S5A_REDUCTASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1295), putative

Species:

Leishmania major

UniProt:

E9AD69_LEIMA

TriTrypDb:

LmjF.27.0920 , LMJLV39_270014900 , LMJSD75_270014900

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AD69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.272
CLV_NRD_NRD_1	72	74	PF00675	0.552
CLV_PCSK_KEX2_1	104	106	PF00082	0.272
CLV_PCSK_KEX2_1	72	74	PF00082	0.513
CLV_PCSK_SKI1_1	167	171	PF00082	0.561
CLV_PCSK_SKI1_1	299	303	PF00082	0.352
DEG_Nend_UBRbox_2	1	3	PF02207	0.481
DOC_CKS1_1	160	165	PF01111	0.286
DOC_CKS1_1	197	202	PF01111	0.513
DOC_PP1_RVXF_1	165	172	PF00149	0.264
DOC_PP1_RVXF_1	95	101	PF00149	0.361
DOC_USP7_MATH_1	236	240	PF00917	0.463
DOC_USP7_MATH_1	75	79	PF00917	0.346
DOC_WW_Pin1_4	126	131	PF00397	0.569
DOC_WW_Pin1_4	159	164	PF00397	0.286
DOC_WW_Pin1_4	196	201	PF00397	0.530
DOC_WW_Pin1_4	283	288	PF00397	0.507
LIG_14-3-3_CanoR_1	116	120	PF00244	0.472
LIG_14-3-3_CanoR_1	97	101	PF00244	0.472
LIG_APCC_ABBA_1	221	226	PF00400	0.496
LIG_Clathr_ClatBox_1	178	182	PF01394	0.409
LIG_deltaCOP1_diTrp_1	113	123	PF00928	0.471
LIG_deltaCOP1_diTrp_1	186	192	PF00928	0.530
LIG_FHA_1	120	126	PF00498	0.505
LIG_FHA_1	144	150	PF00498	0.335
LIG_FHA_1	151	157	PF00498	0.314
LIG_FHA_1	168	174	PF00498	0.339
LIG_FHA_1	19	25	PF00498	0.348
LIG_FHA_1	262	268	PF00498	0.354
LIG_FHA_1	284	290	PF00498	0.511
LIG_FHA_1	295	301	PF00498	0.495
LIG_FHA_1	81	87	PF00498	0.445
LIG_FHA_2	163	169	PF00498	0.326
LIG_LIR_Gen_1	114	125	PF02991	0.407
LIG_LIR_Gen_1	134	144	PF02991	0.133
LIG_LIR_Gen_1	180	187	PF02991	0.349
LIG_LIR_Gen_1	228	237	PF02991	0.322
LIG_LIR_Gen_1	38	44	PF02991	0.533
LIG_LIR_Gen_1	46	54	PF02991	0.405
LIG_LIR_Gen_1	55	61	PF02991	0.213
LIG_LIR_Gen_1	99	108	PF02991	0.512
LIG_LIR_Nem_3	114	120	PF02991	0.429
LIG_LIR_Nem_3	122	126	PF02991	0.472
LIG_LIR_Nem_3	134	139	PF02991	0.133
LIG_LIR_Nem_3	168	174	PF02991	0.356
LIG_LIR_Nem_3	180	184	PF02991	0.316
LIG_LIR_Nem_3	228	233	PF02991	0.317
LIG_LIR_Nem_3	38	43	PF02991	0.528
LIG_LIR_Nem_3	44	50	PF02991	0.528
LIG_LIR_Nem_3	55	59	PF02991	0.213
LIG_LIR_Nem_3	85	90	PF02991	0.427
LIG_LIR_Nem_3	99	103	PF02991	0.442
LIG_MYND_1	287	291	PF01753	0.513
LIG_NRBOX	254	260	PF00104	0.308
LIG_Pex14_1	56	60	PF04695	0.328
LIG_REV1ctd_RIR_1	100	109	PF16727	0.530
LIG_SH2_CRK	282	286	PF00017	0.530
LIG_SH2_STAP1	217	221	PF00017	0.496
LIG_SH2_STAT3	61	64	PF00017	0.463
LIG_SH2_STAT5	119	122	PF00017	0.496
LIG_SH2_STAT5	205	208	PF00017	0.530
LIG_SH2_STAT5	54	57	PF00017	0.370
LIG_SH2_STAT5	61	64	PF00017	0.352
LIG_SH3_3	157	163	PF00018	0.369
LIG_SH3_3	194	200	PF00018	0.513
LIG_Sin3_3	26	33	PF02671	0.347
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.354
LIG_SUMO_SIM_par_1	174	180	PF11976	0.385
LIG_SUMO_SIM_par_1	257	264	PF11976	0.338
LIG_TYR_ITIM	52	57	PF00017	0.393
LIG_UBA3_1	301	306	PF00899	0.562
LIG_WRC_WIRS_1	1	6	PF05994	0.484
LIG_WRC_WIRS_1	141	146	PF05994	0.339
LIG_WRC_WIRS_1	178	183	PF05994	0.269
MOD_CK1_1	143	149	PF00069	0.383
MOD_CK1_1	239	245	PF00069	0.381
MOD_CK1_1	251	257	PF00069	0.409
MOD_CK1_1	292	298	PF00069	0.579
MOD_CK1_1	3	9	PF00069	0.371
MOD_CK1_1	82	88	PF00069	0.415
MOD_CK2_1	162	168	PF00069	0.330
MOD_CMANNOS	147	150	PF00535	0.361
MOD_CMANNOS	247	250	PF00535	0.409
MOD_GlcNHglycan	18	21	PF01048	0.330
MOD_GlcNHglycan	250	253	PF01048	0.421
MOD_GlcNHglycan	5	8	PF01048	0.612
MOD_GSK3_1	115	122	PF00069	0.575
MOD_GSK3_1	12	19	PF00069	0.360
MOD_GSK3_1	139	146	PF00069	0.361
MOD_GSK3_1	261	268	PF00069	0.347
MOD_GSK3_1	289	296	PF00069	0.543
MOD_GSK3_1	75	82	PF00069	0.336
MOD_N-GLC_1	38	43	PF02516	0.272
MOD_NEK2_1	139	144	PF00069	0.329
MOD_NEK2_1	16	21	PF00069	0.337
MOD_NEK2_1	209	214	PF00069	0.464
MOD_NEK2_1	215	220	PF00069	0.442
MOD_NEK2_1	261	266	PF00069	0.370
MOD_NEK2_1	293	298	PF00069	0.541
MOD_NEK2_1	89	94	PF00069	0.402
MOD_PK_1	45	51	PF00069	0.328
MOD_PKA_2	115	121	PF00069	0.472
MOD_PKA_2	96	102	PF00069	0.328
MOD_Plk_1	167	173	PF00069	0.341
MOD_Plk_1	225	231	PF00069	0.409
MOD_Plk_1	38	44	PF00069	0.472
MOD_Plk_2-3	38	44	PF00069	0.569
MOD_Plk_4	143	149	PF00069	0.334
MOD_Plk_4	18	24	PF00069	0.414
MOD_Plk_4	225	231	PF00069	0.331
MOD_Plk_4	251	257	PF00069	0.349
MOD_Plk_4	289	295	PF00069	0.585
MOD_Plk_4	38	44	PF00069	0.396
MOD_Plk_4	52	58	PF00069	0.266
MOD_Plk_4	82	88	PF00069	0.358
MOD_ProDKin_1	126	132	PF00069	0.569
MOD_ProDKin_1	159	165	PF00069	0.286
MOD_ProDKin_1	196	202	PF00069	0.530
MOD_ProDKin_1	283	289	PF00069	0.505
TRG_ENDOCYTIC_2	282	285	PF00928	0.530
TRG_ENDOCYTIC_2	40	43	PF00928	0.496
TRG_ENDOCYTIC_2	54	57	PF00928	0.361
TRG_ER_diArg_1	103	105	PF00400	0.496
TRG_ER_diArg_1	71	73	PF00400	0.313
TRG_ER_diLys_1	305	308	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU3	Leptomonas seymouri	67%	99%
A0A0S4JVU4	Bodo saltans	44%	91%
A0A1X0P416	Trypanosomatidae	49%	97%
A0A3S7X0J3	Leishmania donovani	94%	100%
A4HFL5	Leishmania braziliensis	78%	99%
A4I2P4	Leishmania infantum	94%	100%
E9AYZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O74507	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	90%