Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD72_LEIMA

TriTrypDb:

LmjF.27.0950 , LMJLV39_270015300 , LMJSD75_270015300

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.585
CLV_C14_Caspase3-7	593	597	PF00656	0.711
CLV_C14_Caspase3-7	80	84	PF00656	0.548
CLV_NRD_NRD_1	216	218	PF00675	0.791
CLV_NRD_NRD_1	243	245	PF00675	0.581
CLV_NRD_NRD_1	329	331	PF00675	0.651
CLV_NRD_NRD_1	438	440	PF00675	0.758
CLV_NRD_NRD_1	44	46	PF00675	0.784
CLV_NRD_NRD_1	499	501	PF00675	0.694
CLV_NRD_NRD_1	781	783	PF00675	0.601
CLV_NRD_NRD_1	855	857	PF00675	0.545
CLV_PCSK_KEX2_1	216	218	PF00082	0.787
CLV_PCSK_KEX2_1	329	331	PF00082	0.651
CLV_PCSK_KEX2_1	437	439	PF00082	0.759
CLV_PCSK_KEX2_1	44	46	PF00082	0.803
CLV_PCSK_KEX2_1	498	500	PF00082	0.659
CLV_PCSK_KEX2_1	781	783	PF00082	0.601
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.610
CLV_PCSK_PC7_1	777	783	PF00082	0.478
CLV_PCSK_SKI1_1	351	355	PF00082	0.749
CLV_PCSK_SKI1_1	495	499	PF00082	0.624
CLV_PCSK_SKI1_1	51	55	PF00082	0.750
CLV_PCSK_SKI1_1	660	664	PF00082	0.532
CLV_PCSK_SKI1_1	875	879	PF00082	0.501
DEG_APCC_DBOX_1	56	64	PF00400	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.707
DEG_SPOP_SBC_1	248	252	PF00917	0.566
DEG_SPOP_SBC_1	455	459	PF00917	0.772
DEG_SPOP_SBC_1	504	508	PF00917	0.681
DEG_SPOP_SBC_1	78	82	PF00917	0.414
DOC_CDC14_PxL_1	186	194	PF14671	0.708
DOC_CKS1_1	461	466	PF01111	0.607
DOC_CKS1_1	531	536	PF01111	0.802
DOC_CYCLIN_yCln2_LP_2	616	622	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	711	717	PF00134	0.600
DOC_MAPK_gen_1	54	63	PF00069	0.469
DOC_MAPK_gen_1	673	682	PF00069	0.542
DOC_MAPK_gen_1	730	738	PF00069	0.495
DOC_MAPK_gen_1	820	829	PF00069	0.464
DOC_MAPK_MEF2A_6	820	829	PF00069	0.463
DOC_PP1_SILK_1	333	338	PF00149	0.576
DOC_PP2B_LxvP_1	375	378	PF13499	0.759
DOC_PP2B_LxvP_1	556	559	PF13499	0.578
DOC_PP2B_LxvP_1	616	619	PF13499	0.695
DOC_PP2B_LxvP_1	707	710	PF13499	0.553
DOC_PP2B_LxvP_1	864	867	PF13499	0.634
DOC_PP4_FxxP_1	345	348	PF00568	0.687
DOC_USP7_MATH_1	16	20	PF00917	0.689
DOC_USP7_MATH_1	27	31	PF00917	0.755
DOC_USP7_MATH_1	295	299	PF00917	0.809
DOC_USP7_MATH_1	370	374	PF00917	0.733
DOC_USP7_MATH_1	398	402	PF00917	0.723
DOC_USP7_MATH_1	429	433	PF00917	0.741
DOC_USP7_MATH_1	453	457	PF00917	0.651
DOC_USP7_MATH_1	49	53	PF00917	0.732
DOC_USP7_MATH_1	583	587	PF00917	0.765
DOC_USP7_MATH_1	620	624	PF00917	0.719
DOC_USP7_MATH_1	776	780	PF00917	0.694
DOC_USP7_MATH_1	880	884	PF00917	0.425
DOC_USP7_UBL2_3	748	752	PF12436	0.472
DOC_WW_Pin1_4	222	227	PF00397	0.563
DOC_WW_Pin1_4	351	356	PF00397	0.736
DOC_WW_Pin1_4	366	371	PF00397	0.695
DOC_WW_Pin1_4	377	382	PF00397	0.720
DOC_WW_Pin1_4	460	465	PF00397	0.687
DOC_WW_Pin1_4	516	521	PF00397	0.745
DOC_WW_Pin1_4	530	535	PF00397	0.677
DOC_WW_Pin1_4	550	555	PF00397	0.714
DOC_WW_Pin1_4	717	722	PF00397	0.497
LIG_14-3-3_CanoR_1	123	130	PF00244	0.602
LIG_14-3-3_CanoR_1	137	144	PF00244	0.649
LIG_14-3-3_CanoR_1	172	176	PF00244	0.740
LIG_14-3-3_CanoR_1	195	199	PF00244	0.565
LIG_14-3-3_CanoR_1	26	32	PF00244	0.678
LIG_14-3-3_CanoR_1	437	446	PF00244	0.753
LIG_14-3-3_CanoR_1	527	536	PF00244	0.716
LIG_14-3-3_CanoR_1	609	618	PF00244	0.607
LIG_14-3-3_CanoR_1	777	784	PF00244	0.719
LIG_14-3-3_CanoR_1	850	856	PF00244	0.527
LIG_APCC_ABBA_1	336	341	PF00400	0.681
LIG_APCC_ABBA_1	648	653	PF00400	0.603
LIG_BRCT_BRCA1_1	475	479	PF00533	0.579
LIG_BRCT_BRCA1_1	734	738	PF00533	0.580
LIG_Clathr_ClatBox_1	162	166	PF01394	0.648
LIG_FHA_1	157	163	PF00498	0.622
LIG_FHA_1	233	239	PF00498	0.710
LIG_FHA_1	358	364	PF00498	0.777
LIG_FHA_1	465	471	PF00498	0.758
LIG_FHA_1	531	537	PF00498	0.824
LIG_FHA_1	611	617	PF00498	0.785
LIG_FHA_1	662	668	PF00498	0.446
LIG_FHA_1	677	683	PF00498	0.501
LIG_FHA_1	717	723	PF00498	0.501
LIG_FHA_1	802	808	PF00498	0.621
LIG_FHA_1	809	815	PF00498	0.491
LIG_FHA_2	194	200	PF00498	0.699
LIG_FHA_2	504	510	PF00498	0.762
LIG_FHA_2	53	59	PF00498	0.670
LIG_Integrin_isoDGR_2	545	547	PF01839	0.765
LIG_LIR_Apic_2	29	35	PF02991	0.691
LIG_LIR_Apic_2	343	348	PF02991	0.677
LIG_LIR_Apic_2	458	464	PF02991	0.612
LIG_LIR_Gen_1	183	192	PF02991	0.778
LIG_LIR_Gen_1	218	228	PF02991	0.716
LIG_LIR_Gen_1	235	242	PF02991	0.497
LIG_LIR_Gen_1	638	649	PF02991	0.607
LIG_LIR_Gen_1	90	100	PF02991	0.671
LIG_LIR_Nem_3	125	130	PF02991	0.603
LIG_LIR_Nem_3	183	189	PF02991	0.775
LIG_LIR_Nem_3	218	223	PF02991	0.727
LIG_LIR_Nem_3	235	240	PF02991	0.577
LIG_LIR_Nem_3	638	644	PF02991	0.587
LIG_LIR_Nem_3	90	96	PF02991	0.665
LIG_LIR_Nem_3	99	103	PF02991	0.580
LIG_MYND_1	534	538	PF01753	0.733
LIG_MYND_1	710	714	PF01753	0.640
LIG_MYND_3	189	193	PF01753	0.704
LIG_NRBOX	681	687	PF00104	0.509
LIG_PTB_Apo_2	520	527	PF02174	0.649
LIG_PTB_Apo_2	94	101	PF02174	0.628
LIG_PTB_Phospho_1	94	100	PF10480	0.627
LIG_REV1ctd_RIR_1	342	347	PF16727	0.633
LIG_SH2_CRK	461	465	PF00017	0.609
LIG_SH2_NCK_1	651	655	PF00017	0.743
LIG_SH2_PTP2	32	35	PF00017	0.575
LIG_SH2_SRC	651	654	PF00017	0.667
LIG_SH2_STAP1	651	655	PF00017	0.743
LIG_SH2_STAP1	72	76	PF00017	0.556
LIG_SH2_STAT5	105	108	PF00017	0.627
LIG_SH2_STAT5	301	304	PF00017	0.689
LIG_SH2_STAT5	32	35	PF00017	0.692
LIG_SH2_STAT5	62	65	PF00017	0.591
LIG_SH2_STAT5	763	766	PF00017	0.431
LIG_SH2_STAT5	803	806	PF00017	0.708
LIG_SH3_3	220	226	PF00018	0.564
LIG_SH3_3	353	359	PF00018	0.589
LIG_SH3_3	375	381	PF00018	0.750
LIG_SH3_3	532	538	PF00018	0.789
LIG_SH3_3	548	554	PF00018	0.514
LIG_SUMO_SIM_par_1	713	720	PF11976	0.568
LIG_TRAF2_1	133	136	PF00917	0.621
LIG_TRAF2_1	273	276	PF00917	0.718
LIG_TRAF2_1	369	372	PF00917	0.667
LIG_TRAF2_1	636	639	PF00917	0.614
LIG_TRAF2_1	650	653	PF00917	0.644
LIG_WRC_WIRS_1	385	390	PF05994	0.723
LIG_WRC_WIRS_1	846	851	PF05994	0.604
LIG_WW_3	306	310	PF00397	0.791
MOD_CDC14_SPxK_1	720	723	PF00782	0.506
MOD_CDK_SPK_2	534	539	PF00069	0.736
MOD_CDK_SPxK_1	717	723	PF00069	0.501
MOD_CK1_1	4	10	PF00069	0.696
MOD_CK1_1	451	457	PF00069	0.698
MOD_CK1_1	52	58	PF00069	0.663
MOD_CK1_1	530	536	PF00069	0.721
MOD_CK1_1	623	629	PF00069	0.727
MOD_CK1_1	81	87	PF00069	0.461
MOD_CK1_1	845	851	PF00069	0.528
MOD_CK2_1	130	136	PF00069	0.726
MOD_CK2_1	17	23	PF00069	0.632
MOD_CK2_1	193	199	PF00069	0.735
MOD_CK2_1	366	372	PF00069	0.788
MOD_CK2_1	503	509	PF00069	0.797
MOD_CK2_1	52	58	PF00069	0.675
MOD_CK2_1	81	87	PF00069	0.500
MOD_DYRK1A_RPxSP_1	351	355	PF00069	0.593
MOD_DYRK1A_RPxSP_1	516	520	PF00069	0.644
MOD_GlcNHglycan	119	122	PF01048	0.616
MOD_GlcNHglycan	139	142	PF01048	0.422
MOD_GlcNHglycan	14	17	PF01048	0.706
MOD_GlcNHglycan	257	260	PF01048	0.695
MOD_GlcNHglycan	293	296	PF01048	0.656
MOD_GlcNHglycan	351	354	PF01048	0.597
MOD_GlcNHglycan	372	375	PF01048	0.843
MOD_GlcNHglycan	400	403	PF01048	0.752
MOD_GlcNHglycan	424	427	PF01048	0.671
MOD_GlcNHglycan	429	432	PF01048	0.623
MOD_GlcNHglycan	45	48	PF01048	0.767
MOD_GlcNHglycan	450	453	PF01048	0.787
MOD_GlcNHglycan	469	473	PF01048	0.729
MOD_GlcNHglycan	475	478	PF01048	0.757
MOD_GlcNHglycan	483	486	PF01048	0.457
MOD_GlcNHglycan	622	625	PF01048	0.749
MOD_GlcNHglycan	83	86	PF01048	0.554
MOD_GlcNHglycan	831	834	PF01048	0.681
MOD_GlcNHglycan	882	885	PF01048	0.600
MOD_GlcNHglycan	9	12	PF01048	0.686
MOD_GSK3_1	12	19	PF00069	0.735
MOD_GSK3_1	171	178	PF00069	0.701
MOD_GSK3_1	218	225	PF00069	0.728
MOD_GSK3_1	228	235	PF00069	0.634
MOD_GSK3_1	249	256	PF00069	0.695
MOD_GSK3_1	267	274	PF00069	0.530
MOD_GSK3_1	291	298	PF00069	0.726
MOD_GSK3_1	3	10	PF00069	0.743
MOD_GSK3_1	366	373	PF00069	0.751
MOD_GSK3_1	377	384	PF00069	0.740
MOD_GSK3_1	427	434	PF00069	0.798
MOD_GSK3_1	451	458	PF00069	0.694
MOD_GSK3_1	460	467	PF00069	0.656
MOD_GSK3_1	473	480	PF00069	0.772
MOD_GSK3_1	49	56	PF00069	0.723
MOD_GSK3_1	503	510	PF00069	0.790
MOD_GSK3_1	526	533	PF00069	0.735
MOD_GSK3_1	570	577	PF00069	0.727
MOD_GSK3_1	620	627	PF00069	0.624
MOD_GSK3_1	77	84	PF00069	0.432
MOD_GSK3_1	772	779	PF00069	0.648
MOD_GSK3_1	791	798	PF00069	0.698
MOD_GSK3_1	801	808	PF00069	0.553
MOD_GSK3_1	845	852	PF00069	0.505
MOD_LATS_1	435	441	PF00433	0.830
MOD_N-GLC_1	148	153	PF02516	0.641
MOD_N-GLC_1	232	237	PF02516	0.675
MOD_N-GLC_1	282	287	PF02516	0.745
MOD_N-GLC_1	464	469	PF02516	0.766
MOD_N-GLC_1	473	478	PF02516	0.580
MOD_N-GLC_1	49	54	PF02516	0.564
MOD_N-GLC_1	570	575	PF02516	0.759
MOD_N-GLC_1	676	681	PF02516	0.611
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	21	26	PF00069	0.618
MOD_NEK2_1	228	233	PF00069	0.671
MOD_NEK2_1	349	354	PF00069	0.635
MOD_NEK2_1	526	531	PF00069	0.714
MOD_NEK2_1	570	575	PF00069	0.754
MOD_NEK2_1	716	721	PF00069	0.499
MOD_NEK2_1	829	834	PF00069	0.572
MOD_NEK2_1	839	844	PF00069	0.502
MOD_NEK2_1	849	854	PF00069	0.286
MOD_NEK2_2	27	32	PF00069	0.609
MOD_NEK2_2	49	54	PF00069	0.564
MOD_NEK2_2	810	815	PF00069	0.548
MOD_PIKK_1	148	154	PF00454	0.639
MOD_PIKK_1	21	27	PF00454	0.701
MOD_PIKK_1	218	224	PF00454	0.718
MOD_PIKK_1	4	10	PF00454	0.618
MOD_PIKK_1	446	452	PF00454	0.606
MOD_PIKK_1	527	533	PF00454	0.707
MOD_PIKK_1	740	746	PF00454	0.376
MOD_PIKK_1	776	782	PF00454	0.703
MOD_PIKK_1	791	797	PF00454	0.563
MOD_PKA_1	216	222	PF00069	0.677
MOD_PKA_1	437	443	PF00069	0.752
MOD_PKA_2	122	128	PF00069	0.595
MOD_PKA_2	171	177	PF00069	0.734
MOD_PKA_2	194	200	PF00069	0.588
MOD_PKA_2	201	207	PF00069	0.627
MOD_PKA_2	216	222	PF00069	0.651
MOD_PKA_2	4	10	PF00069	0.818
MOD_PKA_2	43	49	PF00069	0.774
MOD_PKA_2	437	443	PF00069	0.752
MOD_PKA_2	526	532	PF00069	0.756
MOD_PKA_2	776	782	PF00069	0.592
MOD_PKA_2	849	855	PF00069	0.513
MOD_PKB_1	512	520	PF00069	0.744
MOD_Plk_1	148	154	PF00069	0.639
MOD_Plk_1	17	23	PF00069	0.567
MOD_Plk_1	193	199	PF00069	0.578
MOD_Plk_1	232	238	PF00069	0.548
MOD_Plk_1	340	346	PF00069	0.674
MOD_Plk_1	49	55	PF00069	0.553
MOD_Plk_1	565	571	PF00069	0.711
MOD_Plk_1	676	682	PF00069	0.606
MOD_Plk_2-3	194	200	PF00069	0.682
MOD_Plk_2-3	700	706	PF00069	0.661
MOD_Plk_2-3	732	738	PF00069	0.594
MOD_Plk_4	17	23	PF00069	0.626
MOD_Plk_4	171	177	PF00069	0.734
MOD_Plk_4	27	33	PF00069	0.641
MOD_Plk_4	295	301	PF00069	0.711
MOD_Plk_4	340	346	PF00069	0.646
MOD_Plk_4	384	390	PF00069	0.724
MOD_Plk_4	565	571	PF00069	0.688
MOD_Plk_4	629	635	PF00069	0.665
MOD_Plk_4	676	682	PF00069	0.610
MOD_Plk_4	783	789	PF00069	0.665
MOD_ProDKin_1	222	228	PF00069	0.563
MOD_ProDKin_1	351	357	PF00069	0.738
MOD_ProDKin_1	366	372	PF00069	0.696
MOD_ProDKin_1	377	383	PF00069	0.720
MOD_ProDKin_1	460	466	PF00069	0.686
MOD_ProDKin_1	516	522	PF00069	0.737
MOD_ProDKin_1	530	536	PF00069	0.679
MOD_ProDKin_1	550	556	PF00069	0.715
MOD_ProDKin_1	717	723	PF00069	0.501
MOD_SUMO_rev_2	726	735	PF00179	0.598
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.710
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.705
TRG_DiLeu_BaLyEn_6	681	686	PF01217	0.541
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.679
TRG_ENDOCYTIC_2	100	103	PF00928	0.622
TRG_ENDOCYTIC_2	651	654	PF00928	0.643
TRG_ENDOCYTIC_2	72	75	PF00928	0.562
TRG_ENDOCYTIC_2	93	96	PF00928	0.620
TRG_ER_diArg_1	215	217	PF00400	0.800
TRG_ER_diArg_1	437	439	PF00400	0.798
TRG_ER_diArg_1	511	514	PF00400	0.803
TRG_ER_diArg_1	515	518	PF00400	0.675
TRG_ER_diArg_1	781	783	PF00400	0.628
TRG_NES_CRM1_1	180	193	PF08389	0.771
TRG_NLS_MonoCore_2	497	502	PF00514	0.601
TRG_NLS_MonoExtC_3	497	502	PF00514	0.601
TRG_NLS_MonoExtN_4	495	502	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.753
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	875	879	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J7	Leptomonas seymouri	41%	93%
A0A3S7X0M1	Leishmania donovani	84%	97%
A4HFL8	Leishmania braziliensis	59%	98%
A4I2P1	Leishmania infantum	84%	97%
E9AYZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%