LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AD79_LEIMA
TriTrypDb:
LmjF.27.1020 , LMJLV39_270016100 , LMJSD75_270016300
Length:
206

Annotations

LeishMANIAdb annotations

This small family of proteins is restricted to kinetoplastids only.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 9
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

E9AD79
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD79

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 199 201 PF00675 0.384
CLV_PCSK_KEX2_1 140 142 PF00082 0.462
CLV_PCSK_KEX2_1 199 201 PF00082 0.382
CLV_PCSK_PC1ET2_1 140 142 PF00082 0.462
CLV_PCSK_PC1ET2_1 199 201 PF00082 0.400
CLV_PCSK_SKI1_1 201 205 PF00082 0.484
CLV_PCSK_SKI1_1 29 33 PF00082 0.526
CLV_PCSK_SKI1_1 45 49 PF00082 0.450
CLV_PCSK_SKI1_1 93 97 PF00082 0.621
DEG_COP1_1 143 153 PF00400 0.681
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PCX1 Leptomonas seymouri 71% 100%
A0A0S4JB41 Bodo saltans 39% 100%
A0A1X0P566 Trypanosomatidae 52% 100%
A0A3S7X0K5 Leishmania donovani 97% 100%
A0A422N2U5 Trypanosoma rangeli 52% 100%
A4HFM5 Leishmania braziliensis 90% 100%
A4I2Q3 Leishmania infantum 97% 100%
D0A5V5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AZ03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS