LeishMANIAdb
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HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
HECT domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AD80_LEIMA
TriTrypDb:
LmjF.27.1030 * , LMJLV39_270016200 * , LMJSD75_270016400 *
Length:
893

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD80
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD80

PDB structure(s): 7am2_BK

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 522 526 PF00656 0.579
CLV_C14_Caspase3-7 664 668 PF00656 0.410
CLV_NRD_NRD_1 619 621 PF00675 0.504
CLV_NRD_NRD_1 660 662 PF00675 0.412
CLV_NRD_NRD_1 691 693 PF00675 0.553
CLV_NRD_NRD_1 830 832 PF00675 0.480
CLV_PCSK_FUR_1 499 503 PF00082 0.576
CLV_PCSK_KEX2_1 501 503 PF00082 0.469
CLV_PCSK_KEX2_1 619 621 PF00082 0.466
CLV_PCSK_KEX2_1 660 662 PF00082 0.412
CLV_PCSK_KEX2_1 690 692 PF00082 0.566
CLV_PCSK_KEX2_1 830 832 PF00082 0.435
CLV_PCSK_PC1ET2_1 501 503 PF00082 0.514
CLV_PCSK_PC1ET2_1 690 692 PF00082 0.612
CLV_PCSK_PC7_1 826 832 PF00082 0.441
CLV_PCSK_SKI1_1 193 197 PF00082 0.507
CLV_PCSK_SKI1_1 236 240 PF00082 0.549
CLV_PCSK_SKI1_1 329 333 PF00082 0.507
CLV_PCSK_SKI1_1 511 515 PF00082 0.453
CLV_PCSK_SKI1_1 666 670 PF00082 0.446
CLV_PCSK_SKI1_1 691 695 PF00082 0.478
CLV_PCSK_SKI1_1 710 714 PF00082 0.202
CLV_PCSK_SKI1_1 798 802 PF00082 0.454
CLV_PCSK_SKI1_1 83 87 PF00082 0.673
CLV_PCSK_SKI1_1 833 837 PF00082 0.458
DEG_APCC_DBOX_1 328 336 PF00400 0.540
DEG_APCC_DBOX_1 709 717 PF00400 0.447
DEG_Nend_UBRbox_1 1 4 PF02207 0.653
DEG_SCF_FBW7_2 872 879 PF00400 0.591
DEG_SPOP_SBC_1 17 21 PF00917 0.796
DEG_SPOP_SBC_1 460 464 PF00917 0.623
DEG_SPOP_SBC_1 774 778 PF00917 0.626
DOC_ANK_TNKS_1 843 850 PF00023 0.444
DOC_CKS1_1 864 869 PF01111 0.467
DOC_CKS1_1 873 878 PF01111 0.464
DOC_CYCLIN_RxL_1 324 336 PF00134 0.556
DOC_CYCLIN_yClb1_LxF_4 227 233 PF00134 0.498
DOC_MAPK_gen_1 190 200 PF00069 0.515
DOC_MAPK_gen_1 427 437 PF00069 0.448
DOC_MAPK_gen_1 663 671 PF00069 0.470
DOC_MAPK_MEF2A_6 163 170 PF00069 0.594
DOC_MAPK_MEF2A_6 430 437 PF00069 0.503
DOC_MAPK_MEF2A_6 473 481 PF00069 0.633
DOC_MAPK_MEF2A_6 744 751 PF00069 0.409
DOC_MAPK_NFAT4_5 430 438 PF00069 0.501
DOC_PP1_RVXF_1 412 418 PF00149 0.583
DOC_PP1_RVXF_1 858 865 PF00149 0.580
DOC_PP4_FxxP_1 55 58 PF00568 0.503
DOC_PP4_FxxP_1 864 867 PF00568 0.609
DOC_USP7_MATH_1 16 20 PF00917 0.796
DOC_USP7_MATH_1 32 36 PF00917 0.693
DOC_USP7_MATH_1 461 465 PF00917 0.703
DOC_USP7_MATH_1 774 778 PF00917 0.624
DOC_USP7_MATH_1 791 795 PF00917 0.422
DOC_USP7_MATH_1 854 858 PF00917 0.531
DOC_USP7_MATH_1 92 96 PF00917 0.778
DOC_USP7_MATH_2 45 51 PF00917 0.639
DOC_WW_Pin1_4 135 140 PF00397 0.725
DOC_WW_Pin1_4 273 278 PF00397 0.476
DOC_WW_Pin1_4 358 363 PF00397 0.749
DOC_WW_Pin1_4 395 400 PF00397 0.543
DOC_WW_Pin1_4 473 478 PF00397 0.631
DOC_WW_Pin1_4 770 775 PF00397 0.593
DOC_WW_Pin1_4 783 788 PF00397 0.566
DOC_WW_Pin1_4 863 868 PF00397 0.463
DOC_WW_Pin1_4 872 877 PF00397 0.453
LIG_14-3-3_CanoR_1 193 198 PF00244 0.514
LIG_14-3-3_CanoR_1 242 247 PF00244 0.493
LIG_14-3-3_CanoR_1 33 37 PF00244 0.634
LIG_14-3-3_CanoR_1 455 461 PF00244 0.484
LIG_14-3-3_CanoR_1 691 699 PF00244 0.536
LIG_14-3-3_CanoR_1 798 806 PF00244 0.494
LIG_Actin_WH2_2 226 241 PF00022 0.476
LIG_Actin_WH2_2 648 665 PF00022 0.503
LIG_Actin_WH2_2 785 800 PF00022 0.441
LIG_BIR_III_4 102 106 PF00653 0.532
LIG_BRCT_BRCA1_1 219 223 PF00533 0.395
LIG_BRCT_BRCA1_1 48 52 PF00533 0.600
LIG_BRCT_BRCA1_1 62 66 PF00533 0.619
LIG_deltaCOP1_diTrp_1 224 232 PF00928 0.539
LIG_deltaCOP1_diTrp_1 406 412 PF00928 0.511
LIG_EH1_1 621 629 PF00400 0.540
LIG_eIF4E_1 217 223 PF01652 0.510
LIG_eIF4E_1 728 734 PF01652 0.385
LIG_FHA_1 129 135 PF00498 0.756
LIG_FHA_1 192 198 PF00498 0.466
LIG_FHA_1 211 217 PF00498 0.471
LIG_FHA_1 461 467 PF00498 0.753
LIG_FHA_1 474 480 PF00498 0.600
LIG_FHA_1 512 518 PF00498 0.399
LIG_FHA_1 535 541 PF00498 0.493
LIG_FHA_1 596 602 PF00498 0.531
LIG_FHA_1 715 721 PF00498 0.533
LIG_FHA_1 776 782 PF00498 0.504
LIG_FHA_1 784 790 PF00498 0.535
LIG_FHA_2 194 200 PF00498 0.482
LIG_FHA_2 725 731 PF00498 0.444
LIG_FHA_2 774 780 PF00498 0.481
LIG_LIR_Apic_2 311 315 PF02991 0.517
LIG_LIR_Gen_1 112 121 PF02991 0.677
LIG_LIR_Gen_1 251 261 PF02991 0.410
LIG_LIR_Gen_1 429 440 PF02991 0.432
LIG_LIR_Gen_1 492 500 PF02991 0.480
LIG_LIR_Gen_1 556 566 PF02991 0.437
LIG_LIR_Nem_3 112 118 PF02991 0.674
LIG_LIR_Nem_3 251 257 PF02991 0.410
LIG_LIR_Nem_3 35 39 PF02991 0.595
LIG_LIR_Nem_3 429 435 PF02991 0.424
LIG_LIR_Nem_3 49 55 PF02991 0.479
LIG_LIR_Nem_3 492 497 PF02991 0.448
LIG_LIR_Nem_3 556 561 PF02991 0.358
LIG_LIR_Nem_3 582 588 PF02991 0.638
LIG_LIR_Nem_3 63 69 PF02991 0.487
LIG_NRBOX 400 406 PF00104 0.452
LIG_NRBOX 430 436 PF00104 0.448
LIG_NRBOX 445 451 PF00104 0.360
LIG_PCNA_yPIPBox_3 175 185 PF02747 0.497
LIG_PCNA_yPIPBox_3 206 216 PF02747 0.552
LIG_Pex14_2 371 375 PF04695 0.601
LIG_PROFILIN_1 8 14 PF00235 0.667
LIG_SH2_CRK 36 40 PF00017 0.541
LIG_SH2_CRK 432 436 PF00017 0.495
LIG_SH2_CRK 874 878 PF00017 0.476
LIG_SH2_PTP2 612 615 PF00017 0.519
LIG_SH2_STAP1 704 708 PF00017 0.478
LIG_SH2_STAT5 244 247 PF00017 0.434
LIG_SH2_STAT5 299 302 PF00017 0.542
LIG_SH2_STAT5 312 315 PF00017 0.575
LIG_SH2_STAT5 612 615 PF00017 0.481
LIG_SH2_STAT5 721 724 PF00017 0.425
LIG_SH2_STAT5 728 731 PF00017 0.356
LIG_SH2_STAT5 741 744 PF00017 0.369
LIG_SH2_STAT5 865 868 PF00017 0.482
LIG_SH2_STAT5 874 877 PF00017 0.469
LIG_SH3_3 136 142 PF00018 0.738
LIG_SH3_3 300 306 PF00018 0.557
LIG_SH3_3 5 11 PF00018 0.748
LIG_SH3_3 581 587 PF00018 0.670
LIG_SH3_3 803 809 PF00018 0.615
LIG_SH3_3 864 870 PF00018 0.480
LIG_SH3_3 883 889 PF00018 0.516
LIG_Sin3_3 286 293 PF02671 0.469
LIG_SUMO_SIM_anti_2 376 385 PF11976 0.485
LIG_TRAF2_1 208 211 PF00917 0.377
LIG_TRFH_1 299 303 PF08558 0.573
LIG_TYR_ITIM 34 39 PF00017 0.554
LIG_TYR_ITIM 400 405 PF00017 0.409
LIG_TYR_ITIM 872 877 PF00017 0.464
LIG_UBA3_1 539 546 PF00899 0.416
LIG_UBA3_1 788 795 PF00899 0.409
LIG_Vh1_VBS_1 641 659 PF01044 0.384
LIG_WW_3 90 94 PF00397 0.764
MOD_CK1_1 119 125 PF00069 0.757
MOD_CK1_1 130 136 PF00069 0.750
MOD_CK1_1 19 25 PF00069 0.818
MOD_CK1_1 248 254 PF00069 0.435
MOD_CK1_1 35 41 PF00069 0.593
MOD_CK1_1 462 468 PF00069 0.728
MOD_CK1_1 495 501 PF00069 0.526
MOD_CK1_1 542 548 PF00069 0.570
MOD_CK1_1 646 652 PF00069 0.417
MOD_CK1_1 756 762 PF00069 0.461
MOD_CK1_1 773 779 PF00069 0.491
MOD_CK1_1 95 101 PF00069 0.802
MOD_CK2_1 205 211 PF00069 0.424
MOD_CK2_1 218 224 PF00069 0.384
MOD_CK2_1 417 423 PF00069 0.554
MOD_CK2_1 532 538 PF00069 0.430
MOD_CMANNOS 409 412 PF00535 0.521
MOD_Cter_Amidation 617 620 PF01082 0.593
MOD_GlcNHglycan 111 114 PF01048 0.686
MOD_GlcNHglycan 117 121 PF01048 0.714
MOD_GlcNHglycan 28 31 PF01048 0.776
MOD_GlcNHglycan 340 343 PF01048 0.374
MOD_GlcNHglycan 387 390 PF01048 0.455
MOD_GlcNHglycan 419 422 PF01048 0.544
MOD_GlcNHglycan 494 497 PF01048 0.486
MOD_GlcNHglycan 534 537 PF01048 0.421
MOD_GlcNHglycan 546 549 PF01048 0.401
MOD_GlcNHglycan 590 593 PF01048 0.602
MOD_GlcNHglycan 645 648 PF01048 0.426
MOD_GlcNHglycan 663 666 PF01048 0.311
MOD_GlcNHglycan 94 97 PF01048 0.729
MOD_GSK3_1 116 123 PF00069 0.669
MOD_GSK3_1 128 135 PF00069 0.705
MOD_GSK3_1 16 23 PF00069 0.789
MOD_GSK3_1 240 247 PF00069 0.484
MOD_GSK3_1 35 42 PF00069 0.656
MOD_GSK3_1 354 361 PF00069 0.773
MOD_GSK3_1 365 372 PF00069 0.659
MOD_GSK3_1 455 462 PF00069 0.706
MOD_GSK3_1 473 480 PF00069 0.393
MOD_GSK3_1 481 488 PF00069 0.494
MOD_GSK3_1 544 551 PF00069 0.565
MOD_GSK3_1 642 649 PF00069 0.355
MOD_GSK3_1 750 757 PF00069 0.423
MOD_GSK3_1 770 777 PF00069 0.325
MOD_N-GLC_1 318 323 PF02516 0.500
MOD_N-GLC_1 343 348 PF02516 0.621
MOD_N-GLC_1 782 787 PF02516 0.606
MOD_NEK2_1 129 134 PF00069 0.773
MOD_NEK2_1 200 205 PF00069 0.409
MOD_NEK2_1 338 343 PF00069 0.551
MOD_NEK2_1 410 415 PF00069 0.580
MOD_NEK2_1 417 422 PF00069 0.502
MOD_NEK2_1 481 486 PF00069 0.587
MOD_NEK2_1 513 518 PF00069 0.497
MOD_NEK2_1 532 537 PF00069 0.218
MOD_NEK2_1 539 544 PF00069 0.406
MOD_NEK2_1 588 593 PF00069 0.582
MOD_NEK2_1 642 647 PF00069 0.356
MOD_NEK2_1 669 674 PF00069 0.348
MOD_NEK2_1 734 739 PF00069 0.381
MOD_PIKK_1 483 489 PF00454 0.611
MOD_PIKK_1 848 854 PF00454 0.558
MOD_PIKK_1 95 101 PF00454 0.754
MOD_PKA_1 691 697 PF00069 0.566
MOD_PKA_2 205 211 PF00069 0.571
MOD_PKA_2 32 38 PF00069 0.664
MOD_PKA_2 369 375 PF00069 0.556
MOD_PKA_2 410 416 PF00069 0.602
MOD_PKA_2 691 697 PF00069 0.508
MOD_PKA_2 92 98 PF00069 0.727
MOD_Plk_1 173 179 PF00069 0.435
MOD_Plk_1 210 216 PF00069 0.520
MOD_Plk_1 217 223 PF00069 0.510
MOD_Plk_1 60 66 PF00069 0.576
MOD_Plk_2-3 218 224 PF00069 0.531
MOD_Plk_2-3 373 379 PF00069 0.520
MOD_Plk_2-3 700 706 PF00069 0.464
MOD_Plk_2-3 724 730 PF00069 0.433
MOD_Plk_4 193 199 PF00069 0.515
MOD_Plk_4 218 224 PF00069 0.466
MOD_Plk_4 39 45 PF00069 0.610
MOD_Plk_4 465 471 PF00069 0.700
MOD_Plk_4 750 756 PF00069 0.430
MOD_Plk_4 813 819 PF00069 0.569
MOD_ProDKin_1 135 141 PF00069 0.728
MOD_ProDKin_1 273 279 PF00069 0.467
MOD_ProDKin_1 358 364 PF00069 0.747
MOD_ProDKin_1 395 401 PF00069 0.537
MOD_ProDKin_1 473 479 PF00069 0.618
MOD_ProDKin_1 770 776 PF00069 0.586
MOD_ProDKin_1 783 789 PF00069 0.560
MOD_ProDKin_1 863 869 PF00069 0.464
MOD_ProDKin_1 872 878 PF00069 0.462
MOD_SUMO_rev_2 388 397 PF00179 0.567
TRG_DiLeu_BaEn_1 275 280 PF01217 0.535
TRG_DiLeu_BaEn_1 638 643 PF01217 0.467
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.509
TRG_DiLeu_BaLyEn_6 508 513 PF01217 0.534
TRG_DiLeu_BaLyEn_6 784 789 PF01217 0.428
TRG_ENDOCYTIC_2 36 39 PF00928 0.547
TRG_ENDOCYTIC_2 402 405 PF00928 0.411
TRG_ENDOCYTIC_2 432 435 PF00928 0.441
TRG_ENDOCYTIC_2 612 615 PF00928 0.569
TRG_ENDOCYTIC_2 874 877 PF00928 0.464
TRG_ER_diArg_1 619 621 PF00400 0.496
TRG_ER_diArg_1 660 663 PF00400 0.426
TRG_ER_diArg_1 69 72 PF00400 0.558
TRG_ER_diArg_1 81 84 PF00400 0.541
TRG_ER_diArg_1 823 826 PF00400 0.453
TRG_ER_diArg_1 829 831 PF00400 0.442
TRG_NES_CRM1_1 282 294 PF08389 0.471
TRG_NES_CRM1_1 429 443 PF08389 0.522
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 329 333 PF00026 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I525 Leptomonas seymouri 67% 95%
A0A0S4JJP4 Bodo saltans 26% 100%
A0A1X0P5I8 Trypanosomatidae 40% 100%
A0A3S7X0L4 Leishmania donovani 96% 100%
A0A422N2Z0 Trypanosoma rangeli 42% 100%
A4HFM6 Leishmania braziliensis 86% 97%
A4I2Q4 Leishmania infantum 96% 100%
D0A5V6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AZ04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5B8L6 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS