LRAT domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania major

UniProt:

E9AD67_LEIMA

TriTrypDb:

LmjF.27.0900 , LMJLV39_270014700 , LMJSD75_270014700

Length:

196

Annotations

LeishMANIAdb annotations

A small, compact tail-anchored protein related to animal TMEM222 and plant RTE1. Function unknown.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AD67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	106	108	PF00082	0.317
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.294
CLV_PCSK_SKI1_1	70	74	PF00082	0.331
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DOC_MAPK_gen_1	6	15	PF00069	0.659
DOC_PP4_FxxP_1	73	76	PF00568	0.456
DOC_USP7_MATH_1	115	119	PF00917	0.550
DOC_WW_Pin1_4	30	35	PF00397	0.485
DOC_WW_Pin1_4	8	13	PF00397	0.667
LIG_14-3-3_CanoR_1	124	132	PF00244	0.439
LIG_14-3-3_CanoR_1	168	173	PF00244	0.521
LIG_CaM_IQ_9	57	72	PF13499	0.550
LIG_CSL_BTD_1	31	34	PF09270	0.494
LIG_LIR_Apic_2	39	43	PF02991	0.445
LIG_LIR_Nem_3	126	132	PF02991	0.445
LIG_PCNA_PIPBox_1	125	134	PF02747	0.494
LIG_PCNA_yPIPBox_3	124	132	PF02747	0.494
LIG_Pex14_1	40	44	PF04695	0.470
LIG_Pex14_2	28	32	PF04695	0.452
LIG_SH2_PTP2	169	172	PF00017	0.553
LIG_SH2_SRC	86	89	PF00017	0.529
LIG_SH2_STAP1	112	116	PF00017	0.456
LIG_SH2_STAT3	58	61	PF00017	0.531
LIG_SH2_STAT5	169	172	PF00017	0.485
LIG_SH2_STAT5	86	89	PF00017	0.496
LIG_SH3_3	10	16	PF00018	0.600
LIG_SH3_3	28	34	PF00018	0.397
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.428
LIG_TYR_ITIM	77	82	PF00017	0.445
LIG_WRC_WIRS_1	87	92	PF05994	0.543
MOD_CK1_1	118	124	PF00069	0.494
MOD_CK2_1	140	146	PF00069	0.522
MOD_GlcNHglycan	97	100	PF01048	0.328
MOD_N-GLC_2	134	136	PF02516	0.245
MOD_NEK2_1	116	121	PF00069	0.479
MOD_PIKK_1	50	56	PF00454	0.506
MOD_PK_1	168	174	PF00069	0.588
MOD_PKA_2	123	129	PF00069	0.467
MOD_PKB_1	166	174	PF00069	0.525
MOD_Plk_4	135	141	PF00069	0.439
MOD_Plk_4	179	185	PF00069	0.392
MOD_Plk_4	36	42	PF00069	0.445
MOD_Plk_4	86	92	PF00069	0.530
MOD_ProDKin_1	30	36	PF00069	0.492
MOD_ProDKin_1	8	14	PF00069	0.666
MOD_SUMO_for_1	105	108	PF00179	0.535
TRG_ENDOCYTIC_2	129	132	PF00928	0.445
TRG_ENDOCYTIC_2	169	172	PF00928	0.586
TRG_ENDOCYTIC_2	79	82	PF00928	0.445
TRG_ER_diArg_1	166	169	PF00400	0.461
TRG_ER_diArg_1	4	7	PF00400	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I138	Leptomonas seymouri	64%	99%
A0A0S4IX94	Bodo saltans	52%	100%
A0A1X0P8A2	Trypanosomatidae	55%	97%
A0A3S7X0K2	Leishmania donovani	93%	100%
A0A422NWL7	Trypanosoma rangeli	57%	98%
A4HFL3	Leishmania braziliensis	71%	98%
A4I2P7	Leishmania infantum	93%	100%
D0A2W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AYZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F4ITL6	Arabidopsis thaliana	34%	78%
Q8BVA2	Mus musculus	34%	94%
Q9H0R3	Homo sapiens	35%	94%
Q9SD42	Arabidopsis thaliana	31%	85%
V5DL06	Trypanosoma cruzi	55%	98%