LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WD_REPEATS_REGION domain-containing protein
Gene product:
WD domain, G-beta repeat, putative
Species:
Leishmania major
UniProt:
E9AD63_LEIMA
TriTrypDb:
LmjF.27.0860 , LMJLV39_270014300 * , LMJSD75_270014300
Length:
1037

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD63
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD63

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 37 41 PF00656 0.658
CLV_C14_Caspase3-7 696 700 PF00656 0.524
CLV_C14_Caspase3-7 786 790 PF00656 0.571
CLV_NRD_NRD_1 284 286 PF00675 0.618
CLV_NRD_NRD_1 550 552 PF00675 0.528
CLV_NRD_NRD_1 701 703 PF00675 0.483
CLV_NRD_NRD_1 743 745 PF00675 0.509
CLV_NRD_NRD_1 938 940 PF00675 0.662
CLV_NRD_NRD_1 988 990 PF00675 0.476
CLV_PCSK_KEX2_1 284 286 PF00082 0.618
CLV_PCSK_KEX2_1 581 583 PF00082 0.585
CLV_PCSK_KEX2_1 701 703 PF00082 0.483
CLV_PCSK_KEX2_1 743 745 PF00082 0.509
CLV_PCSK_KEX2_1 850 852 PF00082 0.563
CLV_PCSK_KEX2_1 938 940 PF00082 0.668
CLV_PCSK_KEX2_1 988 990 PF00082 0.476
CLV_PCSK_PC1ET2_1 284 286 PF00082 0.618
CLV_PCSK_PC1ET2_1 581 583 PF00082 0.518
CLV_PCSK_PC1ET2_1 850 852 PF00082 0.535
CLV_PCSK_SKI1_1 1029 1033 PF00082 0.524
CLV_PCSK_SKI1_1 182 186 PF00082 0.504
CLV_PCSK_SKI1_1 270 274 PF00082 0.390
CLV_PCSK_SKI1_1 706 710 PF00082 0.406
CLV_PCSK_SKI1_1 722 726 PF00082 0.471
CLV_PCSK_SKI1_1 850 854 PF00082 0.526
CLV_PCSK_SKI1_1 964 968 PF00082 0.384
DEG_APCC_DBOX_1 177 185 PF00400 0.406
DEG_APCC_DBOX_1 269 277 PF00400 0.468
DEG_APCC_DBOX_1 287 295 PF00400 0.511
DEG_APCC_DBOX_1 705 713 PF00400 0.436
DEG_APCC_DBOX_1 873 881 PF00400 0.485
DEG_MDM2_SWIB_1 748 756 PF02201 0.580
DEG_Nend_UBRbox_3 1 3 PF02207 0.639
DEG_SPOP_SBC_1 346 350 PF00917 0.547
DEG_SPOP_SBC_1 430 434 PF00917 0.368
DEG_SPOP_SBC_1 451 455 PF00917 0.402
DOC_CKS1_1 797 802 PF01111 0.660
DOC_CYCLIN_RxL_1 1026 1036 PF00134 0.576
DOC_CYCLIN_yCln2_LP_2 11 17 PF00134 0.546
DOC_CYCLIN_yCln2_LP_2 22 25 PF00134 0.614
DOC_MAPK_gen_1 116 124 PF00069 0.512
DOC_MAPK_gen_1 633 643 PF00069 0.422
DOC_MAPK_gen_1 701 709 PF00069 0.520
DOC_MAPK_MEF2A_6 636 643 PF00069 0.454
DOC_MAPK_MEF2A_6 836 845 PF00069 0.616
DOC_MAPK_NFAT4_5 636 644 PF00069 0.450
DOC_PP1_RVXF_1 119 126 PF00149 0.421
DOC_PP1_RVXF_1 464 471 PF00149 0.392
DOC_PP1_RVXF_1 962 968 PF00149 0.401
DOC_PP2B_LxvP_1 22 25 PF13499 0.642
DOC_PP2B_LxvP_1 566 569 PF13499 0.392
DOC_PP2B_LxvP_1 852 855 PF13499 0.543
DOC_PP2B_PxIxI_1 87 93 PF00149 0.518
DOC_PP4_FxxP_1 1024 1027 PF00568 0.406
DOC_PP4_FxxP_1 654 657 PF00568 0.364
DOC_PP4_FxxP_1 85 88 PF00568 0.582
DOC_USP7_MATH_1 162 166 PF00917 0.588
DOC_USP7_MATH_1 209 213 PF00917 0.379
DOC_USP7_MATH_1 311 315 PF00917 0.366
DOC_USP7_MATH_1 346 350 PF00917 0.634
DOC_USP7_MATH_1 351 355 PF00917 0.625
DOC_USP7_MATH_1 396 400 PF00917 0.577
DOC_USP7_MATH_1 451 455 PF00917 0.474
DOC_USP7_MATH_1 527 531 PF00917 0.450
DOC_USP7_MATH_1 544 548 PF00917 0.675
DOC_USP7_MATH_1 674 678 PF00917 0.521
DOC_USP7_MATH_1 685 689 PF00917 0.510
DOC_USP7_MATH_1 790 794 PF00917 0.583
DOC_USP7_MATH_1 806 810 PF00917 0.536
DOC_USP7_MATH_1 830 834 PF00917 0.598
DOC_USP7_MATH_1 919 923 PF00917 0.620
DOC_USP7_UBL2_3 656 660 PF12436 0.516
DOC_WW_Pin1_4 10 15 PF00397 0.602
DOC_WW_Pin1_4 105 110 PF00397 0.649
DOC_WW_Pin1_4 222 227 PF00397 0.479
DOC_WW_Pin1_4 331 336 PF00397 0.574
DOC_WW_Pin1_4 347 352 PF00397 0.552
DOC_WW_Pin1_4 452 457 PF00397 0.370
DOC_WW_Pin1_4 511 516 PF00397 0.511
DOC_WW_Pin1_4 760 765 PF00397 0.766
DOC_WW_Pin1_4 796 801 PF00397 0.668
DOC_WW_Pin1_4 820 825 PF00397 0.570
DOC_WW_Pin1_4 926 931 PF00397 0.593
LIG_14-3-3_CanoR_1 100 105 PF00244 0.497
LIG_14-3-3_CanoR_1 178 182 PF00244 0.433
LIG_14-3-3_CanoR_1 193 201 PF00244 0.406
LIG_14-3-3_CanoR_1 352 359 PF00244 0.622
LIG_14-3-3_CanoR_1 500 509 PF00244 0.475
LIG_14-3-3_CanoR_1 62 66 PF00244 0.583
LIG_14-3-3_CanoR_1 701 709 PF00244 0.499
LIG_14-3-3_CanoR_1 784 788 PF00244 0.566
LIG_14-3-3_CanoR_1 81 86 PF00244 0.434
LIG_14-3-3_CanoR_1 859 867 PF00244 0.553
LIG_14-3-3_CanoR_1 903 911 PF00244 0.526
LIG_14-3-3_CanoR_1 938 947 PF00244 0.729
LIG_APCC_ABBA_1 666 671 PF00400 0.392
LIG_BIR_III_2 789 793 PF00653 0.594
LIG_BIR_III_4 577 581 PF00653 0.563
LIG_BIR_III_4 993 997 PF00653 0.522
LIG_BRCT_BRCA1_1 254 258 PF00533 0.463
LIG_BRCT_BRCA1_1 313 317 PF00533 0.354
LIG_BRCT_BRCA1_1 81 85 PF00533 0.590
LIG_BRCT_BRCA1_1 822 826 PF00533 0.685
LIG_Clathr_ClatBox_1 840 844 PF01394 0.606
LIG_FHA_1 106 112 PF00498 0.611
LIG_FHA_1 127 133 PF00498 0.520
LIG_FHA_1 139 145 PF00498 0.375
LIG_FHA_1 202 208 PF00498 0.486
LIG_FHA_1 214 220 PF00498 0.288
LIG_FHA_1 245 251 PF00498 0.496
LIG_FHA_1 313 319 PF00498 0.426
LIG_FHA_1 332 338 PF00498 0.543
LIG_FHA_1 362 368 PF00498 0.495
LIG_FHA_1 378 384 PF00498 0.330
LIG_FHA_1 447 453 PF00498 0.440
LIG_FHA_1 512 518 PF00498 0.447
LIG_FHA_1 636 642 PF00498 0.484
LIG_FHA_1 68 74 PF00498 0.526
LIG_FHA_1 797 803 PF00498 0.665
LIG_FHA_1 858 864 PF00498 0.628
LIG_FHA_1 870 876 PF00498 0.408
LIG_FHA_1 927 933 PF00498 0.620
LIG_FHA_1 978 984 PF00498 0.417
LIG_FHA_2 154 160 PF00498 0.474
LIG_FHA_2 35 41 PF00498 0.675
LIG_FHA_2 423 429 PF00498 0.385
LIG_Integrin_RGD_1 633 635 PF01839 0.464
LIG_KLC1_Yacidic_2 401 406 PF13176 0.481
LIG_LIR_Apic_2 1023 1027 PF02991 0.475
LIG_LIR_Apic_2 82 88 PF02991 0.570
LIG_LIR_Gen_1 152 163 PF02991 0.434
LIG_LIR_Gen_1 255 266 PF02991 0.315
LIG_LIR_Gen_1 314 323 PF02991 0.474
LIG_LIR_Gen_1 433 442 PF02991 0.330
LIG_LIR_Gen_1 44 53 PF02991 0.519
LIG_LIR_Gen_1 481 489 PF02991 0.413
LIG_LIR_Gen_1 516 527 PF02991 0.445
LIG_LIR_Nem_3 152 158 PF02991 0.395
LIG_LIR_Nem_3 255 261 PF02991 0.329
LIG_LIR_Nem_3 314 320 PF02991 0.464
LIG_LIR_Nem_3 4 8 PF02991 0.439
LIG_LIR_Nem_3 401 407 PF02991 0.495
LIG_LIR_Nem_3 433 439 PF02991 0.344
LIG_LIR_Nem_3 44 50 PF02991 0.514
LIG_LIR_Nem_3 467 473 PF02991 0.480
LIG_LIR_Nem_3 481 485 PF02991 0.318
LIG_LIR_Nem_3 516 522 PF02991 0.410
LIG_LIR_Nem_3 900 904 PF02991 0.424
LIG_MYND_1 459 463 PF01753 0.396
LIG_NRBOX 862 868 PF00104 0.452
LIG_Pex14_2 138 142 PF04695 0.408
LIG_Pex14_2 748 752 PF04695 0.553
LIG_Pex14_2 986 990 PF04695 0.397
LIG_SH2_CRK 47 51 PF00017 0.586
LIG_SH2_NCK_1 155 159 PF00017 0.470
LIG_SH2_PTP2 404 407 PF00017 0.512
LIG_SH2_SRC 404 407 PF00017 0.512
LIG_SH2_SRC 970 973 PF00017 0.459
LIG_SH2_STAP1 47 51 PF00017 0.510
LIG_SH2_STAP1 482 486 PF00017 0.397
LIG_SH2_STAT5 153 156 PF00017 0.390
LIG_SH2_STAT5 174 177 PF00017 0.566
LIG_SH2_STAT5 366 369 PF00017 0.410
LIG_SH2_STAT5 375 378 PF00017 0.318
LIG_SH2_STAT5 404 407 PF00017 0.512
LIG_SH2_STAT5 928 931 PF00017 0.594
LIG_SH2_STAT5 984 987 PF00017 0.466
LIG_SH3_2 279 284 PF14604 0.603
LIG_SH3_3 20 26 PF00018 0.619
LIG_SH3_3 276 282 PF00018 0.517
LIG_SH3_3 453 459 PF00018 0.398
LIG_SH3_3 994 1000 PF00018 0.538
LIG_SH3_4 656 663 PF00018 0.494
LIG_SUMO_SIM_anti_2 1009 1015 PF11976 0.378
LIG_SUMO_SIM_anti_2 183 188 PF11976 0.395
LIG_SUMO_SIM_anti_2 801 806 PF11976 0.662
LIG_SUMO_SIM_par_1 329 334 PF11976 0.576
LIG_SUMO_SIM_par_1 378 384 PF11976 0.397
LIG_SUMO_SIM_par_1 600 605 PF11976 0.391
LIG_SUMO_SIM_par_1 690 696 PF11976 0.494
LIG_TRAF2_1 166 169 PF00917 0.479
LIG_TRAF2_1 93 96 PF00917 0.526
LIG_WRC_WIRS_1 1021 1026 PF05994 0.455
LIG_WW_3 1026 1030 PF00397 0.461
MOD_CDK_SPK_2 347 352 PF00069 0.517
MOD_CDK_SPK_2 760 765 PF00069 0.609
MOD_CDK_SPK_2 926 931 PF00069 0.669
MOD_CDK_SPxxK_3 511 518 PF00069 0.469
MOD_CK1_1 103 109 PF00069 0.506
MOD_CK1_1 177 183 PF00069 0.555
MOD_CK1_1 252 258 PF00069 0.442
MOD_CK1_1 290 296 PF00069 0.650
MOD_CK1_1 341 347 PF00069 0.614
MOD_CK1_1 36 42 PF00069 0.673
MOD_CK1_1 360 366 PF00069 0.359
MOD_CK1_1 446 452 PF00069 0.501
MOD_CK1_1 478 484 PF00069 0.388
MOD_CK1_1 763 769 PF00069 0.586
MOD_CK1_1 775 781 PF00069 0.545
MOD_CK1_1 835 841 PF00069 0.734
MOD_CK1_1 86 92 PF00069 0.611
MOD_CK1_1 913 919 PF00069 0.583
MOD_CK2_1 112 118 PF00069 0.523
MOD_CK2_1 153 159 PF00069 0.469
MOD_CK2_1 162 168 PF00069 0.489
MOD_CK2_1 395 401 PF00069 0.542
MOD_CK2_1 484 490 PF00069 0.406
MOD_CK2_1 723 729 PF00069 0.582
MOD_CK2_1 806 812 PF00069 0.589
MOD_Cter_Amidation 579 582 PF01082 0.629
MOD_Cter_Amidation 741 744 PF01082 0.481
MOD_GlcNHglycan 1006 1009 PF01048 0.503
MOD_GlcNHglycan 105 108 PF01048 0.511
MOD_GlcNHglycan 159 163 PF01048 0.565
MOD_GlcNHglycan 164 167 PF01048 0.521
MOD_GlcNHglycan 190 193 PF01048 0.437
MOD_GlcNHglycan 326 329 PF01048 0.577
MOD_GlcNHglycan 353 356 PF01048 0.621
MOD_GlcNHglycan 372 375 PF01048 0.317
MOD_GlcNHglycan 387 390 PF01048 0.574
MOD_GlcNHglycan 398 401 PF01048 0.661
MOD_GlcNHglycan 416 419 PF01048 0.339
MOD_GlcNHglycan 445 448 PF01048 0.437
MOD_GlcNHglycan 486 489 PF01048 0.424
MOD_GlcNHglycan 539 542 PF01048 0.593
MOD_GlcNHglycan 546 549 PF01048 0.572
MOD_GlcNHglycan 553 556 PF01048 0.471
MOD_GlcNHglycan 67 70 PF01048 0.535
MOD_GlcNHglycan 687 690 PF01048 0.419
MOD_GlcNHglycan 709 712 PF01048 0.489
MOD_GlcNHglycan 809 812 PF01048 0.684
MOD_GlcNHglycan 81 84 PF01048 0.476
MOD_GlcNHglycan 826 829 PF01048 0.466
MOD_GlcNHglycan 85 88 PF01048 0.470
MOD_GlcNHglycan 919 922 PF01048 0.711
MOD_GlcNHglycan 940 943 PF01048 0.595
MOD_GSK3_1 149 156 PF00069 0.427
MOD_GSK3_1 158 165 PF00069 0.452
MOD_GSK3_1 176 183 PF00069 0.313
MOD_GSK3_1 188 195 PF00069 0.394
MOD_GSK3_1 203 210 PF00069 0.348
MOD_GSK3_1 340 347 PF00069 0.604
MOD_GSK3_1 357 364 PF00069 0.467
MOD_GSK3_1 366 373 PF00069 0.338
MOD_GSK3_1 442 449 PF00069 0.480
MOD_GSK3_1 590 597 PF00069 0.486
MOD_GSK3_1 61 68 PF00069 0.576
MOD_GSK3_1 697 704 PF00069 0.461
MOD_GSK3_1 716 723 PF00069 0.452
MOD_GSK3_1 744 751 PF00069 0.664
MOD_GSK3_1 77 84 PF00069 0.406
MOD_GSK3_1 820 827 PF00069 0.627
MOD_GSK3_1 853 860 PF00069 0.574
MOD_GSK3_1 910 917 PF00069 0.648
MOD_GSK3_1 933 940 PF00069 0.636
MOD_GSK3_1 96 103 PF00069 0.504
MOD_LATS_1 412 418 PF00433 0.375
MOD_N-GLC_1 311 316 PF02516 0.430
MOD_N-GLC_1 323 328 PF02516 0.564
MOD_N-GLC_1 338 343 PF02516 0.495
MOD_N-GLC_1 674 679 PF02516 0.519
MOD_N-GLC_1 913 918 PF02516 0.558
MOD_N-GLC_1 952 957 PF02516 0.450
MOD_NEK2_1 1 6 PF00069 0.566
MOD_NEK2_1 202 207 PF00069 0.556
MOD_NEK2_1 213 218 PF00069 0.322
MOD_NEK2_1 304 309 PF00069 0.440
MOD_NEK2_1 340 345 PF00069 0.606
MOD_NEK2_1 368 373 PF00069 0.429
MOD_NEK2_1 395 400 PF00069 0.539
MOD_NEK2_1 495 500 PF00069 0.504
MOD_NEK2_1 53 58 PF00069 0.506
MOD_NEK2_1 590 595 PF00069 0.655
MOD_NEK2_1 707 712 PF00069 0.498
MOD_NEK2_1 748 753 PF00069 0.552
MOD_NEK2_1 783 788 PF00069 0.565
MOD_NEK2_1 826 831 PF00069 0.625
MOD_NEK2_1 846 851 PF00069 0.579
MOD_NEK2_1 937 942 PF00069 0.675
MOD_PIKK_1 594 600 PF00454 0.494
MOD_PIKK_1 701 707 PF00454 0.541
MOD_PIKK_1 830 836 PF00454 0.546
MOD_PIKK_1 858 864 PF00454 0.610
MOD_PKA_1 551 557 PF00069 0.457
MOD_PKA_1 701 707 PF00069 0.445
MOD_PKA_1 938 944 PF00069 0.655
MOD_PKA_2 1004 1010 PF00069 0.334
MOD_PKA_2 177 183 PF00069 0.430
MOD_PKA_2 192 198 PF00069 0.391
MOD_PKA_2 287 293 PF00069 0.688
MOD_PKA_2 324 330 PF00069 0.533
MOD_PKA_2 351 357 PF00069 0.623
MOD_PKA_2 443 449 PF00069 0.411
MOD_PKA_2 58 64 PF00069 0.611
MOD_PKA_2 701 707 PF00069 0.566
MOD_PKA_2 783 789 PF00069 0.573
MOD_PKA_2 835 841 PF00069 0.632
MOD_PKA_2 858 864 PF00069 0.572
MOD_PKA_2 902 908 PF00069 0.509
MOD_PKA_2 937 943 PF00069 0.796
MOD_Plk_1 202 208 PF00069 0.434
MOD_Plk_1 338 344 PF00069 0.576
MOD_Plk_1 360 366 PF00069 0.496
MOD_Plk_1 377 383 PF00069 0.293
MOD_Plk_1 604 610 PF00069 0.333
MOD_Plk_1 744 750 PF00069 0.597
MOD_Plk_1 952 958 PF00069 0.495
MOD_Plk_4 1 7 PF00069 0.561
MOD_Plk_4 149 155 PF00069 0.483
MOD_Plk_4 182 188 PF00069 0.423
MOD_Plk_4 203 209 PF00069 0.426
MOD_Plk_4 260 266 PF00069 0.438
MOD_Plk_4 287 293 PF00069 0.662
MOD_Plk_4 313 319 PF00069 0.491
MOD_Plk_4 361 367 PF00069 0.470
MOD_Plk_4 431 437 PF00069 0.401
MOD_Plk_4 637 643 PF00069 0.463
MOD_Plk_4 716 722 PF00069 0.560
MOD_Plk_4 748 754 PF00069 0.525
MOD_Plk_4 775 781 PF00069 0.605
MOD_Plk_4 86 92 PF00069 0.585
MOD_ProDKin_1 10 16 PF00069 0.609
MOD_ProDKin_1 105 111 PF00069 0.633
MOD_ProDKin_1 222 228 PF00069 0.492
MOD_ProDKin_1 331 337 PF00069 0.574
MOD_ProDKin_1 347 353 PF00069 0.555
MOD_ProDKin_1 452 458 PF00069 0.365
MOD_ProDKin_1 511 517 PF00069 0.513
MOD_ProDKin_1 760 766 PF00069 0.762
MOD_ProDKin_1 796 802 PF00069 0.663
MOD_ProDKin_1 820 826 PF00069 0.574
MOD_ProDKin_1 926 932 PF00069 0.591
MOD_SUMO_rev_2 36 44 PF00179 0.613
MOD_SUMO_rev_2 577 583 PF00179 0.548
TRG_DiLeu_BaEn_1 118 123 PF01217 0.520
TRG_DiLeu_BaEn_1 203 208 PF01217 0.480
TRG_DiLeu_BaLyEn_6 554 559 PF01217 0.529
TRG_DiLeu_BaLyEn_6 848 853 PF01217 0.564
TRG_DiLeu_LyEn_5 118 123 PF01217 0.520
TRG_ENDOCYTIC_2 155 158 PF00928 0.380
TRG_ENDOCYTIC_2 404 407 PF00928 0.512
TRG_ENDOCYTIC_2 47 50 PF00928 0.514
TRG_ENDOCYTIC_2 482 485 PF00928 0.399
TRG_ER_diArg_1 874 877 PF00400 0.493
TRG_ER_diArg_1 937 939 PF00400 0.659
TRG_ER_diArg_1 988 990 PF00400 0.476
TRG_NLS_MonoExtC_3 283 288 PF00514 0.609
TRG_NLS_MonoExtN_4 282 289 PF00514 0.601
TRG_Pf-PMV_PEXEL_1 1029 1033 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 257 262 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.498
TRG_Pf-PMV_PEXEL_1 999 1003 PF00026 0.451

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ23 Leptomonas seymouri 38% 96%
A0A3S7X0K8 Leishmania donovani 92% 100%
A4HFK8 Leishmania braziliensis 69% 100%
A4I2P0 Leishmania infantum 91% 100%
E9AYY8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS