WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

E9AD63_LEIMA

TriTrypDb:

LmjF.27.0860 , LMJLV39_270014300 , LMJSD75_270014300

Length:

1037

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.658
CLV_C14_Caspase3-7	696	700	PF00656	0.524
CLV_C14_Caspase3-7	786	790	PF00656	0.571
CLV_NRD_NRD_1	284	286	PF00675	0.618
CLV_NRD_NRD_1	550	552	PF00675	0.528
CLV_NRD_NRD_1	701	703	PF00675	0.483
CLV_NRD_NRD_1	743	745	PF00675	0.509
CLV_NRD_NRD_1	938	940	PF00675	0.662
CLV_NRD_NRD_1	988	990	PF00675	0.476
CLV_PCSK_KEX2_1	284	286	PF00082	0.618
CLV_PCSK_KEX2_1	581	583	PF00082	0.585
CLV_PCSK_KEX2_1	701	703	PF00082	0.483
CLV_PCSK_KEX2_1	743	745	PF00082	0.509
CLV_PCSK_KEX2_1	850	852	PF00082	0.563
CLV_PCSK_KEX2_1	938	940	PF00082	0.668
CLV_PCSK_KEX2_1	988	990	PF00082	0.476
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.618
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.518
CLV_PCSK_PC1ET2_1	850	852	PF00082	0.535
CLV_PCSK_SKI1_1	1029	1033	PF00082	0.524
CLV_PCSK_SKI1_1	182	186	PF00082	0.504
CLV_PCSK_SKI1_1	270	274	PF00082	0.390
CLV_PCSK_SKI1_1	706	710	PF00082	0.406
CLV_PCSK_SKI1_1	722	726	PF00082	0.471
CLV_PCSK_SKI1_1	850	854	PF00082	0.526
CLV_PCSK_SKI1_1	964	968	PF00082	0.384
DEG_APCC_DBOX_1	177	185	PF00400	0.406
DEG_APCC_DBOX_1	269	277	PF00400	0.468
DEG_APCC_DBOX_1	287	295	PF00400	0.511
DEG_APCC_DBOX_1	705	713	PF00400	0.436
DEG_APCC_DBOX_1	873	881	PF00400	0.485
DEG_MDM2_SWIB_1	748	756	PF02201	0.580
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_SPOP_SBC_1	346	350	PF00917	0.547
DEG_SPOP_SBC_1	430	434	PF00917	0.368
DEG_SPOP_SBC_1	451	455	PF00917	0.402
DOC_CKS1_1	797	802	PF01111	0.660
DOC_CYCLIN_RxL_1	1026	1036	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	22	25	PF00134	0.614
DOC_MAPK_gen_1	116	124	PF00069	0.512
DOC_MAPK_gen_1	633	643	PF00069	0.422
DOC_MAPK_gen_1	701	709	PF00069	0.520
DOC_MAPK_MEF2A_6	636	643	PF00069	0.454
DOC_MAPK_MEF2A_6	836	845	PF00069	0.616
DOC_MAPK_NFAT4_5	636	644	PF00069	0.450
DOC_PP1_RVXF_1	119	126	PF00149	0.421
DOC_PP1_RVXF_1	464	471	PF00149	0.392
DOC_PP1_RVXF_1	962	968	PF00149	0.401
DOC_PP2B_LxvP_1	22	25	PF13499	0.642
DOC_PP2B_LxvP_1	566	569	PF13499	0.392
DOC_PP2B_LxvP_1	852	855	PF13499	0.543
DOC_PP2B_PxIxI_1	87	93	PF00149	0.518
DOC_PP4_FxxP_1	1024	1027	PF00568	0.406
DOC_PP4_FxxP_1	654	657	PF00568	0.364
DOC_PP4_FxxP_1	85	88	PF00568	0.582
DOC_USP7_MATH_1	162	166	PF00917	0.588
DOC_USP7_MATH_1	209	213	PF00917	0.379
DOC_USP7_MATH_1	311	315	PF00917	0.366
DOC_USP7_MATH_1	346	350	PF00917	0.634
DOC_USP7_MATH_1	351	355	PF00917	0.625
DOC_USP7_MATH_1	396	400	PF00917	0.577
DOC_USP7_MATH_1	451	455	PF00917	0.474
DOC_USP7_MATH_1	527	531	PF00917	0.450
DOC_USP7_MATH_1	544	548	PF00917	0.675
DOC_USP7_MATH_1	674	678	PF00917	0.521
DOC_USP7_MATH_1	685	689	PF00917	0.510
DOC_USP7_MATH_1	790	794	PF00917	0.583
DOC_USP7_MATH_1	806	810	PF00917	0.536
DOC_USP7_MATH_1	830	834	PF00917	0.598
DOC_USP7_MATH_1	919	923	PF00917	0.620
DOC_USP7_UBL2_3	656	660	PF12436	0.516
DOC_WW_Pin1_4	10	15	PF00397	0.602
DOC_WW_Pin1_4	105	110	PF00397	0.649
DOC_WW_Pin1_4	222	227	PF00397	0.479
DOC_WW_Pin1_4	331	336	PF00397	0.574
DOC_WW_Pin1_4	347	352	PF00397	0.552
DOC_WW_Pin1_4	452	457	PF00397	0.370
DOC_WW_Pin1_4	511	516	PF00397	0.511
DOC_WW_Pin1_4	760	765	PF00397	0.766
DOC_WW_Pin1_4	796	801	PF00397	0.668
DOC_WW_Pin1_4	820	825	PF00397	0.570
DOC_WW_Pin1_4	926	931	PF00397	0.593
LIG_14-3-3_CanoR_1	100	105	PF00244	0.497
LIG_14-3-3_CanoR_1	178	182	PF00244	0.433
LIG_14-3-3_CanoR_1	193	201	PF00244	0.406
LIG_14-3-3_CanoR_1	352	359	PF00244	0.622
LIG_14-3-3_CanoR_1	500	509	PF00244	0.475
LIG_14-3-3_CanoR_1	62	66	PF00244	0.583
LIG_14-3-3_CanoR_1	701	709	PF00244	0.499
LIG_14-3-3_CanoR_1	784	788	PF00244	0.566
LIG_14-3-3_CanoR_1	81	86	PF00244	0.434
LIG_14-3-3_CanoR_1	859	867	PF00244	0.553
LIG_14-3-3_CanoR_1	903	911	PF00244	0.526
LIG_14-3-3_CanoR_1	938	947	PF00244	0.729
LIG_APCC_ABBA_1	666	671	PF00400	0.392
LIG_BIR_III_2	789	793	PF00653	0.594
LIG_BIR_III_4	577	581	PF00653	0.563
LIG_BIR_III_4	993	997	PF00653	0.522
LIG_BRCT_BRCA1_1	254	258	PF00533	0.463
LIG_BRCT_BRCA1_1	313	317	PF00533	0.354
LIG_BRCT_BRCA1_1	81	85	PF00533	0.590
LIG_BRCT_BRCA1_1	822	826	PF00533	0.685
LIG_Clathr_ClatBox_1	840	844	PF01394	0.606
LIG_FHA_1	106	112	PF00498	0.611
LIG_FHA_1	127	133	PF00498	0.520
LIG_FHA_1	139	145	PF00498	0.375
LIG_FHA_1	202	208	PF00498	0.486
LIG_FHA_1	214	220	PF00498	0.288
LIG_FHA_1	245	251	PF00498	0.496
LIG_FHA_1	313	319	PF00498	0.426
LIG_FHA_1	332	338	PF00498	0.543
LIG_FHA_1	362	368	PF00498	0.495
LIG_FHA_1	378	384	PF00498	0.330
LIG_FHA_1	447	453	PF00498	0.440
LIG_FHA_1	512	518	PF00498	0.447
LIG_FHA_1	636	642	PF00498	0.484
LIG_FHA_1	68	74	PF00498	0.526
LIG_FHA_1	797	803	PF00498	0.665
LIG_FHA_1	858	864	PF00498	0.628
LIG_FHA_1	870	876	PF00498	0.408
LIG_FHA_1	927	933	PF00498	0.620
LIG_FHA_1	978	984	PF00498	0.417
LIG_FHA_2	154	160	PF00498	0.474
LIG_FHA_2	35	41	PF00498	0.675
LIG_FHA_2	423	429	PF00498	0.385
LIG_Integrin_RGD_1	633	635	PF01839	0.464
LIG_KLC1_Yacidic_2	401	406	PF13176	0.481
LIG_LIR_Apic_2	1023	1027	PF02991	0.475
LIG_LIR_Apic_2	82	88	PF02991	0.570
LIG_LIR_Gen_1	152	163	PF02991	0.434
LIG_LIR_Gen_1	255	266	PF02991	0.315
LIG_LIR_Gen_1	314	323	PF02991	0.474
LIG_LIR_Gen_1	433	442	PF02991	0.330
LIG_LIR_Gen_1	44	53	PF02991	0.519
LIG_LIR_Gen_1	481	489	PF02991	0.413
LIG_LIR_Gen_1	516	527	PF02991	0.445
LIG_LIR_Nem_3	152	158	PF02991	0.395
LIG_LIR_Nem_3	255	261	PF02991	0.329
LIG_LIR_Nem_3	314	320	PF02991	0.464
LIG_LIR_Nem_3	4	8	PF02991	0.439
LIG_LIR_Nem_3	401	407	PF02991	0.495
LIG_LIR_Nem_3	433	439	PF02991	0.344
LIG_LIR_Nem_3	44	50	PF02991	0.514
LIG_LIR_Nem_3	467	473	PF02991	0.480
LIG_LIR_Nem_3	481	485	PF02991	0.318
LIG_LIR_Nem_3	516	522	PF02991	0.410
LIG_LIR_Nem_3	900	904	PF02991	0.424
LIG_MYND_1	459	463	PF01753	0.396
LIG_NRBOX	862	868	PF00104	0.452
LIG_Pex14_2	138	142	PF04695	0.408
LIG_Pex14_2	748	752	PF04695	0.553
LIG_Pex14_2	986	990	PF04695	0.397
LIG_SH2_CRK	47	51	PF00017	0.586
LIG_SH2_NCK_1	155	159	PF00017	0.470
LIG_SH2_PTP2	404	407	PF00017	0.512
LIG_SH2_SRC	404	407	PF00017	0.512
LIG_SH2_SRC	970	973	PF00017	0.459
LIG_SH2_STAP1	47	51	PF00017	0.510
LIG_SH2_STAP1	482	486	PF00017	0.397
LIG_SH2_STAT5	153	156	PF00017	0.390
LIG_SH2_STAT5	174	177	PF00017	0.566
LIG_SH2_STAT5	366	369	PF00017	0.410
LIG_SH2_STAT5	375	378	PF00017	0.318
LIG_SH2_STAT5	404	407	PF00017	0.512
LIG_SH2_STAT5	928	931	PF00017	0.594
LIG_SH2_STAT5	984	987	PF00017	0.466
LIG_SH3_2	279	284	PF14604	0.603
LIG_SH3_3	20	26	PF00018	0.619
LIG_SH3_3	276	282	PF00018	0.517
LIG_SH3_3	453	459	PF00018	0.398
LIG_SH3_3	994	1000	PF00018	0.538
LIG_SH3_4	656	663	PF00018	0.494
LIG_SUMO_SIM_anti_2	1009	1015	PF11976	0.378
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.395
LIG_SUMO_SIM_anti_2	801	806	PF11976	0.662
LIG_SUMO_SIM_par_1	329	334	PF11976	0.576
LIG_SUMO_SIM_par_1	378	384	PF11976	0.397
LIG_SUMO_SIM_par_1	600	605	PF11976	0.391
LIG_SUMO_SIM_par_1	690	696	PF11976	0.494
LIG_TRAF2_1	166	169	PF00917	0.479
LIG_TRAF2_1	93	96	PF00917	0.526
LIG_WRC_WIRS_1	1021	1026	PF05994	0.455
LIG_WW_3	1026	1030	PF00397	0.461
MOD_CDK_SPK_2	347	352	PF00069	0.517
MOD_CDK_SPK_2	760	765	PF00069	0.609
MOD_CDK_SPK_2	926	931	PF00069	0.669
MOD_CDK_SPxxK_3	511	518	PF00069	0.469
MOD_CK1_1	103	109	PF00069	0.506
MOD_CK1_1	177	183	PF00069	0.555
MOD_CK1_1	252	258	PF00069	0.442
MOD_CK1_1	290	296	PF00069	0.650
MOD_CK1_1	341	347	PF00069	0.614
MOD_CK1_1	36	42	PF00069	0.673
MOD_CK1_1	360	366	PF00069	0.359
MOD_CK1_1	446	452	PF00069	0.501
MOD_CK1_1	478	484	PF00069	0.388
MOD_CK1_1	763	769	PF00069	0.586
MOD_CK1_1	775	781	PF00069	0.545
MOD_CK1_1	835	841	PF00069	0.734
MOD_CK1_1	86	92	PF00069	0.611
MOD_CK1_1	913	919	PF00069	0.583
MOD_CK2_1	112	118	PF00069	0.523
MOD_CK2_1	153	159	PF00069	0.469
MOD_CK2_1	162	168	PF00069	0.489
MOD_CK2_1	395	401	PF00069	0.542
MOD_CK2_1	484	490	PF00069	0.406
MOD_CK2_1	723	729	PF00069	0.582
MOD_CK2_1	806	812	PF00069	0.589
MOD_Cter_Amidation	579	582	PF01082	0.629
MOD_Cter_Amidation	741	744	PF01082	0.481
MOD_GlcNHglycan	1006	1009	PF01048	0.503
MOD_GlcNHglycan	105	108	PF01048	0.511
MOD_GlcNHglycan	159	163	PF01048	0.565
MOD_GlcNHglycan	164	167	PF01048	0.521
MOD_GlcNHglycan	190	193	PF01048	0.437
MOD_GlcNHglycan	326	329	PF01048	0.577
MOD_GlcNHglycan	353	356	PF01048	0.621
MOD_GlcNHglycan	372	375	PF01048	0.317
MOD_GlcNHglycan	387	390	PF01048	0.574
MOD_GlcNHglycan	398	401	PF01048	0.661
MOD_GlcNHglycan	416	419	PF01048	0.339
MOD_GlcNHglycan	445	448	PF01048	0.437
MOD_GlcNHglycan	486	489	PF01048	0.424
MOD_GlcNHglycan	539	542	PF01048	0.593
MOD_GlcNHglycan	546	549	PF01048	0.572
MOD_GlcNHglycan	553	556	PF01048	0.471
MOD_GlcNHglycan	67	70	PF01048	0.535
MOD_GlcNHglycan	687	690	PF01048	0.419
MOD_GlcNHglycan	709	712	PF01048	0.489
MOD_GlcNHglycan	809	812	PF01048	0.684
MOD_GlcNHglycan	81	84	PF01048	0.476
MOD_GlcNHglycan	826	829	PF01048	0.466
MOD_GlcNHglycan	85	88	PF01048	0.470
MOD_GlcNHglycan	919	922	PF01048	0.711
MOD_GlcNHglycan	940	943	PF01048	0.595
MOD_GSK3_1	149	156	PF00069	0.427
MOD_GSK3_1	158	165	PF00069	0.452
MOD_GSK3_1	176	183	PF00069	0.313
MOD_GSK3_1	188	195	PF00069	0.394
MOD_GSK3_1	203	210	PF00069	0.348
MOD_GSK3_1	340	347	PF00069	0.604
MOD_GSK3_1	357	364	PF00069	0.467
MOD_GSK3_1	366	373	PF00069	0.338
MOD_GSK3_1	442	449	PF00069	0.480
MOD_GSK3_1	590	597	PF00069	0.486
MOD_GSK3_1	61	68	PF00069	0.576
MOD_GSK3_1	697	704	PF00069	0.461
MOD_GSK3_1	716	723	PF00069	0.452
MOD_GSK3_1	744	751	PF00069	0.664
MOD_GSK3_1	77	84	PF00069	0.406
MOD_GSK3_1	820	827	PF00069	0.627
MOD_GSK3_1	853	860	PF00069	0.574
MOD_GSK3_1	910	917	PF00069	0.648
MOD_GSK3_1	933	940	PF00069	0.636
MOD_GSK3_1	96	103	PF00069	0.504
MOD_LATS_1	412	418	PF00433	0.375
MOD_N-GLC_1	311	316	PF02516	0.430
MOD_N-GLC_1	323	328	PF02516	0.564
MOD_N-GLC_1	338	343	PF02516	0.495
MOD_N-GLC_1	674	679	PF02516	0.519
MOD_N-GLC_1	913	918	PF02516	0.558
MOD_N-GLC_1	952	957	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	202	207	PF00069	0.556
MOD_NEK2_1	213	218	PF00069	0.322
MOD_NEK2_1	304	309	PF00069	0.440
MOD_NEK2_1	340	345	PF00069	0.606
MOD_NEK2_1	368	373	PF00069	0.429
MOD_NEK2_1	395	400	PF00069	0.539
MOD_NEK2_1	495	500	PF00069	0.504
MOD_NEK2_1	53	58	PF00069	0.506
MOD_NEK2_1	590	595	PF00069	0.655
MOD_NEK2_1	707	712	PF00069	0.498
MOD_NEK2_1	748	753	PF00069	0.552
MOD_NEK2_1	783	788	PF00069	0.565
MOD_NEK2_1	826	831	PF00069	0.625
MOD_NEK2_1	846	851	PF00069	0.579
MOD_NEK2_1	937	942	PF00069	0.675
MOD_PIKK_1	594	600	PF00454	0.494
MOD_PIKK_1	701	707	PF00454	0.541
MOD_PIKK_1	830	836	PF00454	0.546
MOD_PIKK_1	858	864	PF00454	0.610
MOD_PKA_1	551	557	PF00069	0.457
MOD_PKA_1	701	707	PF00069	0.445
MOD_PKA_1	938	944	PF00069	0.655
MOD_PKA_2	1004	1010	PF00069	0.334
MOD_PKA_2	177	183	PF00069	0.430
MOD_PKA_2	192	198	PF00069	0.391
MOD_PKA_2	287	293	PF00069	0.688
MOD_PKA_2	324	330	PF00069	0.533
MOD_PKA_2	351	357	PF00069	0.623
MOD_PKA_2	443	449	PF00069	0.411
MOD_PKA_2	58	64	PF00069	0.611
MOD_PKA_2	701	707	PF00069	0.566
MOD_PKA_2	783	789	PF00069	0.573
MOD_PKA_2	835	841	PF00069	0.632
MOD_PKA_2	858	864	PF00069	0.572
MOD_PKA_2	902	908	PF00069	0.509
MOD_PKA_2	937	943	PF00069	0.796
MOD_Plk_1	202	208	PF00069	0.434
MOD_Plk_1	338	344	PF00069	0.576
MOD_Plk_1	360	366	PF00069	0.496
MOD_Plk_1	377	383	PF00069	0.293
MOD_Plk_1	604	610	PF00069	0.333
MOD_Plk_1	744	750	PF00069	0.597
MOD_Plk_1	952	958	PF00069	0.495
MOD_Plk_4	1	7	PF00069	0.561
MOD_Plk_4	149	155	PF00069	0.483
MOD_Plk_4	182	188	PF00069	0.423
MOD_Plk_4	203	209	PF00069	0.426
MOD_Plk_4	260	266	PF00069	0.438
MOD_Plk_4	287	293	PF00069	0.662
MOD_Plk_4	313	319	PF00069	0.491
MOD_Plk_4	361	367	PF00069	0.470
MOD_Plk_4	431	437	PF00069	0.401
MOD_Plk_4	637	643	PF00069	0.463
MOD_Plk_4	716	722	PF00069	0.560
MOD_Plk_4	748	754	PF00069	0.525
MOD_Plk_4	775	781	PF00069	0.605
MOD_Plk_4	86	92	PF00069	0.585
MOD_ProDKin_1	10	16	PF00069	0.609
MOD_ProDKin_1	105	111	PF00069	0.633
MOD_ProDKin_1	222	228	PF00069	0.492
MOD_ProDKin_1	331	337	PF00069	0.574
MOD_ProDKin_1	347	353	PF00069	0.555
MOD_ProDKin_1	452	458	PF00069	0.365
MOD_ProDKin_1	511	517	PF00069	0.513
MOD_ProDKin_1	760	766	PF00069	0.762
MOD_ProDKin_1	796	802	PF00069	0.663
MOD_ProDKin_1	820	826	PF00069	0.574
MOD_ProDKin_1	926	932	PF00069	0.591
MOD_SUMO_rev_2	36	44	PF00179	0.613
MOD_SUMO_rev_2	577	583	PF00179	0.548
TRG_DiLeu_BaEn_1	118	123	PF01217	0.520
TRG_DiLeu_BaEn_1	203	208	PF01217	0.480
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.529
TRG_DiLeu_BaLyEn_6	848	853	PF01217	0.564
TRG_DiLeu_LyEn_5	118	123	PF01217	0.520
TRG_ENDOCYTIC_2	155	158	PF00928	0.380
TRG_ENDOCYTIC_2	404	407	PF00928	0.512
TRG_ENDOCYTIC_2	47	50	PF00928	0.514
TRG_ENDOCYTIC_2	482	485	PF00928	0.399
TRG_ER_diArg_1	874	877	PF00400	0.493
TRG_ER_diArg_1	937	939	PF00400	0.659
TRG_ER_diArg_1	988	990	PF00400	0.476
TRG_NLS_MonoExtC_3	283	288	PF00514	0.609
TRG_NLS_MonoExtN_4	282	289	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	1029	1033	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	999	1003	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ23	Leptomonas seymouri	38%	96%
A0A3S7X0K8	Leishmania donovani	92%	100%
A4HFK8	Leishmania braziliensis	69%	100%
A4I2P0	Leishmania infantum	91%	100%
E9AYY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%