Glutaredoxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin-like protein

Species:

Leishmania major

UniProt:

E9AD58_LEIMA

TriTrypDb:

LmjF.27.0810 , LMJLV39_270013800 , LMJSD75_270013800

Length:

109

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AD58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD58

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0006979	response to oxidative stress	3	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034599	cellular response to oxidative stress	4	2
GO:0042221	response to chemical	2	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0062197	cellular response to chemical stress	4	2
GO:0070887	cellular response to chemical stimulus	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	9
GO:0019153	protein-disulfide reductase (glutathione) activity	4	9
GO:0097573	obsolete glutathione oxidoreductase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.350
CLV_PCSK_SKI1_1	42	46	PF00082	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_PP1_RVXF_1	24	31	PF00149	0.331
DOC_PP2B_PxIxI_1	79	85	PF00149	0.365
DOC_USP7_MATH_1	36	40	PF00917	0.389
DOC_USP7_UBL2_3	42	46	PF12436	0.396
LIG_14-3-3_CanoR_1	9	15	PF00244	0.574
LIG_BRCT_BRCA1_1	2	6	PF00533	0.604
LIG_FHA_1	66	72	PF00498	0.458
LIG_FHA_2	15	21	PF00498	0.554
LIG_Pex14_2	2	6	PF04695	0.487
LIG_PTB_Apo_2	82	89	PF02174	0.365
LIG_SH2_STAT5	37	40	PF00017	0.308
LIG_SH3_3	30	36	PF00018	0.331
LIG_UBA3_1	44	50	PF00899	0.322
MOD_CK1_1	10	16	PF00069	0.591
MOD_CK2_1	14	20	PF00069	0.579
MOD_GlcNHglycan	100	103	PF01048	0.509
MOD_GSK3_1	10	17	PF00069	0.644
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	7	12	PF00069	0.630
MOD_PIKK_1	20	26	PF00454	0.298
MOD_PIKK_1	65	71	PF00454	0.233
MOD_PKA_2	8	14	PF00069	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF5	Leptomonas seymouri	74%	100%
A0A0N1PD78	Leptomonas seymouri	28%	100%
A0A0S4JTJ5	Bodo saltans	24%	88%
A0A0S4JUD4	Bodo saltans	47%	100%
A0A0S4JWT8	Bodo saltans	32%	100%
A0A0S4KNN2	Bodo saltans	33%	100%
A0A1X0NXP8	Trypanosomatidae	29%	100%
A0A3Q8IG95	Leishmania donovani	94%	100%
A0A3S7WVZ7	Leishmania donovani	28%	100%
A0A422NLI8	Trypanosoma rangeli	30%	100%
A4HYU2	Leishmania infantum	28%	100%
B7ZFT1	Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)	36%	100%
C9ZIB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A5S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AHF3	Leishmania infantum	94%	100%
E9AIF1	Leishmania braziliensis	28%	100%
E9AIS6	Leishmania braziliensis	73%	100%
E9AUN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O23417	Arabidopsis thaliana	26%	100%
O23419	Arabidopsis thaliana	26%	100%
O23421	Arabidopsis thaliana	27%	100%
O36032	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P0AC62	Escherichia coli (strain K12)	36%	100%
P0AC63	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AC64	Escherichia coli O157:H7	36%	100%
P10575	Bos taurus	35%	100%
P12309	Sus scrofa	34%	100%
P12864	Oryctolagus cuniculus	38%	100%
P17695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	76%
P25373	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	99%
P35754	Homo sapiens	40%	100%
P55142	Oryza sativa subsp. japonica	36%	97%
P55143	Ricinus communis	38%	100%
P73492	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P74593	Synechocystis sp. (strain PCC 6803 / Kazusa)	33%	100%
Q0DAE4	Oryza sativa subsp. japonica	35%	80%
Q0IMV4	Oryza sativa subsp. japonica	28%	100%
Q0IRB0	Oryza sativa subsp. japonica	31%	100%
Q0J3L4	Oryza sativa subsp. japonica	32%	66%
Q19297	Caenorhabditis elegans	39%	75%
Q1RHJ0	Rickettsia bellii (strain RML369-C)	35%	100%
Q2R073	Oryza sativa subsp. japonica	31%	100%
Q2R075	Oryza sativa subsp. japonica	32%	100%
Q32L67	Bos taurus	33%	69%
Q4QCU5	Leishmania major	28%	100%
Q4UKL7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	35%	100%
Q54GP8	Dictyostelium discoideum	39%	100%
Q5RC53	Pongo abelii	34%	68%
Q68XG4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	34%	100%
Q6AXW1	Rattus norvegicus	35%	69%
Q6H628	Oryza sativa subsp. japonica	33%	83%
Q6K953	Oryza sativa subsp. japonica	39%	82%
Q8L8T2	Arabidopsis thaliana	34%	87%
Q8L8Z8	Arabidopsis thaliana	26%	100%
Q8LFQ6	Arabidopsis thaliana	38%	81%
Q923X4	Mus musculus	34%	70%
Q92J02	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	36%	100%
Q9ESH6	Rattus norvegicus	38%	100%
Q9FNE2	Arabidopsis thaliana	36%	98%
Q9FVX1	Arabidopsis thaliana	38%	84%
Q9HU55	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	39%	100%
Q9LYC8	Arabidopsis thaliana	33%	100%
Q9NS18	Homo sapiens	34%	66%
Q9QUH0	Mus musculus	37%	100%
Q9SA68	Arabidopsis thaliana	32%	100%
Q9UTI2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	99%
Q9ZDW1	Rickettsia prowazekii (strain Madrid E)	35%	100%
Q9ZR41	Solanum lycopersicum	31%	100%