Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD62_LEIMA

TriTrypDb:

LmjF.27.0850 , LMJLV39_270014200 , LMJSD75_270014200

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.725
CLV_C14_Caspase3-7	28	32	PF00656	0.583
CLV_C14_Caspase3-7	510	514	PF00656	0.518
CLV_MEL_PAP_1	382	388	PF00089	0.486
CLV_NRD_NRD_1	151	153	PF00675	0.588
CLV_NRD_NRD_1	213	215	PF00675	0.524
CLV_NRD_NRD_1	301	303	PF00675	0.577
CLV_NRD_NRD_1	316	318	PF00675	0.618
CLV_NRD_NRD_1	360	362	PF00675	0.627
CLV_NRD_NRD_1	45	47	PF00675	0.693
CLV_NRD_NRD_1	454	456	PF00675	0.504
CLV_NRD_NRD_1	464	466	PF00675	0.622
CLV_NRD_NRD_1	527	529	PF00675	0.662
CLV_NRD_NRD_1	561	563	PF00675	0.662
CLV_NRD_NRD_1	64	66	PF00675	0.371
CLV_PCSK_FUR_1	358	362	PF00082	0.618
CLV_PCSK_KEX2_1	151	153	PF00082	0.588
CLV_PCSK_KEX2_1	213	215	PF00082	0.524
CLV_PCSK_KEX2_1	301	303	PF00082	0.577
CLV_PCSK_KEX2_1	315	317	PF00082	0.591
CLV_PCSK_KEX2_1	360	362	PF00082	0.627
CLV_PCSK_KEX2_1	45	47	PF00082	0.682
CLV_PCSK_KEX2_1	454	456	PF00082	0.504
CLV_PCSK_KEX2_1	527	529	PF00082	0.662
CLV_PCSK_KEX2_1	563	565	PF00082	0.735
CLV_PCSK_KEX2_1	63	65	PF00082	0.388
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.735
CLV_PCSK_SKI1_1	366	370	PF00082	0.667
CLV_PCSK_SKI1_1	443	447	PF00082	0.529
CLV_PCSK_SKI1_1	45	49	PF00082	0.565
CLV_PCSK_SKI1_1	483	487	PF00082	0.619
CLV_PCSK_SKI1_1	503	507	PF00082	0.520
CLV_PCSK_SKI1_1	563	567	PF00082	0.652
DEG_SCF_FBW7_1	187	194	PF00400	0.595
DOC_CKS1_1	192	197	PF01111	0.586
DOC_CYCLIN_RxL_1	360	373	PF00134	0.641
DOC_MAPK_gen_1	155	164	PF00069	0.481
DOC_MAPK_gen_1	319	329	PF00069	0.703
DOC_MAPK_MEF2A_6	322	331	PF00069	0.605
DOC_MAPK_MEF2A_6	349	356	PF00069	0.562
DOC_MAPK_MEF2A_6	483	492	PF00069	0.582
DOC_PP2B_LxvP_1	138	141	PF13499	0.455
DOC_PP2B_LxvP_1	230	233	PF13499	0.588
DOC_PP4_FxxP_1	120	123	PF00568	0.618
DOC_PP4_FxxP_1	268	271	PF00568	0.504
DOC_USP7_MATH_1	109	113	PF00917	0.713
DOC_USP7_MATH_1	123	127	PF00917	0.529
DOC_USP7_MATH_1	173	177	PF00917	0.570
DOC_USP7_MATH_1	19	23	PF00917	0.569
DOC_USP7_MATH_1	288	292	PF00917	0.534
DOC_USP7_MATH_1	413	417	PF00917	0.660
DOC_USP7_MATH_1	445	449	PF00917	0.557
DOC_USP7_MATH_1	461	465	PF00917	0.618
DOC_USP7_MATH_1	511	515	PF00917	0.702
DOC_USP7_MATH_1	523	527	PF00917	0.773
DOC_WW_Pin1_4	119	124	PF00397	0.654
DOC_WW_Pin1_4	187	192	PF00397	0.594
DOC_WW_Pin1_4	45	50	PF00397	0.518
DOC_WW_Pin1_4	521	526	PF00397	0.651
LIG_14-3-3_CanoR_1	172	178	PF00244	0.501
LIG_14-3-3_CanoR_1	301	311	PF00244	0.587
LIG_14-3-3_CanoR_1	340	345	PF00244	0.430
LIG_14-3-3_CanoR_1	385	391	PF00244	0.614
LIG_14-3-3_CanoR_1	402	408	PF00244	0.522
LIG_14-3-3_CanoR_1	465	473	PF00244	0.600
LIG_14-3-3_CanoR_1	483	489	PF00244	0.531
LIG_14-3-3_CanoR_1	527	534	PF00244	0.723
LIG_14-3-3_CanoR_1	556	565	PF00244	0.599
LIG_CtBP_PxDLS_1	351	355	PF00389	0.495
LIG_DLG_GKlike_1	304	311	PF00625	0.497
LIG_FAT_LD_1	50	58	PF03623	0.527
LIG_FHA_1	188	194	PF00498	0.589
LIG_FHA_1	292	298	PF00498	0.578
LIG_FHA_1	425	431	PF00498	0.597
LIG_FHA_1	485	491	PF00498	0.644
LIG_FHA_2	433	439	PF00498	0.618
LIG_FHA_2	46	52	PF00498	0.547
LIG_FHA_2	508	514	PF00498	0.611
LIG_FHA_2	545	551	PF00498	0.586
LIG_LIR_Apic_2	117	123	PF02991	0.615
LIG_LIR_Apic_2	219	225	PF02991	0.554
LIG_LIR_Apic_2	403	408	PF02991	0.644
LIG_LIR_Gen_1	196	207	PF02991	0.552
LIG_LIR_Nem_3	133	138	PF02991	0.446
LIG_LIR_Nem_3	196	202	PF02991	0.548
LIG_LIR_Nem_3	219	224	PF02991	0.594
LIG_LIR_Nem_3	343	347	PF02991	0.549
LIG_LIR_Nem_3	406	412	PF02991	0.652
LIG_Pex14_1	502	506	PF04695	0.505
LIG_SH2_CRK	199	203	PF00017	0.482
LIG_SH2_CRK	405	409	PF00017	0.651
LIG_SH2_GRB2like	203	206	PF00017	0.570
LIG_SH2_NCK_1	199	203	PF00017	0.541
LIG_SH2_NCK_1	405	409	PF00017	0.651
LIG_SH2_SRC	203	206	PF00017	0.570
LIG_SH2_STAP1	199	203	PF00017	0.541
LIG_SH2_STAP1	75	79	PF00017	0.599
LIG_SH2_STAT3	339	342	PF00017	0.549
LIG_SH2_STAT3	419	422	PF00017	0.606
LIG_SH2_STAT5	137	140	PF00017	0.495
LIG_SH2_STAT5	203	206	PF00017	0.570
LIG_SH2_STAT5	405	408	PF00017	0.594
LIG_SH3_1	405	411	PF00018	0.650
LIG_SH3_2	522	527	PF14604	0.623
LIG_SH3_3	228	234	PF00018	0.496
LIG_SH3_3	361	367	PF00018	0.703
LIG_SH3_3	405	411	PF00018	0.788
LIG_SH3_3	427	433	PF00018	0.636
LIG_SH3_3	519	525	PF00018	0.621
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.613
LIG_SUMO_SIM_anti_2	487	492	PF11976	0.620
LIG_SUMO_SIM_par_1	484	489	PF11976	0.571
LIG_TRAF2_1	477	480	PF00917	0.592
LIG_TRAF2_1	98	101	PF00917	0.546
LIG_WW_3	152	156	PF00397	0.482
MOD_CDC14_SPxK_1	524	527	PF00782	0.627
MOD_CDK_SPxK_1	521	527	PF00069	0.624
MOD_CDK_SPxxK_3	521	528	PF00069	0.626
MOD_CK1_1	111	117	PF00069	0.655
MOD_CK1_1	22	28	PF00069	0.533
MOD_CK1_1	255	261	PF00069	0.698
MOD_CK1_1	291	297	PF00069	0.508
MOD_CK1_1	306	312	PF00069	0.569
MOD_CK1_1	526	532	PF00069	0.730
MOD_CK1_1	537	543	PF00069	0.549
MOD_CK1_1	544	550	PF00069	0.513
MOD_CK1_1	552	558	PF00069	0.605
MOD_CK2_1	332	338	PF00069	0.516
MOD_CK2_1	432	438	PF00069	0.706
MOD_CK2_1	445	451	PF00069	0.663
MOD_CK2_1	45	51	PF00069	0.553
MOD_CK2_1	456	462	PF00069	0.565
MOD_CK2_1	544	550	PF00069	0.599
MOD_Cter_Amidation	43	46	PF01082	0.609
MOD_GlcNHglycan	114	117	PF01048	0.690
MOD_GlcNHglycan	16	19	PF01048	0.490
MOD_GlcNHglycan	167	170	PF01048	0.500
MOD_GlcNHglycan	234	237	PF01048	0.696
MOD_GlcNHglycan	259	263	PF01048	0.685
MOD_GlcNHglycan	373	376	PF01048	0.579
MOD_GlcNHglycan	388	391	PF01048	0.450
MOD_GlcNHglycan	447	450	PF01048	0.617
MOD_GlcNHglycan	539	542	PF01048	0.683
MOD_GSK3_1	108	115	PF00069	0.702
MOD_GSK3_1	119	126	PF00069	0.595
MOD_GSK3_1	183	190	PF00069	0.559
MOD_GSK3_1	193	200	PF00069	0.573
MOD_GSK3_1	248	255	PF00069	0.684
MOD_GSK3_1	300	307	PF00069	0.636
MOD_GSK3_1	461	468	PF00069	0.703
MOD_GSK3_1	492	499	PF00069	0.605
MOD_GSK3_1	507	514	PF00069	0.556
MOD_GSK3_1	517	524	PF00069	0.658
MOD_GSK3_1	532	539	PF00069	0.685
MOD_GSK3_1	540	547	PF00069	0.696
MOD_GSK3_1	550	557	PF00069	0.653
MOD_N-GLC_1	255	260	PF02516	0.614
MOD_NEK2_1	14	19	PF00069	0.513
MOD_NEK2_1	144	149	PF00069	0.441
MOD_NEK2_1	164	169	PF00069	0.344
MOD_NEK2_1	248	253	PF00069	0.641
MOD_NEK2_1	386	391	PF00069	0.595
MOD_NEK2_1	492	497	PF00069	0.728
MOD_NEK2_1	512	517	PF00069	0.625
MOD_NEK2_1	534	539	PF00069	0.633
MOD_NEK2_2	400	405	PF00069	0.629
MOD_PIKK_1	403	409	PF00454	0.646
MOD_PIKK_1	492	498	PF00454	0.640
MOD_PK_1	527	533	PF00069	0.638
MOD_PKA_1	465	471	PF00069	0.665
MOD_PKA_1	527	533	PF00069	0.638
MOD_PKA_2	144	150	PF00069	0.439
MOD_PKA_2	171	177	PF00069	0.548
MOD_PKA_2	300	306	PF00069	0.590
MOD_PKA_2	384	390	PF00069	0.615
MOD_PKA_2	526	532	PF00069	0.693
MOD_PKA_2	535	541	PF00069	0.705
MOD_PKA_2	555	561	PF00069	0.504
MOD_PKB_1	302	310	PF00069	0.534
MOD_Plk_1	183	189	PF00069	0.533
MOD_Plk_1	512	518	PF00069	0.665
MOD_Plk_2-3	101	107	PF00069	0.534
MOD_Plk_2-3	332	338	PF00069	0.516
MOD_Plk_2-3	475	481	PF00069	0.597
MOD_Plk_4	173	179	PF00069	0.535
MOD_Plk_4	206	212	PF00069	0.573
MOD_Plk_4	340	346	PF00069	0.545
MOD_Plk_4	432	438	PF00069	0.567
MOD_Plk_4	467	473	PF00069	0.529
MOD_Plk_4	512	518	PF00069	0.695
MOD_ProDKin_1	119	125	PF00069	0.654
MOD_ProDKin_1	187	193	PF00069	0.590
MOD_ProDKin_1	45	51	PF00069	0.515
MOD_ProDKin_1	521	527	PF00069	0.654
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.650
TRG_ENDOCYTIC_2	135	138	PF00928	0.390
TRG_ENDOCYTIC_2	199	202	PF00928	0.511
TRG_ENDOCYTIC_2	409	412	PF00928	0.646
TRG_ER_diArg_1	10	13	PF00400	0.559
TRG_ER_diArg_1	151	153	PF00400	0.531
TRG_ER_diArg_1	213	215	PF00400	0.524
TRG_ER_diArg_1	300	302	PF00400	0.529
TRG_ER_diArg_1	315	317	PF00400	0.647
TRG_ER_diArg_1	324	327	PF00400	0.686
TRG_ER_diArg_1	357	360	PF00400	0.562
TRG_ER_diArg_1	562	565	PF00400	0.617
TRG_ER_diArg_1	62	65	PF00400	0.487
TRG_NES_CRM1_1	479	493	PF08389	0.626
TRG_NLS_MonoExtC_3	561	566	PF00514	0.655
TRG_NLS_MonoExtN_4	562	567	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z3	Leptomonas seymouri	51%	100%
A0A3R7MFI4	Trypanosoma rangeli	31%	100%
A0A3S7X0J7	Leishmania donovani	92%	100%
A4HFK7	Leishmania braziliensis	74%	100%
A4I2N9	Leishmania infantum	92%	100%
E9AYY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	96%