Pre-rRNA-processing protein TSR2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD90_LEIMA

TriTrypDb:

LmjF.27.1120 , LMJLV39_270017200 , LMJSD75_270017400

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD90

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.712
CLV_NRD_NRD_1	202	204	PF00675	0.727
CLV_NRD_NRD_1	205	207	PF00675	0.682
CLV_PCSK_FUR_1	203	207	PF00082	0.746
CLV_PCSK_KEX2_1	205	207	PF00082	0.692
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.694
DEG_Nend_UBRbox_3	1	3	PF02207	0.610
DOC_WW_Pin1_4	181	186	PF00397	0.620
LIG_14-3-3_CanoR_1	15	19	PF00244	0.559
LIG_14-3-3_CanoR_1	206	212	PF00244	0.677
LIG_APCC_ABBA_1	79	84	PF00400	0.417
LIG_FHA_1	133	139	PF00498	0.589
LIG_FHA_1	30	36	PF00498	0.514
LIG_FHA_2	24	30	PF00498	0.331
LIG_KLC1_Yacidic_2	73	77	PF13176	0.535
LIG_LIR_Gen_1	118	126	PF02991	0.412
LIG_LIR_Gen_1	25	35	PF02991	0.419
LIG_LIR_Gen_1	80	90	PF02991	0.426
LIG_LIR_Nem_3	118	122	PF02991	0.378
LIG_LIR_Nem_3	215	220	PF02991	0.522
LIG_LIR_Nem_3	25	31	PF02991	0.430
LIG_LIR_Nem_3	80	86	PF02991	0.405
LIG_Pex14_2	83	87	PF04695	0.399
LIG_SH2_STAT3	10	13	PF00017	0.624
LIG_SH2_STAT5	111	114	PF00017	0.367
LIG_SH2_STAT5	125	128	PF00017	0.412
LIG_SH2_STAT5	132	135	PF00017	0.479
LIG_SH2_STAT5	75	78	PF00017	0.503
LIG_SH2_STAT5	82	85	PF00017	0.425
LIG_SH3_2	191	196	PF14604	0.699
LIG_SH3_3	182	188	PF00018	0.730
LIG_SH3_3	189	195	PF00018	0.740
LIG_TRAF2_1	99	102	PF00917	0.543
LIG_TYR_ITIM	59	64	PF00017	0.499
LIG_WW_3	193	197	PF00397	0.731
MOD_CDK_SPK_2	181	186	PF00069	0.581
MOD_CK1_1	17	23	PF00069	0.585
MOD_CK1_1	210	216	PF00069	0.678
MOD_CK2_1	117	123	PF00069	0.433
MOD_CK2_1	23	29	PF00069	0.333
MOD_CK2_1	96	102	PF00069	0.459
MOD_GlcNHglycan	4	7	PF01048	0.660
MOD_GlcNHglycan	91	94	PF01048	0.595
MOD_GSK3_1	2	9	PF00069	0.646
MOD_GSK3_1	206	213	PF00069	0.669
MOD_N-GLC_1	207	212	PF02516	0.670
MOD_N-GLC_1	23	28	PF02516	0.330
MOD_NEK2_1	14	19	PF00069	0.629
MOD_PIKK_1	23	29	PF00454	0.557
MOD_PK_1	207	213	PF00069	0.662
MOD_PKA_1	206	212	PF00069	0.626
MOD_PKA_2	14	20	PF00069	0.563
MOD_Plk_1	117	123	PF00069	0.392
MOD_Plk_1	207	213	PF00069	0.662
MOD_Plk_1	23	29	PF00069	0.333
MOD_Plk_1	96	102	PF00069	0.463
MOD_Plk_2-3	96	102	PF00069	0.478
MOD_Plk_4	102	108	PF00069	0.464
MOD_ProDKin_1	181	187	PF00069	0.618
TRG_DiLeu_BaEn_4	155	161	PF01217	0.538
TRG_ENDOCYTIC_2	61	64	PF00928	0.438
TRG_ER_diArg_1	211	214	PF00400	0.494
TRG_NLS_MonoCore_2	202	207	PF00514	0.710
TRG_NLS_MonoExtC_3	202	207	PF00514	0.658
TRG_NLS_MonoExtN_4	201	208	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL48	Leptomonas seymouri	67%	100%
A0A0S4JFC4	Bodo saltans	34%	97%
A0A1X0P5J5	Trypanosomatidae	47%	100%
A0A3S7X0M3	Leishmania donovani	91%	100%
A0A422N5E3	Trypanosoma rangeli	46%	100%
A4HFN6	Leishmania braziliensis	76%	99%
A4I2R3	Leishmania infantum	91%	100%
D0A5W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AZ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%