Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AD60_LEIMA

TriTrypDb:

LmjF.27.0830 , LMJLV39_270014000 , LMJSD75_270014000

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AD60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.737
CLV_C14_Caspase3-7	50	54	PF00656	0.658
CLV_NRD_NRD_1	174	176	PF00675	0.675
CLV_NRD_NRD_1	19	21	PF00675	0.728
CLV_NRD_NRD_1	296	298	PF00675	0.605
CLV_NRD_NRD_1	312	314	PF00675	0.654
CLV_NRD_NRD_1	394	396	PF00675	0.644
CLV_NRD_NRD_1	397	399	PF00675	0.674
CLV_NRD_NRD_1	463	465	PF00675	0.707
CLV_PCSK_FUR_1	395	399	PF00082	0.661
CLV_PCSK_KEX2_1	174	176	PF00082	0.679
CLV_PCSK_KEX2_1	19	21	PF00082	0.728
CLV_PCSK_KEX2_1	298	300	PF00082	0.616
CLV_PCSK_KEX2_1	311	313	PF00082	0.641
CLV_PCSK_KEX2_1	396	398	PF00082	0.665
CLV_PCSK_KEX2_1	462	464	PF00082	0.698
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.616
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.665
CLV_PCSK_SKI1_1	271	275	PF00082	0.622
CLV_PCSK_SKI1_1	397	401	PF00082	0.599
CLV_PCSK_SKI1_1	439	443	PF00082	0.556
DEG_SPOP_SBC_1	374	378	PF00917	0.610
DOC_CKS1_1	56	61	PF01111	0.616
DOC_MAPK_gen_1	216	224	PF00069	0.697
DOC_PP2B_LxvP_1	110	113	PF13499	0.663
DOC_PP2B_LxvP_1	205	208	PF13499	0.759
DOC_PP4_FxxP_1	326	329	PF00568	0.709
DOC_USP7_MATH_1	114	118	PF00917	0.752
DOC_USP7_MATH_1	133	137	PF00917	0.478
DOC_USP7_MATH_1	233	237	PF00917	0.751
DOC_USP7_MATH_1	259	263	PF00917	0.685
DOC_USP7_MATH_1	364	368	PF00917	0.768
DOC_WW_Pin1_4	126	131	PF00397	0.764
DOC_WW_Pin1_4	169	174	PF00397	0.709
DOC_WW_Pin1_4	229	234	PF00397	0.744
DOC_WW_Pin1_4	331	336	PF00397	0.731
DOC_WW_Pin1_4	55	60	PF00397	0.611
LIG_14-3-3_CanoR_1	115	121	PF00244	0.764
LIG_14-3-3_CanoR_1	189	193	PF00244	0.688
LIG_14-3-3_CanoR_1	199	207	PF00244	0.627
LIG_14-3-3_CanoR_1	271	280	PF00244	0.666
LIG_14-3-3_CanoR_1	311	318	PF00244	0.657
LIG_14-3-3_CanoR_1	445	453	PF00244	0.634
LIG_14-3-3_CanoR_1	78	82	PF00244	0.686
LIG_14-3-3_CanoR_1	90	99	PF00244	0.440
LIG_APCC_ABBA_1	300	305	PF00400	0.758
LIG_APCC_ABBA_1	327	332	PF00400	0.680
LIG_BRCT_BRCA1_1	283	287	PF00533	0.579
LIG_BRCT_BRCA1_2	283	289	PF00533	0.577
LIG_EVH1_1	110	114	PF00568	0.789
LIG_FHA_1	105	111	PF00498	0.693
LIG_FHA_1	304	310	PF00498	0.774
LIG_FHA_1	376	382	PF00498	0.711
LIG_FHA_1	398	404	PF00498	0.629
LIG_FHA_1	430	436	PF00498	0.661
LIG_FHA_1	438	444	PF00498	0.538
LIG_FHA_1	92	98	PF00498	0.640
LIG_FHA_2	272	278	PF00498	0.670
LIG_FHA_2	66	72	PF00498	0.593
LIG_LIR_Apic_2	204	209	PF02991	0.765
LIG_LIR_Apic_2	324	329	PF02991	0.707
LIG_LIR_Gen_1	45	56	PF02991	0.627
LIG_LIR_Nem_3	262	266	PF02991	0.641
LIG_LIR_Nem_3	45	51	PF02991	0.627
LIG_Pex14_2	213	217	PF04695	0.682
LIG_Pex14_2	326	330	PF04695	0.752
LIG_Pex14_2	343	347	PF04695	0.449
LIG_SH2_CRK	266	270	PF00017	0.763
LIG_SH2_GRB2like	346	349	PF00017	0.530
LIG_SH2_NCK_1	318	322	PF00017	0.550
LIG_SH2_SRC	206	209	PF00017	0.765
LIG_SH2_SRC	318	321	PF00017	0.549
LIG_SH2_STAP1	387	391	PF00017	0.589
LIG_SH2_STAT5	206	209	PF00017	0.765
LIG_SH2_STAT5	266	269	PF00017	0.719
LIG_SH2_STAT5	303	306	PF00017	0.659
LIG_SH2_STAT5	346	349	PF00017	0.530
LIG_SH2_STAT5	385	388	PF00017	0.612
LIG_SH2_STAT5	57	60	PF00017	0.782
LIG_SH3_1	206	212	PF00018	0.763
LIG_SH3_2	170	175	PF14604	0.677
LIG_SH3_3	108	114	PF00018	0.689
LIG_SH3_3	167	173	PF00018	0.715
LIG_SH3_3	206	212	PF00018	0.639
LIG_SH3_3	53	59	PF00018	0.659
LIG_SH3_3	96	102	PF00018	0.720
LIG_SUMO_SIM_par_1	100	109	PF11976	0.739
LIG_SUMO_SIM_par_1	220	227	PF11976	0.791
LIG_TRAF2_1	14	17	PF00917	0.762
LIG_TYR_ITSM	262	269	PF00017	0.763
LIG_WW_3	112	116	PF00397	0.712
LIG_WW_3	207	211	PF00397	0.759
MOD_CDC14_SPxK_1	172	175	PF00782	0.667
MOD_CDK_SPK_2	169	174	PF00069	0.709
MOD_CDK_SPK_2	331	336	PF00069	0.731
MOD_CDK_SPxK_1	169	175	PF00069	0.682
MOD_CK1_1	11	17	PF00069	0.768
MOD_CK1_1	129	135	PF00069	0.770
MOD_CK1_1	201	207	PF00069	0.708
MOD_CK1_1	21	27	PF00069	0.559
MOD_CK1_1	437	443	PF00069	0.590
MOD_CK2_1	11	17	PF00069	0.752
MOD_CK2_1	220	226	PF00069	0.787
MOD_CK2_1	44	50	PF00069	0.727
MOD_Cter_Amidation	309	312	PF01082	0.703
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.689
MOD_GlcNHglycan	10	13	PF01048	0.755
MOD_GlcNHglycan	131	134	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.676
MOD_GlcNHglycan	2	5	PF01048	0.762
MOD_GlcNHglycan	246	249	PF01048	0.806
MOD_GlcNHglycan	283	286	PF01048	0.689
MOD_GlcNHglycan	35	38	PF01048	0.632
MOD_GSK3_1	11	18	PF00069	0.748
MOD_GSK3_1	125	132	PF00069	0.712
MOD_GSK3_1	133	140	PF00069	0.746
MOD_GSK3_1	229	236	PF00069	0.824
MOD_GSK3_1	271	278	PF00069	0.651
MOD_GSK3_1	360	367	PF00069	0.672
MOD_GSK3_1	412	419	PF00069	0.712
MOD_GSK3_1	65	72	PF00069	0.671
MOD_N-GLC_1	229	234	PF02516	0.755
MOD_N-GLC_1	69	74	PF02516	0.581
MOD_NEK2_1	188	193	PF00069	0.659
MOD_NEK2_1	330	335	PF00069	0.709
MOD_NEK2_1	434	439	PF00069	0.589
MOD_NEK2_1	8	13	PF00069	0.684
MOD_NEK2_2	261	266	PF00069	0.762
MOD_OFUCOSY	258	265	PF10250	0.766
MOD_PIKK_1	233	239	PF00454	0.815
MOD_PIKK_1	69	75	PF00454	0.563
MOD_PKA_1	311	317	PF00069	0.653
MOD_PKA_1	397	403	PF00069	0.676
MOD_PKA_2	114	120	PF00069	0.807
MOD_PKA_2	18	24	PF00069	0.751
MOD_PKA_2	188	194	PF00069	0.677
MOD_PKA_2	198	204	PF00069	0.639
MOD_PKA_2	311	317	PF00069	0.702
MOD_PKA_2	357	363	PF00069	0.654
MOD_PKA_2	397	403	PF00069	0.676
MOD_PKA_2	415	421	PF00069	0.708
MOD_PKA_2	444	450	PF00069	0.624
MOD_PKA_2	77	83	PF00069	0.734
MOD_PKB_1	311	319	PF00069	0.740
MOD_PKB_1	395	403	PF00069	0.668
MOD_Plk_1	201	207	PF00069	0.685
MOD_Plk_1	304	310	PF00069	0.741
MOD_Plk_1	407	413	PF00069	0.661
MOD_Plk_4	177	183	PF00069	0.652
MOD_Plk_4	201	207	PF00069	0.681
MOD_Plk_4	44	50	PF00069	0.699
MOD_ProDKin_1	126	132	PF00069	0.762
MOD_ProDKin_1	169	175	PF00069	0.704
MOD_ProDKin_1	229	235	PF00069	0.746
MOD_ProDKin_1	331	337	PF00069	0.728
MOD_ProDKin_1	55	61	PF00069	0.613
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.599
TRG_ENDOCYTIC_2	266	269	PF00928	0.703
TRG_ER_diArg_1	173	175	PF00400	0.652
TRG_ER_diArg_1	296	299	PF00400	0.635
TRG_ER_diArg_1	311	313	PF00400	0.608
TRG_ER_diArg_1	395	398	PF00400	0.660
TRG_ER_diArg_1	462	464	PF00400	0.706
TRG_NLS_MonoExtC_3	296	301	PF00514	0.657
TRG_NLS_MonoExtN_4	295	302	PF00514	0.656
TRG_NLS_MonoExtN_4	395	400	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D2	Leptomonas seymouri	38%	83%
A0A3S7X0I5	Leishmania donovani	93%	100%
A4HFK5	Leishmania braziliensis	73%	99%
E9AHF5	Leishmania infantum	93%	100%
E9AYY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DA38	Trypanosoma cruzi	25%	100%