017	0.334
LIG_SH2_STAT5	684	687	PF00017	0.339
LIG_SH3_2	115	120	PF14604	0.592
LIG_SH3_3	112	118	PF00018	0.582
LIG_SH3_3	217	223	PF00018	0.529
LIG_SH3_3	554	560	PF00018	0.380
LIG_SH3_3	571	577	PF00018	0.316
LIG_SUMO_SIM_anti_2	466	472	PF11976	0.441
LIG_TRAF2_1	126	129	PF00917	0.507
LIG_TRAF2_1	32	35	PF00917	0.781
LIG_TYR_ITIM	306	311	PF00017	0.321
LIG_TYR_ITIM	385	390	PF00017	0.420
LIG_UBA3_1	147	152	PF00899	0.452
LIG_UBA3_1	243	251	PF00899	0.287
MOD_CK1_1	123	129	PF00069	0.645
MOD_CK1_1	287	293	PF00069	0.407
MOD_CK1_1	466	472	PF00069	0.378
MOD_CK1_1	715	721	PF00069	0.613
MOD_CK1_1	799	805	PF00069	0.701
MOD_CK1_1	90	96	PF00069	0.579
MOD_CK2_1	123	129	PF00069	0.523
MOD_CK2_1	287	293	PF00069	0.354
MOD_CK2_1	405	411	PF00069	0.363
MOD_CK2_1	61	67	PF00069	0.637
MOD_CK2_1	728	734	PF00069	0.729
MOD_CK2_1	799	805	PF00069	0.692
MOD_Cter_Amidation	758	761	PF01082	0.652
MOD_GlcNHglycan	143	147	PF01048	0.370
MOD_GlcNHglycan	56	59	PF01048	0.620
MOD_GlcNHglycan	723	726	PF01048	0.687
MOD_GlcNHglycan	747	750	PF01048	0.679
MOD_GlcNHglycan	89	92	PF01048	0.688
MOD_GSK3_1	16	23	PF00069	0.642
MOD_GSK3_1	389	396	PF00069	0.412
MOD_GSK3_1	401	408	PF00069	0.347
MOD_GSK3_1	61	68	PF00069	0.592
MOD_GSK3_1	712	719	PF00069	0.600
MOD_GSK3_1	74	81	PF00069	0.547
MOD_LATS_1	742	748	PF00433	0.757
MOD_N-GLC_1	298	303	PF02516	0.434
MOD_N-GLC_1	484	489	PF02516	0.474
MOD_NEK2_1	167	172	PF00069	0.494
MOD_NEK2_1	317	322	PF00069	0.381
MOD_NEK2_1	650	655	PF00069	0.287
MOD_NEK2_1	702	707	PF00069	0.486
MOD_PIKK_1	123	129	PF00454	0.672
MOD_PIKK_1	389	395	PF00454	0.490
MOD_PIKK_1	45	51	PF00454	0.726
MOD_PK_1	770	776	PF00069	0.624
MOD_PKA_1	120	126	PF00069	0.685
MOD_PKA_1	744	750	PF00069	0.769
MOD_PKA_2	588	594	PF00069	0.284
MOD_PKA_2	635	641	PF00069	0.382
MOD_PKA_2	744	750	PF00069	0.731
MOD_PKB_1	442	450	PF00069	0.328
MOD_Plk_1	142	148	PF00069	0.376
MOD_Plk_1	167	173	PF00069	0.533
MOD_Plk_1	186	192	PF00069	0.274
MOD_Plk_1	298	304	PF00069	0.434
MOD_Plk_1	349	355	PF00069	0.502
MOD_Plk_1	437	443	PF00069	0.554
MOD_Plk_1	466	472	PF00069	0.365
MOD_Plk_1	484	490	PF00069	0.483
MOD_Plk_1	729	735	PF00069	0.722
MOD_Plk_1	770	776	PF00069	0.679
MOD_Plk_4	287	293	PF00069	0.372
MOD_Plk_4	466	472	PF00069	0.441
MOD_Plk_4	582	588	PF00069	0.384
MOD_ProDKin_1	11	17	PF00069	0.632
MOD_ProDKin_1	253	259	PF00069	0.321
MOD_SUMO_for_1	622	625	PF00179	0.358
MOD_SUMO_rev_2	778	786	PF00179	0.718
TRG_DiLeu_BaEn_4	143	149	PF01217	0.376
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.324
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.377
TRG_ENDOCYTIC_2	213	216	PF00928	0.351
TRG_ENDOCYTIC_2	249	252	PF00928	0.434
TRG_ENDOCYTIC_2	288	291	PF00928	0.278
TRG_ENDOCYTIC_2	308	311	PF00928	0.103
TRG_ENDOCYTIC_2	387	390	PF00928	0.333
TRG_ENDOCYTIC_2	451	454	PF00928	0.329
TRG_ENDOCYTIC_2	465	468	PF00928	0.367
TRG_ENDOCYTIC_2	606	609	PF00928	0.366
TRG_ENDOCYTIC_2	668	671	PF00928	0.280
TRG_ENDOCYTIC_2	9	12	PF00928	0.544
TRG_ER_diArg_1	227	230	PF00400	0.287
TRG_ER_diArg_1	360	363	PF00400	0.465
TRG_ER_diArg_1	441	444	PF00400	0.364
TRG_ER_diArg_1	656	658	PF00400	0.298
TRG_ER_diArg_1	673	675	PF00400	0.308
TRG_ER_diArg_1	744	746	PF00400	0.773
TRG_NES_CRM1_1	187	201	PF08389	0.341
TRG_NES_CRM1_1	677	691	PF08389	0.349
TRG_NLS_MonoExtC_3	791	796	PF00514	0.699
TRG_NLS_MonoExtN_4	792	799	PF00514	0.736
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ3	Leptomonas seymouri	81%	99%
A0A0S4JJR3	Bodo saltans	67%	100%
A0A1X0P453	Trypanosomatidae	66%	100%
A0A3Q8IDD3	Leishmania donovani	98%	100%
A0A3R7M723	Trypanosoma rangeli	65%	100%
A4HFN8	Leishmania braziliensis	92%	100%
A4I2R4	Leishmania infantum	98%	100%
D0A5X0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AZ16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q13099	Homo sapiens	43%	98%
Q61371	Mus musculus	42%	98%
V5B8M5	Trypanosoma cruzi	67%	93%