LeishMANIAdb
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Putative vesicular transport protein (CDC48 homologue)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vesicular transport protein (CDC48 homologue)
Gene product:
vesicular transport protein (CDC48 homologue), putative
Species:
Leishmania major
UniProt:
E9AD83_LEIMA
TriTrypDb:
LmjF.27.1050 , LMJLV39_270016500 * , LMJSD75_270016700
Length:
666

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AD83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD83

Function

Biological processes
Term Name Level Count
GO:0009889 regulation of biosynthetic process 4 2
GO:0009891 positive regulation of biosynthetic process 5 2
GO:0009893 positive regulation of metabolic process 4 2
GO:0009987 cellular process 1 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010557 positive regulation of macromolecule biosynthetic process 6 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0022613 ribonucleoprotein complex biogenesis 4 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0031328 positive regulation of cellular biosynthetic process 6 2
GO:0042254 ribosome biogenesis 5 2
GO:0043085 positive regulation of catalytic activity 4 2
GO:0044085 cellular component biogenesis 3 2
GO:0044093 positive regulation of molecular function 3 2
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050790 regulation of catalytic activity 3 2
GO:0050794 regulation of cellular process 3 2
GO:0051052 regulation of DNA metabolic process 5 2
GO:0051054 positive regulation of DNA metabolic process 6 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051173 positive regulation of nitrogen compound metabolic process 5 2
GO:0051338 regulation of transferase activity 4 2
GO:0051347 positive regulation of transferase activity 5 2
GO:0051972 regulation of telomerase activity 5 2
GO:0051973 positive regulation of telomerase activity 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0065009 regulation of molecular function 2 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0080090 regulation of primary metabolic process 4 2
GO:2000278 regulation of DNA biosynthetic process 6 2
GO:2000573 positive regulation of DNA biosynthetic process 7 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043021 ribonucleoprotein complex binding 3 2
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044877 protein-containing complex binding 2 2
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:1990275 preribosome binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 473 477 PF00656 0.234
CLV_C14_Caspase3-7 500 504 PF00656 0.234
CLV_C14_Caspase3-7 521 525 PF00656 0.255
CLV_MEL_PAP_1 398 404 PF00089 0.366
CLV_NRD_NRD_1 201 203 PF00675 0.234
CLV_NRD_NRD_1 23 25 PF00675 0.721
CLV_NRD_NRD_1 252 254 PF00675 0.234
CLV_NRD_NRD_1 318 320 PF00675 0.256
CLV_NRD_NRD_1 481 483 PF00675 0.234
CLV_NRD_NRD_1 507 509 PF00675 0.379
CLV_NRD_NRD_1 555 557 PF00675 0.414
CLV_PCSK_KEX2_1 201 203 PF00082 0.234
CLV_PCSK_KEX2_1 252 254 PF00082 0.234
CLV_PCSK_KEX2_1 318 320 PF00082 0.249
CLV_PCSK_KEX2_1 45 47 PF00082 0.608
CLV_PCSK_KEX2_1 481 483 PF00082 0.234
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.657
CLV_PCSK_SKI1_1 176 180 PF00082 0.234
CLV_PCSK_SKI1_1 349 353 PF00082 0.403
CLV_PCSK_SKI1_1 456 460 PF00082 0.234
CLV_PCSK_SKI1_1 612 616 PF00082 0.540
DOC_CYCLIN_RxL_1 173 181 PF00134 0.234
DOC_CYCLIN_yCln2_LP_2 151 157 PF00134 0.234
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.350
DOC_MAPK_gen_1 252 263 PF00069 0.234
DOC_MAPK_gen_1 529 539 PF00069 0.234
DOC_MAPK_MEF2A_6 106 115 PF00069 0.334
DOC_MAPK_MEF2A_6 256 265 PF00069 0.234
DOC_MAPK_MEF2A_6 463 471 PF00069 0.234
DOC_MAPK_MEF2A_6 532 541 PF00069 0.234
DOC_MAPK_NFAT4_5 106 114 PF00069 0.332
DOC_MAPK_RevD_3 187 202 PF00069 0.234
DOC_MAPK_RevD_3 303 319 PF00069 0.249
DOC_PP1_SILK_1 548 553 PF00149 0.364
DOC_PP2B_LxvP_1 151 154 PF13499 0.249
DOC_PP2B_LxvP_1 263 266 PF13499 0.313
DOC_PP2B_LxvP_1 537 540 PF13499 0.234
DOC_USP7_MATH_1 185 189 PF00917 0.249
DOC_USP7_MATH_1 208 212 PF00917 0.255
DOC_USP7_MATH_1 368 372 PF00917 0.439
DOC_USP7_MATH_1 428 432 PF00917 0.234
DOC_USP7_MATH_1 487 491 PF00917 0.234
DOC_USP7_MATH_1 55 59 PF00917 0.807
DOC_USP7_MATH_1 641 645 PF00917 0.390
DOC_USP7_MATH_1 71 75 PF00917 0.452
DOC_USP7_UBL2_3 596 600 PF12436 0.255
DOC_USP7_UBL2_3 69 73 PF12436 0.645
DOC_USP7_UBL2_3 9 13 PF12436 0.652
DOC_WW_Pin1_4 16 21 PF00397 0.645
DOC_WW_Pin1_4 294 299 PF00397 0.234
DOC_WW_Pin1_4 540 545 PF00397 0.468
LIG_14-3-3_CanoR_1 461 467 PF00244 0.234
LIG_Actin_WH2_2 580 598 PF00022 0.293
LIG_BIR_II_1 1 5 PF00653 0.490
LIG_BRCT_BRCA1_1 187 191 PF00533 0.234
LIG_DLG_GKlike_1 588 595 PF00625 0.234
LIG_EH1_1 405 413 PF00400 0.339
LIG_FHA_1 139 145 PF00498 0.234
LIG_FHA_1 333 339 PF00498 0.619
LIG_FHA_1 350 356 PF00498 0.427
LIG_FHA_1 385 391 PF00498 0.322
LIG_FHA_1 619 625 PF00498 0.617
LIG_FHA_2 217 223 PF00498 0.268
LIG_FHA_2 342 348 PF00498 0.393
LIG_FHA_2 498 504 PF00498 0.273
LIG_FHA_2 601 607 PF00498 0.270
LIG_FHA_2 89 95 PF00498 0.359
LIG_GBD_Chelix_1 143 151 PF00786 0.234
LIG_GBD_Chelix_1 213 221 PF00786 0.234
LIG_GBD_Chelix_1 494 502 PF00786 0.234
LIG_LIR_Gen_1 344 351 PF02991 0.311
LIG_LIR_Gen_1 362 370 PF02991 0.397
LIG_LIR_Gen_1 371 378 PF02991 0.519
LIG_LIR_Nem_3 289 293 PF02991 0.289
LIG_LIR_Nem_3 344 348 PF02991 0.406
LIG_LIR_Nem_3 362 367 PF02991 0.417
LIG_LIR_Nem_3 371 375 PF02991 0.348
LIG_NBox_RRM_1 179 189 PF00076 0.214
LIG_NRBOX 532 538 PF00104 0.267
LIG_Pex14_2 341 345 PF04695 0.362
LIG_SH2_CRK 413 417 PF00017 0.234
LIG_SH2_GRB2like 651 654 PF00017 0.375
LIG_SH2_PTP2 538 541 PF00017 0.234
LIG_SH2_SRC 512 515 PF00017 0.234
LIG_SH2_STAT3 23 26 PF00017 0.669
LIG_SH2_STAT5 300 303 PF00017 0.234
LIG_SH2_STAT5 512 515 PF00017 0.234
LIG_SH2_STAT5 538 541 PF00017 0.234
LIG_SH3_3 155 161 PF00018 0.234
LIG_SH3_3 536 542 PF00018 0.234
LIG_SUMO_SIM_anti_2 273 279 PF11976 0.289
LIG_TYR_ITIM 536 541 PF00017 0.249
LIG_UBA3_1 274 281 PF00899 0.310
LIG_UBA3_1 314 322 PF00899 0.227
LIG_UBA3_1 389 397 PF00899 0.390
MOD_CDK_SPxxK_3 540 547 PF00069 0.462
MOD_CK1_1 165 171 PF00069 0.246
MOD_CK1_1 2 8 PF00069 0.552
MOD_CK1_1 273 279 PF00069 0.289
MOD_CK1_1 451 457 PF00069 0.234
MOD_CK1_1 58 64 PF00069 0.711
MOD_CK1_1 618 624 PF00069 0.530
MOD_CK2_1 264 270 PF00069 0.318
MOD_CK2_1 341 347 PF00069 0.391
MOD_CK2_1 600 606 PF00069 0.253
MOD_CK2_1 64 70 PF00069 0.669
MOD_Cter_Amidation 199 202 PF01082 0.234
MOD_Cter_Amidation 506 509 PF01082 0.379
MOD_GlcNHglycan 164 167 PF01048 0.248
MOD_GlcNHglycan 29 32 PF01048 0.635
MOD_GlcNHglycan 357 360 PF01048 0.377
MOD_GlcNHglycan 430 433 PF01048 0.234
MOD_GlcNHglycan 464 467 PF01048 0.234
MOD_GlcNHglycan 524 527 PF01048 0.449
MOD_GlcNHglycan 578 581 PF01048 0.234
MOD_GlcNHglycan 617 620 PF01048 0.542
MOD_GlcNHglycan 643 646 PF01048 0.458
MOD_GlcNHglycan 66 69 PF01048 0.703
MOD_GlcNHglycan 73 76 PF01048 0.639
MOD_GSK3_1 546 553 PF00069 0.339
MOD_GSK3_1 55 62 PF00069 0.807
MOD_N-GLC_1 282 287 PF02516 0.412
MOD_N-GLC_1 294 299 PF02516 0.188
MOD_N-GLC_1 368 373 PF02516 0.350
MOD_N-GLC_1 428 433 PF02516 0.234
MOD_N-GLC_1 652 657 PF02516 0.388
MOD_NEK2_1 238 243 PF00069 0.234
MOD_NEK2_1 385 390 PF00069 0.327
MOD_NEK2_1 522 527 PF00069 0.267
MOD_NEK2_1 632 637 PF00069 0.375
MOD_PIKK_1 222 228 PF00454 0.328
MOD_PKA_1 481 487 PF00069 0.261
MOD_PKA_2 270 276 PF00069 0.289
MOD_PKA_2 462 468 PF00069 0.234
MOD_PKA_2 481 487 PF00069 0.234
MOD_PKA_2 546 552 PF00069 0.337
MOD_PKA_2 573 579 PF00069 0.255
MOD_PKA_2 639 645 PF00069 0.332
MOD_Plk_1 368 374 PF00069 0.350
MOD_Plk_1 451 457 PF00069 0.234
MOD_Plk_1 588 594 PF00069 0.234
MOD_Plk_1 632 638 PF00069 0.423
MOD_Plk_1 652 658 PF00069 0.386
MOD_Plk_2-3 652 658 PF00069 0.585
MOD_Plk_4 185 191 PF00069 0.278
MOD_Plk_4 270 276 PF00069 0.289
MOD_Plk_4 385 391 PF00069 0.383
MOD_Plk_4 418 424 PF00069 0.234
MOD_Plk_4 546 552 PF00069 0.337
MOD_ProDKin_1 16 22 PF00069 0.645
MOD_ProDKin_1 294 300 PF00069 0.234
MOD_ProDKin_1 540 546 PF00069 0.466
MOD_SUMO_rev_2 168 175 PF00179 0.234
MOD_SUMO_rev_2 346 351 PF00179 0.384
TRG_ENDOCYTIC_2 321 324 PF00928 0.328
TRG_ENDOCYTIC_2 538 541 PF00928 0.234
TRG_ENDOCYTIC_2 651 654 PF00928 0.376
TRG_ER_diArg_1 251 253 PF00400 0.234
TRG_ER_diArg_1 317 319 PF00400 0.249
TRG_ER_diArg_1 480 482 PF00400 0.234
TRG_NES_CRM1_1 93 107 PF08389 0.438
TRG_NLS_MonoExtC_3 23 28 PF00514 0.718
TRG_Pf-PMV_PEXEL_1 106 110 PF00026 0.314
TRG_Pf-PMV_PEXEL_1 176 181 PF00026 0.234
TRG_Pf-PMV_PEXEL_1 322 326 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2H1 Leptomonas seymouri 32% 72%
A0A0N0P3G0 Leptomonas seymouri 46% 84%
A0A0N0P640 Leptomonas seymouri 26% 90%
A0A0N0P6J4 Leptomonas seymouri 86% 100%
A0A0N1I568 Leptomonas seymouri 31% 69%
A0A0S4IKL1 Bodo saltans 32% 100%
A0A0S4IMC7 Bodo saltans 44% 100%
A0A0S4JAU3 Bodo saltans 71% 100%
A0A0S4JI00 Bodo saltans 41% 90%
A0A0S4JTC3 Bodo saltans 27% 91%
A0A0S4KLG9 Bodo saltans 33% 100%
A0A1X0NXH5 Trypanosomatidae 24% 94%
A0A1X0NXR8 Trypanosomatidae 27% 92%
A0A1X0P1J4 Trypanosomatidae 32% 85%
A0A1X0P433 Trypanosomatidae 74% 100%
A0A1X0P870 Trypanosomatidae 46% 85%
A0A1X0PA10 Trypanosomatidae 29% 73%
A0A3Q8IIU8 Leishmania donovani 34% 70%
A0A3Q8IKK0 Leishmania donovani 26% 90%
A0A3Q8IQP5 Leishmania donovani 46% 85%
A0A3Q8IS46 Leishmania donovani 33% 69%
A0A3R7M308 Trypanosoma rangeli 32% 85%
A0A3R7M9L0 Trypanosoma rangeli 46% 85%
A0A3R7MK02 Trypanosoma rangeli 32% 86%
A0A3S5H6W4 Leishmania donovani 36% 69%
A0A3S7X0L3 Leishmania donovani 97% 100%
A0A422MWE3 Trypanosoma rangeli 74% 100%
A0A7N9VSG0 Mus musculus 38% 89%
A4HB70 Leishmania braziliensis 32% 70%
A4HFM9 Leishmania braziliensis 92% 100%
A4HII5 Leishmania braziliensis 32% 71%
A4HNZ5 Leishmania braziliensis 46% 85%
A4HWQ5 Leishmania infantum 35% 76%
A4HYS3 Leishmania infantum 26% 90%
A4I2Q7 Leishmania infantum 97% 100%
A4IAB8 Leishmania infantum 34% 70%
A4ICJ9 Leishmania infantum 44% 97%
A7YSY2 Bos taurus 38% 87%
C9ZIP1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 93%
C9ZLX8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 73%
C9ZR48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 84%
D0A2X0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 85%
D0A5V8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 94%
D4A2B7 Rattus norvegicus 38% 89%
E9AID2 Leishmania braziliensis 26% 90%
E9ASQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 85%
E9AUL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 90%
E9AZ07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B124 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 85%
E9B5E1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 70%
O05209 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 43% 89%
O13764 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 70%
O14325 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 50% 85%
O15381 Homo sapiens 51% 78%
O28972 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 47% 91%
O60058 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 82%
O74941 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 71%
P03974 Sus scrofa 45% 83%
P23787 Xenopus laevis 45% 83%
P25694 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 80%
P32794 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 85%
P46462 Rattus norvegicus 45% 83%
P54609 Arabidopsis thaliana 45% 82%
P54774 Glycine max 46% 83%
P54777 Rattus norvegicus 36% 68%
P54811 Caenorhabditis elegans 45% 82%
P54812 Caenorhabditis elegans 46% 82%
P55072 Homo sapiens 45% 83%
Q01853 Mus musculus 45% 83%
Q07590 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 43% 85%
Q07844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 80%
Q13608 Homo sapiens 36% 68%
Q21222 Caenorhabditis elegans 32% 92%
Q3UMC0 Mus musculus 44% 75%
Q3ZBT1 Bos taurus 45% 83%
Q4Q1T9 Leishmania major 46% 85%
Q4Q2J2 Leishmania major 33% 70%
Q4Q741 Leishmania major 31% 83%
Q4QCW5 Leishmania major 26% 90%
Q54SY2 Dictyostelium discoideum 47% 77%
Q58556 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 50% 74%
Q5AWS6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 43% 81%
Q6CPV1 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 67%
Q6GL04 Xenopus tropicalis 45% 83%
Q7KN62 Drosophila melanogaster 45% 83%
Q7ZU99 Danio rerio 44% 83%
Q8NB90 Homo sapiens 44% 75%
Q8RY16 Arabidopsis thaliana 32% 71%
Q8SSJ5 Encephalitozoon cuniculi (strain GB-M1) 43% 85%
Q96372 Capsicum annuum 45% 83%
Q99LC9 Mus musculus 36% 68%
Q9BVQ7 Homo sapiens 40% 88%
Q9DBY8 Mus musculus 50% 78%
Q9HPF0 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 49% 90%
Q9LZF6 Arabidopsis thaliana 45% 82%
Q9NAG4 Caenorhabditis elegans 44% 82%
Q9P3A7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 82%
Q9SCN8 Arabidopsis thaliana 45% 82%
Q9SS94 Arabidopsis thaliana 46% 81%
Q9ZPR1 Arabidopsis thaliana 38% 100%
V5AUZ1 Trypanosoma cruzi 33% 85%
V5B4G8 Trypanosoma cruzi 37% 89%
V5BD45 Trypanosoma cruzi 74% 100%
V5BKY8 Trypanosoma cruzi 31% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS