Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD79_LEIMA

TriTrypDb:

LmjF.27.1020 , LMJLV39_270016100 , LMJSD75_270016300

Length:

206

Annotations

LeishMANIAdb annotations

This small family of proteins is restricted to kinetoplastids only.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AD79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.384
CLV_PCSK_KEX2_1	140	142	PF00082	0.462
CLV_PCSK_KEX2_1	199	201	PF00082	0.382
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.462
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.400
CLV_PCSK_SKI1_1	201	205	PF00082	0.484
CLV_PCSK_SKI1_1	29	33	PF00082	0.526
CLV_PCSK_SKI1_1	45	49	PF00082	0.450
CLV_PCSK_SKI1_1	93	97	PF00082	0.621
DEG_COP1_1	143	153	PF00400	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DOC_CDC14_PxL_1	165	173	PF14671	0.620
DOC_USP7_MATH_1	118	122	PF00917	0.529
DOC_USP7_UBL2_3	25	29	PF12436	0.715
DOC_USP7_UBL2_3	57	61	PF12436	0.664
LIG_14-3-3_CanoR_1	159	167	PF00244	0.664
LIG_14-3-3_CanoR_1	178	186	PF00244	0.550
LIG_14-3-3_CanoR_1	54	60	PF00244	0.600
LIG_FHA_1	144	150	PF00498	0.642
LIG_FHA_1	41	47	PF00498	0.558
LIG_FHA_2	168	174	PF00498	0.649
LIG_FHA_2	183	189	PF00498	0.571
LIG_FHA_2	19	25	PF00498	0.751
LIG_FHA_2	30	36	PF00498	0.621
LIG_LIR_Gen_1	101	111	PF02991	0.298
LIG_LIR_Gen_1	60	70	PF02991	0.562
LIG_LIR_Nem_3	101	106	PF02991	0.294
LIG_LIR_Nem_3	60	65	PF02991	0.546
LIG_LIR_Nem_3	68	73	PF02991	0.456
LIG_PCNA_yPIPBox_3	189	198	PF02747	0.621
LIG_Pex14_1	103	107	PF04695	0.480
LIG_Pex14_1	71	75	PF04695	0.335
LIG_Pex14_2	107	111	PF04695	0.480
LIG_Pex14_2	72	76	PF04695	0.447
LIG_PTB_Apo_2	64	71	PF02174	0.579
LIG_PTB_Phospho_1	64	70	PF10480	0.580
LIG_REV1ctd_RIR_1	94	102	PF16727	0.396
LIG_SH2_CRK	62	66	PF00017	0.551
LIG_SH2_NCK_1	165	169	PF00017	0.611
LIG_SH2_STAP1	37	41	PF00017	0.650
LIG_SH2_STAP1	62	66	PF00017	0.608
LIG_SH2_STAT5	110	113	PF00017	0.355
LIG_SH2_STAT5	153	156	PF00017	0.662
LIG_SH2_STAT5	75	78	PF00017	0.434
LIG_SH3_3	166	172	PF00018	0.652
LIG_SH3_4	29	36	PF00018	0.655
LIG_TRFH_1	165	169	PF08558	0.577
LIG_TYR_ITIM	163	168	PF00017	0.599
MOD_CK1_1	9	15	PF00069	0.763
MOD_CK2_1	167	173	PF00069	0.650
MOD_CK2_1	29	35	PF00069	0.645
MOD_GlcNHglycan	100	103	PF01048	0.595
MOD_GlcNHglycan	62	65	PF01048	0.420
MOD_NEK2_1	48	53	PF00069	0.655
MOD_NEK2_1	80	85	PF00069	0.342
MOD_NEK2_1	96	101	PF00069	0.371
MOD_PIKK_1	158	164	PF00454	0.660
MOD_PIKK_1	29	35	PF00454	0.684
MOD_PKA_2	158	164	PF00069	0.646
MOD_PKA_2	53	59	PF00069	0.624
MOD_Plk_1	182	188	PF00069	0.676
MOD_Plk_4	119	125	PF00069	0.597
MOD_Plk_4	6	12	PF00069	0.754
MOD_SUMO_for_1	163	166	PF00179	0.583
MOD_SUMO_rev_2	135	142	PF00179	0.619
TRG_ENDOCYTIC_2	165	168	PF00928	0.608
TRG_ENDOCYTIC_2	62	65	PF00928	0.533
TRG_ENDOCYTIC_2	73	76	PF00928	0.300
TRG_ER_diArg_1	52	55	PF00400	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX1	Leptomonas seymouri	71%	100%
A0A0S4JB41	Bodo saltans	39%	100%
A0A1X0P566	Trypanosomatidae	52%	100%
A0A3S7X0K5	Leishmania donovani	97%	100%
A0A422N2U5	Trypanosoma rangeli	52%	100%
A4HFM5	Leishmania braziliensis	90%	100%
A4I2Q3	Leishmania infantum	97%	100%
D0A5V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AZ03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%