LeishMANIAdb
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Exocyst complex component Sec6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Exocyst complex component Sec6
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AD78_LEIMA
TriTrypDb:
LmjF.27.1010 , LMJLV39_270016000 * , LMJSD75_270016200 *
Length:
934

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000145 exocyst 3 11
GO:0005737 cytoplasm 2 2
GO:0020016 ciliary pocket 2 2
GO:0032991 protein-containing complex 1 11
GO:0099023 vesicle tethering complex 2 11
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AD78
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD78

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0006887 exocytosis 4 11
GO:0009987 cellular process 1 11
GO:0016192 vesicle-mediated transport 4 11
GO:0031503 protein-containing complex localization 2 2
GO:0032940 secretion by cell 3 11
GO:0046903 secretion 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051601 exocyst localization 3 2
GO:0140352 export from cell 2 11
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 2
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 602 606 PF00656 0.701
CLV_NRD_NRD_1 100 102 PF00675 0.469
CLV_NRD_NRD_1 206 208 PF00675 0.493
CLV_NRD_NRD_1 562 564 PF00675 0.388
CLV_NRD_NRD_1 623 625 PF00675 0.407
CLV_NRD_NRD_1 694 696 PF00675 0.337
CLV_NRD_NRD_1 877 879 PF00675 0.432
CLV_NRD_NRD_1 896 898 PF00675 0.468
CLV_NRD_NRD_1 900 902 PF00675 0.505
CLV_PCSK_KEX2_1 100 102 PF00082 0.486
CLV_PCSK_KEX2_1 206 208 PF00082 0.452
CLV_PCSK_KEX2_1 562 564 PF00082 0.377
CLV_PCSK_KEX2_1 835 837 PF00082 0.275
CLV_PCSK_KEX2_1 877 879 PF00082 0.498
CLV_PCSK_KEX2_1 893 895 PF00082 0.385
CLV_PCSK_KEX2_1 900 902 PF00082 0.519
CLV_PCSK_PC1ET2_1 835 837 PF00082 0.345
CLV_PCSK_PC1ET2_1 893 895 PF00082 0.436
CLV_PCSK_SKI1_1 132 136 PF00082 0.425
CLV_PCSK_SKI1_1 3 7 PF00082 0.663
CLV_PCSK_SKI1_1 562 566 PF00082 0.353
CLV_PCSK_SKI1_1 695 699 PF00082 0.271
CLV_PCSK_SKI1_1 773 777 PF00082 0.264
CLV_PCSK_SKI1_1 872 876 PF00082 0.459
CLV_PCSK_SKI1_1 890 894 PF00082 0.519
CLV_PCSK_SKI1_1 909 913 PF00082 0.693
DEG_SCF_FBW7_1 910 916 PF00400 0.577
DOC_CKS1_1 619 624 PF01111 0.505
DOC_CKS1_1 910 915 PF01111 0.640
DOC_CYCLIN_RxL_1 197 208 PF00134 0.442
DOC_CYCLIN_RxL_1 757 768 PF00134 0.549
DOC_CYCLIN_RxL_1 770 777 PF00134 0.528
DOC_MAPK_gen_1 244 253 PF00069 0.433
DOC_MAPK_gen_1 464 473 PF00069 0.397
DOC_MAPK_gen_1 624 631 PF00069 0.361
DOC_MAPK_gen_1 693 703 PF00069 0.538
DOC_MAPK_MEF2A_6 230 237 PF00069 0.431
DOC_MAPK_MEF2A_6 247 255 PF00069 0.433
DOC_MAPK_MEF2A_6 741 749 PF00069 0.500
DOC_PP4_FxxP_1 619 622 PF00568 0.518
DOC_SPAK_OSR1_1 805 809 PF12202 0.394
DOC_USP7_MATH_1 102 106 PF00917 0.460
DOC_USP7_MATH_1 765 769 PF00917 0.394
DOC_USP7_MATH_1 888 892 PF00917 0.645
DOC_USP7_UBL2_3 60 64 PF12436 0.526
DOC_USP7_UBL2_3 835 839 PF12436 0.501
DOC_WW_Pin1_4 28 33 PF00397 0.642
DOC_WW_Pin1_4 593 598 PF00397 0.572
DOC_WW_Pin1_4 618 623 PF00397 0.428
DOC_WW_Pin1_4 909 914 PF00397 0.642
LIG_14-3-3_CanoR_1 206 210 PF00244 0.366
LIG_14-3-3_CanoR_1 216 221 PF00244 0.443
LIG_14-3-3_CanoR_1 44 53 PF00244 0.505
LIG_14-3-3_CanoR_1 90 99 PF00244 0.407
LIG_Actin_RPEL_3 186 205 PF02755 0.448
LIG_Actin_WH2_2 124 139 PF00022 0.538
LIG_Actin_WH2_2 161 178 PF00022 0.398
LIG_Actin_WH2_2 574 589 PF00022 0.386
LIG_AP2alpha_2 349 351 PF02296 0.435
LIG_APCC_ABBA_1 224 229 PF00400 0.414
LIG_APCC_ABBA_1 354 359 PF00400 0.497
LIG_BIR_II_1 1 5 PF00653 0.731
LIG_BRCT_BRCA1_1 190 194 PF00533 0.494
LIG_BRCT_BRCA1_1 36 40 PF00533 0.700
LIG_BRCT_BRCA1_1 446 450 PF00533 0.487
LIG_BRCT_BRCA1_1 619 623 PF00533 0.523
LIG_BRCT_BRCA1_1 866 870 PF00533 0.573
LIG_BRCT_BRCA1_2 36 42 PF00533 0.558
LIG_BRCT_BRCA1_2 619 625 PF00533 0.474
LIG_CaM_IQ_9 199 214 PF13499 0.453
LIG_CtBP_PxDLS_1 781 785 PF00389 0.394
LIG_deltaCOP1_diTrp_1 557 566 PF00928 0.364
LIG_deltaCOP1_diTrp_1 650 657 PF00928 0.405
LIG_eIF4E_1 46 52 PF01652 0.510
LIG_FHA_1 11 17 PF00498 0.729
LIG_FHA_1 450 456 PF00498 0.518
LIG_FHA_1 489 495 PF00498 0.481
LIG_FHA_1 581 587 PF00498 0.392
LIG_FHA_1 665 671 PF00498 0.454
LIG_FHA_1 71 77 PF00498 0.585
LIG_FHA_1 799 805 PF00498 0.484
LIG_FHA_1 906 912 PF00498 0.650
LIG_FHA_2 45 51 PF00498 0.494
LIG_FHA_2 507 513 PF00498 0.489
LIG_FHA_2 573 579 PF00498 0.395
LIG_FHA_2 674 680 PF00498 0.444
LIG_FHA_2 710 716 PF00498 0.481
LIG_FHA_2 732 738 PF00498 0.490
LIG_FHA_2 77 83 PF00498 0.591
LIG_LIR_Apic_2 402 406 PF02991 0.442
LIG_LIR_Apic_2 593 597 PF02991 0.623
LIG_LIR_Apic_2 617 622 PF02991 0.558
LIG_LIR_Apic_2 843 849 PF02991 0.572
LIG_LIR_Gen_1 219 228 PF02991 0.449
LIG_LIR_Gen_1 288 298 PF02991 0.421
LIG_LIR_Gen_1 325 336 PF02991 0.500
LIG_LIR_Gen_1 439 448 PF02991 0.447
LIG_LIR_Gen_1 495 505 PF02991 0.413
LIG_LIR_Gen_1 525 533 PF02991 0.442
LIG_LIR_Gen_1 650 657 PF02991 0.440
LIG_LIR_Gen_1 682 689 PF02991 0.500
LIG_LIR_Gen_1 731 739 PF02991 0.476
LIG_LIR_LC3C_4 386 389 PF02991 0.433
LIG_LIR_Nem_3 123 128 PF02991 0.441
LIG_LIR_Nem_3 149 155 PF02991 0.442
LIG_LIR_Nem_3 177 183 PF02991 0.442
LIG_LIR_Nem_3 219 223 PF02991 0.467
LIG_LIR_Nem_3 225 231 PF02991 0.383
LIG_LIR_Nem_3 272 277 PF02991 0.634
LIG_LIR_Nem_3 288 293 PF02991 0.524
LIG_LIR_Nem_3 325 331 PF02991 0.446
LIG_LIR_Nem_3 349 354 PF02991 0.507
LIG_LIR_Nem_3 431 437 PF02991 0.348
LIG_LIR_Nem_3 439 443 PF02991 0.526
LIG_LIR_Nem_3 495 500 PF02991 0.392
LIG_LIR_Nem_3 525 531 PF02991 0.441
LIG_LIR_Nem_3 620 626 PF02991 0.453
LIG_LIR_Nem_3 632 638 PF02991 0.401
LIG_LIR_Nem_3 650 656 PF02991 0.384
LIG_LIR_Nem_3 731 735 PF02991 0.458
LIG_MAD2 909 917 PF02301 0.601
LIG_MLH1_MIPbox_1 866 870 PF16413 0.624
LIG_NRBOX 771 777 PF00104 0.448
LIG_NRBOX 783 789 PF00104 0.374
LIG_Pex14_1 653 657 PF04695 0.346
LIG_Pex14_2 220 224 PF04695 0.426
LIG_Pex14_2 566 570 PF04695 0.302
LIG_Pex14_2 588 592 PF04695 0.390
LIG_Pex14_2 619 623 PF04695 0.504
LIG_Pex14_2 802 806 PF04695 0.457
LIG_PTB_Apo_2 237 244 PF02174 0.426
LIG_PTB_Phospho_1 237 243 PF10480 0.422
LIG_REV1ctd_RIR_1 867 876 PF16727 0.512
LIG_RPA_C_Fungi 895 907 PF08784 0.597
LIG_SH2_CRK 125 129 PF00017 0.539
LIG_SH2_CRK 180 184 PF00017 0.525
LIG_SH2_CRK 196 200 PF00017 0.386
LIG_SH2_CRK 243 247 PF00017 0.482
LIG_SH2_CRK 403 407 PF00017 0.398
LIG_SH2_CRK 594 598 PF00017 0.555
LIG_SH2_GRB2like 403 406 PF00017 0.360
LIG_SH2_GRB2like 54 57 PF00017 0.397
LIG_SH2_GRB2like 709 712 PF00017 0.362
LIG_SH2_NCK_1 403 407 PF00017 0.499
LIG_SH2_NCK_1 594 598 PF00017 0.637
LIG_SH2_NCK_1 663 667 PF00017 0.362
LIG_SH2_SRC 663 666 PF00017 0.212
LIG_SH2_STAP1 434 438 PF00017 0.385
LIG_SH2_STAT3 357 360 PF00017 0.397
LIG_SH2_STAT3 786 789 PF00017 0.413
LIG_SH2_STAT5 227 230 PF00017 0.400
LIG_SH2_STAT5 328 331 PF00017 0.298
LIG_SH2_STAT5 357 360 PF00017 0.353
LIG_SH2_STAT5 437 440 PF00017 0.385
LIG_SH2_STAT5 46 49 PF00017 0.494
LIG_SH2_STAT5 530 533 PF00017 0.319
LIG_SH2_STAT5 54 57 PF00017 0.485
LIG_SH2_STAT5 637 640 PF00017 0.345
LIG_SH2_STAT5 680 683 PF00017 0.234
LIG_SH2_STAT5 709 712 PF00017 0.309
LIG_SH2_STAT5 786 789 PF00017 0.414
LIG_SH3_3 220 226 PF00018 0.448
LIG_SH3_3 344 350 PF00018 0.385
LIG_SH3_3 775 781 PF00018 0.300
LIG_SH3_3 80 86 PF00018 0.466
LIG_SUMO_SIM_anti_2 229 236 PF11976 0.487
LIG_SUMO_SIM_anti_2 512 517 PF11976 0.530
LIG_SUMO_SIM_anti_2 768 773 PF11976 0.212
LIG_SUMO_SIM_par_1 490 498 PF11976 0.437
LIG_TRAF2_1 47 50 PF00917 0.517
LIG_TRAF2_1 555 558 PF00917 0.527
LIG_TYR_ITAM 177 199 PF00017 0.513
LIG_TYR_ITIM 150 155 PF00017 0.555
LIG_TYR_ITIM 178 183 PF00017 0.522
LIG_UBA3_1 375 381 PF00899 0.448
LIG_UBA3_1 51 60 PF00899 0.538
LIG_UBA3_1 702 708 PF00899 0.312
LIG_WRC_WIRS_1 217 222 PF05994 0.555
MOD_CDK_SPK_2 913 918 PF00069 0.636
MOD_CDK_SPxK_1 618 624 PF00069 0.438
MOD_CDK_SPxxK_3 28 35 PF00069 0.533
MOD_CDK_SPxxK_3 618 625 PF00069 0.486
MOD_CK1_1 105 111 PF00069 0.426
MOD_CK1_1 31 37 PF00069 0.631
MOD_CK1_1 449 455 PF00069 0.446
MOD_CK1_1 70 76 PF00069 0.573
MOD_CK1_1 731 737 PF00069 0.351
MOD_CK1_1 91 97 PF00069 0.362
MOD_CK2_1 44 50 PF00069 0.509
MOD_CK2_1 572 578 PF00069 0.326
MOD_CK2_1 673 679 PF00069 0.362
MOD_CK2_1 709 715 PF00069 0.320
MOD_CK2_1 76 82 PF00069 0.582
MOD_CK2_1 856 862 PF00069 0.511
MOD_GlcNHglycan 16 19 PF01048 0.715
MOD_GlcNHglycan 36 39 PF01048 0.657
MOD_GlcNHglycan 439 443 PF01048 0.418
MOD_GlcNHglycan 444 449 PF01048 0.379
MOD_GlcNHglycan 484 487 PF01048 0.467
MOD_GlcNHglycan 607 610 PF01048 0.741
MOD_GlcNHglycan 866 869 PF01048 0.578
MOD_GlcNHglycan 889 893 PF01048 0.652
MOD_GSK3_1 10 17 PF00069 0.725
MOD_GSK3_1 102 109 PF00069 0.500
MOD_GSK3_1 26 33 PF00069 0.604
MOD_GSK3_1 261 268 PF00069 0.659
MOD_GSK3_1 34 41 PF00069 0.560
MOD_GSK3_1 456 463 PF00069 0.454
MOD_GSK3_1 478 485 PF00069 0.483
MOD_GSK3_1 572 579 PF00069 0.461
MOD_GSK3_1 691 698 PF00069 0.386
MOD_GSK3_1 840 847 PF00069 0.577
MOD_GSK3_1 848 855 PF00069 0.526
MOD_GSK3_1 905 912 PF00069 0.588
MOD_N-GLC_1 163 168 PF02516 0.529
MOD_N-GLC_1 546 551 PF02516 0.487
MOD_N-GLC_2 572 574 PF02516 0.324
MOD_NEK2_1 1 6 PF00069 0.738
MOD_NEK2_1 371 376 PF00069 0.402
MOD_NEK2_1 428 433 PF00069 0.453
MOD_NEK2_1 446 451 PF00069 0.403
MOD_NEK2_1 500 505 PF00069 0.405
MOD_NEK2_1 81 86 PF00069 0.505
MOD_NEK2_1 870 875 PF00069 0.559
MOD_NEK2_1 88 93 PF00069 0.518
MOD_NEK2_2 352 357 PF00069 0.465
MOD_PIKK_1 106 112 PF00454 0.450
MOD_PIKK_1 317 323 PF00454 0.498
MOD_PIKK_1 809 815 PF00454 0.362
MOD_PIKK_1 844 850 PF00454 0.556
MOD_PKA_1 695 701 PF00069 0.362
MOD_PKA_1 725 731 PF00069 0.362
MOD_PKA_1 835 841 PF00069 0.394
MOD_PKA_2 10 16 PF00069 0.733
MOD_PKA_2 205 211 PF00069 0.389
MOD_PKA_2 816 822 PF00069 0.314
MOD_PKA_2 835 841 PF00069 0.381
MOD_PKB_1 693 701 PF00069 0.413
MOD_Plk_1 163 169 PF00069 0.498
MOD_Plk_1 371 377 PF00069 0.376
MOD_Plk_1 416 422 PF00069 0.458
MOD_Plk_1 438 444 PF00069 0.573
MOD_Plk_1 511 517 PF00069 0.528
MOD_Plk_1 546 552 PF00069 0.580
MOD_Plk_1 572 578 PF00069 0.326
MOD_Plk_1 743 749 PF00069 0.392
MOD_Plk_1 81 87 PF00069 0.503
MOD_Plk_1 828 834 PF00069 0.413
MOD_Plk_1 856 862 PF00069 0.424
MOD_Plk_2-3 261 267 PF00069 0.680
MOD_Plk_2-3 573 579 PF00069 0.357
MOD_Plk_2-3 925 931 PF00069 0.660
MOD_Plk_4 164 170 PF00069 0.434
MOD_Plk_4 233 239 PF00069 0.359
MOD_Plk_4 371 377 PF00069 0.468
MOD_Plk_4 416 422 PF00069 0.480
MOD_Plk_4 446 452 PF00069 0.476
MOD_Plk_4 478 484 PF00069 0.533
MOD_Plk_4 511 517 PF00069 0.531
MOD_Plk_4 526 532 PF00069 0.434
MOD_Plk_4 684 690 PF00069 0.397
MOD_Plk_4 709 715 PF00069 0.335
MOD_Plk_4 728 734 PF00069 0.415
MOD_Plk_4 745 751 PF00069 0.370
MOD_Plk_4 798 804 PF00069 0.315
MOD_Plk_4 848 854 PF00069 0.403
MOD_ProDKin_1 28 34 PF00069 0.641
MOD_ProDKin_1 593 599 PF00069 0.578
MOD_ProDKin_1 618 624 PF00069 0.427
MOD_ProDKin_1 909 915 PF00069 0.642
MOD_SUMO_for_1 63 66 PF00179 0.538
MOD_SUMO_rev_2 57 62 PF00179 0.498
MOD_SUMO_rev_2 579 589 PF00179 0.407
TRG_DiLeu_BaEn_1 411 416 PF01217 0.430
TRG_DiLeu_BaEn_2 416 422 PF01217 0.338
TRG_DiLeu_BaEn_3 683 689 PF01217 0.413
TRG_DiLeu_BaEn_4 324 330 PF01217 0.300
TRG_DiLeu_BaEn_4 58 64 PF01217 0.574
TRG_DiLeu_BaLyEn_6 363 368 PF01217 0.424
TRG_DiLeu_BaLyEn_6 757 762 PF01217 0.337
TRG_DiLeu_BaLyEn_6 84 89 PF01217 0.486
TRG_ENDOCYTIC_2 125 128 PF00928 0.541
TRG_ENDOCYTIC_2 152 155 PF00928 0.418
TRG_ENDOCYTIC_2 180 183 PF00928 0.431
TRG_ENDOCYTIC_2 184 187 PF00928 0.417
TRG_ENDOCYTIC_2 196 199 PF00928 0.413
TRG_ENDOCYTIC_2 217 220 PF00928 0.542
TRG_ENDOCYTIC_2 243 246 PF00928 0.398
TRG_ENDOCYTIC_2 328 331 PF00928 0.424
TRG_ENDOCYTIC_2 425 428 PF00928 0.371
TRG_ENDOCYTIC_2 437 440 PF00928 0.373
TRG_ENDOCYTIC_2 528 531 PF00928 0.442
TRG_ER_diArg_1 205 207 PF00400 0.463
TRG_ER_diArg_1 562 564 PF00400 0.377
TRG_ER_diArg_1 99 101 PF00400 0.488
TRG_NES_CRM1_1 229 241 PF08389 0.432
TRG_NES_CRM1_1 66 80 PF08389 0.582
TRG_NLS_MonoExtC_3 896 901 PF00514 0.503
TRG_NLS_MonoExtN_4 894 901 PF00514 0.518
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 257 261 PF00026 0.506
TRG_Pf-PMV_PEXEL_1 624 628 PF00026 0.401
TRG_Pf-PMV_PEXEL_1 695 700 PF00026 0.352
TRG_Pf-PMV_PEXEL_1 858 862 PF00026 0.427
TRG_Pf-PMV_PEXEL_1 872 876 PF00026 0.489

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY82 Leptomonas seymouri 71% 97%
A0A0S4JGX2 Bodo saltans 35% 100%
A0A1X0P4D3 Trypanosomatidae 52% 100%
A0A3Q8IE79 Leishmania donovani 96% 100%
A0A3R7M5J1 Trypanosoma rangeli 51% 100%
A4HFM4 Leishmania braziliensis 84% 99%
A4I2Q2 Leishmania infantum 96% 100%
D0A5V4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AZ02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS