Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD76_LEIMA

TriTrypDb:

LmjF.27.0990 , LMJLV39_270015800 , LMJSD75_270016000

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.724
CLV_NRD_NRD_1	252	254	PF00675	0.662
CLV_NRD_NRD_1	35	37	PF00675	0.568
CLV_PCSK_KEX2_1	2	4	PF00082	0.593
CLV_PCSK_KEX2_1	23	25	PF00082	0.744
CLV_PCSK_KEX2_1	252	254	PF00082	0.662
CLV_PCSK_KEX2_1	35	37	PF00082	0.604
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.593
CLV_PCSK_SKI1_1	146	150	PF00082	0.460
CLV_PCSK_SKI1_1	35	39	PF00082	0.603
DEG_COP1_1	263	272	PF00400	0.543
DEG_MDM2_SWIB_1	159	166	PF02201	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.634
DEG_SPOP_SBC_1	116	120	PF00917	0.660
DEG_SPOP_SBC_1	26	30	PF00917	0.679
DOC_AGCK_PIF_2	68	73	PF00069	0.603
DOC_CYCLIN_RxL_1	143	153	PF00134	0.474
DOC_CYCLIN_RxL_1	32	42	PF00134	0.422
DOC_MAPK_gen_1	35	45	PF00069	0.546
DOC_MAPK_MEF2A_6	39	47	PF00069	0.541
DOC_USP7_MATH_1	116	120	PF00917	0.654
DOC_USP7_MATH_1	201	205	PF00917	0.761
DOC_USP7_MATH_1	216	220	PF00917	0.772
DOC_USP7_MATH_1	222	226	PF00917	0.788
DOC_USP7_MATH_1	234	238	PF00917	0.570
DOC_USP7_MATH_1	26	30	PF00917	0.664
DOC_USP7_MATH_1	88	92	PF00917	0.648
DOC_USP7_MATH_1	95	99	PF00917	0.564
DOC_WW_Pin1_4	150	155	PF00397	0.631
DOC_WW_Pin1_4	188	193	PF00397	0.536
DOC_WW_Pin1_4	197	202	PF00397	0.779
DOC_WW_Pin1_4	206	211	PF00397	0.725
DOC_WW_Pin1_4	227	232	PF00397	0.671
LIG_14-3-3_CanoR_1	24	34	PF00244	0.629
LIG_FHA_1	121	127	PF00498	0.488
LIG_FHA_1	183	189	PF00498	0.741
LIG_FHA_1	197	203	PF00498	0.517
LIG_FHA_1	228	234	PF00498	0.583
LIG_FHA_1	238	244	PF00498	0.750
LIG_FHA_1	53	59	PF00498	0.569
LIG_FHA_1	81	87	PF00498	0.496
LIG_FHA_2	151	157	PF00498	0.551
LIG_FHA_2	245	251	PF00498	0.541
LIG_FHA_2	26	32	PF00498	0.744
LIG_FHA_2	88	94	PF00498	0.599
LIG_GBD_Chelix_1	235	243	PF00786	0.641
LIG_LIR_Gen_1	160	171	PF02991	0.573
LIG_LIR_Gen_1	263	272	PF02991	0.628
LIG_LIR_Nem_3	160	166	PF02991	0.577
LIG_LIR_Nem_3	263	267	PF02991	0.632
LIG_LIR_Nem_3	72	77	PF02991	0.688
LIG_NRP_CendR_1	278	280	PF00754	0.627
LIG_Pex14_2	159	163	PF04695	0.470
LIG_REV1ctd_RIR_1	71	79	PF16727	0.512
LIG_SH2_NCK_1	264	268	PF00017	0.575
LIG_SH3_3	131	137	PF00018	0.393
LIG_SH3_3	228	234	PF00018	0.691
LIG_SH3_3	40	46	PF00018	0.577
LIG_SH3_3	63	69	PF00018	0.547
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.588
LIG_TRAF2_1	248	251	PF00917	0.654
MOD_CK1_1	100	106	PF00069	0.704
MOD_CK1_1	182	188	PF00069	0.700
MOD_CK1_1	225	231	PF00069	0.713
MOD_CK1_1	237	243	PF00069	0.635
MOD_CK1_1	25	31	PF00069	0.692
MOD_CK2_1	150	156	PF00069	0.548
MOD_CK2_1	244	250	PF00069	0.606
MOD_CK2_1	25	31	PF00069	0.645
MOD_CK2_1	47	53	PF00069	0.517
MOD_GlcNHglycan	102	105	PF01048	0.696
MOD_GlcNHglycan	111	114	PF01048	0.703
MOD_GlcNHglycan	181	184	PF01048	0.660
MOD_GlcNHglycan	222	225	PF01048	0.613
MOD_GlcNHglycan	24	27	PF01048	0.749
MOD_GlcNHglycan	270	273	PF01048	0.618
MOD_GlcNHglycan	97	100	PF01048	0.660
MOD_GSK3_1	105	112	PF00069	0.769
MOD_GSK3_1	116	123	PF00069	0.521
MOD_GSK3_1	18	25	PF00069	0.737
MOD_GSK3_1	197	204	PF00069	0.600
MOD_GSK3_1	216	223	PF00069	0.567
MOD_N-GLC_1	197	202	PF02516	0.708
MOD_NEK2_1	105	110	PF00069	0.771
MOD_NEK2_1	239	244	PF00069	0.704
MOD_NEK2_1	47	52	PF00069	0.569
MOD_PIKK_1	222	228	PF00454	0.655
MOD_PKA_2	22	28	PF00069	0.599
MOD_Plk_1	106	112	PF00069	0.674
MOD_Plk_4	234	240	PF00069	0.582
MOD_Plk_4	47	53	PF00069	0.507
MOD_ProDKin_1	150	156	PF00069	0.630
MOD_ProDKin_1	188	194	PF00069	0.538
MOD_ProDKin_1	197	203	PF00069	0.780
MOD_ProDKin_1	206	212	PF00069	0.725
MOD_ProDKin_1	227	233	PF00069	0.671
MOD_SUMO_rev_2	25	34	PF00179	0.456
MOD_SUMO_rev_2	6	11	PF00179	0.566
TRG_DiLeu_BaEn_2	130	136	PF01217	0.581
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.470
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.429
TRG_ENDOCYTIC_2	264	267	PF00928	0.554
TRG_ER_diArg_1	252	255	PF00400	0.613
TRG_ER_diArg_1	34	36	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J0	Leptomonas seymouri	45%	100%
A0A1X0P427	Trypanosomatidae	34%	100%
A0A3S7X0L8	Leishmania donovani	90%	100%
A0A422N2W4	Trypanosoma rangeli	32%	100%
A4HFM2	Leishmania braziliensis	73%	100%
A4I2Q0	Leishmania infantum	90%	100%
D0A5V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AZ00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%