Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD81_LEIMA

TriTrypDb:

LmjF.27.1040 , LMJLV39_270016300 , LMJSD75_270016500

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AD81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.687
CLV_C14_Caspase3-7	95	99	PF00656	0.550
CLV_NRD_NRD_1	143	145	PF00675	0.656
CLV_NRD_NRD_1	175	177	PF00675	0.480
CLV_NRD_NRD_1	371	373	PF00675	0.565
CLV_NRD_NRD_1	60	62	PF00675	0.704
CLV_PCSK_KEX2_1	143	145	PF00082	0.643
CLV_PCSK_KEX2_1	175	177	PF00082	0.480
CLV_PCSK_KEX2_1	371	373	PF00082	0.565
CLV_PCSK_KEX2_1	60	62	PF00082	0.704
CLV_PCSK_SKI1_1	243	247	PF00082	0.435
CLV_PCSK_SKI1_1	392	396	PF00082	0.498
DEG_APCC_DBOX_1	222	230	PF00400	0.520
DEG_APCC_DBOX_1	391	399	PF00400	0.653
DEG_COP1_1	33	42	PF00400	0.538
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DOC_CYCLIN_RxL_1	389	399	PF00134	0.652
DOC_MAPK_gen_1	389	397	PF00069	0.736
DOC_MAPK_gen_1	58	68	PF00069	0.507
DOC_MAPK_MEF2A_6	60	69	PF00069	0.503
DOC_PP1_RVXF_1	241	247	PF00149	0.640
DOC_PP1_RVXF_1	399	406	PF00149	0.430
DOC_PP4_FxxP_1	68	71	PF00568	0.476
DOC_PP4_FxxP_1	9	12	PF00568	0.567
DOC_USP7_MATH_1	130	134	PF00917	0.552
DOC_USP7_MATH_1	318	322	PF00917	0.739
DOC_USP7_MATH_1	352	356	PF00917	0.756
DOC_USP7_MATH_1	379	383	PF00917	0.672
DOC_USP7_MATH_1	40	44	PF00917	0.565
DOC_USP7_MATH_1	92	96	PF00917	0.551
DOC_USP7_MATH_2	71	77	PF00917	0.440
DOC_WW_Pin1_4	308	313	PF00397	0.698
DOC_WW_Pin1_4	83	88	PF00397	0.473
LIG_14-3-3_CanoR_1	144	154	PF00244	0.327
LIG_14-3-3_CanoR_1	81	86	PF00244	0.603
LIG_Actin_WH2_2	189	206	PF00022	0.601
LIG_Actin_WH2_2	401	419	PF00022	0.385
LIG_BIR_III_2	317	321	PF00653	0.750
LIG_Clathr_ClatBox_1	254	258	PF01394	0.617
LIG_FHA_1	146	152	PF00498	0.353
LIG_FHA_1	188	194	PF00498	0.617
LIG_FHA_1	24	30	PF00498	0.626
LIG_FHA_1	281	287	PF00498	0.726
LIG_FHA_1	389	395	PF00498	0.662
LIG_FHA_2	260	266	PF00498	0.685
LIG_GBD_Chelix_1	403	411	PF00786	0.378
LIG_IRF3_LxIS_1	120	125	PF10401	0.531
LIG_LIR_Apic_2	8	12	PF02991	0.573
LIG_PCNA_yPIPBox_3	167	178	PF02747	0.635
LIG_SH2_CRK	345	349	PF00017	0.739
LIG_SH2_STAP1	263	267	PF00017	0.642
LIG_SH2_STAP1	356	360	PF00017	0.638
LIG_SH2_STAT5	155	158	PF00017	0.430
LIG_SH3_3	296	302	PF00018	0.696
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.478
LIG_SUMO_SIM_anti_2	181	191	PF11976	0.677
LIG_SUMO_SIM_par_1	160	165	PF11976	0.430
LIG_SUMO_SIM_par_1	181	191	PF11976	0.677
LIG_SUMO_SIM_par_1	393	399	PF11976	0.551
LIG_TRAF2_1	199	202	PF00917	0.538
LIG_TRAF2_1	321	324	PF00917	0.747
LIG_TRAF2_1	35	38	PF00917	0.551
LIG_TYR_ITIM	153	158	PF00017	0.430
LIG_UBA3_1	394	401	PF00899	0.397
LIG_Vh1_VBS_1	380	398	PF01044	0.473
LIG_WRC_WIRS_1	124	129	PF05994	0.506
MOD_CK1_1	133	139	PF00069	0.681
MOD_CK1_1	259	265	PF00069	0.370
MOD_CK1_1	366	372	PF00069	0.687
MOD_CK1_1	374	380	PF00069	0.770
MOD_CK1_1	382	388	PF00069	0.585
MOD_CK1_1	53	59	PF00069	0.746
MOD_CK1_1	80	86	PF00069	0.770
MOD_CK2_1	162	168	PF00069	0.621
MOD_CK2_1	259	265	PF00069	0.584
MOD_CK2_1	318	324	PF00069	0.798
MOD_CK2_1	32	38	PF00069	0.831
MOD_GlcNHglycan	15	18	PF01048	0.716
MOD_GlcNHglycan	164	167	PF01048	0.619
MOD_GlcNHglycan	320	323	PF01048	0.745
MOD_GlcNHglycan	373	376	PF01048	0.759
MOD_GlcNHglycan	377	380	PF01048	0.699
MOD_GlcNHglycan	381	384	PF01048	0.639
MOD_GlcNHglycan	412	415	PF01048	0.461
MOD_GlcNHglycan	94	97	PF01048	0.726
MOD_GSK3_1	118	125	PF00069	0.650
MOD_GSK3_1	13	20	PF00069	0.697
MOD_GSK3_1	276	283	PF00069	0.526
MOD_GSK3_1	359	366	PF00069	0.739
MOD_GSK3_1	367	374	PF00069	0.483
MOD_GSK3_1	375	382	PF00069	0.757
MOD_GSK3_1	50	57	PF00069	0.780
MOD_GSK3_1	73	80	PF00069	0.712
MOD_N-GLC_1	233	238	PF02516	0.516
MOD_N-GLC_1	73	78	PF02516	0.717
MOD_N-GLC_1	92	97	PF02516	0.763
MOD_NEK2_1	122	127	PF00069	0.663
MOD_NEK2_1	187	192	PF00069	0.517
MOD_NEK2_1	256	261	PF00069	0.533
MOD_NEK2_1	351	356	PF00069	0.730
MOD_NEK2_2	40	45	PF00069	0.690
MOD_PIKK_1	205	211	PF00454	0.610
MOD_PIKK_1	294	300	PF00454	0.608
MOD_PKA_1	371	377	PF00069	0.706
MOD_PKA_2	358	364	PF00069	0.710
MOD_PKA_2	371	377	PF00069	0.761
MOD_PKA_2	51	57	PF00069	0.785
MOD_PKA_2	80	86	PF00069	0.793
MOD_Plk_1	233	239	PF00069	0.469
MOD_Plk_1	50	56	PF00069	0.721
MOD_Plk_2-3	102	108	PF00069	0.675
MOD_Plk_4	118	124	PF00069	0.727
MOD_Plk_4	188	194	PF00069	0.508
MOD_Plk_4	277	283	PF00069	0.578
MOD_ProDKin_1	308	314	PF00069	0.629
MOD_ProDKin_1	83	89	PF00069	0.593
MOD_SUMO_for_1	199	202	PF00179	0.638
TRG_DiLeu_BaEn_1	181	186	PF01217	0.526
TRG_DiLeu_BaEn_2	250	256	PF01217	0.444
TRG_ENDOCYTIC_2	155	158	PF00928	0.430
TRG_ER_diArg_1	143	145	PF00400	0.605
TRG_ER_diArg_1	174	176	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL1	Leptomonas seymouri	43%	98%
A0A3S7X0L7	Leishmania donovani	88%	100%
A4HFM7	Leishmania braziliensis	63%	100%
A4I2Q5	Leishmania infantum	89%	100%
E9AZ05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AT52	Trypanosoma cruzi	25%	100%