Emopamil-binding protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Emopamil binding protein, putative

Species:

Leishmania major

UniProt:

E9AD87_LEIMA

TriTrypDb:

LmjF.27.1090 , LMJLV39_270016900 , LMJSD75_270017100

Length:

196

Annotations

LeishMANIAdb annotations

This 4-TM protein belongs to broad Eukaryotic family of primarily ER-associated proteins. This family also encompasses the human Emopamil-binding protein and intracellular sigma receptors.. Might be a sterol isomerase.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AD87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.556
CLV_PCSK_KEX2_1	58	60	PF00082	0.515
CLV_PCSK_SKI1_1	111	115	PF00082	0.310
DEG_SIAH_1	39	47	PF03145	0.332
DOC_CYCLIN_yClb5_NLxxxL_5	33	41	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.341
DOC_MAPK_DCC_7	135	145	PF00069	0.257
DOC_MAPK_MEF2A_6	99	106	PF00069	0.347
DOC_PP1_RVXF_1	9	15	PF00149	0.488
DOC_PP2B_LxvP_1	139	142	PF13499	0.341
DOC_USP7_MATH_1	162	166	PF00917	0.549
DOC_USP7_MATH_1	174	178	PF00917	0.593
LIG_14-3-3_CanoR_1	128	133	PF00244	0.326
LIG_14-3-3_CanoR_1	31	36	PF00244	0.352
LIG_FHA_1	135	141	PF00498	0.307
LIG_FHA_1	3	9	PF00498	0.462
LIG_FHA_2	129	135	PF00498	0.386
LIG_GBD_Chelix_1	79	87	PF00786	0.312
LIG_HP1_1	19	23	PF01393	0.372
LIG_LIR_Gen_1	112	121	PF02991	0.393
LIG_LIR_Gen_1	144	154	PF02991	0.301
LIG_LIR_Gen_1	64	74	PF02991	0.320
LIG_LIR_Nem_3	108	113	PF02991	0.300
LIG_LIR_Nem_3	144	149	PF02991	0.335
LIG_LIR_Nem_3	64	70	PF02991	0.329
LIG_LIR_Nem_3	72	76	PF02991	0.255
LIG_SH2_CRK	110	114	PF00017	0.300
LIG_SH2_STAP1	56	60	PF00017	0.315
LIG_SH2_STAT5	115	118	PF00017	0.324
LIG_SH2_STAT5	126	129	PF00017	0.273
LIG_SH2_STAT5	184	187	PF00017	0.611
LIG_SH3_3	163	169	PF00018	0.503
LIG_SH3_3	32	38	PF00018	0.339
LIG_SUMO_SIM_par_1	116	122	PF11976	0.454
LIG_SUMO_SIM_par_1	18	24	PF11976	0.279
LIG_SUMO_SIM_par_1	86	92	PF11976	0.377
LIG_TRAF2_1	131	134	PF00917	0.281
LIG_TYR_ITIM	113	118	PF00017	0.319
LIG_TYR_ITSM	106	113	PF00017	0.300
LIG_UBA3_1	106	111	PF00899	0.341
LIG_UBA3_1	117	125	PF00899	0.310
LIG_UBA3_1	26	33	PF00899	0.442
MOD_CK2_1	128	134	PF00069	0.356
MOD_Cter_Amidation	191	194	PF01082	0.460
MOD_GSK3_1	105	112	PF00069	0.320
MOD_GSK3_1	124	131	PF00069	0.334
MOD_GSK3_1	27	34	PF00069	0.463
MOD_NEK2_1	109	114	PF00069	0.307
MOD_NEK2_1	185	190	PF00069	0.593
MOD_NEK2_1	27	32	PF00069	0.391
MOD_NEK2_1	83	88	PF00069	0.409
MOD_NEK2_2	105	110	PF00069	0.343
MOD_PIKK_1	174	180	PF00454	0.748
MOD_PK_1	31	37	PF00069	0.353
MOD_Plk_1	63	69	PF00069	0.355
MOD_Plk_4	105	111	PF00069	0.300
MOD_Plk_4	134	140	PF00069	0.276
MOD_Plk_4	141	147	PF00069	0.285
MOD_Plk_4	148	154	PF00069	0.280
MOD_Plk_4	63	69	PF00069	0.312
MOD_Plk_4	83	89	PF00069	0.274
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.519
TRG_ENDOCYTIC_2	110	113	PF00928	0.330
TRG_ENDOCYTIC_2	115	118	PF00928	0.317
TRG_ENDOCYTIC_2	49	52	PF00928	0.358
TRG_ER_diArg_1	58	60	PF00400	0.356
TRG_ER_diLys_1	193	196	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I830	Leptomonas seymouri	48%	98%
A0A0S4JB23	Bodo saltans	43%	100%
A0A1X0P436	Trypanosomatidae	55%	100%
A0A3Q8IGA5	Leishmania donovani	91%	99%
A4HFN3	Leishmania braziliensis	74%	100%
A4I2R0	Leishmania infantum	92%	99%
D0A5W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AZ11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%