Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD88_LEIMA

TriTrypDb:

LmjF.27.1100 , LMJLV39_270017000 , LMJSD75_270017200

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.609
CLV_C14_Caspase3-7	46	50	PF00656	0.516
CLV_C14_Caspase3-7	480	484	PF00656	0.591
CLV_NRD_NRD_1	190	192	PF00675	0.513
CLV_NRD_NRD_1	268	270	PF00675	0.596
CLV_NRD_NRD_1	273	275	PF00675	0.591
CLV_NRD_NRD_1	309	311	PF00675	0.599
CLV_NRD_NRD_1	329	331	PF00675	0.620
CLV_NRD_NRD_1	352	354	PF00675	0.587
CLV_NRD_NRD_1	470	472	PF00675	0.546
CLV_NRD_NRD_1	566	568	PF00675	0.681
CLV_NRD_NRD_1	593	595	PF00675	0.714
CLV_NRD_NRD_1	612	614	PF00675	0.505
CLV_NRD_NRD_1	615	617	PF00675	0.677
CLV_NRD_NRD_1	621	623	PF00675	0.629
CLV_PCSK_KEX2_1	273	275	PF00082	0.570
CLV_PCSK_KEX2_1	309	311	PF00082	0.653
CLV_PCSK_KEX2_1	328	330	PF00082	0.583
CLV_PCSK_KEX2_1	352	354	PF00082	0.587
CLV_PCSK_KEX2_1	469	471	PF00082	0.556
CLV_PCSK_KEX2_1	591	593	PF00082	0.694
CLV_PCSK_KEX2_1	595	597	PF00082	0.700
CLV_PCSK_KEX2_1	612	614	PF00082	0.525
CLV_PCSK_KEX2_1	621	623	PF00082	0.629
CLV_PCSK_KEX2_1	66	68	PF00082	0.574
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.694
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.700
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.525
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.629
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.550
CLV_PCSK_PC7_1	269	275	PF00082	0.552
CLV_PCSK_SKI1_1	124	128	PF00082	0.484
CLV_PCSK_SKI1_1	2	6	PF00082	0.579
CLV_PCSK_SKI1_1	274	278	PF00082	0.539
CLV_PCSK_SKI1_1	32	36	PF00082	0.607
CLV_PCSK_SKI1_1	352	356	PF00082	0.590
CLV_PCSK_SKI1_1	394	398	PF00082	0.690
CLV_PCSK_SKI1_1	609	613	PF00082	0.702
CLV_PCSK_SKI1_1	623	627	PF00082	0.579
DEG_APCC_DBOX_1	75	83	PF00400	0.541
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_SCF_FBW7_1	27	33	PF00400	0.480
DEG_SPOP_SBC_1	162	166	PF00917	0.641
DEG_SPOP_SBC_1	171	175	PF00917	0.599
DEG_SPOP_SBC_1	211	215	PF00917	0.573
DEG_SPOP_SBC_1	416	420	PF00917	0.666
DEG_SPOP_SBC_1	624	628	PF00917	0.651
DOC_CKS1_1	27	32	PF01111	0.578
DOC_CKS1_1	39	44	PF01111	0.394
DOC_CYCLIN_RxL_1	66	77	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.501
DOC_MAPK_gen_1	151	158	PF00069	0.528
DOC_MAPK_gen_1	428	435	PF00069	0.513
DOC_MAPK_gen_1	66	75	PF00069	0.506
DOC_MAPK_JIP1_4	67	73	PF00069	0.508
DOC_MAPK_MEF2A_6	66	75	PF00069	0.506
DOC_PP1_RVXF_1	56	62	PF00149	0.487
DOC_PP2B_LxvP_1	195	198	PF13499	0.576
DOC_PP4_FxxP_1	126	129	PF00568	0.487
DOC_PP4_FxxP_1	277	280	PF00568	0.540
DOC_USP7_MATH_1	152	156	PF00917	0.533
DOC_USP7_MATH_1	171	175	PF00917	0.494
DOC_USP7_MATH_1	211	215	PF00917	0.583
DOC_USP7_MATH_1	290	294	PF00917	0.688
DOC_USP7_MATH_1	30	34	PF00917	0.487
DOC_USP7_MATH_1	403	407	PF00917	0.710
DOC_USP7_MATH_1	409	413	PF00917	0.642
DOC_USP7_MATH_1	416	420	PF00917	0.533
DOC_USP7_MATH_1	475	479	PF00917	0.620
DOC_USP7_MATH_1	496	500	PF00917	0.572
DOC_USP7_MATH_1	555	559	PF00917	0.690
DOC_USP7_MATH_1	569	573	PF00917	0.606
DOC_USP7_MATH_1	598	602	PF00917	0.644
DOC_USP7_MATH_1	624	628	PF00917	0.723
DOC_USP7_MATH_1	630	634	PF00917	0.657
DOC_USP7_MATH_2	569	575	PF00917	0.663
DOC_USP7_UBL2_3	591	595	PF12436	0.721
DOC_USP7_UBL2_3	608	612	PF12436	0.527
DOC_USP7_UBL2_3	617	621	PF12436	0.619
DOC_WW_Pin1_4	142	147	PF00397	0.390
DOC_WW_Pin1_4	26	31	PF00397	0.417
DOC_WW_Pin1_4	276	281	PF00397	0.540
DOC_WW_Pin1_4	38	43	PF00397	0.391
DOC_WW_Pin1_4	401	406	PF00397	0.729
DOC_WW_Pin1_4	52	57	PF00397	0.386
DOC_WW_Pin1_4	6	11	PF00397	0.695
LIG_14-3-3_CanoR_1	151	157	PF00244	0.533
LIG_14-3-3_CanoR_1	191	196	PF00244	0.519
LIG_14-3-3_CanoR_1	274	280	PF00244	0.662
LIG_14-3-3_CanoR_1	291	296	PF00244	0.543
LIG_14-3-3_CanoR_1	297	305	PF00244	0.667
LIG_14-3-3_CanoR_1	339	344	PF00244	0.666
LIG_14-3-3_CanoR_1	485	489	PF00244	0.545
LIG_14-3-3_CanoR_1	622	632	PF00244	0.651
LIG_BIR_III_2	216	220	PF00653	0.587
LIG_BRCT_BRCA1_1	258	262	PF00533	0.523
LIG_BRCT_BRCA1_1	8	12	PF00533	0.623
LIG_Clathr_ClatBox_1	261	265	PF01394	0.558
LIG_EH1_1	129	137	PF00400	0.467
LIG_eIF4E_1	130	136	PF01652	0.437
LIG_FHA_1	105	111	PF00498	0.669
LIG_FHA_1	184	190	PF00498	0.436
LIG_FHA_1	226	232	PF00498	0.533
LIG_FHA_1	233	239	PF00498	0.525
LIG_FHA_1	249	255	PF00498	0.436
LIG_FHA_1	418	424	PF00498	0.657
LIG_FHA_1	627	633	PF00498	0.676
LIG_FHA_2	213	219	PF00498	0.646
LIG_FHA_2	250	256	PF00498	0.496
LIG_FHA_2	513	519	PF00498	0.492
LIG_FHA_2	552	558	PF00498	0.660
LIG_KLC1_Yacidic_2	227	232	PF13176	0.577
LIG_LIR_Gen_1	373	383	PF02991	0.672
LIG_LIR_Nem_3	119	125	PF02991	0.529
LIG_LIR_Nem_3	373	379	PF02991	0.672
LIG_LIR_Nem_3	507	513	PF02991	0.569
LIG_REV1ctd_RIR_1	32	41	PF16727	0.411
LIG_SH2_CRK	122	126	PF00017	0.484
LIG_SH2_NCK_1	130	134	PF00017	0.468
LIG_SH2_SRC	230	233	PF00017	0.571
LIG_SH2_SRC	376	379	PF00017	0.677
LIG_SH2_SRC	441	444	PF00017	0.700
LIG_SH2_STAP1	23	27	PF00017	0.613
LIG_SH2_STAT5	230	233	PF00017	0.583
LIG_SH2_STAT5	305	308	PF00017	0.756
LIG_SH2_STAT5	422	425	PF00017	0.642
LIG_SH3_3	146	152	PF00018	0.530
LIG_SH3_3	629	635	PF00018	0.665
LIG_SH3_3	72	78	PF00018	0.488
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.461
LIG_SUMO_SIM_par_1	106	111	PF11976	0.621
LIG_SUMO_SIM_par_1	246	252	PF11976	0.455
LIG_SUMO_SIM_par_1	83	88	PF11976	0.522
LIG_SxIP_EBH_1	527	537	PF03271	0.616
LIG_TRAF2_1	116	119	PF00917	0.430
LIG_WRC_WIRS_1	505	510	PF05994	0.418
MOD_CDC14_SPxK_1	55	58	PF00782	0.383
MOD_CDK_SPK_2	6	11	PF00069	0.622
MOD_CDK_SPxK_1	26	32	PF00069	0.605
MOD_CDK_SPxK_1	52	58	PF00069	0.405
MOD_CDK_SPxxK_3	276	283	PF00069	0.547
MOD_CK1_1	164	170	PF00069	0.608
MOD_CK1_1	256	262	PF00069	0.516
MOD_CK1_1	26	32	PF00069	0.484
MOD_CK1_1	279	285	PF00069	0.696
MOD_CK1_1	342	348	PF00069	0.617
MOD_CK1_1	401	407	PF00069	0.694
MOD_CK1_1	412	418	PF00069	0.612
MOD_CK1_1	421	427	PF00069	0.477
MOD_CK1_1	47	53	PF00069	0.561
MOD_CK1_1	484	490	PF00069	0.545
MOD_CK1_1	514	520	PF00069	0.567
MOD_CK1_1	521	527	PF00069	0.594
MOD_CK1_1	558	564	PF00069	0.664
MOD_CK2_1	162	168	PF00069	0.607
MOD_CK2_1	172	178	PF00069	0.554
MOD_CK2_1	249	255	PF00069	0.495
MOD_CK2_1	290	296	PF00069	0.652
MOD_CK2_1	452	458	PF00069	0.601
MOD_CK2_1	512	518	PF00069	0.496
MOD_CK2_1	551	557	PF00069	0.662
MOD_CK2_1	92	98	PF00069	0.656
MOD_Cter_Amidation	605	608	PF01082	0.708
MOD_GlcNHglycan	102	105	PF01048	0.530
MOD_GlcNHglycan	158	161	PF01048	0.521
MOD_GlcNHglycan	298	301	PF01048	0.727
MOD_GlcNHglycan	400	403	PF01048	0.702
MOD_GlcNHglycan	411	414	PF01048	0.624
MOD_GlcNHglycan	436	439	PF01048	0.630
MOD_GlcNHglycan	46	49	PF01048	0.505
MOD_GlcNHglycan	500	503	PF01048	0.601
MOD_GlcNHglycan	520	523	PF01048	0.480
MOD_GlcNHglycan	560	563	PF01048	0.720
MOD_GlcNHglycan	571	574	PF01048	0.623
MOD_GlcNHglycan	583	586	PF01048	0.620
MOD_GlcNHglycan	588	591	PF01048	0.587
MOD_GlcNHglycan	598	601	PF01048	0.560
MOD_GlcNHglycan	618	621	PF01048	0.519
MOD_GlcNHglycan	632	635	PF01048	0.663
MOD_GlcNHglycan	94	97	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.507
MOD_GSK3_1	152	159	PF00069	0.526
MOD_GSK3_1	183	190	PF00069	0.601
MOD_GSK3_1	249	256	PF00069	0.476
MOD_GSK3_1	26	33	PF00069	0.610
MOD_GSK3_1	275	282	PF00069	0.628
MOD_GSK3_1	291	298	PF00069	0.660
MOD_GSK3_1	335	342	PF00069	0.695
MOD_GSK3_1	359	366	PF00069	0.593
MOD_GSK3_1	37	44	PF00069	0.587
MOD_GSK3_1	394	401	PF00069	0.729
MOD_GSK3_1	412	419	PF00069	0.523
MOD_GSK3_1	448	455	PF00069	0.633
MOD_GSK3_1	48	55	PF00069	0.506
MOD_GSK3_1	484	491	PF00069	0.591
MOD_GSK3_1	513	520	PF00069	0.462
MOD_GSK3_1	551	558	PF00069	0.681
MOD_GSK3_1	586	593	PF00069	0.679
MOD_GSK3_1	612	619	PF00069	0.608
MOD_GSK3_1	624	631	PF00069	0.685
MOD_GSK3_1	88	95	PF00069	0.586
MOD_N-GLC_1	171	176	PF02516	0.613
MOD_N-GLC_1	88	93	PF02516	0.527
MOD_NEK2_1	156	161	PF00069	0.614
MOD_NEK2_1	170	175	PF00069	0.562
MOD_NEK2_1	249	254	PF00069	0.438
MOD_NEK2_1	295	300	PF00069	0.728
MOD_NEK2_1	5	10	PF00069	0.616
MOD_NEK2_1	641	646	PF00069	0.706
MOD_NEK2_2	23	28	PF00069	0.473
MOD_NEK2_2	30	35	PF00069	0.455
MOD_PIKK_1	313	319	PF00454	0.629
MOD_PIKK_1	404	410	PF00454	0.673
MOD_PIKK_1	555	561	PF00454	0.635
MOD_PK_1	339	345	PF00069	0.642
MOD_PK_1	448	454	PF00069	0.680
MOD_PKA_1	191	197	PF00069	0.533
MOD_PKA_1	469	475	PF00069	0.555
MOD_PKA_1	607	613	PF00069	0.686
MOD_PKA_1	616	622	PF00069	0.640
MOD_PKA_2	152	158	PF00069	0.527
MOD_PKA_2	187	193	PF00069	0.519
MOD_PKA_2	282	288	PF00069	0.665
MOD_PKA_2	290	296	PF00069	0.629
MOD_PKA_2	469	475	PF00069	0.555
MOD_PKA_2	484	490	PF00069	0.428
MOD_PKA_2	511	517	PF00069	0.491
MOD_PKA_2	612	618	PF00069	0.704
MOD_PKB_1	594	602	PF00069	0.716
MOD_Plk_1	171	177	PF00069	0.609
MOD_Plk_1	233	239	PF00069	0.464
MOD_Plk_1	431	437	PF00069	0.542
MOD_Plk_1	48	54	PF00069	0.588
MOD_Plk_1	551	557	PF00069	0.711
MOD_Plk_2-3	571	577	PF00069	0.608
MOD_Plk_4	134	140	PF00069	0.571
MOD_Plk_4	152	158	PF00069	0.368
MOD_Plk_4	225	231	PF00069	0.509
MOD_Plk_4	253	259	PF00069	0.561
MOD_Plk_4	418	424	PF00069	0.657
MOD_ProDKin_1	142	148	PF00069	0.389
MOD_ProDKin_1	26	32	PF00069	0.424
MOD_ProDKin_1	276	282	PF00069	0.544
MOD_ProDKin_1	38	44	PF00069	0.397
MOD_ProDKin_1	401	407	PF00069	0.728
MOD_ProDKin_1	52	58	PF00069	0.381
MOD_ProDKin_1	6	12	PF00069	0.695
MOD_SUMO_rev_2	561	569	PF00179	0.715
MOD_SUMO_rev_2	575	585	PF00179	0.601
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.494
TRG_ENDOCYTIC_2	122	125	PF00928	0.478
TRG_ENDOCYTIC_2	376	379	PF00928	0.677
TRG_ENDOCYTIC_2	510	513	PF00928	0.587
TRG_ER_diArg_1	328	330	PF00400	0.667
TRG_ER_diArg_1	352	354	PF00400	0.587
TRG_ER_diArg_1	468	471	PF00400	0.547
TRG_ER_diArg_1	497	500	PF00400	0.433
TRG_NLS_Bipartite_1	591	611	PF00514	0.670
TRG_NLS_MonoCore_2	65	70	PF00514	0.517
TRG_NLS_MonoExtC_3	590	595	PF00514	0.576
TRG_NLS_MonoExtC_3	611	616	PF00514	0.700
TRG_NLS_MonoExtN_4	591	598	PF00514	0.716
TRG_NLS_MonoExtN_4	609	616	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0L5	Leishmania donovani	89%	100%
A4HFN4	Leishmania braziliensis	66%	98%
A4I2R1	Leishmania infantum	90%	100%
E9AZ12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%