XRN_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XRN 5'-3' exonuclease N-terminus, putative

Species:

Leishmania major

UniProt:

E9AD71_LEIMA

TriTrypDb:

LmjF.27.0940 , LMJLV39_270015100 , LMJSD75_270015100

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD71

Function

Biological processes
Term	Name	Level	Count
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	15
GO:0004518	nuclease activity	4	15
GO:0004527	exonuclease activity	5	15
GO:0004532	RNA exonuclease activity	5	2
GO:0004534	5'-3' RNA exonuclease activity	7	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	15
GO:0008409	5'-3' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0097159	organic cyclic compound binding	2	15
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.571
CLV_C14_Caspase3-7	570	574	PF00656	0.744
CLV_MEL_PAP_1	465	471	PF00089	0.517
CLV_NRD_NRD_1	166	168	PF00675	0.332
CLV_NRD_NRD_1	196	198	PF00675	0.361
CLV_NRD_NRD_1	301	303	PF00675	0.387
CLV_NRD_NRD_1	314	316	PF00675	0.380
CLV_NRD_NRD_1	351	353	PF00675	0.599
CLV_NRD_NRD_1	420	422	PF00675	0.537
CLV_NRD_NRD_1	518	520	PF00675	0.594
CLV_NRD_NRD_1	544	546	PF00675	0.700
CLV_NRD_NRD_1	98	100	PF00675	0.258
CLV_PCSK_FUR_1	349	353	PF00082	0.628
CLV_PCSK_KEX2_1	196	198	PF00082	0.361
CLV_PCSK_KEX2_1	301	303	PF00082	0.359
CLV_PCSK_KEX2_1	314	316	PF00082	0.418
CLV_PCSK_KEX2_1	351	353	PF00082	0.615
CLV_PCSK_KEX2_1	518	520	PF00082	0.598
CLV_PCSK_KEX2_1	556	558	PF00082	0.783
CLV_PCSK_KEX2_1	98	100	PF00082	0.256
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.595
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.723
CLV_PCSK_SKI1_1	108	112	PF00082	0.322
CLV_PCSK_SKI1_1	314	318	PF00082	0.497
CLV_PCSK_SKI1_1	331	335	PF00082	0.266
CLV_PCSK_SKI1_1	34	38	PF00082	0.361
CLV_PCSK_SKI1_1	353	357	PF00082	0.538
DEG_APCC_DBOX_1	33	41	PF00400	0.571
DEG_APCC_DBOX_1	75	83	PF00400	0.555
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.484
DOC_MAPK_gen_1	301	308	PF00069	0.398
DOC_MAPK_gen_1	349	359	PF00069	0.590
DOC_MAPK_gen_1	72	81	PF00069	0.522
DOC_MAPK_gen_1	96	104	PF00069	0.500
DOC_MAPK_MEF2A_6	274	282	PF00069	0.335
DOC_MAPK_MEF2A_6	321	329	PF00069	0.509
DOC_PP1_RVXF_1	272	278	PF00149	0.332
DOC_PP2B_LxvP_1	345	348	PF13499	0.574
DOC_USP7_MATH_1	204	208	PF00917	0.579
DOC_USP7_MATH_1	47	51	PF00917	0.532
DOC_USP7_MATH_1	558	562	PF00917	0.767
DOC_WW_Pin1_4	124	129	PF00397	0.567
LIG_14-3-3_CanoR_1	108	114	PF00244	0.498
LIG_14-3-3_CanoR_1	352	359	PF00244	0.586
LIG_14-3-3_CanoR_1	487	497	PF00244	0.551
LIG_14-3-3_CanoR_1	52	59	PF00244	0.555
LIG_14-3-3_CanoR_1	557	567	PF00244	0.723
LIG_14-3-3_CanoR_1	98	103	PF00244	0.498
LIG_AP2alpha_2	240	242	PF02296	0.512
LIG_APCC_ABBA_1	139	144	PF00400	0.541
LIG_APCC_ABBA_1	397	402	PF00400	0.589
LIG_BRCT_BRCA1_1	385	389	PF00533	0.492
LIG_eIF4E_1	171	177	PF01652	0.571
LIG_eIF4E_1	233	239	PF01652	0.482
LIG_eIF4E_1	312	318	PF01652	0.458
LIG_FHA_1	159	165	PF00498	0.558
LIG_FHA_1	340	346	PF00498	0.578
LIG_FHA_1	352	358	PF00498	0.427
LIG_FHA_1	372	378	PF00498	0.464
LIG_FHA_1	437	443	PF00498	0.701
LIG_FHA_1	444	450	PF00498	0.617
LIG_FHA_1	496	502	PF00498	0.480
LIG_FHA_1	508	514	PF00498	0.458
LIG_FHA_1	76	82	PF00498	0.472
LIG_FHA_2	200	206	PF00498	0.533
LIG_FHA_2	235	241	PF00498	0.425
LIG_FHA_2	479	485	PF00498	0.555
LIG_FHA_2	512	518	PF00498	0.436
LIG_FHA_2	92	98	PF00498	0.561
LIG_LIR_Apic_2	14	20	PF02991	0.488
LIG_LIR_Gen_1	172	178	PF02991	0.544
LIG_LIR_Gen_1	234	244	PF02991	0.373
LIG_LIR_Gen_1	276	283	PF02991	0.324
LIG_LIR_Nem_3	172	176	PF02991	0.527
LIG_LIR_Nem_3	234	239	PF02991	0.328
LIG_LIR_Nem_3	276	282	PF02991	0.320
LIG_LIR_Nem_3	286	292	PF02991	0.361
LIG_LIR_Nem_3	394	398	PF02991	0.462
LIG_Rb_LxCxE_1	151	172	PF01857	0.571
LIG_SH2_CRK	17	21	PF00017	0.561
LIG_SH2_CRK	289	293	PF00017	0.434
LIG_SH2_CRK	83	87	PF00017	0.561
LIG_SH2_NCK_1	236	240	PF00017	0.494
LIG_SH2_SRC	9	12	PF00017	0.525
LIG_SH2_STAT3	163	166	PF00017	0.516
LIG_SH2_STAT5	130	133	PF00017	0.545
LIG_SH2_STAT5	159	162	PF00017	0.561
LIG_SH2_STAT5	163	166	PF00017	0.561
LIG_SH2_STAT5	236	239	PF00017	0.397
LIG_SH2_STAT5	312	315	PF00017	0.481
LIG_SH2_STAT5	387	390	PF00017	0.433
LIG_SH2_STAT5	9	12	PF00017	0.488
LIG_SH3_2	106	111	PF14604	0.404
LIG_SH3_3	101	107	PF00018	0.535
LIG_SH3_3	226	232	PF00018	0.522
LIG_SH3_3	257	263	PF00018	0.598
LIG_SH3_3	442	448	PF00018	0.664
LIG_SH3_3	449	455	PF00018	0.415
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.493
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.497
LIG_SUMO_SIM_par_1	77	84	PF11976	0.513
LIG_TRAF2_1	155	158	PF00917	0.554
LIG_TRAF2_1	399	402	PF00917	0.566
LIG_TYR_ITAM	286	306	PF00017	0.517
LIG_TYR_ITIM	81	86	PF00017	0.571
LIG_WW_2	263	266	PF00397	0.591
LIG_WW_3	105	109	PF00397	0.571
MOD_CK1_1	116	122	PF00069	0.508
MOD_CK1_1	234	240	PF00069	0.475
MOD_CK1_1	245	251	PF00069	0.502
MOD_CK1_1	339	345	PF00069	0.594
MOD_CK1_1	383	389	PF00069	0.451
MOD_CK1_1	406	412	PF00069	0.516
MOD_CK1_1	507	513	PF00069	0.553
MOD_CK2_1	245	251	PF00069	0.444
MOD_CK2_1	5	11	PF00069	0.564
MOD_CK2_1	511	517	PF00069	0.450
MOD_CK2_1	569	575	PF00069	0.727
MOD_CK2_1	91	97	PF00069	0.561
MOD_GlcNHglycan	118	121	PF01048	0.299
MOD_GlcNHglycan	178	181	PF01048	0.305
MOD_GlcNHglycan	191	194	PF01048	0.135
MOD_GlcNHglycan	283	286	PF01048	0.410
MOD_GlcNHglycan	318	321	PF01048	0.501
MOD_GlcNHglycan	336	339	PF01048	0.626
MOD_GlcNHglycan	424	427	PF01048	0.592
MOD_GlcNHglycan	469	472	PF01048	0.406
MOD_GSK3_1	109	116	PF00069	0.542
MOD_GSK3_1	120	127	PF00069	0.517
MOD_GSK3_1	332	339	PF00069	0.406
MOD_GSK3_1	47	54	PF00069	0.497
MOD_GSK3_1	486	493	PF00069	0.492
MOD_GSK3_1	500	507	PF00069	0.475
MOD_GSK3_1	518	525	PF00069	0.498
MOD_LATS_1	415	421	PF00433	0.610
MOD_N-GLC_1	120	125	PF02516	0.357
MOD_N-GLC_1	218	223	PF02516	0.277
MOD_N-GLC_1	558	563	PF02516	0.769
MOD_NEK2_1	176	181	PF00069	0.525
MOD_NEK2_1	242	247	PF00069	0.501
MOD_NEK2_1	334	339	PF00069	0.549
MOD_NEK2_1	488	493	PF00069	0.425
MOD_NEK2_2	120	125	PF00069	0.571
MOD_NEK2_2	380	385	PF00069	0.494
MOD_PIKK_1	206	212	PF00454	0.533
MOD_PIKK_1	254	260	PF00454	0.522
MOD_PIKK_1	339	345	PF00454	0.668
MOD_PIKK_1	371	377	PF00454	0.453
MOD_PIKK_1	508	514	PF00454	0.515
MOD_PIKK_1	91	97	PF00454	0.498
MOD_PKA_1	351	357	PF00069	0.612
MOD_PKA_1	518	524	PF00069	0.635
MOD_PKA_1	98	104	PF00069	0.479
MOD_PKA_2	351	357	PF00069	0.590
MOD_PKA_2	467	473	PF00069	0.399
MOD_PKA_2	477	483	PF00069	0.422
MOD_PKA_2	486	492	PF00069	0.495
MOD_PKA_2	51	57	PF00069	0.559
MOD_PKA_2	518	524	PF00069	0.608
MOD_PKA_2	75	81	PF00069	0.531
MOD_PKA_2	98	104	PF00069	0.488
MOD_Plk_1	242	248	PF00069	0.476
MOD_Plk_1	508	514	PF00069	0.479
MOD_Plk_4	159	165	PF00069	0.552
MOD_Plk_4	212	218	PF00069	0.530
MOD_Plk_4	231	237	PF00069	0.230
MOD_Plk_4	500	506	PF00069	0.449
MOD_Plk_4	75	81	PF00069	0.489
MOD_ProDKin_1	124	130	PF00069	0.567
MOD_SUMO_rev_2	183	192	PF00179	0.469
TRG_DiLeu_BaEn_1	372	377	PF01217	0.506
TRG_ENDOCYTIC_2	235	238	PF00928	0.362
TRG_ENDOCYTIC_2	289	292	PF00928	0.386
TRG_ENDOCYTIC_2	303	306	PF00928	0.359
TRG_ENDOCYTIC_2	395	398	PF00928	0.492
TRG_ENDOCYTIC_2	83	86	PF00928	0.561
TRG_ER_diArg_1	195	197	PF00400	0.561
TRG_ER_diArg_1	300	302	PF00400	0.392
TRG_ER_diArg_1	313	315	PF00400	0.385
TRG_ER_diArg_1	465	468	PF00400	0.424
TRG_ER_diArg_1	518	520	PF00400	0.596
TRG_ER_diArg_1	73	76	PF00400	0.566
TRG_NLS_MonoExtN_4	348	355	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I835	Leptomonas seymouri	63%	99%
A0A0S4ILZ5	Bodo saltans	33%	100%
A0A0S4JAK8	Bodo saltans	29%	100%
A0A1X0P557	Trypanosomatidae	39%	100%
A0A3R7RG04	Trypanosoma rangeli	27%	70%
A0A3S7X0L0	Leishmania donovani	92%	100%
A0A422N1U3	Trypanosoma rangeli	41%	100%
A4HFL7	Leishmania braziliensis	78%	99%
A4I352	Leishmania infantum	93%	100%
D0A5U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AT41	Trypanosoma cruzi	38%	100%
V5BDQ7	Trypanosoma cruzi	27%	95%