Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD61_LEIMA

TriTrypDb:

LmjF.27.0840 , LMJLV39_270014100 , LMJSD75_270014100

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.390
CLV_C14_Caspase3-7	824	828	PF00656	0.605
CLV_NRD_NRD_1	190	192	PF00675	0.568
CLV_NRD_NRD_1	222	224	PF00675	0.519
CLV_NRD_NRD_1	411	413	PF00675	0.452
CLV_NRD_NRD_1	476	478	PF00675	0.363
CLV_NRD_NRD_1	6	8	PF00675	0.581
CLV_NRD_NRD_1	61	63	PF00675	0.468
CLV_NRD_NRD_1	799	801	PF00675	0.503
CLV_PCSK_KEX2_1	190	192	PF00082	0.627
CLV_PCSK_KEX2_1	222	224	PF00082	0.504
CLV_PCSK_KEX2_1	411	413	PF00082	0.446
CLV_PCSK_KEX2_1	43	45	PF00082	0.573
CLV_PCSK_KEX2_1	476	478	PF00082	0.363
CLV_PCSK_KEX2_1	6	8	PF00082	0.581
CLV_PCSK_KEX2_1	61	63	PF00082	0.360
CLV_PCSK_KEX2_1	799	801	PF00082	0.503
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.521
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.475
CLV_PCSK_SKI1_1	155	159	PF00082	0.333
CLV_PCSK_SKI1_1	246	250	PF00082	0.419
CLV_PCSK_SKI1_1	265	269	PF00082	0.230
CLV_PCSK_SKI1_1	292	296	PF00082	0.557
CLV_PCSK_SKI1_1	43	47	PF00082	0.451
CLV_PCSK_SKI1_1	516	520	PF00082	0.479
CLV_PCSK_SKI1_1	615	619	PF00082	0.468
CLV_PCSK_SKI1_1	69	73	PF00082	0.498
CLV_PCSK_SKI1_1	799	803	PF00082	0.500
DEG_APCC_DBOX_1	396	404	PF00400	0.351
DEG_APCC_DBOX_1	5	13	PF00400	0.571
DEG_APCC_DBOX_1	68	76	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.519
DEG_SCF_FBW7_2	782	788	PF00400	0.347
DEG_SPOP_SBC_1	303	307	PF00917	0.484
DEG_SPOP_SBC_1	638	642	PF00917	0.457
DOC_CDC14_PxL_1	552	560	PF14671	0.331
DOC_CKS1_1	782	787	PF01111	0.393
DOC_CYCLIN_RxL_1	360	369	PF00134	0.424
DOC_CYCLIN_yClb1_LxF_4	242	248	PF00134	0.393
DOC_MAPK_gen_1	289	297	PF00069	0.558
DOC_MAPK_gen_1	3	11	PF00069	0.549
DOC_MAPK_gen_1	43	53	PF00069	0.573
DOC_MAPK_gen_1	462	472	PF00069	0.474
DOC_MAPK_gen_1	541	549	PF00069	0.320
DOC_MAPK_gen_1	604	613	PF00069	0.296
DOC_MAPK_MEF2A_6	383	390	PF00069	0.536
DOC_MAPK_MEF2A_6	615	622	PF00069	0.424
DOC_MAPK_NFAT4_5	383	391	PF00069	0.422
DOC_MAPK_NFAT4_5	615	623	PF00069	0.426
DOC_PP1_RVXF_1	142	148	PF00149	0.375
DOC_PP1_RVXF_1	153	159	PF00149	0.331
DOC_PP1_SILK_1	512	517	PF00149	0.408
DOC_PP4_FxxP_1	658	661	PF00568	0.472
DOC_PP4_FxxP_1	802	805	PF00568	0.501
DOC_USP7_MATH_1	113	117	PF00917	0.481
DOC_USP7_MATH_1	118	122	PF00917	0.401
DOC_USP7_MATH_1	233	237	PF00917	0.386
DOC_USP7_MATH_1	304	308	PF00917	0.721
DOC_USP7_MATH_1	510	514	PF00917	0.520
DOC_USP7_MATH_1	638	642	PF00917	0.526
DOC_USP7_MATH_1	756	760	PF00917	0.558
DOC_USP7_MATH_1	90	94	PF00917	0.498
DOC_USP7_UBL2_3	188	192	PF12436	0.518
DOC_USP7_UBL2_3	43	47	PF12436	0.525
DOC_WW_Pin1_4	114	119	PF00397	0.447
DOC_WW_Pin1_4	714	719	PF00397	0.538
DOC_WW_Pin1_4	781	786	PF00397	0.364
DOC_WW_Pin1_4	790	795	PF00397	0.442
LIG_14-3-3_CanoR_1	193	201	PF00244	0.508
LIG_14-3-3_CanoR_1	414	423	PF00244	0.385
LIG_14-3-3_CanoR_1	433	443	PF00244	0.483
LIG_14-3-3_CanoR_1	44	54	PF00244	0.485
LIG_14-3-3_CanoR_1	503	507	PF00244	0.468
LIG_14-3-3_CanoR_1	598	602	PF00244	0.492
LIG_14-3-3_CanoR_1	6	10	PF00244	0.543
LIG_14-3-3_CanoR_1	61	71	PF00244	0.389
LIG_14-3-3_CanoR_1	636	646	PF00244	0.480
LIG_14-3-3_CanoR_1	649	653	PF00244	0.331
LIG_14-3-3_CanoR_1	687	697	PF00244	0.426
LIG_14-3-3_CanoR_1	747	753	PF00244	0.734
LIG_Actin_WH2_1	241	258	PF00022	0.464
LIG_Actin_WH2_2	233	248	PF00022	0.435
LIG_Actin_WH2_2	396	413	PF00022	0.393
LIG_Actin_WH2_2	486	502	PF00022	0.412
LIG_Actin_WH2_2	511	529	PF00022	0.488
LIG_Actin_WH2_2	554	572	PF00022	0.394
LIG_Actin_WH2_2	579	597	PF00022	0.388
LIG_APCC_ABBA_1	655	660	PF00400	0.470
LIG_APCC_ABBA_1	676	681	PF00400	0.384
LIG_BIR_III_2	533	537	PF00653	0.406
LIG_BRCT_BRCA1_1	348	352	PF00533	0.519
LIG_Clathr_ClatBox_1	731	735	PF01394	0.303
LIG_DCNL_PONY_1	1	4	PF03556	0.647
LIG_deltaCOP1_diTrp_1	180	186	PF00928	0.422
LIG_FHA_1	418	424	PF00498	0.500
LIG_FHA_1	755	761	PF00498	0.481
LIG_FHA_1	766	772	PF00498	0.512
LIG_FHA_1	817	823	PF00498	0.466
LIG_FHA_1	824	830	PF00498	0.390
LIG_FHA_2	131	137	PF00498	0.423
LIG_FHA_2	147	153	PF00498	0.256
LIG_FHA_2	473	479	PF00498	0.444
LIG_FHA_2	55	61	PF00498	0.457
LIG_FHA_2	598	604	PF00498	0.476
LIG_FHA_2	791	797	PF00498	0.472
LIG_GBD_Chelix_1	582	590	PF00786	0.449
LIG_LIR_Apic_2	550	554	PF02991	0.380
LIG_LIR_Gen_1	162	173	PF02991	0.460
LIG_LIR_Gen_1	199	209	PF02991	0.378
LIG_LIR_Gen_1	273	281	PF02991	0.508
LIG_LIR_Gen_1	467	473	PF02991	0.439
LIG_LIR_Gen_1	677	686	PF02991	0.457
LIG_LIR_Gen_1	735	741	PF02991	0.409
LIG_LIR_Gen_1	78	88	PF02991	0.351
LIG_LIR_Nem_3	135	141	PF02991	0.358
LIG_LIR_Nem_3	162	168	PF02991	0.471
LIG_LIR_Nem_3	199	204	PF02991	0.378
LIG_LIR_Nem_3	273	277	PF02991	0.444
LIG_LIR_Nem_3	283	287	PF02991	0.508
LIG_LIR_Nem_3	355	361	PF02991	0.478
LIG_LIR_Nem_3	447	451	PF02991	0.382
LIG_LIR_Nem_3	467	472	PF02991	0.333
LIG_LIR_Nem_3	533	538	PF02991	0.382
LIG_LIR_Nem_3	677	682	PF02991	0.426
LIG_LIR_Nem_3	735	739	PF02991	0.366
LIG_LIR_Nem_3	78	84	PF02991	0.338
LIG_LYPXL_S_1	137	141	PF13949	0.397
LIG_LYPXL_yS_3	138	141	PF13949	0.402
LIG_LYPXL_yS_3	284	287	PF13949	0.445
LIG_NRBOX	23	29	PF00104	0.460
LIG_NRBOX	557	563	PF00104	0.422
LIG_NRBOX	727	733	PF00104	0.346
LIG_PCNA_PIPBox_1	39	48	PF02747	0.335
LIG_PCNA_yPIPBox_3	33	46	PF02747	0.359
LIG_Pex14_1	182	186	PF04695	0.398
LIG_Pex14_2	270	274	PF04695	0.400
LIG_REV1ctd_RIR_1	849	859	PF16727	0.509
LIG_SH2_PTP2	551	554	PF00017	0.391
LIG_SH2_SRC	551	554	PF00017	0.391
LIG_SH2_STAT3	332	335	PF00017	0.473
LIG_SH2_STAT3	522	525	PF00017	0.435
LIG_SH2_STAT5	126	129	PF00017	0.469
LIG_SH2_STAT5	217	220	PF00017	0.428
LIG_SH2_STAT5	551	554	PF00017	0.431
LIG_SH2_STAT5	736	739	PF00017	0.385
LIG_SH2_STAT5	778	781	PF00017	0.412
LIG_SH3_3	169	175	PF00018	0.451
LIG_SH3_3	341	347	PF00018	0.690
LIG_SH3_3	550	556	PF00018	0.334
LIG_SH3_3	613	619	PF00018	0.408
LIG_Sin3_3	384	391	PF02671	0.373
LIG_Sin3_3	81	88	PF02671	0.363
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.432
LIG_SUMO_SIM_anti_2	819	824	PF11976	0.595
LIG_SUMO_SIM_par_1	138	143	PF11976	0.463
LIG_SUMO_SIM_par_1	674	681	PF11976	0.382
LIG_SUMO_SIM_par_1	818	824	PF11976	0.461
LIG_TRAF2_1	438	441	PF00917	0.513
LIG_TYR_ITIM	356	361	PF00017	0.474
LIG_UBA3_1	27	31	PF00899	0.425
LIG_WRC_WIRS_1	469	474	PF05994	0.444
MOD_CK1_1	196	202	PF00069	0.412
MOD_CK1_1	298	304	PF00069	0.481
MOD_CK1_1	447	453	PF00069	0.419
MOD_CK1_1	482	488	PF00069	0.519
MOD_CK1_1	639	645	PF00069	0.515
MOD_CK1_1	647	653	PF00069	0.387
MOD_CK1_1	714	720	PF00069	0.533
MOD_CK2_1	130	136	PF00069	0.426
MOD_CK2_1	146	152	PF00069	0.362
MOD_CK2_1	334	340	PF00069	0.522
MOD_CK2_1	434	440	PF00069	0.525
MOD_CK2_1	597	603	PF00069	0.474
MOD_CK2_1	647	653	PF00069	0.334
MOD_CK2_1	677	683	PF00069	0.551
MOD_CK2_1	859	865	PF00069	0.563
MOD_Cter_Amidation	4	7	PF01082	0.572
MOD_GlcNHglycan	162	165	PF01048	0.432
MOD_GlcNHglycan	177	180	PF01048	0.403
MOD_GlcNHglycan	198	201	PF01048	0.419
MOD_GlcNHglycan	292	295	PF01048	0.553
MOD_GlcNHglycan	348	351	PF01048	0.529
MOD_GlcNHglycan	375	378	PF01048	0.578
MOD_GlcNHglycan	415	418	PF01048	0.435
MOD_GlcNHglycan	437	440	PF01048	0.620
MOD_GlcNHglycan	563	566	PF01048	0.466
MOD_GlcNHglycan	576	579	PF01048	0.514
MOD_GlcNHglycan	728	731	PF01048	0.381
MOD_GlcNHglycan	806	809	PF01048	0.558
MOD_GlcNHglycan	812	815	PF01048	0.573
MOD_GSK3_1	114	121	PF00069	0.357
MOD_GSK3_1	15	22	PF00069	0.404
MOD_GSK3_1	227	234	PF00069	0.459
MOD_GSK3_1	295	302	PF00069	0.645
MOD_GSK3_1	413	420	PF00069	0.455
MOD_GSK3_1	468	475	PF00069	0.426
MOD_GSK3_1	557	564	PF00069	0.413
MOD_GSK3_1	584	591	PF00069	0.479
MOD_GSK3_1	637	644	PF00069	0.546
MOD_GSK3_1	663	670	PF00069	0.507
MOD_GSK3_1	784	791	PF00069	0.452
MOD_GSK3_1	855	862	PF00069	0.525
MOD_N-GLC_1	193	198	PF02516	0.410
MOD_N-GLC_1	250	255	PF02516	0.391
MOD_N-GLC_1	63	68	PF02516	0.502
MOD_N-GLC_1	663	668	PF02516	0.433
MOD_N-GLC_2	464	466	PF02516	0.282
MOD_NEK2_1	160	165	PF00069	0.526
MOD_NEK2_1	186	191	PF00069	0.560
MOD_NEK2_1	210	215	PF00069	0.396
MOD_NEK2_1	354	359	PF00069	0.483
MOD_NEK2_1	434	439	PF00069	0.602
MOD_NEK2_1	472	477	PF00069	0.442
MOD_NEK2_1	499	504	PF00069	0.459
MOD_NEK2_1	584	589	PF00069	0.374
MOD_NEK2_1	837	842	PF00069	0.553
MOD_PK_1	855	861	PF00069	0.531
MOD_PKA_2	298	304	PF00069	0.641
MOD_PKA_2	372	378	PF00069	0.370
MOD_PKA_2	413	419	PF00069	0.385
MOD_PKA_2	432	438	PF00069	0.421
MOD_PKA_2	5	11	PF00069	0.482
MOD_PKA_2	502	508	PF00069	0.500
MOD_PKA_2	569	575	PF00069	0.471
MOD_PKA_2	597	603	PF00069	0.569
MOD_PKA_2	648	654	PF00069	0.319
MOD_PKA_2	667	673	PF00069	0.428
MOD_PKB_1	191	199	PF00069	0.388
MOD_Plk_1	250	256	PF00069	0.411
MOD_Plk_1	299	305	PF00069	0.532
MOD_Plk_1	354	360	PF00069	0.492
MOD_Plk_1	625	631	PF00069	0.458
MOD_Plk_1	90	96	PF00069	0.377
MOD_Plk_2-3	334	340	PF00069	0.389
MOD_Plk_2-3	677	683	PF00069	0.371
MOD_Plk_4	250	256	PF00069	0.461
MOD_Plk_4	468	474	PF00069	0.432
MOD_Plk_4	488	494	PF00069	0.381
MOD_Plk_4	510	516	PF00069	0.453
MOD_Plk_4	557	563	PF00069	0.348
MOD_Plk_4	667	673	PF00069	0.480
MOD_Plk_4	756	762	PF00069	0.446
MOD_Plk_4	816	822	PF00069	0.425
MOD_Plk_4	855	861	PF00069	0.433
MOD_Plk_4	90	96	PF00069	0.394
MOD_ProDKin_1	114	120	PF00069	0.439
MOD_ProDKin_1	714	720	PF00069	0.539
MOD_ProDKin_1	781	787	PF00069	0.368
MOD_ProDKin_1	790	796	PF00069	0.442
MOD_SUMO_for_1	46	49	PF00179	0.459
TRG_AP2beta_CARGO_1	467	476	PF09066	0.377
TRG_DiLeu_BaEn_1	235	240	PF01217	0.525
TRG_DiLeu_BaEn_1	681	686	PF01217	0.413
TRG_DiLeu_BaEn_2	275	281	PF01217	0.404
TRG_DiLeu_BaEn_2	40	46	PF01217	0.526
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.420
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.383
TRG_DiLeu_BaLyEn_6	671	676	PF01217	0.389
TRG_ENDOCYTIC_2	138	141	PF00928	0.358
TRG_ENDOCYTIC_2	284	287	PF00928	0.495
TRG_ENDOCYTIC_2	358	361	PF00928	0.467
TRG_ENDOCYTIC_2	736	739	PF00928	0.415
TRG_ENDOCYTIC_2	778	781	PF00928	0.362
TRG_ER_diArg_1	108	111	PF00400	0.451
TRG_ER_diArg_1	397	400	PF00400	0.494
TRG_ER_diArg_1	410	412	PF00400	0.385
TRG_ER_diArg_1	798	800	PF00400	0.503
TRG_NLS_MonoCore_2	189	194	PF00514	0.440
TRG_NLS_MonoExtN_4	188	195	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	799	803	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC39	Leptomonas seymouri	49%	98%
A0A1X0P545	Trypanosomatidae	32%	99%
A0A3R7KBK6	Trypanosoma rangeli	33%	100%
A0A3S7X0J4	Leishmania donovani	93%	100%
A4HFK6	Leishmania braziliensis	79%	100%
A4I2N8	Leishmania infantum	92%	100%
D0A5T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AYY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BE63	Trypanosoma cruzi	34%	100%